%PDF-1.4
%
1 0 obj
<<
/Title (Could Terrorists Exploit Synthetic Biology?)
/Author (Jonathan B. Tucker)
/Creator (Adobe InDesign CS2 \(4.0\))
/ModDate (D:20110805171148-04'00')
/Trapped /False
/Producer (PDF-XChange Viewer [Version: 2.0 \(Build 53.0\) \(Jun 28 2010; 18:41:31\)])
/CreationDate (D:20110805171044-04'00')
>>
endobj
2 0 obj
<<
/Type /Catalog
/Pages 3 0 R
/Metadata 4 0 R
/PageLabels 5 0 R
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
3 0 obj
<<
/Kids [6 0 R 7 0 R]
/Type /Pages
/Count 13
>>
endobj
4 0 obj
<<
/Type /Metadata
/Length 15365
/Subtype /XML
>>
stream
2011-08-05T17:10:44-04:00
2011-08-05T17:10:46-04:00
Adobe InDesign CS2 (4.0)
JPEG
256
256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2011-08-05T17:11:48-04:00
384bed63-02c9-11db-ae1d-8fc2e1e1913c
adobe:docid:indd:21d7a101-abf9-11e0-a1cf-b8e6eb772727
proof:pdf
3f17f97a-81b2-11e0-b2d7-b7abe6b6e69a
adobe:docid:indd:f19dc98d-75a9-11e0-8643-92025c2803c4
application/pdf
Could Terrorists Exploit Synthetic Biology?
Jonathan B. Tucker
Print
False
PDF-XChange Viewer [Version: 2.0 (Build 53.0) (Jun 28 2010; 18:41:31)]
endstream
endobj
5 0 obj
<<
/Nums [0 8 0 R]
>>
endobj
6 0 obj
<<
/Kids [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R]
/Type /Pages
/Count 5
/Parent 3 0 R
>>
endobj
7 0 obj
<<
/Kids [14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R]
/Type /Pages
/Count 8
/Parent 3 0 R
>>
endobj
8 0 obj
<<
/S /D
/St 69
>>
endobj
9 0 obj
<<
/Type /Page
/Annots [22 0 R]
/ArtBox [0 0 504 792]
/Parent 6 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 23 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 27 0 R
/T1_4 28 0 R
/T1_5 29 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
10 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 6 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 33 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 27 0 R
/T1_3 26 0 R
/T1_4 28 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
11 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 6 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 34 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
/T1_4 27 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
12 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 6 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 35 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
13 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 6 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 36 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
/T1_4 27 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
14 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 37 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
15 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 38 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 27 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
16 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 39 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 27 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
17 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 40 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
18 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 41 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
/T1_4 27 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
19 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 42 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 43 0 R
/T1_4 28 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
20 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 44 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
21 0 obj
<<
/Type /Page
/ArtBox [0 0 504 792]
/Parent 7 0 R
/CropBox [0 0 504 792]
/TrimBox [0 0 504 792]
/BleedBox [0 0 504 792]
/Contents 45 0 R
/MediaBox [0 0 504 792]
/Resources <<
/Font <<
/T1_0 24 0 R
/T1_1 25 0 R
/T1_2 26 0 R
/T1_3 28 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 30 0 R
/GS1 31 0 R
>>
/ColorSpace <<
/CS0 32 0 R
>>
>>
>>
endobj
22 0 obj
<<
/A <<
/S /URI
/URI (http://www.TheNewAtlantis.com/)
>>
/C [0 0 0]
/H /P
/M (D:20110805171145-04'00')
/P 9 0 R
/NM (16febf14-6d92-42d4-acc40617514c473f)
/Rect [191.25 711.75 315 765]
/Border [0 0 0]
/Subtype /Link
>>
endobj
23 0 obj
<<
/Length 91179
>>
stream
q
0 0 504 792 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(6)-5(9)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
BT
/T1_2 1 Tf
21 0 0 21 73 562.5862 Tm
(T)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 88.0989 562.5862 Tm
[(he )-188(emergence )-188(o)19(v)23(er )-188(the )-188(past )-188(decade )-188(of)-28( )-188(synthetic )-188(genomics)40(, )-188(a )-188(set )-188(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 548.5862 Tm
[(methods )30(f)13(or )30(the )30(synthesis )30(of)-28( )30(entire )30(microbial )30(genomes )30(from )30(simple )30(chemi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 548.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 534.5862 Tm
[(cal )-140(b)14(uilding )-140(b)17(locks)40(, )-140(has )-140(elicited )-140(concer)-40(ns )-140(a)13(bout )-140(the )-140(potential )-140(misuse )-140(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 520.5862 Tm
[(this )-52(technolo)13(g)-40(y )-52(f)13(or )-52(har)-22(mful )-52(pur)-13(poses)40(. )-52(In )-52(2002, )-52(scientists )-52(a)25(t )-52(Stony )-52(Brook )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 506.5862 Tm
[(Univ)23(er)-13(sity )-78(recrea)25(ted )-78(the )-78(polio )-78(vir)-13(us )-78(from )-78(scr)-12(a)25(tch )-78(based )-78(on )-78(its )-78(pub)17(lished )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 492.5862 Tm
[(genetic )-301(sequence)13(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 161.1964 495.5562 Tm
(1)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 165.6964 492.5862 Tm
[( )-301(This )-301(demonstr)-12(a)25(tion )-301(prompted )-301(fear)-13(s )-301(tha)25(t )-301(ter)-13(rorist )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 478.5862 Tm
[(org)22(aniza)25(tions )38(might )38(e)-23(xploit )38(the )38(same )38(technique )38(to )38(synthesize )38(more )38(deadl)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 464.5862 Tm
[(vir)-12(al )-52(a)14(gents)40(, )-52(such )-52(the )-52(smallpo)26(x )-52(vir)-13(us)40(, )-52(as )-52(biolo)13(gical )-52(w)13(eapons)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 368.8727 467.5562 Tm
(2)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 373.3727 464.5862 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 376.9988 464.5862 Tm
[(Since )-52(then, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 450.5862 Tm
[(le)-10(gitima)25(te )39(scientists )39(ha)20(v)23(e )39(recrea)25(ted )39(other )39(pa)25(tho)13(genic )39(vir)-13(uses )39(in )39(the )39(la)13(bor)-12(a)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 450.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 436.5862 Tm
[(tor)-25(y)121(, )-13(including )-13(a )-13(SARS-lik)39(e )-13(vir)-13(us )-13(and )-13(the )-13(f)13(or)-22(merl)25(y )-13(e)-23(xtinct )-13(str)-12(ain )-13(of)-28( )-13(inf)17(lu)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 436.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 422.5862 Tm
[(enza )-163(vir)-13(us )-163(responsib)17(le )-163(f)13(or )-163(the )-163(1918-19 )-163(\223Spanish )-163(F)-20(lu\224)-13( )-163(pandemic)22(, )-163(which )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 408.5862 Tm
[(is )-116(estima)25(ted )-116(to )-116(ha)20(v)23(e )-116(infected )-116(a )-116(third )-116(of)-28( )-116(the )-116(world )-116(popula)25(tion )-116(and )-116(killed )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 394.5862 Tm
[(three )-65(to )-65(fiv)23(e )-65(percent.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 176.194 397.5562 Tm
(3)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 180.694 394.5862 Tm
[( )-65(\(The )-65(scientific )-65(r)-12(a)25(tionale )-65(f)13(or )-65(resur)-13(recting )-65(the )-65(1918 )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 380.5862 Tm
[(inf)17(luenza )6(vir)-13(us )6(was )6(to )6(g)22(ain )6(insight )6(into )6(the )6(genetic )6(factor)-13(s )6(tha)25(t )6(made )6(it )6(so )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 366.5862 Tm
[(vir)-13(ulent, )-68(thereb)13(y )-68(guiding )-68(the )-68(de)10(v)23(elopment )-68(of)-28( )-68(antivir)-12(al )-68(dr)-13(ugs )-68(tha)25(t )-68(would )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 352.5862 Tm
[(be )-25(effectiv)23(e )-25(a)14(g)22(ainst )-25(future )-25(pandemic )-25(str)-12(ains )-25(of)-28( )-25(the )-25(disease)13(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 356.6397 355.5562 Tm
(4)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 361.1397 352.5862 Tm
(\))Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 338.5862 Tm
[(In )38(assessing )38(the )38(risk )38(tha)25(t )38(would-be )38(bioter)-13(rorists )38(could )38(misuse )38(synthet)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 338.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 324.5862 Tm
[(ic )-65(genomics )-65(to )-65(recrea)25(te )-65(dangerous )-65(vir)-13(uses)40(, )-65(a )-65(centr)-12(al )-65(question )-65(is )-65(whether )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 310.5862 Tm
[(they )-95(could )-95(master )-95(the )-95(necessar)-25(y )-95(technical )-95(skills)40(. )-95(Sk)39(e)-13(ptics )-95(point )-95(out )-95(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 296.5862 Tm
[(whole-genome )-171(synthesis )-171(demands )-171(multiple )-171(sets )-171(of)-28( )-171(e)-23(xper)-17(tise)13(, )-171(including )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 282.5862 Tm
[(consider)-12(a)13(b)17(le )-36(\223tacit )-36(kno)13(wledge\224)-13( )-36(tha)25(t )-36(cannot )-36(be )-36(tr)-12(ansmitted )-36(in )-36(writing )-36(b)14(ut )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 268.5862 Tm
[(must )-84(be )-84(g)22(ained )-84(through )-84(y)32(ear)-13(s )-84(of)-28( )-84(hands-on )-84(e)-23(xperience )-84(in )-84(the )-84(la)13(bor)-12(a)25(tor)-25(y)113(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 254.5862 Tm
[(Other )-134(scholar)-13(s )-134(disa)14(g)-33(ree)13(, )-134(arguing )-134(tha)25(t )-134(genome )-134(synthesis )-134(is )-134(subject )-134(to )-134(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 240.5862 Tm
[(process )-85(of)-28( )-85(\223de-skilling)26(,\224)-13( )-85(a )-85(g)-33(r)-12(adual )-85(decline )-85(in )-85(the )-85(amount )-85(of)-28( )-85(tacit )-85(kno)13(wl)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 240.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 226.5862 Tm
[(edge )21(required )21(to )21(master )21(the )21(technolo)13(g)-40(y )21(tha)25(t )21(will )21(e)10(v)23(entuall)25(y )21(mak)39(e )21(it )21(acces)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 226.5862 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 212.5862 Tm
[(sib)17(le )-100(to )-100(non-e)-23(xper)-17(ts)40(, )-100(including )-100(those )-100(with )-100(malicious )-100(intent. )-100(This )-100(deba)25(te )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 198.5862 Tm
[(is )-22(of)-28( )-22(more )-22(than )-22(academic )-22(interest )-22(because )-22(it )-22(is )-22(centr)-12(al )-22(to )-22(deter)-22(mining )-22(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 184.5862 Tm
[(security )-13(risks )-13(associa)25(ted )-13(with )-13(the )-13(r)-12(apid )-13(pro)13(g)-33(ress )-13(of)-28( )-13(biolo)13(gical )-13(science )-13(and )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 170.5862 Tm
[(technolo)13(g)-40(y)113(.)]TJ
ET
BT
/T1_3 1 Tf
22 0 0 22 129.4818 648.874 Tm
[(C)-10(o)-10(u)-10(l)-10(d)-10( )-37(T)21(e)-10(r)3(r)9(o)-10(r)-10(i)-10(s)-10(t)-10(s)-10( )-37(E)-10(x)-10(p)-10(l)-10(o)-10(i)-10(t)]TJ
ET
BT
/T1_3 1 Tf
22 0 0 22 374.5182 648.874 Tm
( )Tj
ET
BT
/T1_3 1 Tf
22 0 0 22 158.792 624.874 Tm
[(S)-10(y)-10(n)-10(t)-10(h)-10(e)-10(t)-10(i)-10(c)-10( )-37(B)-10(i)-10(o)-10(l)-10(o)-10(g)-10(y)-10(?)]TJ
ET
BT
/T1_4 1 Tf
15 0 0 15 195.2408 602.714 Tm
[(J)16(o)-5(n)-5(a)-4(t)-5(h)-5(a)-5(n)-5( )-29(B)-5(.)-5( )-29(T)49(u)-5(c)-5(k)-15(e)-5(r)]TJ
ET
BT
/T1_5 1 Tf
10.5 0 0 10.5 73.0008 127.3343 Tm
[(J)38(onathan )-213(B)-37(. )-213(T)63(uck)13(er)]TJ
ET
BT
/T1_4 1 Tf
10.5 0 0 10.5 164.3797 127.3343 Tm
[( )-192(mana)-1(g)-13(es )-192(the )-192(Biosecurity )-192(Educa)1(tion )-192(Pr)13(oject )-192(a)1(t )-192(the )-192(F)80(eder)55(a)1(tion )-192(of)-42( )]TJ
ET
BT
/T1_4 1 Tf
10.5 0 0 10.5 73.0008 116.8343 Tm
[(American )15(Scientists )15(in )15(W)106(ashington, )15(D)57(.C)23(. )15(His )15(most )15(r)20(ecent )15(book )15(is )]TJ
ET
BT
/T1_2 1 Tf
10.5 0 0 10.5 324.2786 116.8343 Tm
[(W)94(ar )15(of)-28( )15(Ner)-26(v)23(es: )15(Chemical )]TJ
ET
BT
/T1_2 1 Tf
10.5 0 0 10.5 73.0008 106.3343 Tm
[(W)94(arfare )-25(from )-25(W)102(orld )-25(W)94(ar )-25(I )-25(to )-25(Al-Qaeda)]TJ
ET
BT
/T1_4 1 Tf
10.5 0 0 10.5 244.6943 106.3343 Tm
[( )-24(\(P)50(antheon )-24(Books)-33(, )-24(2006\).)]TJ
ET
1 w 4 M
72 146 m
432 146 l
S
1 1 1 scn
/GS1 gs
197.576 712 108.848 44 re
f*
/PlacedGraphic BMC
EMC
q
197.576 712 108.848 44 re
W* n
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
366.616 -550.98 m
365.837 -551.012 365.287 -551.027 364.968 -551.027 c
362.813 -551.027 361.251 -550.578 360.283 -549.679 c
359.315 -548.778 358.752 -547.98 358.593 -547.279 c
358.545 -547.028 358.417 -546.904 358.207 -546.904 c
358.112 -546.904 358.022 -546.954 357.936 -547.057 c
357.986 -548.253 358.177 -549.863 358.512 -551.891 c
359.426 -551.891 l
360.204 -551.891 361.248 -551.85 362.558 -551.77 c
363.967 -551.69 366.124 -551.651 369.032 -551.651 c
372.01 -551.651 373.948 -551.687 374.847 -551.764 c
375.666 -551.849 376.791 -551.891 378.22 -551.891 c
378.338 -551.17 378.416 -550.419 378.458 -549.637 c
378.516 -548.746 378.575 -548.12 378.636 -547.761 c
378.646 -547.681 378.651 -547.595 378.651 -547.505 c
378.651 -547.264 378.547 -547.143 378.341 -547.143 c
378.213 -547.143 378.107 -547.187 378.024 -547.27 c
377.939 -547.354 377.746 -547.637 377.444 -548.114 c
376.918 -548.92 376.372 -549.529 375.806 -549.942 c
375.241 -550.354 374.61 -550.621 373.912 -550.742 c
373.215 -550.86 371.806 -550.939 369.684 -550.98 c
369.588 -549.473 369.54 -547.752 369.54 -545.814 c
369.54 -539.405 369.677 -535.629 369.952 -534.48 c
370.228 -533.333 371.212 -532.759 372.904 -532.759 c
373.316 -532.759 373.52 -532.671 373.52 -532.494 c
373.52 -532.288 373.326 -532.183 372.938 -532.183 c
363.761 -532.183 l
363.522 -532.183 363.403 -532.281 363.403 -532.478 c
363.403 -532.675 363.635 -532.772 364.102 -532.772 c
364.887 -532.772 365.522 -532.996 366.004 -533.439 c
366.486 -533.884 366.764 -534.486 366.839 -535.245 c
366.913 -536.003 366.951 -538.194 366.951 -541.816 c
366.951 -544.911 366.838 -547.966 366.616 -550.98 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
392.129 -539.388 m
392.225 -542.287 l
392.225 -543.558 392.096 -544.394 391.839 -544.794 c
391.582 -545.194 391.153 -545.394 390.547 -545.394 c
390.195 -545.394 390.02 -545.47 390.02 -545.621 c
390.02 -545.758 390.125 -545.825 390.336 -545.825 c
393.397 -545.729 l
395.995 -545.778 l
396.199 -545.778 396.302 -545.714 396.302 -545.587 c
396.302 -545.474 396.235 -545.418 396.102 -545.418 c
395.57 -545.418 395.157 -545.341 394.862 -545.186 c
394.569 -545.034 394.373 -544.771 394.28 -544.401 c
394.186 -544.031 394.108 -542.975 394.048 -541.233 c
393.989 -539.49 393.959 -538.226 393.959 -537.436 c
393.928 -534.859 l
393.928 -534.056 394.004 -533.535 394.157 -533.293 c
394.31 -533.052 394.539 -532.864 394.841 -532.727 c
395.144 -532.591 395.454 -532.506 395.776 -532.471 c
395.998 -532.444 396.11 -532.38 396.11 -532.28 c
396.11 -532.159 396.016 -532.099 395.826 -532.099 c
392.607 -532.183 l
390.506 -532.111 l
390.261 -532.111 390.14 -532.176 390.14 -532.303 c
390.14 -532.408 390.227 -532.465 390.399 -532.471 c
390.956 -532.506 391.319 -532.58 391.489 -532.69 c
391.658 -532.803 391.797 -533.017 391.901 -533.33 c
392.004 -533.645 392.063 -534.176 392.077 -534.924 c
392.129 -538.729 l
391.526 -538.777 390.914 -538.801 390.289 -538.801 c
387.578 -538.801 385.858 -538.751 385.129 -538.654 c
385.073 -537.311 385.046 -536.207 385.046 -535.34 c
385.046 -534.368 385.066 -533.77 385.108 -533.547 c
385.15 -533.323 385.281 -533.115 385.5 -532.923 c
385.72 -532.73 386.02 -532.596 386.405 -532.518 c
386.64 -532.469 386.76 -532.39 386.76 -532.281 c
386.76 -532.153 386.682 -532.088 386.53 -532.088 c
386.481 -532.088 386.41 -532.096 386.32 -532.111 c
385.942 -532.159 385.162 -532.183 383.977 -532.183 c
382.687 -532.183 381.894 -532.154 381.602 -532.099 c
381.539 -532.091 381.477 -532.088 381.414 -532.088 c
381.254 -532.088 381.173 -532.142 381.173 -532.248 c
381.173 -532.369 381.282 -532.443 381.498 -532.471 c
382.035 -532.533 382.42 -532.684 382.65 -532.922 c
382.882 -533.158 383.04 -534.051 383.127 -535.595 c
383.215 -537.139 383.259 -539.014 383.259 -541.222 c
383.259 -543.017 383.175 -544.148 383.007 -544.619 c
382.839 -545.085 382.428 -545.346 381.777 -545.394 c
381.63 -545.409 381.556 -545.465 381.556 -545.565 c
381.556 -545.706 381.706 -545.778 382.008 -545.778 c
386.227 -545.849 l
386.528 -545.849 386.706 -545.841 386.766 -545.824 c
386.824 -545.806 386.855 -545.751 386.855 -545.657 c
386.855 -545.55 386.764 -545.486 386.584 -545.466 c
385.893 -545.395 385.472 -545.269 385.322 -545.088 c
385.173 -544.905 385.097 -543.77 385.097 -541.681 c
385.097 -541.465 385.108 -540.704 385.129 -539.4 c
385.844 -539.337 386.684 -539.304 387.651 -539.304 c
388.899 -539.304 390.391 -539.332 392.129 -539.388 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
409.729 -545.79 m
409.932 -545.01 410.13 -543.914 410.326 -542.505 c
410.294 -542.449 410.256 -542.421 410.217 -542.421 c
410.17 -542.421 410.119 -542.449 410.063 -542.505 c
409.58 -543.278 409.117 -543.868 408.677 -544.273 c
408.236 -544.678 407.793 -544.966 407.349 -545.136 c
406.904 -545.307 406.139 -545.394 405.054 -545.394 c
404.032 -545.394 403.223 -545.335 402.629 -545.215 c
402.573 -545.144 402.543 -545.015 402.543 -544.826 c
402.543 -544.777 402.537 -544.69 402.523 -544.564 c
402.453 -544.005 402.418 -542.486 402.418 -540.01 c
402.418 -539.904 402.425 -539.757 402.439 -539.568 c
402.97 -539.546 403.333 -539.537 403.53 -539.537 c
404.409 -539.537 405.047 -539.668 405.442 -539.93 c
405.836 -540.192 406.18 -540.757 406.475 -541.625 c
406.52 -541.772 406.583 -541.846 406.668 -541.846 c
406.789 -541.846 406.85 -541.744 406.85 -541.54 c
406.819 -541.121 l
406.777 -540.566 406.754 -539.995 406.754 -539.407 c
406.754 -538.455 406.77 -537.597 406.803 -536.833 c
406.803 -536.594 406.741 -536.475 406.616 -536.475 c
406.523 -536.475 406.459 -536.559 406.427 -536.727 c
406.28 -537.556 405.971 -538.152 405.502 -538.517 c
405.033 -538.883 404.014 -539.064 402.446 -539.064 c
402.425 -538.556 402.415 -537.733 402.415 -536.596 c
402.415 -535.125 402.469 -534.19 402.573 -533.791 c
402.676 -533.395 402.928 -533.079 403.326 -532.846 c
403.723 -532.611 404.399 -532.495 405.346 -532.495 c
408.062 -532.495 409.814 -533.428 410.602 -535.292 c
410.699 -535.521 410.799 -535.637 410.904 -535.637 c
411.014 -535.637 411.071 -535.558 411.071 -535.406 c
411.071 -535.321 411.053 -535.23 411.018 -535.133 c
410.975 -535.002 410.874 -534.506 410.712 -533.648 c
410.679 -533.468 410.546 -532.923 410.315 -532.016 c
405.918 -532.025 l
405.287 -532.025 404.364 -532.054 403.143 -532.105 c
401.922 -532.157 400.841 -532.184 399.901 -532.188 c
398.959 -532.192 398.468 -532.212 398.426 -532.246 c
398.384 -532.28 398.364 -532.318 398.364 -532.359 c
398.364 -532.498 398.48 -532.567 398.711 -532.567 c
399.491 -532.567 400.002 -532.772 400.248 -533.185 c
400.494 -533.597 400.617 -534.6 400.617 -536.191 c
400.608 -538.34 l
400.637 -540.351 l
400.637 -540.757 400.616 -541.521 400.57 -542.65 c
400.524 -543.778 400.483 -544.424 400.446 -544.584 c
400.406 -544.744 400.298 -544.903 400.121 -545.06 c
399.944 -545.218 399.552 -545.376 398.948 -545.538 c
398.766 -545.588 398.675 -545.667 398.675 -545.773 c
398.675 -545.904 398.796 -545.97 399.041 -545.97 c
401.182 -545.854 l
401.938 -545.819 403.793 -545.802 406.75 -545.802 c
408.695 -545.802 409.686 -545.799 409.729 -545.79 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
426.618 -551.716 m
427.216 -550.907 428.253 -549.653 429.729 -547.954 c
434.518 -542.391 l
439.128 -537.054 l
439.226 -538.862 439.272 -541.209 439.272 -544.094 c
439.272 -546.261 439.226 -547.712 439.138 -548.446 c
439.046 -549.182 438.716 -549.799 438.14 -550.298 c
437.565 -550.796 436.847 -551.045 435.989 -551.045 c
435.587 -551.045 435.388 -551.13 435.388 -551.3 c
435.388 -551.398 435.431 -551.471 435.515 -551.516 c
435.602 -551.561 436.274 -551.604 437.534 -551.65 c
438.796 -551.695 439.854 -551.716 440.718 -551.716 c
442.743 -551.703 l
443.073 -551.703 l
443.384 -551.703 443.54 -551.61 443.54 -551.43 c
443.54 -551.267 443.405 -551.171 443.136 -551.141 c
442.13 -551.032 441.401 -550.769 440.958 -550.354 c
440.515 -549.941 440.251 -549.345 440.167 -548.565 c
440.083 -547.788 440.04 -545.168 440.04 -540.706 c
439.888 -532.801 l
439.888 -532.401 439.784 -532.201 439.583 -532.201 c
439.534 -532.201 439.466 -532.224 439.378 -532.273 c
439.292 -532.321 438.845 -532.825 438.036 -533.786 c
437.229 -534.746 436.233 -535.9 435.05 -537.249 c
433.866 -538.598 432.938 -539.69 432.259 -540.529 c
430.772 -542.336 429.835 -543.449 429.444 -543.868 c
427.997 -545.407 427.145 -546.395 426.886 -546.835 c
426.716 -547.135 426.561 -547.284 426.423 -547.284 c
426.305 -547.284 426.247 -547.089 426.247 -546.699 c
426.278 -544.374 l
426.278 -541.424 426.356 -539.069 426.518 -537.309 c
426.677 -535.549 426.845 -534.517 427.018 -534.212 c
427.194 -533.907 427.497 -533.599 427.932 -533.29 c
428.366 -532.978 428.827 -532.824 429.317 -532.824 c
429.976 -532.824 430.306 -532.704 430.306 -532.46 c
430.306 -532.276 430.12 -532.186 429.753 -532.186 c
422.567 -532.201 l
422.227 -532.201 422.057 -532.289 422.057 -532.466 c
422.057 -532.673 422.221 -532.777 422.55 -532.777 c
423.772 -532.777 424.587 -533.049 424.995 -533.594 c
425.403 -534.139 425.606 -535.298 425.606 -537.067 c
425.483 -542.33 l
425.47 -545.421 425.378 -547.243 425.208 -547.794 c
425.04 -548.346 424.657 -549.016 424.065 -549.807 c
423.471 -550.598 422.796 -551.042 422.04 -551.141 c
421.7 -551.185 421.532 -551.283 421.532 -551.436 c
421.532 -551.643 421.751 -551.747 422.192 -551.747 c
426.618 -551.716 l
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
457.333 -545.79 m
457.534 -545.01 457.733 -543.914 457.931 -542.505 c
457.895 -542.449 457.858 -542.421 457.819 -542.421 c
457.774 -542.421 457.722 -542.449 457.667 -542.505 c
457.183 -543.278 456.72 -543.868 456.28 -544.273 c
455.839 -544.678 455.395 -544.966 454.95 -545.136 c
454.507 -545.307 453.741 -545.394 452.657 -545.394 c
451.636 -545.394 450.827 -545.335 450.231 -545.215 c
450.175 -545.144 450.147 -545.015 450.147 -544.826 c
450.147 -544.777 450.14 -544.69 450.126 -544.564 c
450.056 -544.005 450.02 -542.486 450.02 -540.01 c
450.02 -539.904 450.028 -539.757 450.042 -539.568 c
450.573 -539.546 450.935 -539.537 451.132 -539.537 c
452.013 -539.537 452.651 -539.668 453.046 -539.93 c
453.44 -540.192 453.784 -540.757 454.079 -541.625 c
454.122 -541.772 454.185 -541.846 454.27 -541.846 c
454.392 -541.846 454.452 -541.744 454.452 -541.54 c
454.423 -541.121 l
454.378 -540.566 454.356 -539.995 454.356 -539.407 c
454.356 -538.455 454.374 -537.597 454.407 -536.833 c
454.407 -536.594 454.343 -536.475 454.218 -536.475 c
454.124 -536.475 454.061 -536.559 454.03 -536.727 c
453.882 -537.556 453.575 -538.152 453.104 -538.517 c
452.636 -538.883 451.62 -539.064 450.048 -539.064 c
450.028 -538.556 450.017 -537.733 450.017 -536.596 c
450.017 -535.125 450.069 -534.19 450.175 -533.791 c
450.278 -533.395 450.53 -533.079 450.929 -532.846 c
451.327 -532.611 452.001 -532.495 452.95 -532.495 c
455.665 -532.495 457.415 -533.428 458.206 -535.292 c
458.302 -535.521 458.403 -535.637 458.507 -535.637 c
458.618 -535.637 458.675 -535.558 458.675 -535.406 c
458.675 -535.321 458.655 -535.23 458.62 -535.133 c
458.579 -535.002 458.477 -534.506 458.315 -533.648 c
458.28 -533.468 458.147 -532.923 457.917 -532.016 c
453.522 -532.025 l
452.892 -532.025 451.966 -532.054 450.745 -532.105 c
449.524 -532.157 448.444 -532.184 447.505 -532.188 c
446.561 -532.192 446.071 -532.212 446.028 -532.246 c
445.987 -532.28 445.968 -532.318 445.968 -532.359 c
445.968 -532.498 446.083 -532.567 446.313 -532.567 c
447.095 -532.567 447.604 -532.772 447.852 -533.185 c
448.099 -533.597 448.22 -534.6 448.22 -536.191 c
448.21 -538.34 l
448.241 -540.351 l
448.241 -540.757 448.218 -541.521 448.173 -542.65 c
448.126 -543.778 448.085 -544.424 448.048 -544.584 c
448.009 -544.744 447.903 -544.903 447.724 -545.06 c
447.546 -545.218 447.155 -545.376 446.548 -545.538 c
446.368 -545.588 446.28 -545.667 446.28 -545.773 c
446.28 -545.904 446.399 -545.97 446.643 -545.97 c
448.784 -545.854 l
449.54 -545.819 451.395 -545.802 454.352 -545.802 c
456.296 -545.802 457.29 -545.799 457.333 -545.79 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
468.198 -531.92 m
467.893 -531.92 l
467.56 -532.645 467.169 -533.544 466.726 -534.615 c
466.282 -535.684 465.532 -537.411 464.477 -539.8 c
463.421 -542.186 462.733 -543.614 462.411 -544.083 c
462.087 -544.551 461.79 -544.874 461.517 -545.05 c
461.245 -545.225 461.003 -545.324 460.792 -545.346 c
460.575 -545.365 460.468 -545.43 460.468 -545.538 c
460.468 -545.665 460.733 -545.729 461.267 -545.729 c
465.845 -545.729 l
466.272 -545.729 466.485 -545.665 466.485 -545.538 c
466.485 -545.416 466.378 -545.352 466.163 -545.346 c
465.247 -545.296 464.79 -544.94 464.79 -544.279 c
464.79 -544.131 464.827 -543.932 464.903 -543.678 c
464.981 -543.423 465.481 -542.182 466.407 -539.952 c
467.333 -537.721 468.065 -536.023 468.606 -534.856 c
468.825 -535.394 469.292 -536.702 470.001 -538.782 c
470.716 -540.86 471.142 -542.166 471.28 -542.698 c
470.776 -544.041 470.407 -544.797 470.175 -544.97 c
469.94 -545.141 469.62 -545.25 469.216 -545.297 c
468.931 -545.325 468.786 -545.398 468.786 -545.519 c
468.786 -545.659 469.042 -545.729 469.55 -545.729 c
474.044 -545.729 l
474.313 -545.729 474.487 -545.717 474.558 -545.693 c
474.624 -545.67 474.661 -545.608 474.661 -545.513 c
474.661 -545.415 474.483 -545.336 474.13 -545.274 c
473.376 -545.155 472.999 -544.783 472.999 -544.16 c
472.999 -543.179 474.101 -540.12 476.302 -534.982 c
476.741 -536.108 477.171 -537.266 477.589 -538.463 c
478.718 -541.65 l
479.046 -542.587 479.233 -543.173 479.278 -543.408 c
479.323 -543.644 479.347 -543.862 479.347 -544.057 c
479.347 -544.903 478.907 -545.331 478.024 -545.346 c
477.825 -545.352 477.729 -545.416 477.729 -545.538 c
477.729 -545.618 477.761 -545.67 477.825 -545.694 c
477.888 -545.717 478.065 -545.729 478.358 -545.729 c
480.911 -545.729 l
481.675 -545.729 482.108 -545.724 482.218 -545.708 c
482.327 -545.694 482.382 -545.629 482.382 -545.516 c
482.382 -545.41 482.3 -545.352 482.14 -545.346 c
481.37 -545.29 480.767 -544.87 480.333 -544.086 c
479.899 -543.302 478.921 -540.714 477.399 -536.323 c
476.599 -534.017 476.058 -532.549 475.786 -531.92 c
475.495 -531.92 l
474.931 -533.458 474.38 -534.864 473.849 -536.138 c
473.317 -537.409 472.567 -539.284 471.595 -541.76 c
468.198 -531.92 l
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
340.657 -530.576 m
341.439 -530.576 l
342.728 -527.937 344.508 -523.425 346.776 -517.039 c
348.238 -512.95 349.241 -510.442 349.786 -509.514 c
350.331 -508.59 351.206 -508.075 352.411 -507.973 c
352.793 -507.936 352.985 -507.803 352.985 -507.575 c
352.985 -507.407 352.887 -507.323 352.691 -507.323 c
352.449 -507.34 l
351.388 -507.446 350.039 -507.497 348.404 -507.497 c
345.89 -507.497 344.277 -507.457 343.563 -507.379 c
343.205 -507.379 343.027 -507.485 343.027 -507.692 c
343.027 -507.844 343.159 -507.936 343.424 -507.973 c
344.404 -508.063 345.081 -508.231 345.456 -508.471 c
345.83 -508.713 346.018 -509.092 346.018 -509.61 c
346.018 -510.104 345.666 -511.342 344.962 -513.33 c
343.942 -516.311 l
343.344 -516.311 340.668 -516.276 335.915 -516.207 c
334.72 -513.006 334.123 -510.987 334.123 -510.153 c
334.123 -509.444 334.42 -508.92 335.016 -508.577 c
335.61 -508.235 336.196 -508.045 336.774 -508.01 c
337.201 -507.977 337.415 -507.85 337.415 -507.629 c
337.415 -507.541 337.345 -507.457 337.207 -507.379 c
335.359 -507.457 334.244 -507.497 333.863 -507.497 c
331.922 -507.497 330.616 -507.473 329.948 -507.42 c
329.578 -507.42 329.393 -507.522 329.393 -507.731 c
329.393 -507.916 329.554 -508.036 329.878 -508.08 c
331.207 -508.254 332.222 -509.155 332.928 -510.78 c
333.632 -512.407 334.725 -515.328 336.209 -519.547 c
337.565 -523.385 339.047 -527.061 340.657 -530.576 c
339.964 -526.809 m
338.895 -524.627 337.649 -521.456 336.225 -517.299 c
337.41 -517.356 338.262 -517.385 338.78 -517.385 c
343.631 -517.299 l
343.204 -518.491 342.604 -520.078 341.831 -522.054 c
340.886 -524.409 340.263 -525.994 339.964 -526.809 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
362.427 -529.192 m
361.524 -529.219 360.888 -529.232 360.518 -529.232 c
358.02 -529.232 356.21 -528.716 355.088 -527.68 c
353.966 -526.644 353.312 -525.724 353.128 -524.922 c
353.07 -524.633 352.919 -524.49 352.671 -524.49 c
352.558 -524.49 352.451 -524.541 352.349 -524.643 c
352.407 -526.02 352.631 -527.881 353.021 -530.22 c
354.079 -530.22 l
354.98 -530.22 356.188 -530.175 357.703 -530.082 c
359.333 -529.989 361.83 -529.943 365.194 -529.943 c
368.638 -529.943 370.881 -529.986 371.921 -530.073 c
372.869 -530.171 374.169 -530.22 375.823 -530.22 c
375.965 -529.386 376.059 -528.517 376.107 -527.612 c
376.177 -526.582 376.248 -525.858 376.319 -525.44 c
376.331 -525.348 376.337 -525.248 376.337 -525.144 c
376.337 -524.867 376.219 -524.726 375.984 -524.726 c
375.838 -524.726 375.717 -524.777 375.622 -524.875 c
375.527 -524.974 375.304 -525.301 374.954 -525.856 c
374.347 -526.795 373.716 -527.504 373.062 -527.985 c
372.407 -528.466 371.678 -528.775 370.872 -528.915 c
370.065 -529.054 368.435 -529.145 365.984 -529.192 c
365.877 -527.449 365.825 -525.459 365.825 -523.221 c
365.825 -515.815 365.984 -511.446 366.301 -510.12 c
366.618 -508.793 367.751 -508.131 369.7 -508.131 c
370.173 -508.131 370.409 -508.034 370.409 -507.84 c
370.409 -507.612 370.184 -507.497 369.734 -507.497 c
359.088 -507.497 l
358.811 -507.497 358.672 -507.606 358.672 -507.821 c
358.672 -508.039 358.943 -508.147 359.484 -508.147 c
360.394 -508.147 361.128 -508.403 361.686 -508.918 c
362.243 -509.432 362.566 -510.125 362.653 -511.002 c
362.74 -511.881 362.783 -514.412 362.783 -518.6 c
362.783 -522.178 362.664 -525.708 362.427 -529.192 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
398.068 -507.395 m
397.502 -507.373 397.178 -507.362 397.098 -507.362 c
396.672 -507.362 395.898 -507.381 394.778 -507.422 c
393.658 -507.461 391.332 -507.481 387.8 -507.481 c
383.401 -507.481 l
383.241 -507.481 382.651 -507.455 381.635 -507.403 c
380.62 -507.348 380.002 -507.323 379.783 -507.323 c
378.905 -507.323 378.468 -507.438 378.468 -507.664 c
378.468 -507.846 378.639 -507.942 378.985 -507.955 c
380.103 -508.022 380.88 -508.262 381.318 -508.672 c
381.756 -509.08 382.054 -509.668 382.217 -510.434 c
382.378 -511.2 382.458 -513.268 382.458 -516.645 c
382.476 -522.831 l
382.476 -524.836 382.386 -526.234 382.208 -527.03 c
382.031 -527.825 381.662 -528.433 381.105 -528.854 c
380.547 -529.275 379.917 -529.513 379.218 -529.57 c
378.849 -529.605 378.664 -529.729 378.664 -529.941 c
378.664 -530.153 378.831 -530.26 379.165 -530.26 c
379.245 -530.26 379.395 -530.254 379.614 -530.243 c
381.442 -530.139 383.58 -530.084 386.03 -530.084 c
389.067 -530.124 l
389.376 -530.124 389.532 -530.009 389.532 -529.779 c
389.532 -529.57 389.366 -529.467 389.035 -529.467 c
388.224 -529.467 387.547 -529.306 387.004 -528.984 c
386.461 -528.661 386.102 -528.289 385.924 -527.869 c
385.748 -527.449 385.659 -526.63 385.659 -525.411 c
385.501 -517.248 l
385.535 -512.688 l
385.535 -511.274 385.596 -510.352 385.718 -509.928 c
385.84 -509.5 386.09 -509.12 386.471 -508.78 c
386.854 -508.44 387.547 -508.27 388.553 -508.27 c
388.633 -508.27 389.668 -508.305 391.657 -508.375 c
393.241 -508.592 394.662 -509.368 395.922 -510.696 c
397.181 -512.024 398.02 -513.211 398.436 -514.262 c
398.559 -514.561 398.709 -514.711 398.889 -514.711 c
399.079 -514.711 399.174 -514.573 399.174 -514.295 c
399.174 -513.971 399.01 -512.813 398.68 -510.821 c
398.352 -508.825 398.147 -507.684 398.068 -507.395 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
411.573 -530.576 m
412.356 -530.576 l
413.645 -527.937 415.424 -523.425 417.694 -517.039 c
419.157 -512.95 420.159 -510.442 420.704 -509.514 c
421.251 -508.59 422.124 -508.075 423.331 -507.973 c
423.712 -507.936 423.905 -507.803 423.905 -507.575 c
423.905 -507.407 423.805 -507.323 423.608 -507.323 c
423.366 -507.34 l
422.305 -507.446 420.958 -507.497 419.321 -507.497 c
416.807 -507.497 415.194 -507.457 414.479 -507.379 c
414.121 -507.379 413.944 -507.485 413.944 -507.692 c
413.944 -507.844 414.076 -507.936 414.34 -507.973 c
415.321 -508.063 415.998 -508.231 416.372 -508.471 c
416.745 -508.713 416.936 -509.092 416.936 -509.61 c
416.936 -510.104 416.583 -511.342 415.879 -513.33 c
414.86 -516.311 l
414.26 -516.311 411.584 -516.276 406.832 -516.207 c
405.637 -513.006 405.039 -510.987 405.039 -510.153 c
405.039 -509.444 405.338 -508.92 405.933 -508.577 c
406.528 -508.235 407.114 -508.045 407.692 -508.01 c
408.117 -507.977 408.332 -507.85 408.332 -507.629 c
408.332 -507.541 408.262 -507.457 408.123 -507.379 c
406.276 -507.457 405.16 -507.497 404.781 -507.497 c
402.839 -507.497 401.533 -507.473 400.866 -507.42 c
400.494 -507.42 400.309 -507.522 400.309 -507.731 c
400.309 -507.916 400.471 -508.036 400.795 -508.08 c
402.123 -508.254 403.139 -509.155 403.844 -510.78 c
404.549 -512.407 405.643 -515.328 407.125 -519.547 c
408.482 -523.385 409.964 -527.061 411.573 -530.576 c
410.881 -526.809 m
409.813 -524.627 408.566 -521.456 407.143 -517.299 c
408.327 -517.356 409.178 -517.385 409.697 -517.385 c
414.547 -517.299 l
414.121 -518.491 413.521 -520.078 412.748 -522.054 c
411.803 -524.409 411.181 -525.994 410.881 -526.809 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
431.595 -530.027 m
432.284 -529.093 433.479 -527.644 435.185 -525.684 c
440.71 -519.264 l
446.028 -513.104 l
446.136 -515.188 446.188 -517.893 446.188 -521.222 c
446.188 -523.722 446.136 -525.394 446.032 -526.24 c
445.929 -527.085 445.546 -527.798 444.886 -528.373 c
444.226 -528.948 443.401 -529.237 442.411 -529.237 c
441.952 -529.237 441.722 -529.336 441.722 -529.536 c
441.722 -529.653 441.772 -529.738 441.87 -529.791 c
441.966 -529.844 442.739 -529.895 444.188 -529.949 c
445.638 -530.002 446.854 -530.027 447.847 -530.027 c
450.173 -530.011 l
450.554 -530.011 l
450.909 -530.011 451.087 -529.911 451.087 -529.711 c
451.087 -529.533 450.933 -529.429 450.624 -529.395 c
449.464 -529.268 448.628 -528.966 448.116 -528.486 c
447.604 -528.008 447.302 -527.318 447.202 -526.419 c
447.106 -525.518 447.058 -522.49 447.058 -517.332 c
446.893 -508.196 l
446.893 -507.731 446.782 -507.502 446.563 -507.502 c
446.503 -507.502 446.423 -507.53 446.321 -507.582 c
446.218 -507.633 445.7 -508.215 444.768 -509.327 c
443.837 -510.438 442.688 -511.772 441.323 -513.328 c
439.96 -514.885 438.888 -516.145 438.102 -517.114 c
436.388 -519.2 435.306 -520.485 434.856 -520.97 c
433.186 -522.744 432.202 -523.885 431.905 -524.393 c
431.708 -524.737 431.53 -524.911 431.37 -524.911 c
431.241 -524.911 431.177 -524.685 431.177 -524.235 c
431.21 -521.552 l
431.21 -518.145 431.302 -515.424 431.487 -513.393 c
431.673 -511.36 431.866 -510.166 432.069 -509.817 c
432.27 -509.463 432.622 -509.108 433.124 -508.75 c
433.628 -508.391 434.163 -508.215 434.729 -508.215 c
435.493 -508.215 435.874 -508.075 435.874 -507.797 c
435.874 -507.588 435.661 -507.485 435.233 -507.485 c
426.899 -507.502 l
426.507 -507.502 426.311 -507.598 426.311 -507.793 c
426.311 -508.022 426.501 -508.135 426.88 -508.135 c
428.296 -508.135 429.241 -508.45 429.714 -509.08 c
430.183 -509.711 430.421 -511.051 430.421 -513.098 c
430.296 -519.19 l
430.272 -522.769 430.163 -524.879 429.968 -525.518 c
429.772 -526.157 429.333 -526.934 428.645 -527.849 c
427.962 -528.766 427.18 -529.28 426.305 -529.395 c
425.913 -529.444 425.716 -529.551 425.716 -529.721 c
425.716 -529.949 425.971 -530.062 426.483 -530.062 c
431.595 -530.027 l
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
463.376 -529.192 m
462.474 -529.219 461.837 -529.232 461.466 -529.232 c
458.968 -529.232 457.157 -528.716 456.036 -527.68 c
454.915 -526.644 454.261 -525.724 454.077 -524.922 c
454.02 -524.633 453.866 -524.49 453.618 -524.49 c
453.505 -524.49 453.399 -524.541 453.298 -524.643 c
453.354 -526.02 453.579 -527.881 453.97 -530.22 c
455.028 -530.22 l
455.929 -530.22 457.138 -530.175 458.651 -530.082 c
460.28 -529.989 462.778 -529.943 466.142 -529.943 c
469.587 -529.943 471.829 -529.986 472.87 -530.073 c
473.817 -530.171 475.116 -530.22 476.772 -530.22 c
476.913 -529.386 477.007 -528.517 477.054 -527.612 c
477.124 -526.582 477.196 -525.858 477.268 -525.44 c
477.278 -525.348 477.284 -525.248 477.284 -525.144 c
477.284 -524.867 477.167 -524.726 476.931 -524.726 c
476.786 -524.726 476.665 -524.777 476.571 -524.875 c
476.476 -524.974 476.253 -525.301 475.903 -525.856 c
475.296 -526.795 474.665 -527.504 474.011 -527.985 c
473.356 -528.466 472.626 -528.775 471.819 -528.915 c
471.015 -529.054 469.384 -529.145 466.931 -529.192 c
466.825 -527.449 466.774 -525.459 466.774 -523.221 c
466.774 -515.815 466.931 -511.446 467.249 -510.12 c
467.565 -508.793 468.7 -508.131 470.647 -508.131 c
471.12 -508.131 471.358 -508.034 471.358 -507.84 c
471.358 -507.612 471.132 -507.497 470.683 -507.497 c
460.036 -507.497 l
459.759 -507.497 459.62 -507.606 459.62 -507.821 c
459.62 -508.039 459.892 -508.147 460.433 -508.147 c
461.341 -508.147 462.075 -508.403 462.634 -508.918 c
463.192 -509.432 463.515 -510.125 463.602 -511.002 c
463.686 -511.881 463.731 -514.412 463.731 -518.6 c
463.731 -522.178 463.614 -525.708 463.376 -529.192 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
481.044 -530.299 m
484.194 -530.22 l
489.024 -530.299 l
489.601 -530.299 489.89 -530.184 489.89 -529.952 c
489.89 -529.779 489.733 -529.668 489.425 -529.622 c
488.149 -529.46 487.356 -529 487.042 -528.24 c
486.726 -527.48 486.567 -524.671 486.567 -519.811 c
486.567 -518.026 486.616 -516.016 486.706 -513.782 c
486.798 -511.549 486.899 -510.213 487.017 -509.774 c
487.13 -509.338 487.349 -508.981 487.671 -508.705 c
487.991 -508.428 488.587 -508.233 489.458 -508.118 c
489.745 -508.082 489.89 -507.969 489.89 -507.78 c
489.89 -507.565 489.755 -507.457 489.491 -507.457 c
485.208 -507.497 l
481.563 -507.457 l
481.159 -507.457 480.958 -507.573 480.958 -507.807 c
480.958 -508.047 481.12 -508.17 481.442 -508.17 c
482.515 -508.192 483.143 -508.549 483.327 -509.239 c
483.513 -509.93 483.606 -512.137 483.606 -515.856 c
483.606 -519.45 483.573 -522.355 483.511 -524.578 c
483.444 -526.801 483.257 -528.16 482.944 -528.655 c
482.632 -529.151 482.04 -529.46 481.167 -529.588 c
480.843 -529.645 480.681 -529.779 480.681 -529.987 c
480.681 -530.195 480.802 -530.299 481.044 -530.299 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
506.413 -528.907 m
506.724 -529.22 506.931 -529.545 507.036 -529.882 c
507.128 -530.159 507.261 -530.299 507.435 -530.299 c
507.528 -530.299 507.632 -530.241 507.747 -530.127 c
507.825 -529.71 507.94 -528.875 508.089 -527.619 c
508.499 -524.367 l
508.499 -524.159 508.37 -524.056 508.114 -524.056 c
507.974 -524.056 507.852 -524.171 507.747 -524.402 c
507.134 -525.915 506.224 -527.173 505.02 -528.177 c
503.817 -529.171 502.503 -529.667 501.077 -529.667 c
499.677 -529.667 498.62 -529.245 497.909 -528.402 c
497.196 -527.557 496.841 -526.664 496.841 -525.717 c
496.841 -524.561 497.227 -523.678 498.005 -523.067 c
498.78 -522.455 500.376 -521.763 502.798 -520.991 c
504.579 -520.438 505.913 -519.9 506.796 -519.383 c
507.679 -518.864 508.419 -518.137 509.02 -517.203 c
509.622 -516.27 509.921 -515.268 509.921 -514.198 c
509.921 -512.375 509.167 -510.743 507.659 -509.303 c
506.151 -507.862 504.302 -507.143 502.116 -507.143 c
500.147 -507.143 498.167 -507.756 496.177 -508.991 c
495.784 -508.666 495.532 -508.288 495.417 -507.852 c
495.327 -507.485 495.181 -507.299 494.977 -507.299 c
494.798 -507.299 494.665 -507.536 494.585 -508.01 c
494.503 -508.483 494.331 -510.719 494.073 -514.721 c
494.122 -514.858 494.243 -514.926 494.442 -514.926 c
494.618 -514.926 494.759 -514.799 494.864 -514.547 c
496.636 -510.084 499.106 -507.854 502.278 -507.854 c
503.852 -507.854 505.085 -508.327 505.976 -509.28 c
506.868 -510.229 507.311 -511.321 507.311 -512.555 c
507.311 -513.407 507.073 -514.19 506.591 -514.905 c
506.11 -515.62 505.474 -516.194 504.681 -516.633 c
503.888 -517.071 502.634 -517.563 500.923 -518.102 c
498.722 -518.805 497.231 -519.471 496.454 -520.099 c
495.675 -520.727 495.102 -521.436 494.737 -522.226 c
494.374 -523.015 494.192 -523.779 494.192 -524.518 c
494.192 -526.05 494.888 -527.41 496.278 -528.598 c
497.669 -529.784 499.374 -530.379 501.393 -530.379 c
502.155 -530.379 502.952 -530.257 503.792 -530.014 c
504.626 -529.773 505.501 -529.404 506.413 -528.907 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
352.307 -493.666 m
352.503 -493.666 l
352.825 -493.006 353.27 -491.879 353.836 -490.282 c
354.202 -489.258 354.453 -488.631 354.59 -488.401 c
354.725 -488.17 354.944 -488.041 355.245 -488.016 c
355.342 -488.004 355.388 -487.973 355.388 -487.914 c
355.388 -487.873 355.365 -487.854 355.315 -487.854 c
355.255 -487.858 l
354.99 -487.883 354.653 -487.897 354.243 -487.897 c
353.615 -487.897 353.213 -487.887 353.033 -487.868 c
352.944 -487.868 352.899 -487.893 352.899 -487.946 c
352.899 -487.985 352.933 -488.006 352.998 -488.016 c
353.243 -488.038 353.413 -488.079 353.507 -488.141 c
353.6 -488.2 353.647 -488.295 353.647 -488.424 c
353.647 -488.547 353.559 -488.858 353.383 -489.354 c
353.128 -490.1 l
352.979 -490.1 352.309 -490.09 351.122 -490.075 c
350.823 -489.274 350.674 -488.768 350.674 -488.561 c
350.674 -488.385 350.748 -488.252 350.897 -488.166 c
351.045 -488.08 351.192 -488.034 351.337 -488.026 c
351.443 -488.018 351.497 -487.985 351.497 -487.93 c
351.497 -487.907 351.479 -487.885 351.444 -487.868 c
350.983 -487.887 350.704 -487.897 350.608 -487.897 c
350.123 -487.897 349.797 -487.891 349.63 -487.877 c
349.537 -487.877 349.491 -487.903 349.491 -487.954 c
349.491 -488.002 349.532 -488.03 349.612 -488.043 c
349.945 -488.086 350.199 -488.311 350.374 -488.717 c
350.551 -489.123 350.824 -489.854 351.195 -490.911 c
351.534 -491.87 351.904 -492.788 352.307 -493.666 c
352.134 -492.725 m
351.866 -492.178 351.555 -491.385 351.199 -490.346 c
351.495 -490.362 351.708 -490.368 351.838 -490.368 c
353.05 -490.346 l
352.944 -490.645 352.793 -491.041 352.601 -491.534 c
352.365 -492.123 352.209 -492.522 352.134 -492.725 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
359.187 -493.547 m
359.257 -493.543 l
359.564 -493.52 359.967 -493.508 360.467 -493.508 c
360.687 -493.508 360.879 -493.512 361.041 -493.52 c
361.137 -493.526 361.21 -493.528 361.259 -493.528 c
361.349 -493.528 361.394 -493.502 361.394 -493.446 c
361.394 -493.389 361.356 -493.362 361.281 -493.362 c
361.049 -493.362 360.885 -493.313 360.786 -493.219 c
360.689 -493.125 360.629 -492.879 360.607 -492.479 c
360.586 -492.077 360.574 -491.637 360.574 -491.159 c
360.574 -489.584 l
360.574 -488.948 360.402 -488.491 360.058 -488.213 c
359.715 -487.936 359.374 -487.799 359.039 -487.799 c
358.782 -487.799 358.565 -487.862 358.388 -487.989 c
358.212 -488.116 358.124 -488.288 358.124 -488.504 c
358.124 -488.635 358.16 -488.741 358.233 -488.817 c
358.305 -488.895 358.397 -488.934 358.51 -488.934 c
358.62 -488.934 358.708 -488.899 358.775 -488.832 c
358.842 -488.764 358.874 -488.688 358.874 -488.6 c
358.874 -488.549 358.857 -488.491 358.822 -488.424 c
358.771 -488.338 358.747 -488.276 358.747 -488.233 c
358.747 -488.161 358.777 -488.1 358.838 -488.055 c
358.899 -488.008 358.974 -487.985 359.061 -487.985 c
359.268 -487.985 359.438 -488.055 359.572 -488.196 c
359.706 -488.336 359.784 -488.553 359.807 -488.854 c
359.832 -489.151 359.843 -489.791 359.843 -490.778 c
359.843 -491.979 359.826 -492.702 359.794 -492.944 c
359.76 -493.186 359.565 -493.327 359.208 -493.362 c
359.124 -493.37 359.082 -493.399 359.082 -493.45 c
359.082 -493.514 359.116 -493.547 359.187 -493.547 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
361.978 -489.942 m
361.978 -490.221 362.062 -490.526 362.231 -490.858 c
362.399 -491.192 362.646 -491.465 362.969 -491.682 c
363.292 -491.899 363.657 -492.008 364.064 -492.008 c
364.633 -492.008 365.103 -491.801 365.473 -491.395 c
365.843 -490.987 366.029 -490.522 366.029 -489.998 c
366.029 -489.444 365.824 -488.942 365.412 -488.498 c
365.002 -488.059 364.508 -487.838 363.931 -487.838 c
363.378 -487.838 362.915 -488.03 362.54 -488.418 c
362.165 -488.805 361.978 -489.313 361.978 -489.942 c
362.66 -490.041 m
362.66 -489.705 362.711 -489.36 362.814 -489.006 c
362.917 -488.653 363.078 -488.393 363.299 -488.235 c
363.52 -488.075 363.756 -487.997 364.007 -487.997 c
364.412 -487.997 364.737 -488.194 364.981 -488.588 c
365.225 -488.983 365.347 -489.44 365.347 -489.961 c
365.347 -490.465 365.222 -490.907 364.973 -491.286 c
364.724 -491.668 364.399 -491.86 363.998 -491.86 c
363.694 -491.86 363.442 -491.756 363.24 -491.553 c
363.038 -491.35 362.891 -491.106 362.799 -490.825 c
362.706 -490.541 362.66 -490.28 362.66 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
366.764 -491.938 m
368.31 -491.938 l
368.399 -491.938 368.443 -491.918 368.443 -491.879 c
368.443 -491.838 368.41 -491.815 368.345 -491.809 c
368.199 -491.793 368.091 -491.754 368.022 -491.688 c
367.953 -491.623 367.9 -491.506 367.864 -491.34 c
367.828 -491.176 367.81 -490.817 367.81 -490.272 c
367.81 -489.618 367.829 -489.163 367.868 -488.909 c
367.906 -488.659 368.026 -488.457 368.227 -488.309 c
368.427 -488.159 368.701 -488.084 369.047 -488.084 c
369.41 -488.084 369.686 -488.153 369.875 -488.289 c
370.064 -488.428 370.188 -488.633 370.245 -488.905 c
370.301 -489.178 370.33 -489.766 370.33 -490.672 c
370.33 -491.141 370.282 -491.446 370.184 -491.59 c
370.087 -491.737 369.943 -491.809 369.753 -491.809 c
369.676 -491.809 369.638 -491.83 369.638 -491.873 c
369.638 -491.916 369.689 -491.938 369.788 -491.938 c
371.017 -491.938 l
371.073 -491.938 371.1 -491.916 371.1 -491.873 c
371.1 -491.844 371.077 -491.829 371.034 -491.823 c
370.88 -491.797 370.765 -491.748 370.694 -491.674 c
370.621 -491.596 370.574 -491.459 370.551 -491.258 c
370.529 -491.059 370.517 -490.766 370.517 -490.379 c
370.517 -489.895 370.499 -489.483 370.463 -489.147 c
370.428 -488.809 370.35 -488.557 370.231 -488.393 c
370.112 -488.225 369.932 -488.092 369.693 -487.989 c
369.453 -487.889 369.158 -487.838 368.808 -487.838 c
368.45 -487.838 368.145 -487.895 367.893 -488.008 c
367.641 -488.123 367.471 -488.274 367.382 -488.461 c
367.292 -488.653 367.247 -488.934 367.247 -489.307 c
367.258 -490.163 l
367.258 -490.922 367.225 -491.387 367.159 -491.557 c
367.095 -491.729 366.955 -491.815 366.74 -491.819 c
366.67 -491.819 366.634 -491.836 366.634 -491.872 c
366.634 -491.914 366.678 -491.938 366.764 -491.938 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
373.941 -489.967 m
374.228 -489.842 374.428 -489.713 374.541 -489.577 c
374.654 -489.444 374.735 -489.237 374.786 -488.955 c
374.853 -488.586 374.947 -488.34 375.068 -488.215 c
375.19 -488.09 375.35 -488.024 375.547 -488.016 c
375.602 -488.01 375.629 -487.989 375.629 -487.954 c
375.629 -487.914 375.597 -487.897 375.533 -487.897 c
374.962 -487.897 374.615 -487.914 374.494 -487.954 c
374.373 -487.991 374.282 -488.2 374.222 -488.58 c
374.167 -488.952 374.108 -489.221 374.047 -489.393 c
373.985 -489.563 373.888 -489.694 373.754 -489.786 c
373.62 -489.877 373.411 -489.922 373.126 -489.922 c
373.018 -489.922 372.896 -489.911 372.759 -489.887 c
372.749 -489.76 372.744 -489.625 372.744 -489.487 c
372.744 -488.959 372.752 -488.62 372.765 -488.465 c
372.78 -488.311 372.823 -488.2 372.897 -488.127 c
372.97 -488.057 373.091 -488.02 373.262 -488.016 c
373.337 -488.014 373.373 -487.995 373.373 -487.959 c
373.373 -487.918 373.328 -487.897 373.238 -487.897 c
371.72 -487.897 l
371.633 -487.897 371.588 -487.918 371.588 -487.959 c
371.588 -487.997 371.622 -488.016 371.693 -488.016 c
371.847 -488.016 371.955 -488.039 372.016 -488.086 c
372.076 -488.133 372.123 -488.207 372.159 -488.307 c
372.193 -488.407 372.211 -488.586 372.211 -488.85 c
372.204 -489.479 l
372.207 -490.438 l
372.207 -490.93 372.197 -491.252 372.175 -491.411 c
372.154 -491.569 372.115 -491.676 372.059 -491.729 c
372.004 -491.786 371.875 -491.829 371.673 -491.86 c
371.63 -491.866 371.608 -491.883 371.608 -491.909 c
371.608 -491.942 371.651 -491.957 371.738 -491.957 c
373.566 -491.987 l
374.072 -491.987 374.437 -491.891 374.665 -491.698 c
374.892 -491.506 375.006 -491.27 375.006 -490.991 c
375.006 -490.813 374.96 -490.653 374.869 -490.508 c
374.777 -490.362 374.669 -490.256 374.544 -490.19 c
374.419 -490.125 374.218 -490.051 373.941 -489.967 c
372.765 -490.041 m
373.162 -490.047 373.46 -490.077 373.657 -490.123 c
373.857 -490.17 374.025 -490.276 374.164 -490.436 c
374.304 -490.594 374.374 -490.786 374.374 -491.004 c
374.374 -491.235 374.297 -491.438 374.142 -491.61 c
373.987 -491.782 373.739 -491.87 373.397 -491.87 c
373.212 -491.87 373.007 -491.844 372.782 -491.793 c
372.756 -491.231 372.744 -490.78 372.744 -490.448 c
372.744 -490.332 372.752 -490.196 372.765 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
376.916 -491.922 m
377.039 -491.754 377.253 -491.495 377.558 -491.145 c
378.545 -490 l
379.494 -488.899 l
379.514 -489.272 379.524 -489.756 379.524 -490.352 c
379.524 -490.795 379.514 -491.096 379.496 -491.248 c
379.477 -491.401 379.408 -491.526 379.29 -491.629 c
379.172 -491.731 379.024 -491.784 378.847 -491.784 c
378.764 -491.784 378.723 -491.799 378.723 -491.834 c
378.723 -491.856 378.733 -491.87 378.749 -491.879 c
378.767 -491.889 378.905 -491.899 379.165 -491.907 c
379.425 -491.916 379.644 -491.922 379.821 -491.922 c
380.239 -491.918 l
380.306 -491.918 l
380.371 -491.918 380.403 -491.899 380.403 -491.864 c
380.403 -491.829 380.375 -491.809 380.32 -491.803 c
380.112 -491.78 379.963 -491.727 379.871 -491.639 c
379.78 -491.555 379.724 -491.432 379.707 -491.272 c
379.69 -491.112 379.681 -490.573 379.681 -489.653 c
379.65 -488.024 l
379.65 -487.942 379.629 -487.901 379.587 -487.901 c
379.577 -487.901 379.563 -487.905 379.546 -487.914 c
379.528 -487.924 379.435 -488.03 379.27 -488.227 c
379.102 -488.424 378.896 -488.663 378.654 -488.94 c
378.409 -489.217 378.219 -489.444 378.079 -489.618 c
377.772 -489.989 377.578 -490.217 377.499 -490.303 c
377.201 -490.622 377.024 -490.825 376.971 -490.914 c
376.937 -490.977 376.905 -491.008 376.876 -491.008 c
376.852 -491.008 376.841 -490.967 376.841 -490.887 c
376.846 -490.409 l
376.846 -489.799 376.862 -489.315 376.895 -488.953 c
376.928 -488.59 376.963 -488.377 376.999 -488.315 c
377.034 -488.252 377.097 -488.19 377.188 -488.125 c
377.277 -488.059 377.372 -488.03 377.472 -488.03 c
377.608 -488.03 377.677 -488.004 377.677 -487.954 c
377.677 -487.914 377.638 -487.897 377.561 -487.897 c
376.081 -487.901 l
376.011 -487.901 375.977 -487.918 375.977 -487.954 c
375.977 -487.997 376.011 -488.02 376.078 -488.02 c
376.329 -488.02 376.499 -488.075 376.581 -488.188 c
376.666 -488.299 376.708 -488.538 376.708 -488.903 c
376.682 -489.989 l
376.679 -490.623 376.661 -490.998 376.626 -491.112 c
376.591 -491.227 376.512 -491.366 376.39 -491.528 c
376.267 -491.69 376.129 -491.782 375.972 -491.803 c
375.902 -491.813 375.868 -491.832 375.868 -491.864 c
375.868 -491.905 375.913 -491.928 376.005 -491.928 c
376.916 -491.922 l
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
382.4 -492.018 m
382.533 -492.018 l
382.763 -491.545 383.082 -490.741 383.487 -489.6 c
383.748 -488.87 383.928 -488.424 384.026 -488.26 c
384.124 -488.094 384.282 -488.004 384.499 -487.985 c
384.567 -487.979 384.602 -487.954 384.602 -487.911 c
384.602 -487.879 384.584 -487.864 384.55 -487.864 c
384.507 -487.868 l
384.317 -487.887 384.076 -487.897 383.783 -487.897 c
383.335 -487.897 383.047 -487.887 382.92 -487.868 c
382.855 -487.868 382.824 -487.889 382.824 -487.93 c
382.824 -487.959 382.847 -487.979 382.895 -487.985 c
383.07 -488.002 383.191 -488.032 383.258 -488.075 c
383.324 -488.116 383.358 -488.184 383.358 -488.274 c
383.358 -488.362 383.295 -488.584 383.169 -488.938 c
382.988 -489.467 l
382.88 -489.467 382.4 -489.461 381.55 -489.45 c
381.335 -488.879 381.228 -488.518 381.228 -488.37 c
381.228 -488.245 381.282 -488.149 381.388 -488.086 c
381.494 -488.026 381.598 -487.991 381.701 -487.985 c
381.778 -487.981 381.816 -487.954 381.816 -487.914 c
381.816 -487.897 381.804 -487.881 381.779 -487.868 c
381.449 -487.887 381.25 -487.897 381.182 -487.897 c
380.835 -487.897 380.602 -487.893 380.483 -487.887 c
380.417 -487.887 380.384 -487.909 380.384 -487.95 c
380.384 -487.987 380.413 -488.01 380.47 -488.018 c
380.708 -488.049 380.889 -488.205 381.015 -488.491 c
381.141 -488.776 381.336 -489.295 381.602 -490.047 c
381.846 -490.731 382.111 -491.389 382.4 -492.018 c
382.276 -491.344 m
382.085 -490.954 381.861 -490.389 381.604 -489.645 c
381.818 -489.657 381.97 -489.661 382.062 -489.661 c
382.932 -489.645 l
382.854 -489.86 382.747 -490.141 382.61 -490.495 c
382.44 -490.916 382.33 -491.2 382.276 -491.344 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
388.473 -487.873 m
388.371 -487.868 388.315 -487.864 388.299 -487.864 c
388.224 -487.864 388.086 -487.868 387.886 -487.879 c
387.686 -487.889 387.271 -487.893 386.641 -487.893 c
385.855 -487.893 l
385.827 -487.893 385.723 -487.889 385.541 -487.879 c
385.361 -487.868 385.249 -487.864 385.211 -487.864 c
385.053 -487.864 384.976 -487.885 384.976 -487.928 c
384.976 -487.963 385.006 -487.981 385.068 -487.983 c
385.267 -487.995 385.406 -488.038 385.483 -488.11 c
385.562 -488.184 385.615 -488.288 385.644 -488.426 c
385.672 -488.563 385.687 -488.932 385.687 -489.536 c
385.691 -490.641 l
385.691 -490.998 385.674 -491.25 385.642 -491.391 c
385.61 -491.534 385.544 -491.643 385.444 -491.717 c
385.343 -491.791 385.231 -491.834 385.104 -491.844 c
385.038 -491.85 385.006 -491.873 385.006 -491.911 c
385.006 -491.948 385.034 -491.967 385.095 -491.967 c
385.11 -491.967 385.136 -491.967 385.175 -491.965 c
385.502 -491.944 385.886 -491.934 386.324 -491.934 c
386.868 -491.944 l
386.924 -491.944 386.951 -491.924 386.951 -491.883 c
386.951 -491.844 386.922 -491.827 386.864 -491.827 c
386.717 -491.827 386.596 -491.797 386.5 -491.741 c
386.403 -491.684 386.339 -491.616 386.307 -491.541 c
386.276 -491.467 386.26 -491.321 386.26 -491.104 c
386.231 -489.645 l
386.237 -488.83 l
386.237 -488.578 386.247 -488.414 386.268 -488.338 c
386.29 -488.262 386.336 -488.194 386.403 -488.133 c
386.471 -488.073 386.594 -488.041 386.774 -488.041 c
386.788 -488.041 386.972 -488.049 387.326 -488.059 c
387.61 -488.098 387.863 -488.235 388.086 -488.469 c
388.311 -488.704 388.461 -488.914 388.535 -489.098 c
388.558 -489.153 388.586 -489.178 388.619 -489.178 c
388.654 -489.178 388.671 -489.153 388.671 -489.102 c
388.671 -489.045 388.641 -488.838 388.582 -488.483 c
388.524 -488.127 388.487 -487.924 388.473 -487.873 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
391.517 -489.942 m
391.517 -490.221 391.602 -490.526 391.77 -490.858 c
391.938 -491.192 392.184 -491.465 392.508 -491.682 c
392.83 -491.899 393.196 -492.008 393.602 -492.008 c
394.17 -492.008 394.641 -491.801 395.012 -491.395 c
395.383 -490.987 395.569 -490.522 395.569 -489.998 c
395.569 -489.444 395.363 -488.942 394.951 -488.498 c
394.541 -488.059 394.047 -487.838 393.471 -487.838 c
392.917 -487.838 392.453 -488.03 392.079 -488.418 c
391.703 -488.805 391.517 -489.313 391.517 -489.942 c
392.199 -490.041 m
392.199 -489.705 392.25 -489.36 392.354 -489.006 c
392.457 -488.653 392.618 -488.393 392.839 -488.235 c
393.059 -488.075 393.295 -487.997 393.545 -487.997 c
393.951 -487.997 394.276 -488.194 394.52 -488.588 c
394.764 -488.983 394.886 -489.44 394.886 -489.961 c
394.886 -490.465 394.761 -490.907 394.512 -491.286 c
394.264 -491.668 393.938 -491.86 393.535 -491.86 c
393.235 -491.86 392.981 -491.756 392.78 -491.553 c
392.578 -491.35 392.43 -491.106 392.338 -490.825 c
392.244 -490.541 392.199 -490.28 392.199 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
397.369 -489.952 m
397.36 -489.19 l
397.36 -488.657 397.367 -488.36 397.383 -488.297 c
397.401 -488.233 397.436 -488.168 397.491 -488.1 c
397.545 -488.034 397.66 -487.997 397.832 -487.985 c
397.926 -487.981 397.973 -487.959 397.973 -487.916 c
397.973 -487.87 397.939 -487.848 397.873 -487.848 c
397.849 -487.848 397.783 -487.854 397.678 -487.864 c
397.463 -487.885 397.275 -487.897 397.11 -487.897 c
396.969 -487.897 396.774 -487.891 396.526 -487.875 c
396.352 -487.868 l
396.285 -487.868 396.253 -487.887 396.253 -487.926 c
396.253 -487.965 396.302 -487.985 396.399 -487.985 c
396.532 -487.985 396.628 -488.024 396.686 -488.096 c
396.744 -488.172 396.782 -488.36 396.799 -488.663 c
396.817 -488.967 396.826 -489.368 396.826 -489.868 c
396.826 -490.336 396.817 -490.705 396.801 -490.977 c
396.784 -491.248 396.761 -491.424 396.731 -491.51 c
396.701 -491.594 396.656 -491.653 396.596 -491.69 c
396.535 -491.727 396.422 -491.748 396.253 -491.76 c
396.188 -491.764 396.155 -491.784 396.155 -491.823 c
396.155 -491.854 396.183 -491.873 396.241 -491.879 c
396.756 -491.918 397.729 -491.938 399.16 -491.938 c
399.407 -491.938 399.539 -491.934 399.561 -491.926 c
399.582 -491.918 399.598 -491.905 399.608 -491.885 c
399.616 -491.868 399.645 -491.725 399.69 -491.459 c
399.737 -491.196 399.76 -491.055 399.76 -491.043 c
399.76 -491 399.742 -490.979 399.708 -490.979 c
399.683 -490.979 399.658 -490.998 399.635 -491.039 c
399.346 -491.539 398.873 -491.789 398.221 -491.789 c
397.998 -491.789 397.816 -491.78 397.678 -491.76 c
397.538 -491.741 397.457 -491.717 397.435 -491.69 c
397.412 -491.661 397.397 -491.534 397.39 -491.305 c
397.383 -491.075 397.379 -490.672 397.379 -490.102 c
397.54 -490.094 397.653 -490.09 397.713 -490.09 c
398.006 -490.09 398.211 -490.153 398.326 -490.28 c
398.442 -490.407 398.502 -490.538 398.508 -490.676 c
398.512 -490.766 398.535 -490.811 398.578 -490.811 c
398.621 -490.811 398.645 -490.78 398.645 -490.717 c
398.645 -490.698 398.641 -490.67 398.637 -490.641 c
398.621 -490.522 398.615 -490.213 398.615 -489.719 c
398.615 -489.36 l
398.615 -489.274 398.588 -489.231 398.537 -489.231 c
398.493 -489.231 398.472 -489.262 398.469 -489.327 c
398.463 -489.512 398.405 -489.664 398.295 -489.782 c
398.184 -489.903 397.964 -489.961 397.639 -489.961 c
397.586 -489.961 397.495 -489.957 397.369 -489.952 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
405.16 -493.321 m
404.936 -493.327 404.778 -493.33 404.685 -493.33 c
404.059 -493.33 403.608 -493.202 403.326 -492.942 c
403.046 -492.682 402.883 -492.454 402.836 -492.252 c
402.823 -492.182 402.785 -492.145 402.723 -492.145 c
402.694 -492.145 402.667 -492.159 402.643 -492.184 c
402.657 -492.528 402.713 -492.993 402.811 -493.579 c
403.075 -493.579 l
403.301 -493.579 403.602 -493.565 403.981 -493.543 c
404.388 -493.52 405.012 -493.508 405.854 -493.508 c
406.714 -493.508 407.276 -493.518 407.535 -493.541 c
407.772 -493.565 408.098 -493.579 408.51 -493.579 c
408.547 -493.37 408.571 -493.153 408.582 -492.924 c
408.6 -492.668 408.616 -492.485 408.635 -492.383 c
408.637 -492.36 408.639 -492.334 408.639 -492.309 c
408.639 -492.239 408.61 -492.204 408.549 -492.204 c
408.514 -492.204 408.485 -492.217 408.46 -492.241 c
408.437 -492.266 408.38 -492.348 408.293 -492.485 c
408.141 -492.721 407.985 -492.899 407.821 -493.018 c
407.657 -493.137 407.474 -493.217 407.274 -493.25 c
407.072 -493.286 406.663 -493.309 406.051 -493.321 c
406.025 -492.885 406.011 -492.389 406.011 -491.829 c
406.011 -489.977 406.051 -488.883 406.13 -488.553 c
406.209 -488.219 406.492 -488.055 406.98 -488.055 c
407.098 -488.055 407.157 -488.03 407.157 -487.983 c
407.157 -487.924 407.101 -487.897 406.989 -487.897 c
404.327 -487.897 l
404.258 -487.897 404.223 -487.924 404.223 -487.977 c
404.223 -488.032 404.29 -488.059 404.426 -488.059 c
404.653 -488.059 404.836 -488.123 404.976 -488.252 c
405.116 -488.379 405.197 -488.553 405.217 -488.774 c
405.24 -488.993 405.25 -489.625 405.25 -490.67 c
405.25 -491.567 405.221 -492.448 405.16 -493.321 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
412.512 -491.905 m
412.573 -491.674 412.631 -491.352 412.688 -490.936 c
412.68 -490.916 412.668 -490.911 412.657 -490.911 c
412.641 -490.911 412.626 -490.916 412.612 -490.936 c
412.467 -491.164 412.332 -491.338 412.201 -491.457 c
412.073 -491.577 411.942 -491.663 411.811 -491.713 c
411.68 -491.764 411.455 -491.789 411.136 -491.789 c
410.835 -491.789 410.598 -491.772 410.423 -491.737 c
410.407 -491.715 410.397 -491.676 410.397 -491.622 c
410.397 -491.606 410.397 -491.582 410.392 -491.545 c
410.372 -491.379 410.362 -490.93 410.362 -490.2 c
410.362 -490.17 410.363 -490.125 410.367 -490.071 c
410.524 -490.065 410.631 -490.061 410.689 -490.061 c
410.948 -490.061 411.135 -490.098 411.252 -490.176 c
411.368 -490.256 411.469 -490.42 411.557 -490.678 c
411.569 -490.719 411.588 -490.743 411.615 -490.743 c
411.653 -490.743 411.67 -490.711 411.67 -490.651 c
411.66 -490.528 l
411.649 -490.366 411.641 -490.198 411.641 -490.026 c
411.641 -489.743 411.649 -489.493 411.66 -489.266 c
411.66 -489.198 411.643 -489.163 411.605 -489.163 c
411.576 -489.163 411.557 -489.186 411.546 -489.237 c
411.502 -489.479 411.412 -489.655 411.274 -489.762 c
411.136 -489.868 410.837 -489.922 410.376 -489.922 c
410.371 -489.772 410.367 -489.53 410.367 -489.192 c
410.367 -488.76 410.383 -488.485 410.414 -488.368 c
410.444 -488.25 410.518 -488.159 410.637 -488.09 c
410.752 -488.02 410.951 -487.985 411.233 -487.985 c
412.033 -487.985 412.55 -488.262 412.783 -488.813 c
412.81 -488.879 412.84 -488.914 412.869 -488.914 c
412.901 -488.914 412.916 -488.891 412.916 -488.846 c
412.916 -488.821 412.911 -488.793 412.901 -488.766 c
412.887 -488.727 412.858 -488.58 412.811 -488.329 c
412.801 -488.274 412.762 -488.114 412.694 -487.848 c
411.399 -487.85 l
411.213 -487.85 410.94 -487.858 410.579 -487.873 c
410.221 -487.889 409.903 -487.897 409.625 -487.899 c
409.348 -487.899 409.201 -487.905 409.19 -487.914 c
409.178 -487.926 409.172 -487.938 409.172 -487.952 c
409.172 -487.995 409.205 -488.016 409.274 -488.016 c
409.502 -488.016 409.654 -488.077 409.726 -488.198 c
409.798 -488.319 409.834 -488.614 409.834 -489.082 c
409.83 -489.717 l
409.84 -490.311 l
409.84 -490.428 409.833 -490.655 409.819 -490.987 c
409.806 -491.321 409.793 -491.51 409.782 -491.557 c
409.771 -491.604 409.739 -491.651 409.685 -491.698 c
409.632 -491.745 409.514 -491.789 409.332 -491.838 c
409.279 -491.852 409.251 -491.873 409.251 -491.903 c
409.251 -491.938 409.287 -491.957 409.36 -491.957 c
409.991 -491.924 l
410.213 -491.914 410.761 -491.909 411.634 -491.909 c
412.207 -491.909 412.5 -491.907 412.512 -491.905 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
416.702 -491.682 m
416.813 -491.782 416.878 -491.848 416.895 -491.883 c
416.915 -491.932 416.946 -491.957 416.985 -491.957 c
417.027 -491.957 417.049 -491.92 417.054 -491.846 c
417.122 -490.766 l
417.122 -490.704 417.119 -490.666 417.114 -490.653 c
417.111 -490.641 417.095 -490.633 417.07 -490.633 c
417.037 -490.633 417 -490.678 416.965 -490.768 c
416.828 -491.098 416.639 -491.37 416.397 -491.577 c
416.153 -491.784 415.886 -491.889 415.602 -491.889 c
415.35 -491.889 415.12 -491.807 414.91 -491.643 c
414.701 -491.483 414.537 -491.252 414.422 -490.954 c
414.307 -490.655 414.246 -490.332 414.246 -489.989 c
414.246 -489.403 414.408 -488.928 414.731 -488.565 c
415.051 -488.2 415.41 -488.016 415.805 -488.016 c
416.074 -488.016 416.323 -488.1 416.549 -488.27 c
416.774 -488.442 416.945 -488.637 417.059 -488.862 c
417.092 -488.922 417.122 -488.953 417.155 -488.953 c
417.2 -488.953 417.224 -488.93 417.224 -488.879 c
417.224 -488.819 417.146 -488.688 416.989 -488.489 c
416.832 -488.284 416.628 -488.122 416.373 -487.997 c
416.119 -487.872 415.846 -487.807 415.555 -487.807 c
415.211 -487.807 414.883 -487.897 414.574 -488.071 c
414.264 -488.247 414.02 -488.489 413.838 -488.797 c
413.657 -489.108 413.566 -489.469 413.566 -489.887 c
413.566 -490.293 413.654 -490.663 413.83 -490.991 c
414.006 -491.319 414.254 -491.571 414.574 -491.754 c
414.895 -491.936 415.224 -492.028 415.563 -492.028 c
415.745 -492.028 415.93 -491.998 416.119 -491.942 c
416.309 -491.885 416.504 -491.797 416.702 -491.682 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
420.882 -490.016 m
420.909 -490.877 l
420.909 -491.252 420.87 -491.502 420.796 -491.622 c
420.718 -491.741 420.591 -491.799 420.413 -491.799 c
420.311 -491.799 420.259 -491.819 420.259 -491.862 c
420.259 -491.899 420.288 -491.918 420.352 -491.918 c
421.257 -491.889 l
422.026 -491.899 l
422.085 -491.899 422.116 -491.877 422.116 -491.834 c
422.116 -491.797 422.096 -491.78 422.055 -491.78 c
421.899 -491.78 421.776 -491.756 421.69 -491.711 c
421.604 -491.666 421.546 -491.588 421.518 -491.481 c
421.489 -491.373 421.466 -491.063 421.45 -490.555 c
421.432 -490.041 421.423 -489.672 421.423 -489.44 c
421.415 -488.684 l
421.415 -488.45 421.436 -488.297 421.481 -488.227 c
421.524 -488.157 421.595 -488.1 421.682 -488.061 c
421.772 -488.02 421.864 -487.997 421.956 -487.985 c
422.024 -487.977 422.055 -487.957 422.055 -487.926 c
422.055 -487.891 422.028 -487.873 421.971 -487.873 c
421.022 -487.897 l
420.405 -487.868 l
420.333 -487.868 420.298 -487.889 420.298 -487.93 c
420.298 -487.965 420.323 -487.985 420.374 -487.985 c
420.536 -487.997 420.641 -488.018 420.692 -488.049 c
420.741 -488.084 420.782 -488.145 420.813 -488.239 c
420.843 -488.33 420.86 -488.485 420.866 -488.707 c
420.882 -489.823 l
420.702 -489.836 420.522 -489.842 420.341 -489.842 c
419.544 -489.842 419.039 -489.829 418.824 -489.799 c
418.809 -489.403 418.8 -489.077 418.8 -488.819 c
418.8 -488.532 418.807 -488.356 418.819 -488.289 c
418.832 -488.225 418.869 -488.161 418.936 -488.104 c
419 -488.049 419.09 -488.008 419.203 -487.985 c
419.274 -487.971 419.309 -487.95 419.309 -487.92 c
419.309 -487.885 419.287 -487.868 419.241 -487.868 c
419.227 -487.868 419.205 -487.87 419.18 -487.875 c
419.069 -487.891 418.838 -487.897 418.487 -487.897 c
418.106 -487.897 417.871 -487.889 417.785 -487.87 c
417.766 -487.868 417.748 -487.868 417.729 -487.868 c
417.683 -487.868 417.658 -487.883 417.658 -487.916 c
417.658 -487.954 417.69 -487.977 417.753 -487.985 c
417.913 -488.004 418.024 -488.049 418.092 -488.12 c
418.16 -488.188 418.207 -488.45 418.235 -488.903 c
418.259 -489.356 418.272 -489.907 418.272 -490.555 c
418.272 -491.082 418.246 -491.414 418.197 -491.551 c
418.146 -491.69 418.027 -491.764 417.832 -491.78 c
417.789 -491.784 417.768 -491.799 417.768 -491.832 c
417.768 -491.875 417.811 -491.899 417.901 -491.899 c
419.153 -491.918 l
419.241 -491.918 419.294 -491.914 419.312 -491.909 c
419.328 -491.905 419.339 -491.887 419.339 -491.86 c
419.339 -491.827 419.312 -491.807 419.257 -491.799 c
419.053 -491.78 418.926 -491.741 418.883 -491.688 c
418.838 -491.635 418.815 -491.301 418.815 -490.688 c
418.815 -490.627 418.819 -490.403 418.824 -490.022 c
419.034 -490 419.282 -489.993 419.565 -489.993 c
419.932 -489.993 420.37 -489.998 420.882 -490.016 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
423.542 -491.922 m
423.665 -491.754 423.88 -491.495 424.184 -491.145 c
425.169 -490 l
426.12 -488.899 l
426.139 -489.272 426.149 -489.756 426.149 -490.352 c
426.149 -490.795 426.141 -491.096 426.122 -491.248 c
426.102 -491.401 426.036 -491.526 425.917 -491.629 c
425.798 -491.731 425.651 -491.784 425.473 -491.784 c
425.391 -491.784 425.35 -491.799 425.35 -491.834 c
425.35 -491.856 425.358 -491.87 425.376 -491.879 c
425.393 -491.889 425.532 -491.899 425.792 -491.907 c
426.053 -491.916 426.27 -491.922 426.448 -491.922 c
426.864 -491.918 l
426.932 -491.918 l
426.999 -491.918 427.028 -491.899 427.028 -491.864 c
427.028 -491.829 427.001 -491.809 426.944 -491.803 c
426.739 -491.78 426.589 -491.727 426.497 -491.639 c
426.405 -491.555 426.352 -491.432 426.333 -491.272 c
426.315 -491.112 426.307 -490.573 426.307 -489.653 c
426.274 -488.024 l
426.274 -487.942 426.257 -487.901 426.216 -487.901 c
426.204 -487.901 426.19 -487.905 426.171 -487.914 c
426.153 -487.924 426.063 -488.03 425.895 -488.227 c
425.729 -488.424 425.524 -488.663 425.278 -488.94 c
425.036 -489.217 424.845 -489.444 424.704 -489.618 c
424.399 -489.989 424.206 -490.217 424.124 -490.303 c
423.827 -490.622 423.651 -490.825 423.598 -490.914 c
423.563 -490.977 423.532 -491.008 423.503 -491.008 c
423.479 -491.008 423.466 -490.967 423.466 -490.887 c
423.471 -490.409 l
423.471 -489.799 423.489 -489.315 423.522 -488.953 c
423.555 -488.59 423.589 -488.377 423.626 -488.315 c
423.661 -488.252 423.725 -488.19 423.813 -488.125 c
423.903 -488.059 423.999 -488.03 424.1 -488.03 c
424.235 -488.03 424.302 -488.004 424.302 -487.954 c
424.302 -487.914 424.264 -487.897 424.188 -487.897 c
422.708 -487.901 l
422.637 -487.901 422.602 -487.918 422.602 -487.954 c
422.602 -487.997 422.637 -488.02 422.704 -488.02 c
422.958 -488.02 423.124 -488.075 423.21 -488.188 c
423.292 -488.299 423.333 -488.538 423.333 -488.903 c
423.309 -489.989 l
423.305 -490.623 423.286 -490.998 423.253 -491.112 c
423.218 -491.227 423.139 -491.366 423.016 -491.528 c
422.893 -491.69 422.755 -491.782 422.598 -491.803 c
422.528 -491.813 422.493 -491.832 422.493 -491.864 c
422.493 -491.905 422.54 -491.928 422.632 -491.928 c
423.542 -491.922 l
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
427.552 -489.942 m
427.552 -490.221 427.636 -490.526 427.803 -490.858 c
427.971 -491.192 428.218 -491.465 428.542 -491.682 c
428.864 -491.899 429.229 -492.008 429.636 -492.008 c
430.204 -492.008 430.675 -491.801 431.046 -491.395 c
431.415 -490.987 431.602 -490.522 431.602 -489.998 c
431.602 -489.444 431.395 -488.942 430.985 -488.498 c
430.575 -488.059 430.081 -487.838 429.505 -487.838 c
428.952 -487.838 428.489 -488.03 428.112 -488.418 c
427.737 -488.805 427.552 -489.313 427.552 -489.942 c
428.233 -490.041 m
428.233 -489.705 428.284 -489.36 428.387 -489.006 c
428.489 -488.653 428.651 -488.393 428.872 -488.235 c
429.093 -488.075 429.327 -487.997 429.577 -487.997 c
429.985 -487.997 430.311 -488.194 430.556 -488.588 c
430.796 -488.983 430.919 -489.44 430.919 -489.961 c
430.919 -490.465 430.796 -490.907 430.546 -491.286 c
430.296 -491.668 429.972 -491.86 429.569 -491.86 c
429.268 -491.86 429.014 -491.756 428.811 -491.553 c
428.61 -491.35 428.464 -491.106 428.372 -490.825 c
428.28 -490.541 428.233 -490.28 428.233 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
435.645 -487.873 m
435.546 -487.868 435.487 -487.864 435.472 -487.864 c
435.397 -487.864 435.257 -487.868 435.06 -487.879 c
434.858 -487.889 434.444 -487.893 433.813 -487.893 c
433.028 -487.893 l
433.001 -487.893 432.895 -487.889 432.712 -487.879 c
432.532 -487.868 432.421 -487.864 432.384 -487.864 c
432.226 -487.864 432.147 -487.885 432.147 -487.928 c
432.147 -487.963 432.179 -487.981 432.241 -487.983 c
432.44 -487.995 432.579 -488.038 432.655 -488.11 c
432.735 -488.184 432.788 -488.288 432.815 -488.426 c
432.847 -488.563 432.86 -488.932 432.86 -489.536 c
432.862 -490.641 l
432.862 -490.998 432.849 -491.25 432.815 -491.391 c
432.782 -491.534 432.718 -491.643 432.616 -491.717 c
432.517 -491.791 432.403 -491.834 432.276 -491.844 c
432.212 -491.85 432.179 -491.873 432.179 -491.911 c
432.179 -491.948 432.206 -491.967 432.268 -491.967 c
432.282 -491.967 432.308 -491.967 432.349 -491.965 c
432.675 -491.944 433.058 -491.934 433.497 -491.934 c
434.04 -491.944 l
434.097 -491.944 434.124 -491.924 434.124 -491.883 c
434.124 -491.844 434.093 -491.827 434.036 -491.827 c
433.89 -491.827 433.77 -491.797 433.673 -491.741 c
433.577 -491.684 433.511 -491.616 433.479 -491.541 c
433.446 -491.467 433.433 -491.321 433.433 -491.104 c
433.403 -489.645 l
433.409 -488.83 l
433.409 -488.578 433.419 -488.414 433.442 -488.338 c
433.464 -488.262 433.509 -488.194 433.577 -488.133 c
433.642 -488.073 433.767 -488.041 433.946 -488.041 c
433.962 -488.041 434.145 -488.049 434.499 -488.059 c
434.782 -488.098 435.034 -488.235 435.261 -488.469 c
435.483 -488.704 435.634 -488.914 435.708 -489.098 c
435.731 -489.153 435.759 -489.178 435.792 -489.178 c
435.827 -489.178 435.845 -489.153 435.845 -489.102 c
435.845 -489.045 435.813 -488.838 435.757 -488.483 c
435.696 -488.127 435.661 -487.924 435.645 -487.873 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
436.143 -489.942 m
436.143 -490.221 436.226 -490.526 436.393 -490.858 c
436.563 -491.192 436.81 -491.465 437.134 -491.682 c
437.456 -491.899 437.821 -492.008 438.229 -492.008 c
438.796 -492.008 439.267 -491.801 439.638 -491.395 c
440.007 -490.987 440.194 -490.522 440.194 -489.998 c
440.194 -489.444 439.987 -488.942 439.577 -488.498 c
439.165 -488.059 438.673 -487.838 438.097 -487.838 c
437.544 -487.838 437.079 -488.03 436.704 -488.418 c
436.329 -488.805 436.143 -489.313 436.143 -489.942 c
436.825 -490.041 m
436.825 -489.705 436.874 -489.36 436.977 -489.006 c
437.081 -488.653 437.243 -488.393 437.464 -488.235 c
437.683 -488.075 437.919 -487.997 438.171 -487.997 c
438.577 -487.997 438.901 -488.194 439.145 -488.588 c
439.39 -488.983 439.511 -489.44 439.511 -489.961 c
439.511 -490.465 439.386 -490.907 439.14 -491.286 c
438.89 -491.668 438.563 -491.86 438.161 -491.86 c
437.858 -491.86 437.606 -491.756 437.405 -491.553 c
437.202 -491.35 437.056 -491.106 436.962 -490.825 c
436.87 -490.541 436.825 -490.28 436.825 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
444.786 -490.643 m
444.757 -490.643 444.731 -490.676 444.7 -490.743 c
444.53 -491.112 444.306 -491.397 444.028 -491.596 c
443.751 -491.797 443.452 -491.899 443.14 -491.899 c
442.884 -491.899 442.632 -491.821 442.39 -491.664 c
442.149 -491.508 441.952 -491.268 441.8 -490.944 c
441.645 -490.618 441.569 -490.274 441.569 -489.907 c
441.569 -489.381 441.727 -488.93 442.04 -488.547 c
442.354 -488.166 442.745 -487.977 443.216 -487.977 c
443.382 -487.977 443.526 -488.002 443.643 -488.055 c
443.761 -488.106 443.872 -488.18 443.977 -488.278 c
444.079 -488.375 444.143 -488.448 444.165 -488.495 c
444.186 -488.543 444.198 -488.668 444.198 -488.873 c
444.198 -489.213 444.153 -489.438 444.063 -489.547 c
443.974 -489.653 443.829 -489.707 443.632 -489.707 c
443.538 -489.705 l
443.477 -489.705 443.446 -489.723 443.446 -489.762 c
443.446 -489.809 443.479 -489.834 443.546 -489.834 c
443.71 -489.827 l
444.413 -489.834 l
445.272 -489.852 l
445.319 -489.852 445.345 -489.832 445.345 -489.788 c
445.345 -489.743 445.317 -489.717 445.263 -489.715 c
445.136 -489.702 445.028 -489.674 444.948 -489.629 c
444.866 -489.588 444.817 -489.538 444.798 -489.483 c
444.78 -489.428 444.77 -489.332 444.77 -489.202 c
444.77 -488.719 444.759 -488.454 444.737 -488.405 c
444.714 -488.36 444.522 -488.25 444.161 -488.08 c
443.8 -487.913 443.436 -487.828 443.071 -487.828 c
442.468 -487.828 441.95 -488.02 441.522 -488.409 c
441.093 -488.793 440.878 -489.286 440.878 -489.877 c
440.878 -490.286 440.981 -490.653 441.183 -490.985 c
441.386 -491.315 441.663 -491.571 442.018 -491.752 c
442.368 -491.936 442.729 -492.028 443.093 -492.028 c
443.435 -492.028 443.804 -491.93 444.2 -491.735 c
444.311 -491.678 444.39 -491.651 444.436 -491.651 c
444.499 -491.651 444.548 -491.68 444.583 -491.737 c
444.616 -491.784 444.643 -491.809 444.667 -491.809 c
444.716 -491.809 444.741 -491.748 444.751 -491.629 c
444.763 -491.442 444.794 -491.157 444.845 -490.774 c
444.847 -490.752 444.851 -490.735 444.851 -490.717 c
444.851 -490.668 444.829 -490.643 444.786 -490.643 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
447.993 -490.006 m
448.11 -490.133 448.286 -490.364 448.522 -490.696 c
448.757 -491.03 448.895 -491.237 448.94 -491.319 c
448.981 -491.401 449.001 -491.465 449.001 -491.512 c
449.001 -491.596 448.96 -491.664 448.872 -491.713 c
448.788 -491.764 448.7 -491.789 448.612 -491.789 c
448.542 -491.789 448.507 -491.809 448.507 -491.846 c
448.507 -491.887 448.565 -491.909 448.683 -491.909 c
449.849 -491.909 l
449.956 -491.909 450.009 -491.885 450.009 -491.84 c
450.009 -491.805 449.985 -491.786 449.938 -491.786 c
449.815 -491.786 449.7 -491.758 449.589 -491.704 c
449.476 -491.649 449.339 -491.524 449.179 -491.33 c
448.638 -490.604 l
448.356 -490.227 448.204 -490.004 448.183 -489.938 c
448.149 -489.842 448.134 -489.586 448.134 -489.17 c
448.134 -488.62 448.155 -488.291 448.202 -488.19 c
448.249 -488.086 448.399 -488.024 448.655 -488 c
448.722 -487.995 448.755 -487.973 448.755 -487.94 c
448.755 -487.897 448.72 -487.877 448.645 -487.877 c
447.813 -487.897 l
447.612 -487.897 447.45 -487.893 447.321 -487.881 c
447.218 -487.873 447.153 -487.868 447.124 -487.868 c
447.044 -487.868 447.007 -487.889 447.007 -487.932 c
447.007 -487.965 447.032 -487.985 447.093 -487.985 c
447.292 -487.995 447.423 -488.067 447.489 -488.209 c
447.556 -488.348 447.589 -488.553 447.589 -488.829 c
447.589 -489.127 447.569 -489.372 447.528 -489.555 c
447.52 -489.602 447.433 -489.772 447.265 -490.061 c
447.099 -490.35 446.89 -490.668 446.647 -491.02 c
446.405 -491.37 446.231 -491.584 446.126 -491.659 c
446.022 -491.735 445.921 -491.778 445.821 -491.786 c
445.749 -491.791 445.712 -491.815 445.712 -491.85 c
445.712 -491.873 445.722 -491.889 445.741 -491.899 c
445.761 -491.905 445.819 -491.909 445.915 -491.909 c
447.265 -491.909 l
447.358 -491.909 447.415 -491.905 447.433 -491.899 c
447.452 -491.891 447.46 -491.873 447.46 -491.846 c
447.46 -491.813 447.433 -491.793 447.382 -491.789 c
447.12 -491.77 446.989 -491.69 446.989 -491.555 c
446.989 -491.485 447.036 -491.375 447.13 -491.225 c
447.226 -491.075 447.515 -490.668 447.993 -490.006 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
456.776 -489.297 m
457.042 -488.797 457.243 -488.493 457.384 -488.379 c
457.526 -488.27 457.667 -488.213 457.81 -488.213 c
457.999 -488.213 458.183 -488.289 458.358 -488.45 c
458.378 -488.469 458.395 -488.479 458.411 -488.479 c
458.468 -488.479 458.497 -488.45 458.497 -488.393 c
458.497 -488.336 458.366 -488.225 458.102 -488.057 c
457.839 -487.891 457.579 -487.807 457.317 -487.807 c
457.163 -487.807 457.018 -487.856 456.886 -487.948 c
456.751 -488.041 456.558 -488.307 456.306 -488.745 c
455.661 -488.12 455.044 -487.807 454.45 -487.807 c
454.044 -487.807 453.702 -487.932 453.423 -488.18 c
453.143 -488.428 453.005 -488.741 453.005 -489.116 c
453.005 -489.467 453.118 -489.788 453.347 -490.078 c
453.571 -490.368 453.956 -490.688 454.499 -491.034 c
453.976 -491.549 453.716 -492.002 453.716 -492.391 c
453.716 -492.719 453.833 -492.985 454.065 -493.192 c
454.298 -493.397 454.565 -493.498 454.868 -493.498 c
455.136 -493.498 455.374 -493.413 455.583 -493.241 c
455.794 -493.069 455.897 -492.846 455.897 -492.569 c
455.897 -492.198 455.642 -491.791 455.13 -491.354 c
455.808 -490.795 456.323 -490.174 456.679 -489.487 c
457.052 -490.065 457.239 -490.512 457.239 -490.834 c
457.239 -490.979 457.192 -491.094 457.102 -491.182 c
457.011 -491.27 456.886 -491.315 456.724 -491.315 c
456.583 -491.315 456.511 -491.342 456.511 -491.393 c
456.511 -491.454 456.542 -491.483 456.602 -491.483 c
457.364 -491.454 l
458.386 -491.463 l
458.468 -491.463 458.507 -491.436 458.507 -491.377 c
458.507 -491.323 458.454 -491.295 458.352 -491.295 c
458.142 -491.289 457.966 -491.213 457.819 -491.067 c
457.673 -490.92 457.497 -490.631 457.294 -490.196 c
457.101 -489.778 456.929 -489.477 456.776 -489.297 c
454.64 -490.891 m
454.351 -490.696 454.122 -490.491 453.954 -490.276 c
453.79 -490.057 453.706 -489.795 453.706 -489.483 c
453.706 -489.125 453.819 -488.825 454.048 -488.578 c
454.278 -488.334 454.544 -488.213 454.849 -488.213 c
455.29 -488.213 455.745 -488.45 456.212 -488.922 c
455.974 -489.354 455.767 -489.684 455.587 -489.913 c
455.407 -490.143 455.091 -490.469 454.64 -490.891 c
454.983 -491.497 m
455.351 -491.823 455.534 -492.159 455.534 -492.504 c
455.534 -492.715 455.462 -492.899 455.317 -493.055 c
455.175 -493.211 455.007 -493.291 454.815 -493.291 c
454.636 -493.291 454.491 -493.225 454.382 -493.092 c
454.272 -492.959 454.22 -492.805 454.22 -492.629 c
454.22 -492.289 454.474 -491.913 454.983 -491.497 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
464.692 -493.248 m
464.77 -493.327 464.823 -493.409 464.849 -493.493 c
464.87 -493.561 464.905 -493.596 464.948 -493.596 c
464.972 -493.596 464.997 -493.582 465.026 -493.555 c
465.044 -493.452 465.073 -493.241 465.112 -492.928 c
465.214 -492.114 l
465.214 -492.063 465.181 -492.038 465.118 -492.038 c
465.083 -492.038 465.052 -492.065 465.026 -492.123 c
464.872 -492.5 464.645 -492.817 464.345 -493.067 c
464.042 -493.315 463.716 -493.44 463.358 -493.44 c
463.009 -493.44 462.743 -493.332 462.567 -493.123 c
462.388 -492.913 462.298 -492.688 462.298 -492.452 c
462.298 -492.163 462.395 -491.942 462.591 -491.789 c
462.784 -491.637 463.183 -491.463 463.788 -491.27 c
464.233 -491.131 464.567 -490.998 464.79 -490.868 c
465.009 -490.739 465.194 -490.557 465.345 -490.325 c
465.493 -490.09 465.569 -489.838 465.569 -489.573 c
465.569 -489.116 465.38 -488.709 465.005 -488.348 c
464.626 -487.987 464.163 -487.807 463.618 -487.807 c
463.126 -487.807 462.63 -487.961 462.134 -488.27 c
462.036 -488.19 461.972 -488.094 461.944 -487.985 c
461.921 -487.893 461.886 -487.848 461.833 -487.848 c
461.788 -487.848 461.755 -487.905 461.735 -488.024 c
461.716 -488.143 461.671 -488.704 461.606 -489.702 c
461.62 -489.737 461.649 -489.754 461.7 -489.754 c
461.743 -489.754 461.778 -489.721 461.806 -489.659 c
462.247 -488.543 462.866 -487.985 463.659 -487.985 c
464.054 -487.985 464.36 -488.104 464.583 -488.342 c
464.804 -488.58 464.917 -488.854 464.917 -489.161 c
464.917 -489.373 464.856 -489.571 464.737 -489.748 c
464.616 -489.928 464.458 -490.071 464.259 -490.182 c
464.061 -490.291 463.747 -490.413 463.319 -490.547 c
462.77 -490.723 462.397 -490.891 462.202 -491.047 c
462.007 -491.205 461.866 -491.383 461.774 -491.578 c
461.683 -491.776 461.638 -491.967 461.638 -492.151 c
461.638 -492.534 461.811 -492.875 462.159 -493.172 c
462.507 -493.467 462.933 -493.618 463.438 -493.618 c
463.628 -493.618 463.827 -493.586 464.038 -493.526 c
464.247 -493.467 464.464 -493.372 464.692 -493.248 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
466.317 -489.942 m
466.317 -490.221 466.401 -490.526 466.569 -490.858 c
466.739 -491.192 466.983 -491.465 467.308 -491.682 c
467.634 -491.899 467.995 -492.008 468.403 -492.008 c
468.972 -492.008 469.442 -491.801 469.813 -491.395 c
470.183 -490.987 470.368 -490.522 470.368 -489.998 c
470.368 -489.444 470.163 -488.942 469.753 -488.498 c
469.341 -488.059 468.849 -487.838 468.27 -487.838 c
467.718 -487.838 467.255 -488.03 466.88 -488.418 c
466.505 -488.805 466.317 -489.313 466.317 -489.942 c
466.999 -490.041 m
466.999 -489.705 467.05 -489.36 467.153 -489.006 c
467.257 -488.653 467.417 -488.393 467.638 -488.235 c
467.858 -488.075 468.095 -487.997 468.345 -487.997 c
468.751 -487.997 469.077 -488.194 469.319 -488.588 c
469.563 -488.983 469.685 -489.44 469.685 -489.961 c
469.685 -490.465 469.563 -490.907 469.313 -491.286 c
469.063 -491.668 468.737 -491.86 468.337 -491.86 c
468.034 -491.86 467.782 -491.756 467.581 -491.553 c
467.378 -491.35 467.231 -491.106 467.138 -490.825 c
467.046 -490.541 466.999 -490.28 466.999 -490.041 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
474.218 -491.682 m
474.331 -491.782 474.393 -491.848 474.413 -491.883 c
474.433 -491.932 474.464 -491.957 474.503 -491.957 c
474.544 -491.957 474.565 -491.92 474.569 -491.846 c
474.64 -490.766 l
474.64 -490.704 474.638 -490.666 474.632 -490.653 c
474.626 -490.641 474.612 -490.633 474.587 -490.633 c
474.554 -490.633 474.518 -490.678 474.481 -490.768 c
474.345 -491.098 474.157 -491.37 473.913 -491.577 c
473.669 -491.784 473.405 -491.889 473.118 -491.889 c
472.868 -491.889 472.638 -491.807 472.427 -491.643 c
472.218 -491.483 472.054 -491.252 471.938 -490.954 c
471.823 -490.655 471.765 -490.332 471.765 -489.989 c
471.765 -489.403 471.927 -488.928 472.247 -488.565 c
472.567 -488.2 472.927 -488.016 473.323 -488.016 c
473.591 -488.016 473.841 -488.1 474.065 -488.27 c
474.292 -488.442 474.462 -488.637 474.577 -488.862 c
474.608 -488.922 474.642 -488.953 474.673 -488.953 c
474.718 -488.953 474.741 -488.93 474.741 -488.879 c
474.741 -488.819 474.661 -488.688 474.507 -488.489 c
474.351 -488.284 474.143 -488.122 473.89 -487.997 c
473.638 -487.872 473.362 -487.807 473.069 -487.807 c
472.727 -487.807 472.401 -487.897 472.089 -488.071 c
471.782 -488.247 471.536 -488.489 471.352 -488.797 c
471.175 -489.108 471.083 -489.469 471.083 -489.887 c
471.083 -490.293 471.171 -490.663 471.349 -490.991 c
471.522 -491.319 471.772 -491.571 472.089 -491.754 c
472.411 -491.936 472.741 -492.028 473.081 -492.028 c
473.261 -492.028 473.448 -491.998 473.638 -491.942 c
473.827 -491.885 474.02 -491.797 474.218 -491.682 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
475.409 -491.967 m
475.974 -491.957 l
476.837 -491.967 l
476.942 -491.967 476.993 -491.948 476.993 -491.905 c
476.993 -491.872 476.966 -491.852 476.911 -491.844 c
476.683 -491.815 476.542 -491.735 476.485 -491.6 c
476.429 -491.463 476.399 -490.961 476.399 -490.094 c
476.399 -489.776 476.409 -489.416 476.425 -489.018 c
476.44 -488.62 476.46 -488.379 476.479 -488.301 c
476.501 -488.225 476.54 -488.161 476.597 -488.11 c
476.655 -488.061 476.761 -488.026 476.917 -488.004 c
476.968 -488 476.993 -487.979 476.993 -487.946 c
476.993 -487.905 476.97 -487.887 476.923 -487.887 c
476.155 -487.897 l
475.501 -487.887 l
475.429 -487.887 475.392 -487.909 475.392 -487.95 c
475.392 -487.995 475.423 -488.016 475.479 -488.016 c
475.671 -488.02 475.784 -488.084 475.817 -488.205 c
475.851 -488.33 475.868 -488.723 475.868 -489.389 c
475.868 -490.03 475.86 -490.547 475.849 -490.946 c
475.839 -491.342 475.806 -491.584 475.749 -491.672 c
475.692 -491.76 475.587 -491.815 475.431 -491.838 c
475.372 -491.848 475.343 -491.873 475.343 -491.911 c
475.343 -491.948 475.366 -491.967 475.409 -491.967 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
481.013 -491.905 m
481.073 -491.674 481.132 -491.352 481.19 -490.936 c
481.181 -490.916 481.169 -490.911 481.157 -490.911 c
481.143 -490.911 481.126 -490.916 481.112 -490.936 c
480.97 -491.164 480.833 -491.338 480.702 -491.457 c
480.573 -491.577 480.444 -491.663 480.313 -491.713 c
480.183 -491.764 479.958 -491.789 479.638 -491.789 c
479.339 -491.789 479.099 -491.772 478.925 -491.737 c
478.907 -491.715 478.899 -491.676 478.899 -491.622 c
478.899 -491.606 478.895 -491.582 478.893 -491.545 c
478.872 -491.379 478.862 -490.93 478.862 -490.2 c
478.862 -490.17 478.864 -490.125 478.868 -490.071 c
479.024 -490.065 479.132 -490.061 479.19 -490.061 c
479.448 -490.061 479.636 -490.098 479.755 -490.176 c
479.87 -490.256 479.972 -490.42 480.058 -490.678 c
480.069 -490.719 480.091 -490.743 480.116 -490.743 c
480.153 -490.743 480.173 -490.711 480.173 -490.651 c
480.161 -490.528 l
480.149 -490.366 480.143 -490.198 480.143 -490.026 c
480.143 -489.743 480.149 -489.493 480.161 -489.266 c
480.161 -489.198 480.143 -489.163 480.104 -489.163 c
480.075 -489.163 480.058 -489.186 480.048 -489.237 c
480.005 -489.479 479.913 -489.655 479.776 -489.762 c
479.638 -489.868 479.339 -489.922 478.878 -489.922 c
478.872 -489.772 478.868 -489.53 478.868 -489.192 c
478.868 -488.76 478.884 -488.485 478.915 -488.368 c
478.946 -488.25 479.02 -488.159 479.138 -488.09 c
479.255 -488.02 479.452 -487.985 479.733 -487.985 c
480.534 -487.985 481.052 -488.262 481.284 -488.813 c
481.311 -488.879 481.341 -488.914 481.37 -488.914 c
481.401 -488.914 481.417 -488.891 481.417 -488.846 c
481.417 -488.821 481.411 -488.793 481.403 -488.766 c
481.39 -488.727 481.358 -488.58 481.313 -488.329 c
481.3 -488.274 481.263 -488.114 481.196 -487.848 c
479.899 -487.85 l
479.714 -487.85 479.44 -487.858 479.083 -487.873 c
478.722 -487.889 478.403 -487.897 478.126 -487.899 c
477.849 -487.899 477.702 -487.905 477.692 -487.914 c
477.679 -487.926 477.673 -487.938 477.673 -487.952 c
477.673 -487.995 477.708 -488.016 477.774 -488.016 c
478.005 -488.016 478.153 -488.077 478.226 -488.198 c
478.298 -488.319 478.335 -488.614 478.335 -489.082 c
478.333 -489.717 l
478.339 -490.311 l
478.339 -490.428 478.335 -490.655 478.319 -490.987 c
478.308 -491.321 478.296 -491.51 478.282 -491.557 c
478.272 -491.604 478.239 -491.651 478.186 -491.698 c
478.132 -491.745 478.015 -491.789 477.835 -491.838 c
477.778 -491.852 477.753 -491.873 477.753 -491.903 c
477.753 -491.938 477.788 -491.957 477.86 -491.957 c
478.491 -491.924 l
478.714 -491.914 479.261 -491.909 480.136 -491.909 c
480.708 -491.909 481.001 -491.907 481.013 -491.905 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
483.688 -491.77 m
483.526 -491.776 483.413 -491.78 483.347 -491.78 c
482.903 -491.78 482.583 -491.686 482.384 -491.5 c
482.183 -491.315 482.067 -491.151 482.036 -491.006 c
482.024 -490.954 481.997 -490.93 481.954 -490.93 c
481.935 -490.93 481.917 -490.94 481.899 -490.961 c
481.909 -491.209 481.95 -491.539 482.017 -491.957 c
482.206 -491.957 l
482.366 -491.957 482.583 -491.95 482.852 -491.932 c
483.143 -491.914 483.587 -491.909 484.185 -491.909 c
484.798 -491.909 485.198 -491.914 485.384 -491.93 c
485.552 -491.95 485.784 -491.957 486.079 -491.957 c
486.102 -491.809 486.118 -491.653 486.126 -491.493 c
486.14 -491.309 486.151 -491.18 486.163 -491.106 c
486.167 -491.09 486.167 -491.073 486.167 -491.053 c
486.167 -491.004 486.145 -490.979 486.102 -490.979 c
486.079 -490.979 486.056 -490.987 486.038 -491.004 c
486.02 -491.022 485.981 -491.08 485.919 -491.18 c
485.81 -491.344 485.698 -491.471 485.581 -491.555 c
485.464 -491.639 485.335 -491.696 485.192 -491.721 c
485.048 -491.745 484.759 -491.762 484.319 -491.77 c
484.3 -491.459 484.29 -491.104 484.29 -490.705 c
484.29 -489.385 484.317 -488.606 484.374 -488.37 c
484.431 -488.133 484.636 -488.016 484.985 -488.016 c
485.067 -488.016 485.11 -487.997 485.11 -487.961 c
485.11 -487.918 485.069 -487.897 484.991 -487.897 c
483.101 -487.897 l
483.05 -487.897 483.026 -487.916 483.026 -487.957 c
483.026 -487.998 483.073 -488.018 483.169 -488.018 c
483.331 -488.018 483.462 -488.063 483.561 -488.155 c
483.661 -488.247 483.718 -488.372 483.735 -488.528 c
483.749 -488.684 483.757 -489.135 483.757 -489.883 c
483.757 -490.518 483.735 -491.149 483.688 -491.77 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
488.823 -490.006 m
488.938 -490.133 489.114 -490.364 489.351 -490.696 c
489.587 -491.03 489.726 -491.237 489.768 -491.319 c
489.811 -491.401 489.831 -491.465 489.831 -491.512 c
489.831 -491.596 489.788 -491.664 489.702 -491.713 c
489.618 -491.764 489.53 -491.789 489.44 -491.789 c
489.37 -491.789 489.335 -491.809 489.335 -491.846 c
489.335 -491.887 489.395 -491.909 489.511 -491.909 c
490.679 -491.909 l
490.784 -491.909 490.837 -491.885 490.837 -491.84 c
490.837 -491.805 490.815 -491.786 490.767 -491.786 c
490.645 -491.786 490.528 -491.758 490.417 -491.704 c
490.306 -491.649 490.167 -491.524 490.007 -491.33 c
489.468 -490.604 l
489.185 -490.227 489.032 -490.004 489.011 -489.938 c
488.977 -489.842 488.962 -489.586 488.962 -489.17 c
488.962 -488.62 488.985 -488.291 489.032 -488.19 c
489.077 -488.086 489.227 -488.024 489.483 -488 c
489.55 -487.995 489.583 -487.973 489.583 -487.94 c
489.583 -487.897 489.548 -487.877 489.476 -487.877 c
488.643 -487.897 l
488.442 -487.897 488.278 -487.893 488.149 -487.881 c
488.048 -487.873 487.981 -487.868 487.952 -487.868 c
487.874 -487.868 487.835 -487.889 487.835 -487.932 c
487.835 -487.965 487.864 -487.985 487.923 -487.985 c
488.12 -487.995 488.251 -488.067 488.319 -488.209 c
488.386 -488.348 488.417 -488.553 488.417 -488.829 c
488.417 -489.127 488.397 -489.372 488.358 -489.555 c
488.351 -489.602 488.261 -489.772 488.095 -490.061 c
487.927 -490.35 487.72 -490.668 487.477 -491.02 c
487.235 -491.37 487.06 -491.584 486.954 -491.659 c
486.851 -491.735 486.749 -491.778 486.651 -491.786 c
486.577 -491.791 486.54 -491.815 486.54 -491.85 c
486.54 -491.873 486.552 -491.889 486.569 -491.899 c
486.589 -491.905 486.647 -491.909 486.745 -491.909 c
488.095 -491.909 l
488.188 -491.909 488.243 -491.905 488.261 -491.899 c
488.28 -491.891 488.29 -491.873 488.29 -491.846 c
488.29 -491.813 488.263 -491.793 488.21 -491.789 c
487.948 -491.77 487.817 -491.69 487.817 -491.555 c
487.817 -491.485 487.864 -491.375 487.958 -491.225 c
488.054 -491.075 488.341 -490.668 488.823 -490.006 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
470.474 -499.256 m
459.173 -498.914 l
380.199 -498.914 l
368.84 -499.266 l
380.199 -499.622 l
459.173 -499.622 l
h
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
424.1 -499.096 m
424.47 -498.989 l
424.235 -498.36 423.858 -497.907 423.345 -497.637 c
422.829 -497.37 422.29 -497.317 421.721 -497.483 c
421.442 -497.565 421.159 -497.7 420.868 -497.887 c
420.579 -498.077 419.932 -498.551 418.936 -499.317 c
418.176 -499.897 417.615 -500.241 417.25 -500.348 c
416.426 -500.588 415.752 -500.276 415.23 -499.411 c
414.861 -499.518 l
415.121 -500.207 415.512 -500.67 416.031 -500.905 c
416.548 -501.141 417.043 -501.188 417.518 -501.051 c
418.024 -500.903 418.975 -500.286 420.37 -499.202 c
421.116 -498.622 421.678 -498.276 422.063 -498.164 c
422.542 -498.026 422.954 -498.051 423.302 -498.239 c
423.649 -498.428 423.915 -498.713 424.1 -499.096 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
433.485 -499.096 m
433.854 -498.989 l
433.62 -498.36 433.245 -497.907 432.729 -497.637 c
432.214 -497.37 431.677 -497.317 431.108 -497.483 c
430.829 -497.565 430.546 -497.7 430.255 -497.887 c
429.964 -498.077 429.319 -498.551 428.319 -499.317 c
427.565 -499.897 427.001 -500.241 426.636 -500.348 c
425.811 -500.588 425.137 -500.276 424.616 -499.411 c
424.247 -499.518 l
424.507 -500.207 424.899 -500.67 425.415 -500.905 c
425.932 -501.141 426.428 -501.188 426.903 -501.051 c
427.411 -500.903 428.362 -500.286 429.757 -499.202 c
430.503 -498.622 431.065 -498.276 431.45 -498.164 c
431.929 -498.026 432.341 -498.051 432.688 -498.239 c
433.034 -498.428 433.3 -498.713 433.485 -499.096 c
f
Q
q
0.6015625 0 0 -0.6015625 -0.5761871 424 cm
0 0 0 scn
414.697 -499.096 m
415.066 -498.989 l
414.83 -498.36 414.455 -497.907 413.94 -497.637 c
413.426 -497.37 412.885 -497.317 412.318 -497.483 c
412.039 -497.565 411.754 -497.7 411.465 -497.887 c
411.174 -498.077 410.531 -498.551 409.532 -499.317 c
408.774 -499.897 408.212 -500.241 407.846 -500.348 c
407.023 -500.588 406.35 -500.276 405.826 -499.411 c
405.457 -499.518 l
405.719 -500.207 406.108 -500.67 406.627 -500.905 c
407.145 -501.141 407.641 -501.188 408.114 -501.051 c
408.619 -500.903 409.572 -500.286 410.969 -499.202 c
411.713 -498.622 412.276 -498.276 412.66 -498.164 c
413.137 -498.026 413.551 -498.051 413.899 -498.239 c
414.244 -498.428 414.511 -498.713 414.697 -499.096 c
f
Q
Q
Q
endstream
endobj
24 0 obj
<<
/Type /Font
/Widths [250 250 250 250 250 250 250 250 250 250 250 250 250 250 250 250
250 250 250 250 250 250 250 250 250 250 250 250 250 250 250 250
250 219 406 667 500 740 479 177 302 302 500 667 219 344 219 500
500 500 500 500 500 500 500 500 500 500 219 219 667 667 667 427
917 688 615 646 760 656 625 771 760 375 385 677 615 927 750 729
615 729 677 521 719 760 677 1031 740 708 635 510 500 510 469 500
333 521 448 458 521 448 427 552 542 281 313 490 417 646 510 490
458 490 500 375 500 490 542 750 531 531 469 479 500 479 667 354
250 354 208 708 385 1000 688 521 333 1063 521 281 1094 354 635 354
354 208 208 354 354 354 500 1000 333 979 375 281 719 354 469 708
250 219 417 833 677 708 500 469 333 760 302 510 667 344 760 333
396 667 344 344 333 500 719 219 333 344 313 510 719 719 719 427
688 688 688 688 688 688 1021 646 656 656 656 656 375 375 375 375
760 750 729 729 729 729 729 667 729 760 760 760 760 708 615 700
521 521 521 521 521 521 667 458 448 448 448 448 281 281 281 281
521 510 490 490 490 490 490 667 490 490 490 490 490 531 458 531]
/Subtype /Type1
/BaseFont /BellMT-RegularSC
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 46 0 R
/FontDescriptor 47 0 R
>>
endobj
25 0 obj
<<
/Type /Font
/Widths [296 296 296 296 296 296 296 296 296 296 296 296 296 296 296 296
296 296 296 296 296 296 296 296 296 296 296 296 296 296 296 296
296 333 407 500 500 759 611 167 370 370 500 500 296 352 296 444
500 500 500 500 500 500 500 500 500 500 296 296 500 500 500 426
944 556 556 463 556 463 426 537 611 370 444 519 444 667 574 556
500 556 519 463 444 593 500 704 481 481 444 370 444 370 500 500
308 463 500 426 500 463 315 500 519 278 278 444 259 722 519 500
500 481 315 389 352 500 444 630 444 444 407 426 304 426 500 500
296 500 185 500 407 1000 500 500 308 1111 463 296 759 500 444 500
500 185 185 407 407 500 500 1000 308 704 389 296 778 500 407 481
296 333 500 500 500 500 304 500 308 556 426 481 500 352 556 308
500 500 352 352 308 556 611 500 308 352 407 481 833 833 833 426
556 556 556 556 556 556 741 463 463 463 463 463 370 370 370 370
556 574 556 556 556 556 556 500 556 593 593 593 593 481 500 556
463 463 463 463 463 463 704 426 463 463 463 463 278 278 278 278
500 519 500 500 500 500 500 500 500 500 500 500 500 444 481 444]
/Subtype /Type1
/BaseFont /OfficinaSans-Book
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 48 0 R
/FontDescriptor 49 0 R
>>
endobj
26 0 obj
<<
/Type /Font
/Widths [250 250 250 250 250 250 250 250 250 250 250 250 250 250 250 250
250 250 250 250 250 250 250 250 250 250 250 250 250 250 250 250
250 219 406 667 500 740 688 177 302 302 500 667 219 344 219 500
500 500 500 500 500 500 500 500 500 500 219 219 667 667 667 427
917 688 615 646 760 656 625 771 760 375 385 677 615 927 750 729
615 729 677 521 719 760 677 1031 740 708 635 510 500 510 469 500
333 438 500 417 510 427 281 542 521 260 271 500 281 781 531 490
500 510 396 396 344 510 500 719 531 500 448 479 500 479 667 354
250 354 208 708 385 1000 688 521 333 1063 521 281 1094 354 635 354
354 208 208 354 354 354 500 1000 333 979 396 281 781 354 448 708
250 219 417 833 677 708 500 469 333 760 302 510 667 344 760 333
396 667 344 344 333 500 719 219 333 344 313 510 719 719 719 427
688 688 688 688 688 688 1021 646 656 656 656 656 375 375 375 375
760 750 729 729 729 729 729 667 729 760 760 760 760 708 615 500
438 438 438 438 438 438 667 417 427 427 427 427 260 260 260 260
490 531 490 490 490 490 490 667 490 510 510 510 510 500 500 500]
/Subtype /Type1
/BaseFont /BellMT-Regular
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 50 0 R
/FontDescriptor 51 0 R
>>
endobj
27 0 obj
<<
/Type /Font
/Widths [266 266 266 266 266 266 266 266 266 266 266 266 266 266 266 266
266 266 266 266 266 266 266 266 266 266 266 266 266 266 266 266
266 281 552 667 531 823 740 281 333 333 500 667 271 365 240 531
531 531 531 531 531 531 531 531 531 531 240 271 667 667 667 469
927 698 635 667 792 656 615 813 771 385 469 698 625 938 760 771
646 771 698 542 750 760 698 1063 750 719 677 510 531 510 583 500
333 479 552 469 552 479 333 563 552 302 302 552 302 823 542 542
542 552 406 417 385 542 500 719 542 500 458 396 531 396 667 354
266 354 219 760 479 1000 729 563 333 1198 542 302 1104 354 677 354
354 219 219 417 417 354 500 1000 333 1000 417 302 813 354 458 719
266 281 469 875 688 719 531 500 333 750 302 531 667 365 750 333
396 667 396 396 333 552 760 240 333 396 344 531 833 833 833 469
698 698 698 698 698 698 1000 667 656 656 656 656 385 385 385 385
792 760 771 771 771 771 771 667 771 760 760 760 760 719 646 573
479 479 479 479 479 479 708 469 479 479 479 479 302 302 302 302
542 542 542 542 542 542 542 667 542 542 542 542 542 500 542 500]
/Subtype /Type1
/BaseFont /BellMT-Bold
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 52 0 R
/FontDescriptor 53 0 R
>>
endobj
28 0 obj
<<
/Type /Font
/Widths [245 245 245 245 245 245 245 245 245 245 245 245 245 245 245 245
245 245 245 245 245 245 245 245 245 245 245 245 245 245 245 245
245 302 417 667 490 740 813 219 313 240 500 667 188 385 219 500
490 490 490 490 490 490 490 490 490 490 177 188 667 667 667 396
917 635 625 604 740 677 656 729 771 344 490 646 656 885 771 688
646 677 667 552 708 729 604 917 708 698 625 448 500 448 427 500
333 458 417 333 479 344 281 469 458 281 250 417 260 698 479 417
438 438 375 313 281 469 448 688 490 375 479 479 500 479 667 354
245 354 188 678 365 1000 667 479 333 1063 552 302 1063 354 625 354
354 250 250 396 396 354 500 1000 333 979 313 302 625 354 479 698
245 302 333 833 677 698 500 448 333 760 302 510 667 385 760 333
396 667 344 344 333 500 719 219 333 344 271 510 719 719 719 396
635 635 635 635 635 635 938 604 677 677 677 677 344 344 344 344
740 771 688 688 688 688 688 667 688 729 729 729 729 698 605 458
458 458 458 458 458 458 583 333 344 344 344 344 281 281 281 281
417 479 417 417 417 417 417 667 417 469 469 469 469 375 438 375]
/Subtype /Type1
/BaseFont /BellMT-Italic
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 54 0 R
/FontDescriptor 55 0 R
>>
endobj
29 0 obj
<<
/Type /Font
/Widths [271 271 271 271 271 271 271 271 271 271 271 271 271 271 271 271
271 271 271 271 271 271 271 271 271 271 271 271 271 271 271 271
271 427 552 667 542 833 833 281 323 323 500 667 240 406 208 531
542 542 542 542 542 542 542 542 542 542 208 240 667 667 667 458
833 656 635 635 760 677 635 740 781 375 479 677 677 958 802 729
646 719 688 573 719 750 635 958 740 729 667 510 531 510 573 500
333 531 500 385 531 438 292 531 531 333 292 490 281 802 552 490
542 490 417 323 333 521 490 750 552 448 500 396 531 396 667 354
271 354 292 705 469 1000 708 531 333 1188 573 344 1083 354 667 354
354 292 292 469 469 354 500 1000 333 1000 323 344 729 354 500 729
271 427 385 875 688 729 531 417 333 750 344 573 667 406 750 333
396 667 396 396 333 573 760 188 333 396 313 573 823 823 823 458
656 656 656 656 656 656 969 635 677 677 677 677 375 375 375 375
760 802 729 729 729 729 729 667 729 750 750 750 750 729 646 510
531 531 531 531 531 531 667 385 438 438 438 438 333 333 333 333
490 552 490 490 490 490 490 667 490 521 521 521 521 448 542 448]
/Subtype /Type1
/BaseFont /BellMT-BoldItalic
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 56 0 R
/FontDescriptor 57 0 R
>>
endobj
30 0 obj
<<
/BM /Normal
/CA 1
/OP true
/SA true
/ca 1
/op true
/AIS false
/OPM 0
/Type /ExtGState
/SMask /None
>>
endobj
31 0 obj
<<
/BM /Normal
/CA 1
/OP false
/SA true
/ca 1
/op false
/AIS false
/OPM 1
/Type /ExtGState
/SMask /None
>>
endobj
32 0 obj
[/ICCBased 58 0 R]
endobj
33 0 obj
<<
/Length 10437
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(7)-5(0)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126.002 360 557.998 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 14 0 0 14 159.6265 672.738 Tm
[(T)-5(h)-5(e)-5( )-32(R)8(o)-5(l)-5(e)-5( )-31(o)-5(f)-33( )-32(T)27(a)-5(c)-5(i)-5(t)-5( )-32(K)-5(n)-5(o)20(w)-5(l)-5(e)-5(d)-5(g)-5(e)]TJ
ET
BT
/T1_3 1 Tf
16 0 0 16 73 653.4691 Tm
(S)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 81.3359 653.4691 Tm
[(ociolo)13(gists )4(of)-28( )4(science )4(distinguish )4(betw)13(een )4(two )4(types )4(of)-28( )4(technical )4(kno)13(wl)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 653.4691 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 639.2402 Tm
[(edge: )-162(e)-23(xplicit )-162(and )-162(tacit. )-162(Explicit )-162(kno)13(wledge )-162(is )-162(inf)13(or)-22(ma)25(tion )-162(tha)25(t )-162(can )-162(be )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 625.0114 Tm
[(codified, )-19(written )-19(do)13(wn )-19(in )-19(the )-19(f)13(or)-22(m )-19(of)-28( )-19(a )-19(recipe )-19(or )-19(la)13(bor)-12(a)25(tor)-25(y )-19(protocol, )-19(and )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 610.7825 Tm
[(tr)-12(ansfer)-13(red )-40(from )-40(one )-40(individual )-40(to )-40(another )-40(b)13(y )-40(imper)-13(sonal )-40(means)40(, )-40(such )-40(as )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 596.5536 Tm
[(pub)17(lica)25(tion )-49(in )-49(a )-49(scientific )-49(jour)-40(nal. )-49(T)29(acit )-49(kno)13(wledge)13(, )-49(b)13(y )-49(contr)-12(ast, )-49(in)13(v)37(olv)23(es )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 582.3248 Tm
[(skills)40(, )-63(kno)13(w-ho)13(w)109(, )-63(and )-63(sensor)-25(y )-63(cues )-63(tha)25(t )-63(are )-63(vital )-63(to )-63(the )-63(successful )-63(use )-63(of)-28( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 568.0959 Tm
[(a )-16(technolo)13(g)-40(y )-16(b)14(ut )-16(tha)25(t )-16(cannot )-16(be )-16(reduced )-16(to )-16(writing )-16(and )-16(must )-16(be )-16(acquired )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 553.8671 Tm
[(through )-242(hands-on )-242(pr)-12(actice )-242(and )-242(e)-23(xperience)13(.)]TJ
ET
BT
/T1_3 1 Tf
9 0 0 9 292.7889 556.837 Tm
(5)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 297.2889 553.8671 Tm
[( )-242(Scientific )-242(procedures )-242(and )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 539.6382 Tm
[(techniques )-119(requiring )-119(tacit )-119(kno)13(wledge )-119(do )-119(not )-119(diffuse )-119(as )-119(r)-12(apidl)25(y )-119(as )-119(those )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 525.4094 Tm
[(tha)25(t )-25(are )-25(readil)25(y )-25(codified.)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 91 511.1806 Tm
[(T)29(acit )-140(kno)13(wledge )-140(can )-140(itself)-28( )-140(be )-140(divided )-140(into )-140(two )-140(types)40(. )]TJ
ET
BT
/T1_4 1 Tf
12 0 0 12 365.8521 511.1806 Tm
[(P)36(er)20(sonal)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 404.6836 511.1806 Tm
[( )-140(tacit )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 496.9517 Tm
[(kno)13(wledge )-6(is )-6(held )-6(b)13(y )-6(individuals )-6(and )-6(can )-6(be )-6(con)13(v)23(ey)32(ed )-6(from )-6(one )-6(per)-13(son )-6(to )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 482.7229 Tm
[(another )-78(through )-78(a )-78(master-apprentice )-78(rela)25(tionship )-78(\(lear)-40(ning )-78(b)13(y )-78(e)-23(xample\) )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 468.494 Tm
[(or )-276(acquired )-276(b)13(y )-276(a )-276(length)13(y )-276(process )-276(of)-28( )-276(trial-and-er)-13(ror )-276(prob)17(lem )-276(solving )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 454.2652 Tm
[(\(lear)-40(ning )-75(b)13(y )-75(doing\). )-75(The )-75(amount )-75(of)-28( )-75(time )-75(required )-75(to )-75(g)22(ain )-75(per)-13(sonal )-75(tacit )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 440.0363 Tm
[(kno)13(wledge )-179(de)-13(pends )-179(on )-179(the )-179(comple)-23(xity )-179(of)-28( )-179(a )-179(task )-179(and )-179(the )-179(le)10(v)23(el )-179(of)-28( )-179(skill )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 425.8075 Tm
[(in)13(v)37(olv)23(ed )-128(in )-128(its )-128(e)-23(x)13(ecution.)]TJ
ET
BT
/T1_3 1 Tf
9 0 0 9 199.2014 428.7775 Tm
(6)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 203.7014 425.8075 Tm
[( )-128(Moreo)19(v)23(er)66(, )-128(such )-128(kno)13(wledge )-128(tends )-128(to )-128(deca)29(y )-128(if)-28( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 411.5786 Tm
[(it )-33(is )-33(not )-33(pr)-12(acticed )-33(on )-33(a )-33(re)-10(gular )-33(basis )-33(and )-33(tr)-12(ansmitted )-33(to )-33(the )-33(ne)-23(xt )-33(gener)-12(a)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 411.5786 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 397.3498 Tm
(tion. )Tj
ET
BT
/T1_4 1 Tf
12 0 0 12 98.1513 397.3498 Tm
(Communal)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 147.1467 397.3498 Tm
[( )-2(tacit )-2(kno)13(wledge )-2(is )-2(more )-2(comple)-23(x )-2(because )-2(it )-2(is )-2(not )-2(held )-2(b)13(y )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 383.1209 Tm
[(a )-67(single )-67(individual )-67(b)14(ut )-67(resides )-67(in )-67(an )-67(interdisciplinar)-25(y )-67(team )-67(of)-28( )-67(specialists)40(, )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 368.8921 Tm
[(each )3(of)-28( )2(whom )3(has )2(skills )3(and )2(e)-23(xperience )3(tha)25(t )2(cohere )3(into )3(a )2(larger )3(scientific )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 354.6632 Tm
[(project )-2(or )-2(e)-23(xperimental )-2(protocol. )-2(This )-2(social )-2(dimension )-2(mak)39(es )-2(communal )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 340.4344 Tm
[(tacit )-101(kno)13(wledge )-101(par)-17(ticularl)25(y )-101(difficult )-101(to )-101(tr)-12(ansfer )-101(from )-101(one )-101(la)13(bor)-12(a)25(tor)-25(y )-101(to )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 326.2055 Tm
[(another)66(, )-83(because )-83(doing )-83(so )-83(requires )-83(tr)-12(ansplanting )-83(and )-83(re)-13(plica)25(ting )-83(a )-83(com)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 326.2055 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 311.9767 Tm
[(ple)-23(x )-25(set )-25(of)-28( )-25(technical )-25(pr)-12(actices )-25(in )-25(a )-25(ne)10(w )-25(conte)-23(xt.)]TJ
ET
BT
/T1_3 1 Tf
9 0 0 9 305.712 314.9467 Tm
(7)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 91 297.7478 Tm
[(Field )-197(research )-197(b)13(y )-197(sociolo)13(gists )-197(of)-28( )-197(science )-197(has )-197(sho)13(wn )-197(tha)25(t )-197(adv)13(anced )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 283.519 Tm
[(biotechnolo)13(gies )-115(such )-115(as )-115(whole-genome )-115(synthesis )-115(demand )-115(high )-115(le)10(v)23(els )-115(of)-28( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 269.2901 Tm
[(both )-210(per)-13(sonal )-210(and )-210(communal )-210(tacit )-210(kno)13(wledge)13(. )-210(F)61(or )-210(e)-23(xample)13(, )-210(K)-10(a)25(thleen )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 255.0613 Tm
[(V)69(o)13(gel )-26(of)-28( )-26(Cor)-40(nell )-26(Univ)23(er)-13(sity )-26(f)13(ound )-26(tha)25(t )-26(the )-26(Stony )-26(Brook )-26(researcher)-13(s )-26(who )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 240.8324 Tm
[(synthesized )-62(the )-62(polio )-62(vir)-13(us )-62(did )-62(not )-62(rel)25(y )-62(e)-23(x)13(clusiv)23(el)25(y )-62(on )-62(written )-62(protocols )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 226.6036 Tm
[(b)14(ut )-9(made )-9(e)-23(xtensiv)23(e )-9(use )-9(of)-28( )-9(intuitiv)23(e )-10(skills )-9(acquired )-9(through )-9(y)32(ear)-13(s )-9(of)-28( )-9(e)-23(xpe)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 226.6036 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 212.3747 Tm
[(rience)13(. )-169(T)29(acit )-169(kno)13(wledge )-169(was )-169(par)-17(ticularl)25(y )-169(impor)-17(tant )-169(in )-169(one )-169(ste)-13(p )-169(of)-28( )-169(the )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 198.1459 Tm
[(process: )-18(pre)-13(paring )-18(the )-18(cell-free )-18(e)-23(xtr)-12(acts )-18(needed )-17(to )-18(tr)-12(ansla)25(te )-18(the )-18(synthetic )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 183.917 Tm
[(genome )-176(into )-176(infectious )-176(vir)-13(us )-176(par)-17(ticles)40(. )-176(If)-28( )-176(the )-176(cell-free )-176(e)-23(xtr)-12(act )-176(was )-176(not )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 169.6882 Tm
[(pre)-13(pared )-16(cor)-13(rectl)25(y )-16(b)13(y )-16(rel)25(ying )-16(on )-16(subtle )-16(tricks )-16(and )-16(sensor)-25(y )-16(cues)40(, )-16(it )-16(pro)19(v)23(ed )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 155.4593 Tm
[(impossib)17(le )-25(to )-25(re)-13(produce )-25(the )-25(pub)17(lished )-25(e)-23(xperiment.)]TJ
ET
BT
/T1_3 1 Tf
9 0 0 9 320.3763 158.4293 Tm
(8)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 91 141.2305 Tm
[(B)-4(a)-4(s)-4(e)-4(d)-4( )-177(o)-4(n)-4( )-178(h)-4(e)-4(r)-4( )-178(e)-4(m)-4(p)-4(i)-4(r)-4(i)-4(c)-4(a)-4(l)-4( )-178(r)-4(e)-4(s)-4(e)-4(a)-4(r)-4(c)-4(h)-4(,)-4( )-178(V)65(o)9(g)-4(e)-4(l)-4( )-178(c)-4(o)-4(n)-4(c)-4(l)-4(u)-4(d)-4(e)-4(s)-4( )-177(t)-4(h)-4(a)21(t)-4( )-178(b)-4(i)-4(o)-4(t)-4(e)-4(c)-4(h)-4(n)-4(o)-4(l)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 141.2305 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 127.0016 Tm
[(o)9(g)-44(y)-4( )-101(i)-4(s)-4( )-101(a)-4( )-101(\223)-4(s)-4(o)-4(c)-4(i)-4(o)-4(-)-4(t)-4(e)-4(c)-4(h)-4(n)-4(i)-4(c)-4(a)-4(l)]TJ
ET
BT
/T1_4 1 Tf
12 0 0 12 195.1674 127.0016 Tm
( )Tj
/T1_3 1 Tf
0.344 0 Td
[(a)-4(s)-4(s)-4(e)-4(m)-4(b)13(l)-4(a)10(g)-4(e)-4(\224)]TJ
/Span<>> BDC
5.006 0 Td
( )Tj
EMC
0.046 0 Td
(\227)Tj
/Span<>> BDC
1.004 0 Td
( )Tj
EMC
0.046 0 Td
[(a)-4(n)-4( )-101(a)-4(c)-4(t)-4(i)-4(v)-4(i)-4(t)-4(y)-4( )-101(w)-4(h)-4(o)-4(s)-4(e)-4( )-101(t)-4(e)-4(c)-4(h)-4(n)-4(i)-4(c)-4(a)-4(l)-4( )-101(a)-4(n)-4(d )]TJ
ET
Q
endstream
endobj
34 0 obj
<<
/Length 11705
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(7)-5(1)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126.004 360 557.996 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(s)-4(o)-4(c)-4(i)-4(a)-4(l)-4( )-111(d)-4(i)-4(m)-4(e)-4(n)-4(s)-4(i)-4(o)-4(n)-4(s)-4( )-111(a)-4(r)-4(e)-4( )-111(i)-4(n)-4(e)-27(x)-4(t)-4(r)-4(i)-4(c)-4(a)9(b)13(l)21(y)-4( )-111(l)-4(i)-4(n)-4(k)35(e)-4(d)-4(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 280.1412 677.162 Tm
(9)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 284.6772 674.1921 Tm
[( )-111(S)-4(u)-4(c)-4(h)-4( )-111(f)-4(a)-4(c)-4(t)-4(o)-4(r)-17(s)-4( )-111(h)-4(e)-4(l)-4(p)-4( )-111(t)-4(o)-4( )-111(e)-27(x)-4(p)-4(l)-4(a)-4(i)-4(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 659.9124 Tm
[(t)-4(h)-4(e)-4( )-96(p)-4(r)-4(o)-4(b)13(l)-4(e)-4(m)-4(s)-4( )-96(t)-4(h)-4(a)21(t)-4( )-96(s)-4(c)-4(i)-4(e)-4(n)-4(t)-4(i)-4(s)-4(t)-4(s)-4( )-96(o)-4(f)-4(t)-4(e)-4(n)-4( )-96(e)-4(n)-4(c)-4(o)-4(u)-4(n)-4(t)-4(e)-4(r)-4( )-96(w)-4(h)-4(e)-4(n)-4( )-96(t)-4(r)-29(y)-4(i)-4(n)-4(g)-4( )-96(t)-4(o)-4( )-96(r)-4(e)-17(p)-4(l)-4(i)-4(c)-4(a)21(t)-4(e)-4( )-96(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 645.6327 Tm
[(r)-4(e)-4(s)-4(e)-4(a)-4(r)-4(c)-4(h)-4( )-17(p)-4(r)-4(o)-4(t)-4(o)-4(c)-4(o)-4(l)-4( )-17(d)-4(e)6(v)19(e)-4(l)-4(o)-4(p)-4(e)-4(d)-4( )-17(i)-4(n)-4( )-17(a)-4(n)-4(o)-4(t)-4(h)-4(e)-4(r)-4( )-17(l)-4(a)9(b)-4(o)-4(r)-16(a)21(t)-4(o)-4(r)-29(y)117(,)-4( )-17(o)-4(r)-4( )-17(w)-4(h)-4(e)-4(n)-4( )-17(t)-4(r)-16(a)-4(n)-4(s)-4(l)-4(a)21(t)-4(i)-4(n)-4(g)-4( )-17(a )]TJ
0 -1.19 TD
[(s)-4(c)-4(i)-4(e)-4(n)-4(t)-4(i)-4(f)-4(i)-4(c)-4( )-16(d)-4(i)-4(s)-4(c)-4(o)15(v)19(e)-4(r)-29(y)-4( )-16(f)-4(r)-4(o)-4(m)-4( )-16(t)-4(h)-4(e)-4( )-16(r)-4(e)-4(s)-4(e)-4(a)-4(r)-4(c)-4(h)-4( )-16(b)-4(e)-4(n)-4(c)-4(h)-4( )-16(t)-4(o)-4( )-16(c)-4(o)-4(m)-4(m)-4(e)-4(r)-4(c)-4(i)-4(a)-4(l)]TJ
/Span<>> BDC
24.113 0 Td
( )Tj
EMC
0.266 0 Td
[(a)-4(p)-4(p)-4(l)-4(i)-4(c)-4(a)21(t)-4(i)-4(o)-4(n)-4(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 421.9641 634.323 Tm
[(1)-4(0)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 431 631.353 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 617.0734 Tm
[(D)-4(e)-4(s)-4(p)-4(i)-4(t)-4(e)-4( )-161(t)-4(h)-4(e)-4( )-161(o)-4(n)-4(g)6(o)-4(i)-4(n)-4(g)-4( )-161(\223)-4(r)-4(e)6(v)33(o)-4(l)-4(u)-4(t)-4(i)-4(o)-4(n)-4(\224)-17( )-161(i)-4(n)-4( )-161(t)-4(h)-4(e)-4( )-161(l)-4(i)-4(f)-4(e)-4( )-161(s)-4(c)-4(i)-4(e)-4(n)-4(c)-4(e)-4(s)36(,)-4( )-161(t)-4(h)-4(e)-4(s)-4(e)-4( )-161(t)-4(r)-16(a)-4(d)-4(i)-4(t)-4(i)-4(o)-4(n)-4(a)-4(l )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 602.7937 Tm
[(b)-6(o)-6(t)-6(t)-6(l)-6(e)-6(n)-6(e)-5(c)-6(k)-6(s)-5( )-381(p)-6(e)-5(r)-19(s)-6(i)-6(s)-6(t)-6(.)-6( )-381(O)-6(t)-6(h)-6(e)-6(r)-6( )-381(c)-6(a)-6(s)-6(e)-6( )-381(s)-6(t)-6(u)-6(d)-5(i)-6(e)-5(s)-6( )-381(o)-6(f)-34( )-381(t)-6(e)-6(c)-6(h)-6(n)-6(o)-6(l)-6(o)7(g)-6(i)-6(c)-6(a)-6(l)-6( )-381(i)-6(n)-5(n)-6(o)13(v)7(a)19(t)-5(i)-6(o)-6(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 588.514 Tm
[(h)-4(a)16(v)19(e)-4( )-97(c)-4(o)-4(n)-4(f)-4(i)-4(r)-26(m)-4(e)-4(d)-4( )-97(t)-4(h)-4(e)-4( )-97(i)-4(m)-4(p)-4(o)-4(r)-21(t)-4(a)-4(n)-4(c)-4(e)-4( )-97(o)-4(f)-32( )-97(t)-4(h)-4(e)-4( )-97(s)-4(o)-4(c)-4(i)-4(o)-4(-)-4(t)-4(e)-4(c)-4(h)-4(n)-4(i)-4(c)-4(a)-4(l)-4( )-97(d)-4(i)-4(m)-4(e)-4(n)-4(s)-4(i)-4(o)-4(n)-4(,)-4( )-97(w)-4(h)-4(i)-4(c)-4(h )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 574.2344 Tm
[(i)-4(n)-4(c)-4(l)-4(u)-4(d)-4(e)-4(s)-4( )8(t)-4(a)-4(c)-4(i)-4(t)-4( )8(k)-4(n)-4(o)9(w)-4(l)-4(e)-4(d)-4(g)-4(e)9(,)-4( )8(t)-4(e)-4(a)-4(m)-4(w)-4(o)-4(r)-4(k)-4(,)-4( )8(l)-4(a)9(b)-4(o)-4(r)-16(a)21(t)-4(o)-4(r)-29(y)-4( )8(i)-4(n)-4(f)-4(r)-16(a)-4(s)-4(t)-4(r)-17(u)-4(c)-4(t)-4(u)-4(r)-4(e)9(,)-4( )8(a)-4(n)-4(d)-4( )8(o)-4(r)-4(g)18(a)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 574.2344 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 559.9547 Tm
[(n)-4(i)-4(z)-4(a)21(t)-4(i)-4(o)-4(n)-4(a)-4(l)-4( )-29(f)-4(a)-4(c)-4(t)-4(o)-4(r)-17(s)36(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 545.675 Tm
[(In )-82(the )-82(field )-82(of)-28( )-82(whole-genome )-82(synthesis)40(, )-82(f)13(or )-82(e)-23(xample)13(, )-82(the )-82(impor)-17(tance )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 531.3954 Tm
[(of)-28( )-104(socio-technical )-104(factor)-13(s )-104(continues )-104(to )-104(g)-33(ro)13(w )-104(as )-104(scientists )-104(tak)39(e )-104(on )-104(larger )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 517.1157 Tm
[(and )-51(more )-51(comple)-23(x )-51(genomes)40(. )-51(R)31(esearcher)-13(s )-51(a)25(t )-51(the )-51(J)82(. )-51(Cr)-12(aig )-51(V)69(enter )-51(Institute )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 502.8361 Tm
[(announced )-185(in )-185(Ma)29(y )-185(2010 )-185(tha)25(t )-185(they )-185(had )-185(synthesized )-185(an )-185(ar)-17(tificial )-185(bacte)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 502.8361 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 488.5564 Tm
[(rial )-77(genome )-77(consisting )-77(of)-28( )-77(more )-77(than )-77(one )-77(million )-77(DN)45(A )-77(units)40(, )-77(a )-77(task )-77(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 474.2767 Tm
[(required )-25(a )-25(unique )-25(configur)-12(a)25(tion )-25(of)-28( )-25(e)-23(xper)-17(tise )-25(and )-25(resources)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 361.9848 477.2467 Tm
(11)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 370.9848 474.2767 Tm
[( )-25(In )-25(an )-25(inter)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 474.2767 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 459.997 Tm
[(vie)10(w)109(, )-40(Dr)66(. )-40(V)69(enter )-40(noted )-40(tha)25(t )-40(a)25(t )-40(each )-40(sta)14(ge )-40(in )-40(the )-40(process)40(, )-40(a )-40(team )-40(of)-28( )-40(highl)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 445.7173 Tm
[(skilled )-124(and )-124(e)-23(xperienced )-124(molecular )-124(biolo)13(gists )-124(had )-124(to )-124(de)10(v)23(elop )-124(ne)10(w )-124(meth)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 445.7173 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 431.4377 Tm
[(odolo)13(gies)40(, )-61(which )-61(could )-61(be )-61(made )-61(to )-61(work )-61(onl)25(y )-61(through )-61(a )-61(length)13(y )-61(process )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 417.158 Tm
[(of)-28( )-92(trial )-92(and )-92(er)-13(ror)66(. )-92(F)61(or )-92(instance)13(, )-92(because )-92(the )-92(long )-92(molecules )-92(of)-28( )-92(synthetic )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 402.8783 Tm
[(bacterial )-154(DN)45(A )-154(w)13(ere )-154(fr)-12(a)14(gile)13(, )-154(they )-154(had )-154(to )-154(be )-154(stored )-154(in )-154(supercoiled )-154(f)13(or)-22(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 388.5986 Tm
[(inside )-13(of)-28( )-13(gel )-13(b)17(locks )-13(and )-13(handled )-13(carefull)25(y )-13(to )-13(k)39(ee)-13(p )-13(them )-13(from )-13(breaking )-13(up)33(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 374.3189 Tm
[(\223)127(As )6(with )5(all )6(things )5(in )6(science)13(,\224)-13( )5(V)69(enter )6(e)-23(xplained, )6(\223it\222s )5(the )6(little )6(tiny )5(break)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 374.3189 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 360.0392 Tm
[(throughs )-25(on )-25(a )-25(dail)25(y )-25(basis )-25(tha)25(t )-25(mak)39(e )-25(f)13(or )-25(the )-25(big )-25(breakthrough.\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 379.2126 363.0092 Tm
(12)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 345.7596 Tm
[(R)31(ecent )-54(de)10(v)23(elopments )-54(in )-54(scientific )-54(pub)17(lishing )-54(also )-54(ref)17(lect )-54(the )-54(fact )-54(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 331.4799 Tm
[(the )-171(g)-33(ro)13(wing )-171(comple)-23(xity )-171(of)-28( )-171(research )-171(tools )-171(and )-171(processes )-171(has )-171(increased )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 317.2002 Tm
[(the )-74(impor)-17(tance )-74(of)-28( )-74(tacit )-74(kno)13(wledge)13(. )-74(One )-74(online )-74(scientific )-74(pub)17(lica)25(tion, )-74(the )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 302.9205 Tm
[(J)21(our)-21(nal )-20(of)-42( )-20(V)34(isualized )-20(Experiments)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 230.6585 302.9205 Tm
[(, )-21(has )-21(since )-21(2006 )-21(used )-21(video )-21(recordings )-21(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 288.6408 Tm
[(e)-23(xperimental )-2(techniques )-2(to )-2(por)-17(tr)-12(a)29(y )-2(subtle )-2(details )-2(tha)25(t )-2(cannot )-2(be )-2(captured )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 274.3611 Tm
[(in )-101(written )-101(f)13(or)-22(m.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 153.2902 277.3311 Tm
(13)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 162.2902 274.3611 Tm
[( )-101(Other )-101(online )-101(re)-13(positories )-101(of)-28( )-101(research-protocol )-101(videos )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 260.0815 Tm
[(include )62(Dna)25(tube)13(.com )62(and )62(SciV)69(ee)13(.tv)117(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 243.0528 263.0515 Tm
(14)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 252.0528 260.0815 Tm
[( )62(Based )62(on )62(such )62(e)10(vidence)13(, )62(V)69(o)13(gel, )62(along )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 245.8018 Tm
[(with )-106(Sonia )-106(Ben )-106(Oua)14(g)-33(rham-Gor)-22(mley )-106(of)-28( )-106(George )-106(Mason )-106(Univ)23(er)-13(sity)121(, )-106(ha)20(v)23(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 231.5221 Tm
[(concluded )-27(tha)25(t )-27(the )-27(technical )-27(and )-27(socio-org)22(aniza)25(tional )-27(hurdles )-27(in)13(v)37(olv)23(ed )-27(in )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 217.2424 Tm
[(whole-genome )-70(synthesis )-70(pose )-71(a )-70(major )-71(obstacle )-70(to )-70(the )-71(a)13(bility )-71(of)-28( )-71(ter)-13(rorist )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 202.9627 Tm
[(org)22(aniza)25(tions )-25(to )-25(e)-23(xploit )-25(this )-25(technolo)13(g)-40(y )-25(f)13(or )-25(har)-22(mful )-25(pur)-13(poses)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 377.9637 205.9327 Tm
(15)Tj
ET
BT
/T1_4 1 Tf
14 0 0 14 172.893 174.883 Tm
[(T)-5(h)-5(e)-5( )-32(D)-5(e)-5(-)-5(s)-5(k)-5(i)-5(l)-5(l)-5(i)-5(n)-5(g)-5( )-31(D)-5(y)-5(n)-5(a)-5(m)-5(i)-5(c)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 155.5634 Tm
(S)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 81.336 155.5634 Tm
[(ome )-105(scholar)-13(s)40(, )-105(ho)13(w)13(e)10(v)23(er)66(, )-105(ha)20(v)23(e )-105(come )-105(to )-105(the )-105(opposite )-105(conclusion )-105(of)-28( )-105(those )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.2837 Tm
[(who )-168(emphasize )-168(the )-168(hurdles )-168(associa)25(ted )-168(with )-168(tacit )-168(kno)13(wledge)13(. )-168(Member)-13(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.004 Tm
[(of)-28( )-101(this )-100(second )-101(school )-100(point )-100(to )-101(a )-101(contr)-12(adictor)-25(y )-100(trend )-101(in )-101(biotechnolo)13(gical )]TJ
ET
Q
endstream
endobj
35 0 obj
<<
/Length 11683
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(7)-5(2)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr /Span<>> BDC
12 0 0 12 73 674.1921 Tm
( )Tj
EMC
T*
[(de)10(v)23(elopment )-138(tha)25(t )-138(they )-138(claim )-138(will )-138(ultima)25(tel)25(y )-138(pro)19(v)23(e )-138(stronger)66(. )-138(They )-138(note )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1615 Tm
[(tha)25(t )-227(the )-227(e)10(v)37(olution )-227(of)-28( )-227(many )-227(emerging )-227(technolo)13(gies )-227(in)13(v)37(olv)23(es )-227(a )-227(process )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.1309 Tm
[(of)-28( )-209(de-skilling )-209(tha)25(t, )-209(o)19(v)23(er )-209(time)13(, )-209(reduces )-209(the )-209(amount )-209(of)-28( )-209(tacit )-209(kno)13(wledge )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1003 Tm
[(required )-100(f)13(or )-100(their )-100(use)13(. )-100(Chris )-100(Ch)13(yba )-100(of)-28( )-100(Princeton, )-100(f)13(or )-100(e)-23(xample)13(, )-100(contends )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.0698 Tm
[(t)-1(h)-1(a)24(t)-1( )-376(a)-1(s)-1( )-376(w)-1(h)-1(o)-1(l)-1(e)-1(-)-1(g)-1(e)-1(n)-1(o)-1(m)-1(e)-1( )-376(s)-1(y)-1(n)-1(t)-1(h)-1(e)-1(s)-1(i)-1(s)-1( )-376(i)-1(s)-1( )-376(a)-1(u)-1(t)-1(o)-1(m)-1(a)24(t)-1(e)-1(d)-1(,)-1( )-376(c)-1(o)-1(m)-1(m)-1(e)-1(r)-1(c)-1(i)-1(a)-1(l)-1(i)-1(z)-1(e)-1(d)-1(,)-1( )-376(a)-1(n)-1(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0392 Tm
[(\223b)17(lack-bo)26(x)13(ed,\224)-13( )-181(it )-181(will )-181(become )-181(more )-181(accessib)17(le )-181(to )-181(individuals )-181(with )-181(onl)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 590.0086 Tm
[(basic )-25(scientific )-25(skills)40(, )-25(including )-25(ter)-13(rorists )-25(and )-25(other )-25(malicious )-25(actor)-13(s)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 408.5146 592.9786 Tm
(16)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 575.978 Tm
[(De-skilling )-34(has )-34(alread)13(y )-34(occur)-13(red )-34(in )-34(se)10(v)23(er)-12(al )-34(genetic-engineering )-34(tech)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 575.978 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9474 Tm
[(niques )-19(tha)25(t )-19(ha)20(v)23(e )-19(been )-18(around )-19(f)13(or )-19(more )-19(than )-19(tw)13(enty )-19(y)32(ear)-13(s)40(, )-19(including )-19(gene )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 547.9169 Tm
[(cloning )-255(\(cop)26(ying )-255(f)13(oreign )-255(genes )-255(in )-255(bacteria\), )-255(tr)-12(ansfection )-255(\(introducing )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8863 Tm
[(f)13(oreign )-4(genetic )-4(ma)25(terial )-4(into )-4(a )-4(cell\), )-4(lig)22(a)25(tion )-4(\(stitching )-4(fr)-12(a)14(gments )-4(of)-28( )-4(DN)45(A )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.8557 Tm
[(to)13(gether\), )36(and )36(the )36(pol)25(ymer)-12(ase )36(chain )36(reaction, )36(or )36(PCR )36(\(which )36(mak)39(es )36(it )36(pos)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 519.8557 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 505.8251 Tm
[(sib)17(le )31(to )31(cop)26(y )31(any )31(par)-17(ticular )31(DN)45(A )31(sequence )31(se)10(v)23(er)-12(al )31(million-f)13(old\). )31(Although )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 491.7946 Tm
[(one )-38(must )-38(ha)20(v)23(e )-38(access )-38(to )-38(na)25(tur)-12(al )-38(genetic )-38(ma)25(terial )-38(to )-38(use )-38(these )-38(techniques)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 477.764 Tm
[(the )-45(associa)25(ted )-45(skill )-45(sets )-45(ha)20(v)23(e )-45(diffused )-45(widel)25(y )-45(across )-45(the )-45(inter)-40(na)25(tional )-45(sci)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 477.764 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7334 Tm
[(entific )-8(community)113(. )-8(In )-8(fact, )-8(a )-8(fe)10(w )-8(standard )-8(genetic-engineering )-8(techniques )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7029 Tm
[(ha)20(v)23(e )-85(been )-85(de-skilled )-85(to )-85(the )-85(point )-85(tha)25(t )-85(they )-85(are )-85(no)13(w )-85(accessib)17(le )-85(to )-85(under)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 449.7029 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6723 Tm
[(g)-33(r)-12(adua)25(tes )16(and )16(e)10(v)23(en )16(adv)13(anced )16(high )16(school )16(students)40(, )16(and )16(could )16(theref)13(ore )16(be )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6417 Tm
[(appropria)25(ted )-25(fairl)25(y )-25(easil)25(y )-25(b)13(y )-25(ter)-13(rorist )-25(g)-33(roups)40(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 407.6111 Tm
[(Ger)-12(ald )-95(Epstein, )-95(of)-28( )-95(the )-95(Center )-95(f)13(or )-95(Science)13(, )-95(T)56(echnolo)13(g)-40(y)121(, )-95(and )-95(Security )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5806 Tm
[(P)56(olicy)121(, )-173(writes )-173(tha)25(t )-173(whole-genome )-172(synthesis )-173(\223appear)-13(s )-173(to )-173(be )-173(f)13(ollo)13(wing )-173(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 379.55 Tm
[(tr)-12(ajector)-25(y )-93(familiar )-93(to )-93(other )-93(useful )-93(techniques: )-93(Originall)25(y )-93(accessib)17(le )-93(onl)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5194 Tm
[(to )-62(a )-62(handful )-62(of)-28( )-62(top )-62(research )-62(g)-33(roups )-62(working )-62(a)25(t )-62(sta)25(te-of-the-ar)-17(t )-62(facilities)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 351.4889 Tm
[(synthesis )-234(techniques )-234(are )-234(becoming )-234(more )-234(widel)25(y )-234(a)20(v)13(aila)13(b)17(le )-234(as )-234(they )-234(are )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4583 Tm
[(refined, )-175(simplified, )-175(and )-175(impro)19(v)23(ed )-175(b)13(y )-175(skilled )-175(technicians )-175(and )-175(cr)-12(aftsmen. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.4277 Tm
[(Indeed, )1(they )1(are )1(increasingl)25(y )1(becoming )1(\221commoditized,\222 )1(as )1(kits)40(, )1(processes)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.3972 Tm
[(rea)14(gents)40(, )-220(and )-220(ser)-26(vices )-220(become )-220(a)20(v)13(aila)13(b)17(le )-220(f)13(or )-220(individuals )-220(with )-220(basic )-220(la)13(b )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3666 Tm
[(tr)-12(aining)26(.\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 119.3312 298.3366 Tm
(17)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 128.3312 295.3666 Tm
[( )-214(In )-214(2007 )-215(Epstein )-214(and )-214(three )-214(co-author)-13(s )-214(predicted )-214(tha)25(t )-214(\223ten )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3361 Tm
[(y)32(ear)-13(s )37(from )37(no)13(w)109(, )37(it )37(ma)29(y )37(be )37(easier )37(to )37(synthesize )37(almost )37(any )37(pa)25(tho)13(genic )37(vir)-13(us )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3055 Tm
[(than )-31(to )-31(obtain )-31(it )-31(through )-31(other )-31(means)40(,\224)-13( )-31(although )-31(they )-31(did )-31(not )-31(impl)25(y )-31(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 253.2749 Tm
[(individuals )-93(with )-93(onl)25(y )-93(basic )-93(scientific )-93(tr)-12(aining )-93(will )-93(be )-93(among )-93(the )-93(fir)-13(st )-93(to )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2444 Tm
[(acquire )-25(this )-25(capa)13(bility)113(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 181.7187 242.2144 Tm
(18)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 225.2138 Tm
[(T)60(o)-3( )-22(d)-3(a)22(t)-3(e)10(,)-3( )-22(t)-3(h)-3(e)-3( )-22(d)-3(e)-3(-)-3(s)-3(k)-3(i)-3(l)-3(l)-3(i)-3(n)-3(g)-3( )-22(o)-3(f)-31( )-22(s)-3(y)-3(n)-3(t)-3(h)-3(e)-3(t)-3(i)-3(c)-3( )-22(g)-3(e)-3(n)-3(o)-3(m)-3(i)-3(c)-3(s)-3( )-22(h)-3(a)-3(s)-3( )-22(a)-3(f)-3(f)-3(e)-3(c)-3(t)-3(e)-3(d)-3( )-22(o)-3(n)-3(l)22(y)-3( )-22(a)-3( )-22(f)-3(e)7(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1832 Tm
[(e)-3(l)-3(e)-3(m)-3(e)-3(n)-3(t)-3(s)-3( )-33(o)-3(f)-31( )-33(w)-3(h)-3(a)22(t)-3( )-33(i)-3(s)-3( )-33(a)-3(c)-3(t)-3(u)-3(a)-3(l)-3(l)22(y)-3( )-33(a)-3( )-33(c)-3(o)-3(m)-3(p)-3(l)-3(e)-26(x)-3(,)-3( )-33(m)-3(u)-3(l)-3(t)-3(i)-3(-)-3(s)-3(t)-3(e)-16(p)-3( )-33(p)-3(r)-3(o)-3(c)-3(e)-3(s)-3(s)37(.)-3( )-33(P)-3(r)-15(a)-3(c)-3(t)-3(i)-3(t)-3(i)-3(o)-3(n)-3(e)-3(r)-16(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1526 Tm
[(o)-3(f)-31( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 87.3674 197.1526 Tm
[(d)-3(e)-3( )-139(n)-3(o)17(v)-16(o)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 123.1208 197.1526 Tm
[( )-142(v)-3(i)-3(r)-15(a)-3(l)-3( )-142(s)-3(y)-3(n)-3(t)-3(h)-3(e)-3(s)-3(i)-3(s)-3( )-142(n)-3(o)-3(t)-3(e)-3( )-142(t)-3(h)-3(a)22(t)-3( )-142(t)-3(h)-3(e)-3( )-142(m)-3(o)-3(s)-3(t)-3( )-142(c)-3(h)-3(a)-3(l)-3(l)-3(e)-3(n)-3(g)-3(i)-3(n)-3(g)-3( )-142(s)-3(t)-3(e)-16(p)-3(s)-3( )-142(d)-3(o)-3( )-142(n)-3(o)-3(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.1221 Tm
[(i)-3(n)10(v)34(o)-3(l)-3(v)20(e)-3( )20(t)-3(h)-3(e)-3( )20(s)-3(y)-3(n)-3(t)-3(h)-3(e)-3(s)-3(i)-3(s)-3( )20(o)-3(f)-31( )20(D)-3(N)42(A)-3( )20(f)-3(r)-15(a)11(g)-3(m)-3(e)-3(n)-3(t)-3(s)37(,)-3( )20(w)-3(h)-3(i)-3(c)-3(h)-3( )20(c)-3(a)-3(n)-3( )20(b)-3(e)-3( )20(o)-3(r)-3(d)-3(e)-3(r)-3(e)-3(d)-3( )20(f)-3(r)-3(o)-3(m)-3( )20(c)-3(o)-3(m)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 183.1221 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.0915 Tm
[(m)-3(e)-3(r)-3(c)-3(i)-3(a)-3(l)-3( )-79(s)-3(u)-3(p)-3(p)-3(l)-3(i)-3(e)-3(r)-16(s)37(,)-3( )-79(b)11(u)-3(t)-3( )-79(t)-3(h)-3(e)-3( )-79(a)-3(s)-3(s)-3(e)-3(m)-3(b)14(l)22(y)-3( )-79(o)-3(f)-31( )-79(t)-3(h)-3(e)-3(s)-3(e)-3( )-79(f)-3(r)-15(a)11(g)-3(m)-3(e)-3(n)-3(t)-3(s)-3( )-79(i)-3(n)-3(t)-3(o)-3( )-79(a)-3( )-79(f)-3(u)-3(n)-3(c)-3(t)-3(i)-3(o)-3(n)-3(a)-3(l )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.061 Tm
[(g)-3(e)-3(n)-3(o)-3(m)-3(e)-3( )-87(a)-3(n)-3(d)-3( )-87(t)-3(h)-3(e)-3( )-87(e)-26(x)-3(p)-3(r)-3(e)-3(s)-3(s)-3(i)-3(o)-3(n)-3( )-87(o)-3(f)-31( )-87(t)-3(h)-3(e)-3( )-87(v)-3(i)-3(r)-15(a)-3(l)-3( )-87(p)-3(r)-3(o)-3(t)-3(e)-3(i)-3(n)-3(s)37(.)-3( )-87(A)-3(c)-3(c)-3(o)-3(r)-3(d)-3(i)-3(n)-3(g)-3( )-87(t)-3(o)-3( )-87(a)-3( )-87(r)-3(e)-16(p)-3(o)-3(r)-20(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0304 Tm
[(b)10(y)-3( )-144(t)-3(h)-3(e)-3( )-144(U)79(.)-3(S)-3(.)-3( )-144(N)-3(a)22(t)-3(i)-3(o)-3(n)-3(a)-3(l)-3( )-144(S)-3(c)-3(i)-3(e)-3(n)-3(c)-3(e)-3( )-144(A)-3(d)-3(v)-3(i)-3(s)-3(o)-3(r)-28(y)-3( )-144(B)-3(o)-3(a)-3(r)-3(d)-3( )-144(f)10(o)-3(r)-3( )-144(B)-3(i)-3(o)-3(s)-3(e)-3(c)-3(u)-3(r)-3(i)-3(t)-3(y)118(,)-3( )-144(a)-3( )-144(f)-3(e)-3(d)-3(e)-3(r)-15(a)-3(l )]TJ
0 -1.169 TD
[(a)-3(d)-3(v)-3(i)-3(s)-3(o)-3(r)-28(y)-3( )-146(c)-3(o)-3(m)-3(m)-3(i)-3(t)-3(t)-3(e)-3(e)10(,)-3( )-146(\223)-3(T)-3(h)-3(e)-3( )-146(t)-3(e)-3(c)-3(h)-3(n)-3(o)-3(l)-3(o)10(g)-43(y)-3( )-146(f)10(o)-3(r)-3( )-146(s)-3(y)-3(n)-3(t)-3(h)-3(e)-3(s)-3(i)-3(z)-3(i)-3(n)-3(g)-3( )-146(D)-3(N)42(A)-3( )-146(i)-3(s)]TJ
/Span<>> BDC
26.632 0 Td
( )Tj
EMC
0.396 0 Td
[(r)-3(e)-3(a)-3(d)-3(i)-3(l)22(y )]TJ
ET
Q
endstream
endobj
36 0 obj
<<
/Length 12983
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(7)-5(3)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126.004 360 557.996 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr /Span<>> BDC
12 0 0 12 73 674.1921 Tm
( )Tj
EMC
T*
[(a)-3(c)-3(c)-3(e)-3(s)-3(s)-3(i)-3(b)14(l)-3(e)10(,)-3( )-103(s)-3(t)-3(r)-15(a)-3(i)-3(g)-3(h)-3(t)-3(f)10(o)-3(r)-3(w)-3(a)-3(r)-3(d)-3( )-103(a)-3(n)-3(d)-3( )-103(a)-3( )-103(f)-3(u)-3(n)-3(d)-3(a)-3(m)-3(e)-3(n)-3(t)-3(a)-3(l)-3( )-103(t)-3(o)-3(o)-3(l)-3( )-103(u)-3(s)-3(e)-3(d)-3( )-103(i)-3(n)-3( )-103(c)-3(u)-3(r)-16(r)-3(e)-3(n)-3(t)-3( )-103(b)-3(i)-3(o)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 674.1921 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 659.9124 Tm
[(l)-3(o)10(g)-3(i)-3(c)-3(a)-3(l)-3( )-166(r)-3(e)-3(s)-3(e)-3(a)-3(r)-3(c)-3(h)-3(.)-3( )-166(I)-3(n)-3( )-167(c)-3(o)-3(n)-3(t)-3(r)-15(a)-3(s)-3(t)-3(,)-3( )-166(t)-3(h)-3(e)-3( )-167(s)-3(c)-3(i)-3(e)-3(n)-3(c)-3(e)-3( )-166(o)-3(f)-31( )-166(c)-3(o)-3(n)-3(s)-3(t)-3(r)-16(u)-3(c)-3(t)-3(i)-3(n)-3(g)-3( )-166(a)-3(n)-3(d)-3( )-166(e)-26(x)-3(p)-3(r)-3(e)-3(s)-3(s)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 659.9124 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 645.6327 Tm
[(i)-3(n)-3(g)-3( )-95(v)-3(i)-3(r)-16(u)-3(s)-3(e)-3(s)-3( )-95(i)-3(n)-3( )-95(t)-3(h)-3(e)-3( )-95(l)-3(a)10(b)-3(o)-3(r)-15(a)22(t)-3(o)-3(r)-28(y)-3( )-95(i)-3(s)-3( )-95(m)-3(o)-3(r)-3(e)-3( )-95(c)-3(o)-3(m)-3(p)-3(l)-3(e)-26(x)-3( )-95(a)-3(n)-3(d)-3( )-95(s)-3(o)-3(m)-3(e)7(w)-3(h)-3(a)22(t)-3( )-95(o)-3(f)-31( )-95(a)-3(n)-3( )-95(a)-3(r)-20(t)-3(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 631.353 Tm
[(I)-3(t)-3( )-171(i)-3(s)-3( )-171(t)-3(h)-3(e)-3( )-171(l)-3(a)10(b)-3(o)-3(r)-15(a)22(t)-3(o)-3(r)-28(y)-3( )-171(p)-3(r)-3(o)-3(c)-3(e)-3(d)-3(u)-3(r)-3(e)-3(s)-3( )-172(d)-3(o)10(w)-3(n)-3(s)-3(t)-3(r)-3(e)-3(a)-3(m)-3( )-171(f)-3(r)-3(o)-3(m)-3( )-171(t)-3(h)-3(e)-3( )-171(a)-3(c)-3(t)-3(u)-3(a)-3(l)-3( )-171(s)-3(y)-3(n)-3(t)-3(h)-3(e)-3(s)-3(i)-3(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 617.0734 Tm
[(o)-3(f)-31( )-138(D)-3(N)42(A)-3( )-138(t)-3(h)-3(a)22(t)-3( )-138(a)-3(r)-3(e)-3( )-138(t)-3(h)-3(e)-3( )-138(l)-3(i)-3(m)-3(i)-3(t)-3(i)-3(n)-3(g)-3( )-138(s)-3(t)-3(e)-16(p)-3(s)-3( )-138(i)-3(n)-3( )-138(r)-3(e)-3(c)-3(o)16(v)20(e)-3(r)-3(i)-3(n)-3(g)-3( )-138(v)-3(i)-3(r)-16(u)-3(s)-3(e)-3(s)-3( )-138(f)-3(r)-3(o)-3(m)-3( )-138(g)-3(e)-3(n)-3(e)-3(t)-3(i)-3(c )]TJ
/Span<>> BDC
0 -1.19 TD
( )Tj
EMC
0 0 TD
[(m)-3(a)22(t)-3(e)-3(r)-3(i)-3(a)-3(l)-3(.)-3(\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 120.315 605.7637 Tm
[(1)-3(9)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 588.514 Tm
[(Along )42(similar )42(lines)40(, )42(virolo)13(gist )42(J)42(ens )42(K)10(uhn )42(has )42(called )42(f)13(or )42(a )42(more )42(nuanced )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 574.2344 Tm
[(assessment )-19(of)-28( )-19(the )-19(technical )-19(challenges )-19(in)13(v)37(olv)23(ed )-19(in )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 320.4208 574.2344 Tm
[(de )-18(no)20(v)-13(o)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 354.5054 574.2344 Tm
[( )-19(vir)-12(al )-19(synthesis)40(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 559.9547 Tm
[(He )-13(notes)40(, )-13(f)13(or )-13(e)-23(xample)13(, )-13(tha)25(t )-13(constr)-13(ucting )-13(the )-13(polio )-13(vir)-13(us )-13(from )-13(scr)-12(a)25(tch )-13(was )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 545.675 Tm
[(fairl)25(y )4(str)-12(aightf)13(orward )4(because )4(its )4(genome )4(is )4(small )4(and )4(consists )4(of)-28( )4(a )4(single )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 531.3954 Tm
[(positiv)23(e )-14(str)-12(and )-14(of)-28( )-14(RN)45(A )-14(tha)25(t, )-14(when )-14(placed )-14(in )-14(a )-14(cell-free )-14(e)-23(xtr)-12(act, )-14(spontane)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 531.3954 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 517.1157 Tm
[(ousl)25(y )-124(directs )-124(the )-124(production )-124(of)-28( )-124(vir)-12(al )-124(proteins)40(, )-124(which )-124(then )-124(self-assemb)17(le )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 502.8361 Tm
[(to )-92(yield )-92(infectious )-92(vir)-12(al )-92(par)-17(ticles)40(. )-92(By )-92(contr)-12(ast, )-92(the )-92(genomes )-92(of)-28( )-92(ne)-10(g)22(a)25(tiv)23(e-)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 488.5564 Tm
[(str)-12(and )9(RN)45(A )9(vir)-13(uses)40(, )9(such )10(as )9(Ebola )9(or )9(the )9(1918 )10(str)-12(ain )9(of)-28( )9(inf)17(luenza, )10(are )9(not )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 474.2767 Tm
[(infectious )-11(b)13(y )-11(themselv)23(es )-11(b)14(ut )-11(require )-11(the )-11(presence )-11(of)-28( )-11(vir)-12(al )-11(helper )-11(proteins)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 459.997 Tm
[(which )2(must )2(be )2(synthesized )2(and )2(present )2(in )2(the )2(host )2(cells )2(in )2(the )2(right )2(num)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 459.997 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 445.7173 Tm
[(ber)-13(s)40(. )-57(Because )-57(such )-57(re)10(v)23(er)-13(se-genetic )-57(systems )-57(are )-57(rela)25(tiv)23(el)25(y )-57(difficult )-57(to )-57(cre)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 445.7173 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 431.4377 Tm
[(a)25(te)13(, )-49(onl)25(y )-49(a )-49(limited )-49(number )-49(of)-28( )-49(scientists )-49(ha)20(v)23(e )-49(the )-49(requisite )-49(skills )-49(and )-49(tacit )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 417.158 Tm
[(kno)13(wledge)13(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 128.4394 420.128 Tm
(20)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 402.8783 Tm
[(I)5(t)5( )-15(i)5(s)5( )-15(a)5(l)5(s)5(o)5( )-15(i)5(m)5(p)5(o)5(r)-12(t)5(a)5(n)5(t)5( )-15(t)5(o)5( )-15(n)5(o)5(t)5(e)5( )-15(t)5(h)5(a)30(t)5( )-15(d)5(e)15(v)28(e)5(l)5(o)5(p)5(i)5(n)5(g)5( )-15(a)5(n)5(d)5( )-15(p)5(r)5(o)5(d)5(u)5(c)5(i)5(n)5(g)5( )-15(a)5(n)5( )-15(e)5(f)5(f)5(e)5(c)5(t)5(i)5(v)28(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 388.5986 Tm
[(b)5(i)5(o)5(l)5(o)18(g)5(i)5(c)5(a)5(l)5( )61(w)18(e)5(a)5(p)5(o)5(n)5( )61(i)5(n)18(v)42(o)5(l)5(v)28(e)5(s)5( )61(f)5(a)5(r)5( )61(m)5(o)5(r)5(e)5( )61(t)5(h)5(a)5(n)5( )61(s)5(i)5(m)5(p)5(l)30(y)5( )61(a)5(c)5(q)5(u)5(i)5(r)5(i)5(n)5(g)5( )61(a)5( )61(v)5(i)5(r)-8(u)5(l)5(e)5(n)5(t)5( )61(p)5(a)30(t)5(h)5(o)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 388.5986 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 374.3189 Tm
[(g)5(e)5(n)5(,)5( )-83(w)5(h)5(e)5(t)5(h)5(e)5(r)5( )-83(b)18(y)5( )-83(i)5(s)5(o)5(l)5(a)30(t)5(i)5(n)5(g)5( )-83(i)5(t)5( )-83(f)5(r)5(o)5(m)5( )-83(n)5(a)30(t)5(u)5(r)5(e)5( )-83(o)5(r)5( )-83(s)5(y)5(n)5(t)5(h)5(e)5(s)5(i)5(z)5(i)5(n)5(g)5( )-83(i)5(t)5( )-83(f)5(r)5(o)5(m)5( )-83(s)5(c)5(r)-7(a)30(t)5(c)5(h)5(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 360.0392 Tm
[(T)34(a)5(c)5(i)5(t)5( )-5(k)5(n)5(o)18(w)5(l)5(e)5(d)5(g)5(e)5( )-6(a)5(l)5(s)5(o)5( )-6(p)5(l)5(a)34(y)5(s)5( )-6(a)5(n)5( )-6(i)5(m)5(p)5(o)5(r)-12(t)5(a)5(n)5(t)5( )-5(r)5(o)5(l)5(e)5( )-5(i)5(n)5( )-5(t)5(h)5(e)5( )-5(\223)5(w)18(e)5(a)5(p)5(o)5(n)5(i)5(z)5(a)30(t)5(i)5(o)5(n)5(\224)-8( )-6(o)5(f)-23( )-5(a)5(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 345.7596 Tm
[(i)5(n)5(f)5(e)5(c)5(t)5(i)5(o)5(u)5(s)5( )12(a)19(g)5(e)5(n)5(t)5(,)5( )12(w)5(h)5(i)5(c)5(h)5( )12(i)5(n)5(c)5(l)5(u)5(d)5(e)5(s)5( )12(t)5(h)5(e)5( )12(f)18(o)5(l)5(l)5(o)18(w)5(i)5(n)5(g)5( )12(s)5(t)5(e)-8(p)5(s)5(:)5( )12(\()5(1)5(\))5( )12(g)-28(r)5(o)18(w)5(i)5(n)5(g)5( )12(t)5(h)5(e)5( )12(a)19(g)5(e)5(n)5(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 331.4799 Tm
[(i)5(n)5( )-68(t)5(h)5(e)5( )-68(n)5(e)5(e)5(d)5(e)5(d)5( )-68(q)5(u)5(a)5(n)5(t)5(i)5(t)5(y)126(,)5( )-68(\()5(2)5(\))5( )-68(f)18(o)5(r)-17(m)5(u)5(l)5(a)30(t)5(i)5(n)5(g)5( )-68(t)5(h)5(e)5( )-68(a)19(g)5(e)5(n)5(t)5( )-68(w)5(i)5(t)5(h)5( )-68(c)5(h)5(e)5(m)5(i)5(c)5(a)5(l)5( )-68(a)5(d)5(d)5(i)5(t)5(i)5(v)28(e)5(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 317.2002 Tm
[(t)5(o)5( )-56(e)5(n)5(h)5(a)5(n)5(c)5(e)5( )-56(i)5(t)5(s)5( )-56(s)5(t)5(a)18(b)5(i)5(l)5(i)5(t)5(y)5( )-56(a)5(n)5(d)5( )-56(s)5(h)5(e)5(l)5(f)-23( )-56(l)5(i)5(f)5(e)18(,)5( )-56(\()5(3)5(\))5( )-56(p)5(r)5(o)5(c)5(e)5(s)5(s)5(i)5(n)5(g)5( )-56(t)5(h)5(e)5( )-56(a)19(g)5(e)5(n)5(t)5( )-56(i)5(n)5(t)5(o)5( )-56(a)5( )-56(c)5(o)5(n)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 317.2002 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 302.9205 Tm
[(c)5(e)5(n)5(t)5(r)-7(a)30(t)5(e)5(d)5( )-56(s)5(l)5(u)5(r)-8(r)-20(y)5( )-56(o)5(r)5( )-56(a)5( )-56(d)5(r)-20(y)5( )-56(p)5(o)18(w)30(d)5(e)5(r)71(,)5( )-56(a)5(n)5(d)5( )-56(\()5(4)5(\))5( )-56(d)5(e)15(v)5(i)5(s)5(i)5(n)5(g)5( )-56(a)5( )-56(d)5(e)5(l)5(i)5(v)28(e)5(r)-20(y)5( )-56(s)5(y)5(s)5(t)5(e)5(m)5( )-56(t)5(h)5(a)30(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 288.6408 Tm
[(c)5(a)5(n)5( )-124(d)5(i)5(s)5(s)5(e)5(m)5(i)5(n)5(a)30(t)5(e)5( )-124(t)5(h)5(e)5( )-124(a)19(g)5(e)5(n)5(t)5( )-124(a)5(s)5( )-124(a)5( )-124(f)5(i)5(n)5(e)5(-)5(p)5(a)5(r)-12(t)5(i)5(c)5(l)5(e)5( )-124(a)5(e)5(r)5(o)5(s)5(o)5(l)5( )-124(t)5(h)5(a)30(t)5( )-124(i)5(n)5(f)5(e)5(c)5(t)5(s)5( )-124(t)5(h)5(r)5(o)5(u)5(g)5(h )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 274.3611 Tm
[(t)5(h)5(e)5( )-57(l)5(u)5(n)5(g)5(s)45(.)5( )-57(A)5(c)5(c)5(o)5(r)5(d)5(i)5(n)5(g)5( )-57(t)5(o)5( )-57(K)15(u)5(h)5(n)5(,)5( )-57(\223)5(T)5(h)5(e)5( )-57(m)5(e)5(t)5(h)5(o)5(d)5(s)5( )-57(t)5(o)5( )-57(s)5(t)5(a)18(b)5(i)5(l)5(i)5(z)5(e)18(,)5( )-57(c)5(o)5(a)30(t)5(,)5( )-58(s)5(t)5(o)5(r)5(e)18(,)5( )-58(a)5(n)5(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 260.0815 Tm
[(d)5(i)5(s)5(p)5(e)5(r)-8(s)5(e)5( )-114(a)5( )-114(b)5(i)5(o)5(l)5(o)18(g)5(i)5(c)5(a)5(l)5( )-114(a)19(g)5(e)5(n)5(t)5( )-114(a)5(r)5(e)5( )-114(h)5(i)5(g)5(h)5(l)30(y)5( )-114(c)5(o)5(m)5(p)5(l)5(i)5(c)5(a)30(t)5(e)5(d)5(,)5( )-114(k)5(n)5(o)18(w)5(n)5( )-114(o)5(n)5(l)30(y)5( )-114(t)5(o)5( )-114(a)5( )-114(f)5(e)15(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 245.8018 Tm
[(p)5(e)5(o)5(p)5(l)5(e)18(,)5( )-79(a)5(n)5(d)5( )-80(r)-7(a)5(r)5(e)5(l)30(y)5( )-80(p)5(u)5(b)22(l)5(i)5(s)5(h)5(e)5(d)5(.)5(\224)-8( )-80(T)5(h)5(u)5(s)45(,)5( )-80(e)15(v)28(e)5(n)5( )-80(i)5(f)-23( )-80(t)5(e)5(r)-8(r)5(o)5(r)5(i)5(s)5(t)5(s)5( )-80(w)18(e)5(r)5(e)5( )-79(t)5(o)5( )-80(s)5(y)5(n)5(t)5(h)5(e)5(s)5(i)5(z)5(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 231.5221 Tm
[(a)5( )-58(v)5(i)5(r)-7(a)5(l)5( )-58(a)19(g)5(e)5(n)5(t)5( )-58(s)5(u)5(c)5(c)5(e)5(s)5(s)5(f)5(u)5(l)5(l)30(y)126(,)5( )-58(\223)5(t)5(h)5(e)5(y)5( )-58(w)5(i)5(l)5(l)5( )-58(i)5(n)5( )-58(a)5(l)5(l)5( )-58(l)5(i)5(k)44(e)5(l)5(i)5(h)5(o)5(o)5(d)5( )-58(g)5(e)5(t)5( )-58(s)5(t)5(u)5(c)5(k)5( )-58(d)5(u)5(r)5(i)5(n)5(g)5( )-58(t)5(h)5(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 217.2424 Tm
[(w)18(e)5(a)5(p)5(o)5(n)5(i)5(z)5(a)30(t)5(i)5(o)5(n)5( )-20(p)5(r)5(o)5(c)5(e)5(s)5(s)45(.)5(\224)]TJ
ET
BT
/T1_4 1 Tf
14 0 0 14 130.1406 189.1627 Tm
[(S)-5(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-32(B)-5(i)-5(o)-5(l)-5(o)-5(g)-5(y)-5(\222)58(s)-5( )-32(D)-5(e)-5(-)-5(s)-5(k)-5(i)-5(l)-5(l)-5(i)-5(n)-5(g)-5( )-32(A)-5(g)-5(e)-5(n)-5(d)-5(a)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 169.843 Tm
(T)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 84.5039 169.843 Tm
[(he )88(deba)25(te )88(o)19(v)23(er )88(de-skilling )88(has )88(f)13(ocused )88(not )88(onl)25(y )88(on )88(whole-genome )88(synthe)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 169.843 Tm
(-)Tj
-29.489 -1.19 Td
[(sis )-18(b)14(ut )-18(also )-18(on )-18(the )-18(rela)25(ted )-18(b)14(ut )-18(broader )-18(field )-18(kno)13(wn )-18(as )-18(\223synthetic)]TJ
/Span<>> BDC
( )Tj
EMC
26.27 0 Td
[(biolo)13(g)-40(y)113(.\224)-13( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.2837 Tm
[(Despite )-140(the )-140(o)19(v)23(erlap )-140(betw)13(een )-140(these )-140(two )-140(disciplines)40(, )-140(there )-140(are )-140(impor)-17(tant )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.004 Tm
[(differences)40(. )-6(W)-18(hereas )-6(synthetic )-6(genomics )-6(is )-6(an )-6(\223ena)13(b)17(ling\224)-13( )-6(technolo)13(g)-40(y )-6(tha)25(t )]TJ
ET
Q
endstream
endobj
37 0 obj
<<
/Length 10114
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(7)-5(4)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(mak)39(es )-93(possib)17(le )-93(many )-93(other )-93(technolo)13(gical )-93(applica)25(tions)40(, )-93(synthetic )-93(biolo)13(g)-40(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1615 Tm
[(is )-53(an )-53(umbrella )-53(ter)-22(m )-53(tha)25(t )-53(co)19(v)23(er)-13(s )-53(se)10(v)23(er)-12(al )-53(distinct )-53(research )-53(pro)13(g)-33(r)-12(ams)40(. )-53(T)30(wo )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.1309 Tm
[(prominent )-43(and )-43(outspok)39(en )-43(scientists)40(, )-43(Thomas )-43(Knight )-43(of)-28( )-43(M.I.T)110(. )-43(and )-43(Dre)10(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1003 Tm
[(End)13(y )-65(of)-28( )-65(Stanf)13(ord, )-65(adv)37(oca)25(te )-65(a )-65(par)-17(ticular )-65(synthetic-biolo)13(g)-40(y )-65(par)-12(adigm )-65(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.0698 Tm
[(aims )-172(to )-172(facilita)25(te )-172(biolo)13(gical )-172(engineering )-172(through )-172(the )-172(de)10(v)23(elopment )-172(of)-28( )-172(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0392 Tm
[(\223tool )-105(kit\224)-13( )-106(called )-105(the )-106(R)31(e)-10(gistr)-25(y )-106(of)-28( )-105(Standard )-106(Biolo)13(gical )-106(P)37(ar)-17(ts)40(. )-106(These )-106(par)-17(ts)40(, )]TJ
0 -1.169 TD
[(also kno)13(wn as \223BioBricks)40(,\224)-13( are pieces of)-28( DN)45(A with kno)13(wn protein)]TJ
/Span<>> BDC
(-)Tj
EMC
(coding )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.978 Tm
[(or )-104(re)-10(gula)25(tor)-25(y )-104(functions )-104(tha)25(t )-104(beha)20(v)23(e )-104(in )-104(a )-104(predicta)13(b)17(le )-104(manner )-104(and )-104(ha)20(v)23(e )-104(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9474 Tm
[(standard )33(interface)13(. )33(In )33(principle)13(, )33(such )33(par)-17(ts )33(can )33(be )33(joined )33(to)13(gether )33(to )33(crea)25(te )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 547.9169 Tm
[(functional )-158(genetic )-158(\223circuits)40(,\224)-13( )-158(much )-158(as )-158(tr)-12(ansistor)-13(s)40(, )-158(capacitor)-13(s)40(, )-158(and )-158(resis)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 547.9169 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8863 Tm
[(tor)-13(s )-126(are )-126(assemb)17(led )-126(into )-126(electronic )-126(de)10(vices)40(. )-126(A )-126(major )-126(g)10(oal )-126(of)-28( )-126(par)-17(ts-based )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.8557 Tm
[(synthetic )-36(biolo)13(g)-40(y )-37(is )-36(to )-36(design )-36(and )-36(b)14(uild )-36(genetic )-36(modules )-36(tha)25(t )-37(will )-36(endo)13(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 505.8251 Tm
[(microbes )-41(with )-41(useful )-41(functions )-41(not )-41(f)13(ound )-41(in )-41(na)25(ture)13(, )-41(such )-41(as )-41(the )-41(a)13(bility )-41(to )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 491.7946 Tm
[(produce )-25(biofuels )-25(or )-25(phar)-22(maceuticals)40(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 477.764 Tm
[(At )63(least )63(in )63(theor)-25(y)121(, )63(the )63(use )63(of)-28( )63(standard )63(genetic )63(par)-17(ts )63(and )63(modular )63(design )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7334 Tm
[(techniques )6(should )6(significantl)25(y )6(reduce )6(the )6(need )6(f)13(or )6(tacit )6(kno)13(wledge )6(in )6(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7029 Tm
[(constr)-13(uction )-113(of)-28( )-113(synthetic )-113(org)22(anisms)40(. )-113(As )-113(Gautam )-113(Mukunda, )-113(K)13(enneth )-113(A. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6723 Tm
[(Oy)32(e)13(, )-138(and )-138(Scott )-138(C)17(. )-138(Mohr )-138(of)-28( )-138(M.I.T)110(. )-138(and )-138(Boston )-138(Univ)23(er)-13(sity )-138(ha)20(v)23(e )-138(argued, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6417 Tm
[(\223De-skilling )-143(and )-143(modularit)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 207.5257 421.6417 Tm
[(y)-7(.)-120(.)-120(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 225.8136 421.6417 Tm
[(ha)20(v)23(e )-143(the )-143(potential )-143(t)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 325.0819 421.6417 Tm
[(o)-86(.)-120(.)-120(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 344.1977 421.6417 Tm
[(decrease )-143(the )-143(skill )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6111 Tm
[(g)-33(r)-12(adient )6(se)-13(par)-12(a)25(ting )6(elite )6(pr)-12(actitioner)-13(s )6(from )6(non-e)-23(xper)-17(ts)40(.\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 353.6152 410.5811 Tm
(21)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 362.6152 407.6111 Tm
[( )6(Ne)10(v)23(er)-17(theless)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5806 Tm
[(not )-160(e)10(v)23(er)-25(y)30(one )-160(in )-160(the )-160(synthetic )-160(biolo)13(g)-40(y )-160(community )-160(has )-160(bought )-160(into )-160(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 379.55 Tm
[(standardized-par)-17(ts )-282(approach, )-282(and )-282(some )-282(belie)10(v)23(e )-282(tha)25(t )-282(it )-282(is )-282(destined )-282(to )]TJ
T*
(fail)Tj
/Span<>> BDC
( )Tj
EMC
1.302 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(or)66(, )32(a)25(t )32(the )32(v)23(er)-25(y )32(least, )32(not )32(to )32(liv)23(e )31(up )32(to )32(its )32(ambitious )32(claim )32(of)-28( )32(pro)19(viding )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 351.4889 Tm
[(a )-50(simple )-50(and )-50(predicta)13(b)17(le )-50(wa)29(y )-50(to )-50(design )-50(and )-50(b)14(uild )-50(ar)-17(tificial )-49(genomes)40(. )-50(One )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4583 Tm
[(prob)17(lem )17(is )17(tha)25(t )17(many )17(biolo)13(gical )17(par)-17(ts )17(ha)20(v)23(e )17(not )17(been )17(adequa)25(tel)25(y )17(char)-12(acter)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 337.4583 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.4277 Tm
[(ized, )-69(so )-69(their )-69(activity )-69(v)13(aries )-69(de)-13(pending )-69(on )-69(cell )-69(type )-69(or )-69(la)13(bor)-12(a)25(tor)-25(y )-69(condi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 323.4277 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.3972 Tm
[(tions)40(, )-1(and )-1(some )-1(par)-17(ts )-1(do )-1(not )-1(function )-1(optimall)25(y)121(, )-1(or )-1(a)25(t )-1(all, )-1(because )-1(they )-1(are )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3666 Tm
[(incompa)25(tib)17(le )-25(with )-25(the )-25(biochemical )-25(machiner)-25(y )-25(of)-28( )-25(the )-25(host )-25(cell.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 373.9315 298.3366 Tm
(22)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 281.3361 Tm
[(In )-366(other )-366(cases)40(, )-366(the )-366(char)-12(acteristics )-366(of)-28( )-366(individual )-366(biolo)13(gical )-366(par)-17(ts )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3055 Tm
[(ma)29(y )-99(be )-99(w)13(ell )-99(under)-13(stood, )-99(b)14(ut )-99(the )-99(par)-17(ts )-99(do )-99(not )-99(beha)20(v)23(e )-99(as )-99(e)-23(xpected )-99(when )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 253.2749 Tm
[(combined )-157(as )-157(an )-157(intended )-157(functional )-157(module)13(. )-157(Indeed, )-157(e)10(v)23(en )-157(fairl)25(y )-157(simple )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2444 Tm
[(genetic )-146(circuits )-146(tend )-146(to )-146(be )-146(\223noisy)121(,\224)-13( )-146(oper)-12(a)25(ting )-146(stochasticall)25(y )-146(r)-12(a)25(ther )-146(than )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 225.2138 Tm
[(predicta)13(b)17(l)25(y)113(. )-157(Fur)-17(ther)-22(more)13(, )-157(as )-157(the )-157(size )-157(of)-28( )-157(synthetic )-157(biolo)13(gical )-157(constr)-13(ucts )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1832 Tm
[(increases)40(, )-138(nonlinear )-138(inter)-12(actions )-138(among )-138(the )-138(genetic )-138(and )-138(e)-13(pigenetic )-138(ele)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 211.1832 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1526 Tm
[(ments )-94(ma)29(y )-94(become )-94(increasingl)25(y )-94(difficult )-94(to )-94(predict )-94(or )-94(control, )-94(resulting )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.1221 Tm
[(in )-143(une)-23(xpected )-143(beha)20(vior)-13(s )-143(and )-143(other )-143(emergent )-143(proper)-17(ties)40(. )-143(It )-143(is )-143(theref)13(ore )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.0915 Tm
[(conceiv)13(a)13(b)17(le )-95(tha)25(t )-95(large )-95(genetic )-95(constr)-13(ucts )-95(could )-95(pose )-95(safety )-95(hazards )-95(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.061 Tm
[(are )-131(impossib)17(le )-131(to )-131(predict )-131(in )-131(adv)13(ance)13(. )-131(\(This )-131(possibility )-131(was )-131(discussed )-131(in )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0304 Tm
[(these )-11(pa)14(ges )-11(b)13(y )-11(R)10(a)29(ymond )-11(Zalinskas )-11(and )-11(the )-11(author; )-11(see )-11(\223The )-11(Promise )-11(and )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 126.9998 Tm
[(P)56(erils )-180(of)-28( )-180(Synthetic )-180(Biolo)13(g)-40(y)121(,\224)-13( )-180(Spring )-180(2006.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 286.2661 129.9698 Tm
(23)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 295.2661 126.9998 Tm
[(\) )-180(In )-180(sum, )-180(although )-180(cer)-17(tain )]TJ
ET
Q
endstream
endobj
38 0 obj
<<
/Length 12105
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(7)-5(5)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(aspects )15(of)-28( )15(par)-17(ts-based )15(synthetic )15(biolo)13(g)-40(y )15(ma)29(y )15(w)13(ell )15(become )15(more )15(accessib)17(le )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 659.9123 Tm
[(to )21(non-e)-23(xper)-17(ts)40(, )21(the )21(field\222s )21(e)-23(xplicit )21(de-skilling )21(a)14(genda )21(is )21(far )21(from )21(becoming )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 645.6325 Tm
[(an )-25(oper)-12(a)25(tional )-25(reality)113(.)]TJ
ET
BT
/T1_3 1 Tf
14 0 0 14 148.4491 617.5527 Tm
[(D)-5(e)-5(m)-5(o)-5(c)-5(r)8(a)8(t)-5(i)-5(z)-5(i)-5(n)-5(g)-5( )-32(S)-5(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-32(B)-5(i)-5(o)-5(l)-5(o)-5(g)-5(y)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 598.2329 Tm
(A)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 84.0078 598.2329 Tm
[(nother )-48(element )-48(in )-48(the )-48(a)14(genda )-48(of)-28( )-48(par)-17(ts-based )-48(synthetic )-48(biolo)13(g)-40(y)121(, )-48(as )-48(con)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 598.2329 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 583.9531 Tm
[(ceiv)23(ed )24(b)13(y )24(Knight )24(and )24(End)13(y)121(, )24(is )24(to )24(mak)39(e )24(the )24(R)31(e)-10(gistr)-25(y )24(of)-28( )24(Standard )24(Biolo)13(gical )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 569.6733 Tm
[(P)37(ar)-17(ts )-97(freel)25(y )-97(a)20(v)13(aila)13(b)17(le )-97(to )-97(interested )-97(researcher)-13(s )-97(without )-97(pa)25(tents )-97(or )-97(other )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 555.3936 Tm
[(restrictions)40(. )3(Ov)23(er )3(130 )3(academic )3(la)13(bs )3(no)13(w )3(par)-17(ticipa)25(te )3(in )3(the )3(R)31(e)-10(gistr)-25(y )3(com)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 555.3936 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 541.1138 Tm
[(munity)113(. )-29(An )-29(impor)-17(tant )-29(v)23(ehicle )-29(f)13(or )-29(this )-29(\223open-access )-29(biolo)13(g)-40(y\224)-13( )-29(mo)19(v)23(ement )-28(is )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 526.834 Tm
[(the )-80(Inter)-40(na)25(tional )-80(Geneticall)25(y )-80(Engineered )-80(Machine )-80(competition )-80(\(iGEM\), )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 512.5542 Tm
[(held )-234(annuall)25(y )-234(a)25(t )-234(M.I.T)110(. )-234(b)13(y )-234(the )-234(BioBricks )-234(F)61(ounda)25(tion.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 349.335 515.5242 Tm
(24)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 358.335 512.5542 Tm
[( )-234(The )-234(g)10(oals )-234(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 498.2744 Tm
[(iGEM )-100(are )-100(\223to )-100(ena)13(b)17(le )-100(the )-100(systema)25(tic )-100(engineering )-100(of)-28( )-100(biolo)13(g)-40(y)121(, )-100(to )-100(promote )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 483.9946 Tm
[(the )-101(open )-101(and )-101(tr)-12(ansparent )-101(de)10(v)23(elopment )-101(of)-28( )-101(tools )-101(f)13(or )-101(engineering )-101(biolo)13(g)-40(y)121(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 469.7148 Tm
[(and )-193(to )-193(help )-193(constr)-13(uct )-193(a )-193(society )-193(tha)25(t )-193(can )-193(productiv)23(el)25(y )-193(appl)25(y )-193(biolo)13(gical )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 455.4351 Tm
[(technolo)13(g)-40(y)113(.\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 133.3591 458.4051 Tm
(25)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 142.3591 455.4351 Tm
[( )1(Star)-17(ting )1(in )1(2003 )1(with )1(a )1(small )1(g)-33(roup )1(of)-28( )1(student )1(teams )1(from )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 441.1553 Tm
[(American )-108(univ)23(er)-13(sities)40(, )-108(iGEM )-108(has )-108(since )-108(become )-108(a )-108(global )-108(e)10(v)23(ent: )-108(in )-108(2010, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 426.8755 Tm
[(118 )-154(teams )-154(from )-154(26 )-154(countries )-154(par)-17(ticipa)25(ted.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 285.0487 429.8455 Tm
(26)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 294.0487 426.8755 Tm
[( )-154(Ne)10(v)23(er)-17(theless)40(, )-154(many )-154(of)-28( )-154(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 412.5957 Tm
[(teams )-48(ha)20(v)23(e )-48(had )-48(troub)17(le )-48(crea)25(ting )-48(or )-48(using )-48(biolo)13(gical )-48(par)-17(ts )-48(tha)25(t )-48(work )-48(reli)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 412.5957 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 398.3159 Tm
[(a)13(b)17(l)25(y )-25(and )-25(predicta)13(b)17(l)25(y )-25(in )-25(different )-25(conte)-23(xts)40(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 384.0361 Tm
[(I)-12(n)-12( )-457(M)-12(a)17(y)-12( )-457(2)-12(0)-12(0)-12(8)-12(,)-12( )-457(a)-12( )-457(g)-45(r)-12(o)-12(u)-12(p)-12( )-457(o)-12(f)-40( )-457(a)-12(m)-12(a)13(t)-12(e)-12(u)-12(r)-12( )-457(b)-12(i)-12(o)-12(l)-12(o)1(g)-12(i)-12(s)-12(t)-12(s)-12( )-457(i)-12(n)-12( )-457(C)-12(a)-12(m)-12(b)-12(r)-12(i)-12(d)-12(g)-12(e)1(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 369.7563 Tm
[(Massachusetts)40(, )-269(launched )-269(another )-269(open-access )-269(initia)25(tiv)23(e )-269(called )-269(DIYbio )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 355.4766 Tm
[(\(\223do-it-y)30(our)-13(self)-28( )-151(biolo)13(g)-40(y\224\) )-151(with )-151(the )-151(g)10(oal )-151(of)-28( )-151(making )-151(biotechnolo)13(g)-40(y )-151(more )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 341.1968 Tm
[(accessib)17(le )17(to )17(non-e)-23(xper)-17(ts)40(, )17(including )17(the )17(potential )17(use )17(of)-28( )17(synthetic-biolo)13(g)-40(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 326.917 Tm
[(techniques )23(to )22(car)-13(r)-25(y )22(out )22(per)-13(sonal )22(projects)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 273.8274 329.887 Tm
(27)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 282.8274 326.917 Tm
[( )22(DIYbio )23(has )22(since )23(e)-23(xpanded )23(to )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 312.6372 Tm
[(other )61(U)82(.S. )61(cities )61(as )61(w)13(ell )61(as )61(inter)-40(na)25(tionall)25(y)121(, )61(with )61(local )61(chapter)-13(s )61(in )61(Bang)22(alore)13(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 298.3574 Tm
[(London, )-63(Madrid, )-63(and )-63(Sing)22(apore)13(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 233.2508 301.3274 Tm
(28)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 242.2508 298.3574 Tm
[( )-63(Although )-63(the )-63(g)-33(roup\222s )-63(technical )-63(infr)-12(a)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 298.3574 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 284.0776 Tm
[(str)-13(ucture )-130(and )-130(capa)13(bilities )-130(are )-130(still )-130(r)-13(udimentar)-25(y)121(, )-130(they )-130(ma)29(y )-130(become )-130(more )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 269.7979 Tm
[(sophistica)25(ted )-25(as )-25(gene-synthesis )-25(technolo)13(g)-40(y )-25(ma)25(tures)40(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 255.5181 Tm
[(S)-1(o)-1(m)-1(e)-1( )-11(o)-1(b)-1(s)-1(e)-1(r)-27(v)22(e)-1(r)-14(s)-1( )-11(c)-1(o)-1(n)-1(t)-1(e)-1(n)-1(d)-1( )-11(t)-1(h)-1(a)24(t)-1( )-11(t)-1(h)-1(e)-1( )-11(d)-1(e)-1(-)-1(s)-1(k)-1(i)-1(l)-1(l)-1(i)-1(n)-1(g)-1( )-11(a)-1(n)-1(d)-1( )-11(o)-1(p)-1(e)-1(n)-1(-)-1(a)-1(c)-1(c)-1(e)-1(s)-1(s)-1( )-11(a)13(g)-1(e)-1(n)-1(d)-1(a)-1(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 241.2383 Tm
[(b)-1(e)-1(i)-1(n)-1(g)-1( )-152(p)-1(r)-1(o)-1(m)-1(o)-1(t)-1(e)-1(d)-1( )-152(b)12(y)-1( )-152(i)-1(G)-1(E)-1(M)-1( )-152(a)-1(n)-1(d)-1( )-152(D)-1(I)-1(Y)-1(b)-1(i)-1(o)-1( )-152(w)-1(i)-1(l)-1(l)-1( )-152(u)-1(n)-1(l)-1(e)-1(a)-1(s)-1(h)-1( )-152(a)-1( )-152(w)-1(a)19(v)22(e)-1( )-152(o)-1(f)-29( )-152(i)-1(n)-1(n)-1(o)18(v)12(a)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 241.2383 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 226.9585 Tm
[(t)-1(i)-1(o)-1(n)-1( )-89(a)-1(s)-1( )-89(a)-1( )-89(g)-34(r)-1(o)12(w)-1(i)-1(n)-1(g)-1( )-89(n)-1(u)-1(m)-1(b)-1(e)-1(r)-1( )-89(o)-1(f)-29( )-89(p)-1(e)-1(o)-1(p)-1(l)-1(e)-1( )-89(f)-1(r)-1(o)-1(m)-1( )-89(d)-1(i)-1(f)-1(f)-1(e)-1(r)-1(e)-1(n)-1(t)-1( )-89(w)-1(a)-1(l)-1(k)-1(s)-1( )-89(o)-1(f)-29( )-89(l)-1(i)-1(f)-1(e)-1( )-89(a)-1(c)-1(q)-1(u)-1(i)-1(r)-1(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 212.6787 Tm
[(t)-1(h)-1(e)-1( )-74(a)12(b)-1(i)-1(l)-1(i)-1(t)-1(y)-1( )-74(t)-1(o)-1( )-74(e)-1(n)-1(g)-1(i)-1(n)-1(e)-1(e)-1(r)-1( )-74(b)-1(i)-1(o)-1(l)-1(o)12(g)-41(y)-1( )-74(f)12(o)-1(r)-1( )-74(u)-1(s)-1(e)-1(f)-1(u)-1(l)-1( )-74(p)-1(u)-1(r)-14(p)-1(o)-1(s)-1(e)-1(s)39(.)-1( )-74(A)-1(c)-1(c)-1(o)-1(r)-1(d)-1(i)-1(n)-1(g)-1( )-74(t)-1(o)-1( )-74(a)-1( )-74(t)-1(e)-1(a)-1(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 198.3989 Tm
[(o)-1(f)-29( )-265(s)-1(o)-1(c)-1(i)-1(a)-1(l)-1( )-265(s)-1(c)-1(i)-1(e)-1(n)-1(t)-1(i)-1(s)-1(t)-1(s)-1( )-265(a)-1(f)-1(f)-1(i)-1(l)-1(i)-1(a)24(t)-1(e)-1(d)-1( )-265(w)-1(i)-1(t)-1(h)-1( )-265(t)-1(h)-1(e)-1( )-265(S)-1(y)-1(n)-1(t)-1(h)-1(e)-1(t)-1(i)-1(c)-1( )-265(B)-1(i)-1(o)-1(l)-1(o)12(g)-41(y)-1( )-265(E)-1(n)-1(g)-1(i)-1(n)-1(e)-1(e)-1(r)-1(i)-1(n)-1(g )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 184.1192 Tm
[(R)30(e)-1(s)-1(e)-1(a)-1(r)-1(c)-1(h)-1( )-189(C)-1(e)-1(n)-1(t)-1(e)-1(r)-1( )-189(\()-1(S)-1(y)-1(n)-1(B)-1(E)-1(R)39(C)-1(\))-1( )-189(a)24(t)-1( )-189(t)-1(h)-1(e)-1( )-189(U)-1(n)-1(i)-1(v)22(e)-1(r)-14(s)-1(i)-1(t)-1(y)-1( )-189(o)-1(f)-29( )-189(C)-1(a)-1(l)-1(i)-1(f)12(o)-1(r)-41(n)-1(i)-1(a)-1(,)-1( )-189(B)-1(e)-1(r)-1(k)38(e)-1(l)-1(e)-1(y)120(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.8394 Tm
[(\223)-1(T)-1(h)-1(e)-1( )-66(g)9(o)-1(o)-1(d)-1( )-66(n)-1(e)9(w)-1(s)-1( )-66(i)-1(s)-1( )-66(t)-1(h)-1(a)24(t)-1( )-66(o)-1(p)-1(e)-1(n)-1( )-66(a)-1(c)-1(c)-1(e)-1(s)-1(s)-1( )-66(b)-1(i)-1(o)-1(l)-1(o)12(g)-41(y)120(,)-1( )-66(t)-1(o)-1( )-66(t)-1(h)-1(e)-1( )-66(e)-24(x)-1(t)-1(e)-1(n)-1(t)-1( )-66(t)-1(h)-1(a)24(t)-1( )-66(i)-1(t)-1( )-66(w)-1(o)-1(r)-1(k)-1(s)39(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.5596 Tm
[(m)-1(a)28(y)-1( )-269(h)-1(e)-1(l)-1(p)-1( )-269(a)-1(c)-1(t)-1(u)-1(a)-1(l)-1(i)-1(z)-1(e)-1( )-269(t)-1(h)-1(e)-1( )-269(l)-1(o)-1(n)-1(g)-1(-)-1(p)-1(r)-1(o)-1(m)-1(i)-1(s)-1(e)-1(d)-1( )-269(b)-1(i)-1(o)-1(t)-1(e)-1(c)-1(h)-1(n)-1(i)-1(c)-1(a)-1(l)-1( )-269(f)-1(u)-1(t)-1(u)-1(r)-1(e)-1(:)-1( )-269(g)-34(r)-1(o)12(w)-1(t)-1(h)-1( )-269(o)-1(f)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.2798 Tm
[(g)-34(r)-1(e)-1(e)-1(n)-1( )13(i)-1(n)-1(d)-1(u)-1(s)-1(t)-1(r)-26(y)120(,)-1( )13(p)-1(r)-1(o)-1(d)-1(u)-1(c)-1(t)-1(i)-1(o)-1(n)-1( )13(o)-1(f)-29( )13(c)-1(h)-1(e)-1(a)-1(p)-1(e)-1(r)-1( )13(d)-1(r)-14(u)-1(g)-1(s)39(,)-1( )13(d)-1(e)9(v)22(e)-1(l)-1(o)-1(p)-1(m)-1(e)-1(n)-1(t)-1( )13(o)-1(f)-29( )13(n)-1(e)9(w)-1( )13(b)-1(i)-1(o)-1(f)-1(u)-1(e)-1(l)-1(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127 Tm
[(a)-1(n)-1(d)-1( )-110(t)-1(h)-1(e)-1( )-110(l)-1(i)-1(k)38(e)12(.)-1(\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 138.9103 129.97 Tm
[(2)-1(9)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 147.9283 127 Tm
[( )-110(E)-1(x)-1(t)-1(r)-13(a)-1(p)-1(o)-1(l)-1(a)24(t)-1(i)-1(n)-1(g)-1( )-110(f)-1(r)-1(o)-1(m)-1( )-110(t)-1(h)-1(e)-1(s)-1(e)-1( )-110(t)-1(r)-1(e)-1(n)-1(d)-1(s)-1( )-110(a)-1( )-110(f)-1(e)9(w)-1( )-110(d)-1(e)-1(c)-1(a)-1(d)-1(e)-1(s)-1( )-110(i)-1(n)-1(t)-1(o)-1( )-110(t)-1(h)-1(e )]TJ
ET
Q
endstream
endobj
39 0 obj
<<
/Length 10197
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(7)-5(6)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126.002 360 557.998 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(f)-1(u)-1(t)-1(u)-1(r)-1(e)12(,)-1( )-72(t)-1(h)-1(e)-1( )-72(p)-1(h)12(y)-1(s)-1(i)-1(c)-1(i)-1(s)-1(t)-1( )-72(F)13(r)-1(e)-1(e)-1(m)-1(a)-1(n)-1( )-73(D)-1(y)-1(s)-1(o)-1(n)-1( )-73(p)-1(u)-1(b)16(l)-1(i)-1(s)-1(h)-1(e)-1(d)-1( )-72(a)-1( )-73(c)-1(o)-1(n)-1(t)-1(r)-1(o)18(v)22(e)-1(r)-14(s)-1(i)-1(a)-1(l)-1( )-73(a)-1(r)-18(t)-1(i)-1(c)-1(l)-1(e)-1( )-72(i)-1(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.094 Tm
[(2)-1(0)-1(0)-1(7)-1( )-49(e)-1(n)12(v)-1(i)-1(s)-1(i)-1(o)-1(n)-1(i)-1(n)-1(g)-1( )-49(a)-1( )-49(w)-1(o)-1(r)-1(l)-1(d)-1( )-49(i)-1(n)-1( )-49(w)-1(h)-1(i)-1(c)-1(h)-1( )-49(s)-1(y)-1(n)-1(t)-1(h)-1(e)-1(t)-1(i)-1(c)-1( )-49(b)-1(i)-1(o)-1(l)-1(o)12(g)-41(y)-1( )-49(h)-1(a)-1(s)-1( )-49(b)-1(e)-1(e)-1(n)-1( )-49(d)-1(e)-1(-)-1(s)-1(k)-1(i)-1(l)-1(l)-1(e)-1(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 645.9958 Tm
[(t)-1(o)-1( )-19(t)-1(h)-1(e)-1( )-19(p)-1(o)-1(i)-1(n)-1(t)-1( )-19(t)-1(h)-1(a)24(t)-1( )-19(i)-1(t)-1( )-19(i)-1(s)-1( )-19(f)-1(u)-1(l)-1(l)24(y)-1( )-19(a)-1(c)-1(c)-1(e)-1(s)-1(s)-1(i)-1(b)16(l)-1(e)-1( )-19(t)-1(o)-1( )-19(a)-1(m)-1(a)24(t)-1(e)-1(u)-1(r)-1( )-19(s)-1(c)-1(i)-1(e)-1(n)-1(t)-1(i)-1(s)-1(t)-1(s)39(,)-1( )-19(h)-1(o)-1(b)12(b)12(y)-1(i)-1(s)-1(t)-1(s)39(,)-1( )-19(a)-1(n)-1(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 631.8977 Tm
[(e)9(v)22(e)-1(n)-1( )-26(c)-1(h)-1(i)-1(l)-1(d)-1(r)-1(e)-1(n)-1(:)]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 609.4396 Tm
[(There )-132(will )-132(be )-132(do-it-y)30(our)-13(self)-28( )-132(kits )-132(f)13(or )-132(g)22(ardener)-13(s )-132(who )-132(will )-132(use )-132(genetic )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 596.3414 Tm
[(engineering )-67(to )-67(breed )-67(ne)10(w )-67(v)13(arieties )-67(of)-28( )-67(roses )-67(and )-67(orchids)40(. )-67(Also )-67(kits )-67(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 583.2433 Tm
[(lo)19(v)23(er)-13(s )22(of)-28( )22(pigeons )22(and )22(par)-13(rots )22(and )22(lizards )22(and )22(snak)39(es )22(to )22(breed )22(ne)10(w )22(v)13(ari)]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 405.6161 583.2433 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 570.1451 Tm
[(eties )-47(of)-28( )-47(pets)40(. )-47(Breeder)-13(s )-47(of)-28( )-47(do)13(gs )-47(and )-47(ca)25(ts )-47(will )-47(ha)20(v)23(e )-47(their )-47(kits )-47(too)]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 375.7842 570.1451 Tm
[(.)-120(.)-120(.)-120(.)]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 390.7 570.1451 Tm
[(F)61(e)10(w )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 557.047 Tm
[(of)-28( )-30(the )-30(ne)10(w )-30(crea)25(tions )-30(will )-30(be )-30(master)-13(pieces)40(, )-30(b)14(ut )-30(a )-30(g)-33(rea)25(t )-30(many )-30(will )-30(bring )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 543.9489 Tm
[(jo)13(y )-44(to )-44(their )-44(crea)25(tor)-13(s )-44(and )-44(v)13(ariety )-44(to )-44(our )-44(fauna )-44(and )-44(f)17(lor)-12(a. )-44(The )-44(final )-44(ste)-13(p )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 530.8507 Tm
[(in )-26(the )-26(domestica)25(tion )-26(of)-28( )-26(biotechnolo)13(g)-40(y )-26(will )-26(be )-26(biotech )-26(g)22(ames)40(, )-26(designed )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 517.7526 Tm
[(lik)39(e )-7(computer )-7(g)22(ames )-7(f)13(or )-7(children )-7(do)13(wn )-7(to )-7(kinderg)22(ar)-17(ten )-7(a)14(ge )-7(b)14(ut )-7(pla)29(y)32(ed )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 504.6544 Tm
[(with )-22(real )-22(e)-10(g)10(gs )-22(and )-22(seeds )-22(r)-12(a)25(ther )-22(than )-22(with )-22(ima)14(ges )-22(on )-22(a )-22(screen. )-22(Pla)29(ying )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 491.5563 Tm
[(such )21(g)22(ames)40(, )22(kids )21(will )21(acquire )22(an )21(intima)25(te )21(feeling )22(f)13(or )21(the )21(org)22(anisms )21(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 478.4582 Tm
[(they )-40(are )-40(g)-33(ro)13(wing)26(. )-40(The )-40(winner )-40(could )-40(be )-40(the )-40(kid )-40(whose )-40(seed )-40(g)-33(ro)13(ws )-40(the )]TJ
ET
BT
/T1_2 1 Tf
11 0 0 11 94.6 465.3601 Tm
[(prickliest )-25(cactus)40(, )-25(or )-25(the )-25(kid )-25(whose )-25(e)-10(g)10(g )-25(ha)25(tches )-25(the )-25(cutest )-25(dinosaur)66(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 393.7631 468.3301 Tm
(30)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 441.902 Tm
[(W)-18(hether )-217(such )-217(rosy )-217(predictions )-217(come )-217(tr)-13(ue )-217(will )-217(de)-13(pend )-217(on, )-217(among )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 427.8039 Tm
[(other )-117(things)40(, )-117(the )-117(de)-10(g)-33(ree )-117(to )-117(which )-117(synthetic )-117(biolo)13(g)-40(y )-117(is )-117(de-skilled )-117(in )-117(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 413.7057 Tm
[(future)13(. )-1(Looking )-1(a)25(t )-1(the )-1(historical )-1(record, )-1(scientific )-1(claims )-1(a)13(bout )-1(de-skilling )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 399.6076 Tm
[(ha)20(v)23(e )-84(been )-84(made )-84(re)-13(pea)25(tedl)25(y )-84(in )-84(the )-84(past )-84(b)14(ut )-84(ha)20(v)23(e )-84(often )-84(failed )-84(to )-84(ma)25(terial)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 399.6076 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 385.5095 Tm
[(ize)13(. )-25(F)61(or )-25(e)-23(xample)13(, )-25(Helen )-25(Anne )-25(Cur)-13(r)-25(y)121(, )-25(a )-25(g)-33(r)-12(adua)25(te )-25(student )-25(in )-25(the )-25(histor)-25(y )-25(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 371.4114 Tm
[(science )-1(a)25(t )-1(Y)80(ale)13(, )-1(has )-1(studied )-1(the )-1(de)10(v)23(elopment )-1(of)-28( )-1(plant-breeding )-1(techniques )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 357.3133 Tm
[(from )-42(1925 )-42(to )-42(1955. )-42(She )-42(f)13(ound )-42(tha)25(t )-42(during )-42(this )-42(period, )-42(a)14(g)-33(ricultur)-12(al )-42(inter)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 357.3133 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 343.2151 Tm
[(ests )-96(promised )-96(tha)25(t )-96(the )-95(use )-96(of)-28( )-96(r)-12(adium, )-96(x-r)-12(a)29(ys)40(, )-96(and )-96(chemicals )-95(to )-96(gener)-12(a)25(te )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 329.117 Tm
[(genetic )-133(muta)25(tions )-133(would )-133(facilita)25(te )-133(the )-133(crea)25(tion )-133(of)-28( )-133(ne)10(w )-133(and )-133(useful )-133(plant )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 315.0189 Tm
[(v)13(arieties)40(, )-124(and )-124(tha)25(t )-124(these )-124(methods )-124(would )-124(soon )-124(become )-124(a)20(v)13(aila)13(b)17(le )-124(to )-124(ama)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 315.0189 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 300.9208 Tm
[(teur )-95(g)22(ardener)-13(s)40(. )-96(But )-95(in )-96(fact, )-95(although )-95(the )-96(breeding )-95(techniques )-95(did )-96(result )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 286.8227 Tm
[(in )-94(no)19(v)23(el )-94(v)13(arieties )-94(of)-28( )-94(roses )-94(and )-94(orchids)40(, )-94(the )-94(predictions )-94(a)13(bout )-94(de-skilling )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 272.7245 Tm
[(ne)10(v)23(er )-25(came )-25(to )-25(pass)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 167.5468 275.6945 Tm
(31)Tj
ET
BT
/T1_3 1 Tf
14 0 0 14 170.3152 244.8264 Tm
[(H)-5(o)20(w)-5( )-32(G)-5(r)8(e)-5(a)8(t)-5( )-32(A)-5(r)8(e)-5( )-31(t)-5(h)-5(e)-5( )-32(R)-5(i)-5(s)-5(k)-5(s)-5(?)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 225.6883 Tm
(I)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 79 225.6883 Tm
[(n )23(addition )23(to )23(the )23(potential )23(benefits )23(of)-28( )23(de-skilling )23(and )23(open )23(access)40(, )23(a )23(num)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 225.6883 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.5902 Tm
[(ber )-83(of)-28( )-83(commenta)25(tor)-13(s )-83(ha)20(v)23(e )-83(war)-40(ned )-83(tha)25(t )-83(the )-83(democr)-12(a)25(tiza)25(tion )-83(of)-28( )-83(synthetic )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.4921 Tm
[(biolo)13(g)-40(y )66(could )66(giv)23(e )66(rise )66(to )66(ne)10(w )66(safety )66(and )66(security )66(risks)40(. )66(One )66(concer)-40(n )66(is )66(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.394 Tm
[(substantiall)25(y )-59(e)-23(xpanding )-59(the )-59(pool )-59(of)-28( )-59(individuals )-59(with )-59(access )-59(to )-59(synthetic-)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.2959 Tm
[(biolo)13(g)-40(y )-79(techniques )-79(would )-79(ine)10(vita)13(b)17(l)25(y )-79(increase )-79(the )-79(lik)39(elihood )-79(of)-28( )-79(accidents)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.1978 Tm
[(crea)25(ting )-40(unprecedented )-40(hazards )-40(f)13(or )-40(the )-40(en)13(vironment )-40(and )-40(pub)17(lic )-40(health.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 422 158.1678 Tm
(32)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 431 155.1978 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0996 Tm
[(Ev)23(en )3(Dyson\222s )3(gener)-12(all)25(y )3(upbea)25(t )3(ar)-17(ticle )3(ackno)13(wledges )3(tha)25(t )3(the )3(recrea)25(tional )]TJ
0 -1.175 TD
[(use )-30(of)-28( )-30(synthetic )-30(biolo)13(g)-40(y )-30(\223will )-30(be )-30(messy )-30(and )-30(possib)17(l)25(y)]TJ
/Span<>> BDC
( )Tj
EMC
21.565 0 Td
[(dangerous\224)-13( )-30(and )-30(tha)25(t )]TJ
ET
Q
endstream
endobj
40 0 obj
<<
/Length 11698
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(7)-5(7)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126.004 360 557.996 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(\223r)-13(ules )-85(and )-85(re)-10(gula)25(tions )-85(will )-85(be )-85(needed )-85(to )-85(mak)39(e )-85(sure )-85(tha)25(t )-85(our )-85(kids )-85(do )-85(not )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(endanger )-25(themselv)23(es )-25(and )-25(other)-13(s)40(.\224)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 646.1312 Tm
[(Bey)30(ond )-22(the )-22(possib)17(le )-22(safety )-22(risks)40(, )-22(Mukunda, )-22(Oy)32(e)13(, )-22(and )-22(Mohr )-22(war)-40(n )-22(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1007 Tm
[(the )-140(de-skilling )-140(of)-28( )-140(synthetic )-140(biolo)13(g)-40(y )-140(would )-140(mak)39(e )-140(this )-140(po)13(w)13(erful )-140(technol)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 632.1007 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.0703 Tm
[(o)13(g)-40(y )-127(accessib)17(le )-127(to )-127(individuals )-127(and )-127(g)-33(roups )-127(who )-127(would )-127(use )-127(it )-127(deliber)-12(a)25(tel)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0398 Tm
[(to )-130(cause )-130(har)-22(m. )-130(\223)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 155.7029 604.0398 Tm
[(Synthetic )-130(biolo)13(g)-40(y)121(,\224)-13( )-130(they )-130(write)13(, )-130(\223includes)40(, )-130(as )-130(a )-130(principal )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 590.0093 Tm
[(par)-17(t )-146(of)-28( )-146(its )-146(a)14(genda, )-146(a )-146(sustained, )-146(w)13(ell-funded )-146(assault )-146(on )-146(the )-146(necessity )-146(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.9789 Tm
[(tacit )-3(kno)13(wledge )-3(in )-3(bioengineering )-3(and )-3(thus )-3(on )-3(one )-3(of)-28( )-3(the )-3(most )-3(impor)-17(tant )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9484 Tm
[(cur)-13(rent )-63(bar)-13(rier)-13(s )-63(to )-63(the )-63(production )-63(of)-28( )-63(biolo)13(gical )-63(w)13(eapons)40(.\224)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 358.6027 564.9183 Tm
(33)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 367.6027 561.9484 Tm
[( )-63(Dr)-12(a)22(wing )-63(on )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 547.9179 Tm
[(the )-158(precedent )-158(of)-28( )-158(\223b)17(lack-ha)25(tted\224)-13( )-158(computer )-158(hack)39(er)-13(s)40(, )-158(who )-158(crea)25(te )-158(software )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8875 Tm
[(vir)-13(uses)40(, )-83(wor)-22(ms)40(, )-83(and )-83(other )-83(mal)40(ware )-83(f)13(or )-83(criminal )-83(pur)-13(poses)40(, )-83(f)13(or )-83(espiona)14(ge)13(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.857 Tm
[(or )23(simpl)25(y )23(to )23(demonstr)-12(a)25(te )23(their )23(technical )23(pro)13(w)13(ess)40(, )23(some )23(ha)20(v)23(e )23(predicted )23(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 505.8265 Tm
[(emergence )-85(of)-28( )-85(\223bio-hack)39(er)-13(s\224)-13( )-85(who )-85(eng)22(a)14(ge )-85(in )-85(reckless )-85(or )-85(malicious )-85(e)-23(xperi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 505.8265 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 491.7961 Tm
[(ments )-82(with )-82(synthetic )-82(org)22(anisms )-82(in )-82(basement )-82(la)13(bor)-12(a)25(tories)40(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 359.8956 494.7661 Tm
(34)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 368.8956 491.7961 Tm
[( )-82(Such )-82(night)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 491.7961 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 477.7656 Tm
[(mare )-85(scenarios )-85(are )-85(proba)13(b)17(l)25(y )-85(e)-23(xa)14(g)10(ger)-12(a)25(ted, )-85(ho)13(w)13(e)10(v)23(er)66(, )-85(because )-85(the )-85(effectiv)23(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7351 Tm
[(use )49(of)-28( )49(synthetic )49(biolo)13(g)-40(y )49(techniques )49(relies )49(on )49(socio-technical )49(resources )49(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7047 Tm
[(are )-30(not )-30(gener)-12(all)25(y )-30(a)20(v)13(aila)13(b)17(le )-30(to )-30(hob)13(b)13(yists)40(. )-30(According )-30(to )-30(Andre)10(w )-30(Ellington, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6742 Tm
[(a )-54(biochemistr)-25(y )-54(professor )-54(a)25(t )-54(the )-54(Univ)23(er)-13(sity )-54(of)-28( )-54(T)56(e)-23(xas)40(, )-54(\223There )-54(is )-54(no )-54(\221R)10(adio )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6437 Tm
[(Shack\222 )-30(f)13(or )-30(DN)45(A )-30(par)-17(ts)40(, )-30(and )-29(e)10(v)23(en )-29(if)-28( )-30(there )-30(w)13(ere)13(, )-30(the )-30(infr)-12(astr)-13(ucture )-30(required )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6133 Tm
[(to )-146(manipula)25(te )-146(those )-146(par)-17(ts )-146(is )-146(non-trivial )-146(f)13(or )-146(all )-146(b)14(ut )-146(the )-146(richest )-146(ama)25(teur )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5828 Tm
(scientist.\224)Tj
ET
BT
/T1_2 1 Tf
9 0 0 9 120.3751 396.5528 Tm
(35)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 379.5523 Tm
[(Indeed, )-104(when )-104(assessing )-104(the )-104(risk )-104(of)-28( )-104(misuse)13(, )-104(it )-104(is )-104(impor)-17(tant )-104(to )-104(distin)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 379.5523 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5219 Tm
[(guish )-142(among )-142(potential )-142(actor)-13(s )-142(tha)25(t )-142(differ )-142(g)-33(rea)25(tl)25(y )-142(in )-142(financial )-142(assets )-142(and )]TJ
0 -1.169 TD
[(technical )-66(capa)13(bilities)]TJ
/Span<>> BDC
( )Tj
EMC
8.502 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(from )-66(sta)25(tes )-66(with )-66(adv)13(anced )-66(bio-warfare )-66(pro)13(g)-33(r)-12(ams)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4609 Tm
[(to )-245(ter)-13(rorist )-245(org)22(aniza)25(tions )-245(of)-28( )-245(v)13(ar)-25(ying )-245(size )-245(and )-245(sophistica)25(tion, )-245(to )-245(indi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 337.4609 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.4305 Tm
[(viduals )-96(motiv)13(a)25(ted )-96(b)13(y )-96(ideolo)13(g)-40(y )-96(or )-97(per)-13(sonal )-96(g)-33(rie)10(v)13(ance)13(. )-97(The )-96(stud)13(y )-97(of)-28( )-96(past )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.4 Tm
[(sta)25(te-le)10(v)23(el )-82(bio-warfare )-82(pro)13(g)-33(r)-12(ams)40(, )-82(such )-82(as )-82(those )-82(of)-28( )-82(the )-82(So)19(viet )-82(Union )-82(and )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3695 Tm
[(Ir)-12(aq, )-89(has )-89(also )-89(sho)13(wn )-89(tha)25(t )-89(the )-89(acquisition )-89(of)-28( )-89(biolo)13(gical )-89(w)13(eapons )-89(requires )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3391 Tm
[(an )-64(interdisciplinar)-25(y )-64(team )-64(of)-28( )-64(scientists )-64(and )-64(engineer)-13(s )-64(who )-64(ha)20(v)23(e )-64(e)-23(xper)-17(tise )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3086 Tm
[(and )-29(tacit )-29(kno)13(wledge )-29(in )-29(fields )-29(such )-29(as )-29(microbiolo)13(g)-40(y)121(, )-29(aerobiolo)13(g)-40(y)121(, )-29(f)13(or)-22(mula)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 267.3086 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 253.2781 Tm
[(tion, )-58(and )-58(deliv)23(er)-25(y)113(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 161.1669 256.2481 Tm
(36)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 170.1669 253.2781 Tm
[( )-58(Sta)25(tes )-58(are )-58(gener)-12(all)25(y )-58(more )-58(capa)13(b)17(le )-58(of)-28( )-58(org)22(anizing )-58(and )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2476 Tm
[(sustaining )-25(such )-25(teams )-25(than )-25(are )-25(non-sta)25(te )-25(actor)-13(s)40(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 225.2172 Tm
[(C)2(o)2(n)2(c)2(e)2(i)2(v)15(a)15(b)19(l)27(y)123(,)2( )-2(t)2(h)2(e)2( )-2(o)2(b)2(s)2(t)2(a)2(c)2(l)2(e)2(s)2( )-2(p)2(o)2(s)2(e)2(d)2( )-2(b)15(y)2( )-2(t)2(h)2(e)2( )-2(n)2(e)2(e)2(d)2( )-2(f)15(o)2(r)2( )-2(p)2(e)2(r)-11(s)2(o)2(n)2(a)2(l)2( )-2(a)2(n)2(d)2( )-2(c)2(o)2(m)2(m)2(u)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 225.2172 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1867 Tm
[(n)2(a)2(l)2( )38(t)2(a)2(c)2(i)2(t)2( )38(k)2(n)2(o)15(w)2(l)2(e)2(d)2(g)2(e)2( )38(m)2(i)2(g)2(h)2(t)2( )38(d)2(i)2(m)2(i)2(n)2(i)2(s)2(h)2( )38(i)2(f)-26( )38(a)2( )38(t)2(e)2(r)-11(r)2(o)2(r)2(i)2(s)2(t)2( )38(g)-31(r)2(o)2(u)2(p)2( )38(m)2(a)2(n)2(a)16(g)2(e)2(d)2( )38(t)2(o)2( )38(r)2(e)2(c)2(r)-11(u)2(i)2(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1562 Tm
[(a)2( )38(g)-31(r)2(o)2(u)2(p)2( )38(o)2(f)-26( )38(s)2(c)2(i)2(e)2(n)2(t)2(i)2(s)2(t)2(s)2( )38(w)2(i)2(t)2(h)2( )38(t)2(h)2(e)2( )38(r)2(e)2(q)2(u)2(i)2(r)2(e)2(d)2( )38(t)2(y)2(p)2(e)2(s)2( )38(o)2(f)-26( )38(e)-21(x)2(p)2(e)2(r)-15(t)2(i)2(s)2(e)15(,)2( )38(a)2(n)2(d)2( )38(e)2(i)2(t)2(h)2(e)2(r)2( )38(b)2(r)2(i)2(b)2(e)2(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.1258 Tm
[(o)2(r)2( )-88(c)2(o)2(e)2(r)2(c)2(e)2(d)2( )-88(t)2(h)2(e)2(m)2( )-88(i)2(n)2(t)2(o)2( )-88(d)2(e)12(v)25(e)2(l)2(o)2(p)2(i)2(n)2(g)2( )-88(b)2(i)2(o)2(l)2(o)15(g)2(i)2(c)2(a)2(l)2( )-88(w)15(e)2(a)2(p)2(o)2(n)2(s)42(.)2( )-88(B)2(u)2(t)2( )-88(V)71(o)15(g)2(e)2(l)2( )-88(a)2(n)2(d)2( )-88(B)2(e)2(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.0953 Tm
[(O)2(u)2(a)16(g)-31(r)2(h)2(a)2(m)2(-)2(G)2(o)2(r)-20(m)2(l)2(e)2(y)2( )-162(c)2(o)2(u)2(n)2(t)2(e)2(r)2( )-162(t)2(h)2(i)2(s)2( )-162(a)2(r)2(g)2(u)2(m)2(e)2(n)2(t)2( )-162(b)15(y)2( )-162(n)2(o)2(t)2(i)2(n)2(g)2( )-162(t)2(h)2(a)27(t)2( )-162(e)12(v)25(e)2(n)2( )-162(i)2(n)2( )-162(t)2(h)2(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.0648 Tm
[(u)2(n)2(l)2(i)2(k)41(e)2(l)27(y)2( )-147(e)12(v)25(e)2(n)2(t)2( )-147(t)2(h)2(a)27(t)2( )-147(t)2(e)2(r)-11(r)2(o)2(r)2(i)2(s)2(t)2(s)2( )-147(c)2(o)2(u)2(l)2(d)2( )-147(r)2(e)2(c)2(r)-11(u)2(i)2(t)2( )-147(s)2(u)2(c)2(h)2( )-147(a)2( )-147(s)2(c)2(i)2(e)2(n)2(t)2(i)2(f)2(i)2(c)2( )-147(A)2(-)2(t)2(e)2(a)2(m)2(,)2( )-147(i)2(t)2(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0343 Tm
[(m)2(e)2(m)2(b)2(e)2(r)-11(s)2( )-108(w)2(o)2(u)2(l)2(d)2( )-108(s)2(t)2(i)2(l)2(l)2( )-108(f)2(a)2(c)2(e)2( )-108(t)2(h)2(e)2( )-108(c)2(h)2(a)2(l)2(l)2(e)2(n)2(g)2(e)2( )-108(o)2(f)-26( )-108(a)2(d)2(a)2(p)2(t)2(i)2(n)2(g)2( )-108(t)2(h)2(e)2( )-108(t)2(e)2(c)2(h)2(n)2(o)2(l)2(o)15(g)-38(y)2( )-108(t)2(o)2( )-108(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0039 Tm
[(l)2(o)2(c)2(a)2(l)2( )-34(c)2(o)2(n)2(t)2(e)-21(x)2(t)2(.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 138.8866 129.9739 Tm
[(3)2(7)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 147.8506 127.0039 Tm
[( )-34(D)2(y)2(s)2(f)2(u)2(n)2(c)2(t)2(i)2(o)2(n)2(a)2(l)2( )-34(g)-31(r)2(o)2(u)2(p)2( )-34(d)15(y)2(n)2(a)2(m)2(i)2(c)2(s)42(,)2( )-34(s)2(u)2(c)2(h)2( )-34(a)2(s)2( )-34(a)2( )-34(r)2(e)2(f)2(u)2(s)2(a)2(l)2( )-34(b)15(y)2( )-34(s)2(o)2(m)2(e )]TJ
ET
Q
endstream
endobj
41 0 obj
<<
/Length 9668
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(7)-5(8)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(t)2(e)2(a)2(m)2( )3(m)2(e)2(m)2(b)2(e)2(r)-11(s)2( )3(t)2(o)2( )3(w)2(o)2(r)2(k)2( )3(t)2(o)15(g)2(e)2(t)2(h)2(e)2(r)68(,)2( )3(w)2(o)2(u)2(l)2(d)2( )3(a)2(l)2(s)2(o)2( )3(c)2(r)2(e)2(a)27(t)2(e)2( )3(o)2(b)2(s)2(t)2(a)2(c)2(l)2(e)2(s)2( )3(t)2(o)2( )3(i)2(n)2(t)2(e)2(r)2(d)2(i)2(s)2(c)2(i)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 674.1921 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 659.9123 Tm
[(p)2(l)2(i)2(n)2(a)2(r)-23(y)2( )-23(c)2(o)2(l)2(l)2(a)15(b)2(o)2(r)-10(a)27(t)2(i)2(o)2(n)2( )-23(i)2(n)2( )-23(a)2(r)2(e)2(a)2(s)2( )-23(r)2(e)2(q)2(u)2(i)2(r)2(i)2(n)2(g)2( )-23(c)2(o)2(m)2(m)2(u)2(n)2(a)2(l)2( )-23(t)2(a)2(c)2(i)2(t)2( )-23(k)2(n)2(o)15(w)2(l)2(e)2(d)2(g)2(e)15(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 645.6325 Tm
[(T)29(aking )-195(such )-195(factor)-13(s )-195(into )-195(account, )-195(Michael )-195(Le)10(vi )-195(of)-28( )-195(the )-195(Council )-195(on )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 631.3527 Tm
[(F)61(oreign )-39(R)31(ela)25(tions )-40(has )-39(questioned )-39(the )-40(a)13(bility )-39(of)-28( )-40(ter)-13(rorists )-39(to )-40(constr)-13(uct )-40(an )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 617.0729 Tm
[(impro)19(vised )-38(nuclear )-38(de)10(vice )-38(from )-38(stolen )-38(fissile )-38(ma)25(terials)40(. )-38(He )-38(notes )-38(tha)25(t )-38(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 602.7932 Tm
[(process )13(of)-28( )13(b)14(uilding )13(a )13(functional )13(w)13(eapon )13(would )13(in)13(v)37(olv)23(e )13(a )13(comple)-23(x )13(series )13(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 588.5134 Tm
[(technical )29(ste)-13(ps)40(, )29(all )29(of)-28( )29(which )29(the )29(ter)-13(rorists )29(would )29(ha)20(v)23(e )29(to )29(perf)13(or)-22(m )29(cor)-13(rectl)25(y )]TJ
0 -1.19 TD
[(in )7(order )7(to)]TJ
/Span<>> BDC
( )Tj
EMC
4.572 0 Td
(succeed.)Tj
ET
BT
/T1_2 1 Tf
9 0 0 9 167.7409 577.2036 Tm
(38)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 176.7409 574.2336 Tm
[( )7(The )7(same )7(is )7(tr)-13(ue )7(of)-28( )7(assessing )7(bioter)-13(rorism )7(risk: )7(one )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 559.9538 Tm
[(must )-46(e)-23(xamine )-46(not )-47(onl)25(y )-46(the )-47(lik)39(elihood )-46(of)-28( )-47(v)13(arious )-46(ena)13(b)17(ling )-46(conditions)40(, )-46(b)14(ut )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 545.674 Tm
[(also )-52(the )-52(proba)13(bility )-52(tha)25(t )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 195.1935 545.674 Tm
(all)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 206.9293 545.674 Tm
[( )-52(of)-28( )-52(the )-52(ste)-13(ps )-52(in )-52(the )-52(w)13(eapon )-52(de)10(v)23(elopment )-52(pro)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 545.674 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 531.3942 Tm
[(cess )-25(will )-25(be )-25(car)-13(ried )-25(out )-25(successfull)25(y)113(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 517.1144 Tm
[(Finall)25(y)121(, )-206(prob)17(lem-solving )-206(is )-206(cr)-13(ucial )-206(to )-206(the )-206(master)-25(y )-206(of)-28( )-206(any )-206(comple)-23(x )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 502.8347 Tm
[(technolo)13(g)-40(y)113(. )-2(Biotechnolo)13(gists )-2(must )-2(be )-2(crea)25(tiv)23(e )-2(and )-2(per)-13(sistent )-2(to )-2(o)19(v)23(ercome )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 488.5549 Tm
[(the )-20(technical )-20(difficulties )-20(tha)25(t )-20(ine)10(vita)13(b)17(l)25(y )-20(arise )-20(during )-20(the )-20(de)10(v)23(elopment )-20(of)-28( )-20(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 474.2751 Tm
[(ne)10(w )-74(process)40(. )-74(Thus)40(, )-74(a )-74(k)39(ey )-74(v)13(aria)13(b)17(le )-74(affecting )-74(the )-74(risk )-74(tha)25(t )-74(ter)-13(rorists )-74(could )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 459.9953 Tm
[(e)-23(xploit )-214(synthetic )-214(biolo)13(g)-40(y )-214(f)13(or )-214(har)-22(mful )-214(pur)-13(poses )-214(would )-214(be )-214(their )-214(a)13(bility )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 445.7155 Tm
[(to )-160(perf)13(or)-22(m )-160(multiple )-160(iter)-12(a)25(tions )-160(of)-28( )-160(a )-160(technique )-160(until )-160(they )-160(get )-160(it )-160(right, )-160(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 431.4357 Tm
[(requirement )-115(tha)25(t )-115(presupposes )-115(a )-115(sta)13(b)17(le )-115(working )-115(en)13(vironment )-115(and )-115(ample )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 417.1559 Tm
[(time )-248(f)13(or )-248(e)-23(xperimenta)25(tion. )-248(Such )-248(amenities )-248(would )-248(proba)13(b)17(l)25(y )-248(be )-248(lacking)26(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 402.8762 Tm
[(ho)13(w)13(e)10(v)23(er)66(, )37(f)13(or )37(individuals )37(working )37(in )37(a )37(co)19(v)23(er)-17(t )37(hidea)22(wa)29(y )37(or )37(conducting )37(illicit )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 388.5964 Tm
[(activities )16(\(such )16(as )16(the )16(synthesis )16(and )16(w)13(eaponiza)25(tion )16(of)-28( )16(a )16(deadl)25(y )16(vir)-13(us\) )16(in )16(an )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 374.3166 Tm
[(otherwise )-25(le)-10(gitima)25(te )-25(la)13(bor)-12(a)25(tor)-25(y)113(.)]TJ
ET
BT
/T1_4 1 Tf
14 0 0 14 184.9675 346.2368 Tm
[(R)8(e)-5(s)-5(o)-5(l)-5(v)-5(i)-5(n)-5(g)-5( )-32(t)-5(h)-5(e)-5( )-32(D)-5(eb)-5(a)8(t)-5(e)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 326.917 Tm
(W)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 89.4958 326.917 Tm
[(hether )-52(commercial )-52(kits )-52(and )-52(automa)25(tion )-52(will )-52(merel)25(y )-52(mak)39(e )-52(it )-52(easier )-52(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 312.6372 Tm
[(e)-23(xperienced )-127(scientists )-127(to )-127(perf)13(or)-22(m )-127(cer)-17(tain )-127(difficult )-127(or )-127(tedious )-127(oper)-12(a)25(tions )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 298.3574 Tm
[(more )-43(quickl)25(y )-43(and )-43(easil)25(y)121(, )-43(or )-43(whether )-43(de-skilling )-43(will )-43(tr)-13(ul)25(y )-43(mak)39(e )-43(adv)13(anced )]TJ
T*
[(biotechnolo)13(gies )-120(a)20(v)13(aila)13(b)17(le )-119(to )-120(non-e)-23(xper)-17(ts)]TJ
/Span<>> BDC
( )Tj
EMC
16.804 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(par)-17(ticularl)25(y )-120(those )-119(with )-120(mali)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 284.0776 Tm
(-)Tj
-29.489 -1.19 Td
[(cious )-131(intent)]TJ
/Span<>> BDC
( )Tj
EMC
4.933 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(is )-131(still )-131(an )-131(open )-131(question )-131(and )-131(will )-131(proba)13(b)17(l)25(y )-131(remain )-131(so )-131(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 255.5181 Tm
[(some )22(time)13(. )22(T)63(o )22(resolv)23(e )22(the )22(deba)25(te )22(o)19(v)23(er )22(the )22(e)-23(xtent )22(to )22(which )22(ter)-13(rorists )22(could )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 241.2383 Tm
[(misuse )-201(synthetic )-201(biolo)13(g)-40(y )-201(to )-201(cause )-201(har)-22(m, )-201(it )-201(is )-201(impor)-17(tant )-201(to )-201(deter)-22(mine )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 226.9585 Tm
[(whether )-16(de-skilling )-16(affects )-16(those )-16(aspects )-16(of)-28( )-16(the )-16(technolo)13(g)-40(y )-16(tha)25(t )-16(cur)-13(rentl)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 212.6787 Tm
[(require )-25(per)-13(sonal )-25(or )-25(communal )-25(tacit )-25(kno)13(wledge)13(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 198.3989 Tm
[(Preliminar)-25(y )-161(e)10(vidence )-161(sug)10(gests )-161(tha)25(t )-161(de-skilling )-161(does )-161(not )-161(proceed )-161(in )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 184.1192 Tm
[(a )-77(unif)13(or)-22(m )-77(manner )-77(b)14(ut )-77(affects )-77(some )-77(biotechnolo)13(gies )-77(more )-77(than )-77(other)-13(s)40(. )-77(A )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.8394 Tm
[(number )-18(of)-28( )-18(techniques )-18(ha)20(v)23(e )-18(pro)19(v)23(en )-18(resistant )-18(to )-18(de-skilling )-18(f)13(or )-18(the )-18(reasons )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.5596 Tm
[(mentioned, )12(including )12(the )12(comple)-23(xity )12(of)-28( )12(biolo)13(gical )12(org)22(anisms )12(and )12(the )12(crit)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 155.5596 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.2798 Tm
[(ical )-85(role )-85(of)-28( )-85(tacit )-85(kno)13(wledge )-85(and )-85(other )-85(socio-technical )-85(factor)-13(s)40(. )-85(Moreo)19(v)23(er)66(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127 Tm
[(although )-101(scientists )-101(commonl)25(y )-101(use )-101(genetic-engineering )-101(\223kits\224)-13( )-101(containing )]TJ
ET
Q
endstream
endobj
42 0 obj
<<
/Length 11554
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(7)-5(9)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(all )-24(of)-28( )-24(the )-24(ma)25(terials )-24(and )-24(rea)14(gents )-24(required )-24(f)13(or )-24(a )-24(par)-17(ticular )-24(la)13(bor)-12(a)25(tor)-25(y )-24(pro)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 674.1921 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 659.8524 Tm
[(cedure)13(, )-21(these )-21(kits )-21(do )-21(not )-21(necessaril)25(y )-21(remo)19(v)23(e )-21(the )-21(need )-21(f)13(or )-21(tacit )-21(kno)13(wledge )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 645.5127 Tm
[(when )-25(applied )-25(in )-25(the )-25(conte)-23(xt )-25(of)-28( )-25(a )-25(par)-17(ticular )-25(e)-23(xperiment.)]TJ
ET
BT
/T1_2 1 Tf
9 0 0 9 344.2437 648.4827 Tm
(39)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 631.173 Tm
[(Instead )-305(of)-28( )-306(making )-306(asser)-17(tions )-306(based )-305(on )-306(anecdotal )-306(e)10(vidence )-306(a)13(bout )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 616.8333 Tm
[(whether )-12(or )-12(not )-12(synthetic )-12(biolo)13(g)-40(y )-12(will )-12(become )-12(de-skilled )-12(and )-12(accessib)17(le )-12(to )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 602.4935 Tm
[(non-e)-23(xper)-17(ts)40(, )12(it )12(would )12(be )12(more )12(useful )12(to )12(conduct )12(empirical )13(research )12(on )12(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 588.1538 Tm
[(na)25(ture )-109(of)-28( )-109(tacit )-109(kno)13(wledge )-109(and )-109(the )-109(process )-109(of)-28( )-109(de-skilling)26(. )-109(Shedding )-109(ne)10(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 573.8141 Tm
[(light )-131(on )-131(the )-131(deba)25(te )-131(will )-131(require )-131(addressing )-131(se)10(v)23(er)-12(al )-131(questions )-131(a)13(bout )-131(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 559.4744 Tm
[(role )19(of)-28( )19(tacit )19(kno)13(wledge )19(and )19(other )19(socio-technical )19(factor)-13(s )19(in )19(biotechnolo)13(gi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 559.4744 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 545.1346 Tm
[(cal )-46(de)10(v)23(elopment: )-45(Fir)-13(st, )-46(wha)25(t )-45(are )-46(the )-45(specific )-46(conditions)40(, )-46(skills)40(, )-46(and )-46(socio-)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 530.7949 Tm
[(org)22(aniza)25(tional )-164(conte)-23(xts )-164(tha)25(t )-164(are )-164(required )-164(f)13(or )-164(adv)13(anced )-164(biotechnolo)13(gies )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 516.4553 Tm
[(to )-48(work )-48(relia)13(b)17(l)25(y? )-48(Second, )-48(wh)13(y )-48(do )-48(cer)-17(tain )-48(tools)40(, )-48(techniques)40(, )-48(and )-48(pr)-12(actices )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 502.1156 Tm
[(of)-28( )-173(biotechnolo)13(g)-40(y )-173(become )-173(de-skilled, )-173(while )-173(other)-13(s )-173(do )-173(not? )-173(Third, )-173(wha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 487.7759 Tm
[(are )-29(the )-29(conditions)40(, )-29(both )-29(technical )-29(and )-29(social, )-29(tha)25(t )-29(facilita)25(te )-29(or )-29(hamper )-29(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 473.4362 Tm
[(process )-25(of)-28( )-25(de-skilling?)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 459.0965 Tm
[(P)65(o)9(s)9(s)9(i)9(b)26(l)9(e)9( )-323(m)9(e)9(t)9(h)9(o)9(d)9(o)9(l)9(o)22(g)9(i)9(c)9(a)9(l)9( )-323(a)9(p)9(p)9(r)9(o)9(a)9(c)9(h)9(e)9(s)9( )-323(f)22(o)9(r)9( )-323(a)9(n)9(s)36(w)22(e)9(r)9(i)9(n)9(g)9( )-323(t)9(h)9(e)9(s)9(e)9( )-323(q)9(u)9(e)9(s)9(t)9(i)9(o)9(n)9(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 444.7568 Tm
[(i)9(n)9(c)9(l)9(u)9(d)9(e)9( )-80(t)9(h)9(e)9( )-80(a)9(n)9(a)9(l)34(y)9(s)9(i)9(s)9( )-80(o)9(f)-19( )-80(p)9(a)9(s)9(t)9( )-80(e)9(f)9(f)22(o)9(r)-8(t)9(s)9( )-80(t)9(o)9( )-79(t)9(r)-3(a)9(n)9(s)9(f)9(e)9(r)9( )-80(c)9(o)9(m)9(p)9(l)9(e)-14(x)9( )-80(t)9(e)9(c)9(h)9(n)9(o)9(l)9(o)22(g)9(i)9(e)9(s)9( )-80(f)9(r)9(o)9(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 430.4171 Tm
[(o)9(n)9(e)9( )-41(l)9(a)22(b)9(o)9(r)-3(a)34(t)9(o)9(r)-16(y)9( )-41(s)9(e)9(t)9(t)9(i)9(n)9(g)9( )-41(t)9(o)9( )-41(a)9(n)9(o)9(t)9(h)9(e)9(r)75(,)9( )-41(i)9(n)9(-)9(d)9(e)-4(p)9(t)9(h)9( )-41(i)9(n)9(t)9(e)9(r)-17(v)9(i)9(e)19(w)9(s)9( )-41(w)9(i)9(t)9(h)9( )-41(p)9(r)-3(a)9(c)9(t)9(i)9(c)9(i)9(n)9(g)9( )-41(s)9(c)9(i)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 430.4171 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 416.0774 Tm
[(e)9(n)9(t)9(i)9(s)9(t)9(s)9( )-58(a)22(b)9(o)9(u)9(t)9( )-58(t)9(h)9(e)9( )-58(r)9(o)9(l)9(e)9( )-58(o)9(f)-19( )-58(t)9(a)9(c)9(i)9(t)9( )-58(k)9(n)9(o)22(w)9(l)9(e)9(d)9(g)9(e)9( )-58(a)9(n)9(d)9( )-58(o)9(t)9(h)9(e)9(r)9( )-57(s)9(o)9(c)9(i)9(o)9(-)9(t)9(e)9(c)9(h)9(n)9(i)9(c)9(a)9(l)9( )-58(f)9(a)9(c)9(t)9(o)9(r)-4(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 401.7377 Tm
[(i)9(n)9( )-192(t)9(h)9(e)9(i)9(r)9( )-192(r)9(e)9(s)9(e)9(a)9(r)9(c)9(h)9(,)9( )-192(a)9(n)9(d)9( )-192(t)9(h)9(e)9( )-192(c)9(l)9(o)9(s)9(e)9( )-192(e)9(t)9(h)9(n)9(o)22(g)-24(r)-3(a)9(p)9(h)9(i)9(c)9( )-192(o)9(b)9(s)9(e)9(r)-17(v)22(a)34(t)9(i)9(o)9(n)9( )-192(o)9(f)-19( )-192(l)9(a)22(b)9(o)9(r)-3(a)34(t)9(o)9(r)-16(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 387.3979 Tm
[(w)9(o)9(r)9(k)9(.)9( )-13(S)9(u)9(c)9(h)9( )-13(s)9(t)9(u)9(d)9(i)9(e)9(s)9( )-13(s)9(h)9(o)9(u)9(l)9(d)9( )-13(p)9(e)9(r)-13(m)9(i)9(t)9( )-13(a)9( )-13(m)9(o)9(r)9(e)9( )-13(n)9(u)9(a)9(n)9(c)9(e)9(d)9( )-13(a)9(s)9(s)9(e)9(s)9(s)9(m)9(e)9(n)9(t)9( )-13(o)9(f)-19( )-13(t)9(h)9(e)9( )-13(s)9(a)9(f)9(e)9(t)9(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 373.0583 Tm
[(a)9(n)9(d)9( )-125(s)9(e)9(c)9(u)9(r)9(i)9(t)9(y)9( )-125(r)9(i)9(s)9(k)9(s)9( )-125(a)9(s)9(s)9(o)9(c)9(i)9(a)34(t)9(e)9(d)9( )-125(w)9(i)9(t)9(h)9( )-125(s)9(y)9(n)9(t)9(h)9(e)9(t)9(i)9(c)9( )-125(b)9(i)9(o)9(l)9(o)22(g)-31(y)9( )-125(a)9(n)9(d)9( )-125(o)9(t)9(h)9(e)9(r)9( )-125(e)9(m)9(e)9(r)9(g)9(i)9(n)9(g )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 358.7186 Tm
[(b)9(i)9(o)9(t)9(e)9(c)9(h)9(n)9(o)9(l)9(o)22(g)9(i)9(e)9(s)49(,)9( )23(a)9(n)9(d)9( )23(w)9(i)9(l)9(l)9( )23(h)9(e)9(l)9(p)9( )23(p)9(o)9(l)9(i)9(c)9(y)9(m)9(a)9(k)48(e)9(r)-4(s)9( )23(d)9(e)9(t)9(e)9(r)-13(m)9(i)9(n)9(e)9( )23(w)9(h)9(i)9(c)9(h)9( )23(a)9(r)9(e)9(a)9(s)9( )23(w)9(a)9(r)-4(r)-3(a)9(n)9(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 344.3789 Tm
[(o)28(v)32(e)9(r)-4(s)9(i)9(g)9(h)9(t)9( )-16(o)9(r)9( )-16(r)9(e)-1(g)9(u)9(l)9(a)34(t)9(i)9(o)9(n)9( )-16(t)9(o)9( )-16(p)9(r)9(e)19(v)32(e)9(n)9(t)9( )-16(d)9(e)9(l)9(i)9(b)9(e)9(r)-3(a)34(t)9(e)9( )-16(m)9(i)9(s)9(u)9(s)9(e)22(.)]TJ
ET
BT
/T1_3 1 Tf
16 0 0 16 231.4 293.6201 Tm
[(N)25(o)13(tes)]TJ
/T1_2 1 Tf
9.5 0 0 9.5 73 273.7804 Tm
(1.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(J)42(eronimo )-123(Cello)34(, )-123(Anik)39(o )-123(V)188(. )-123(P)37(aul, )-123(and )-123(Eckard )-123(W)10(immer)66(, )-123(\223Chemical )-123(Synthesis )-123(of)-28( )-123(P)56(olio)19(vir)-13(us )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 262.9407 Tm
[(cDN)45(A: )-42(Gener)-12(a)25(tion )-42(of)-28( )-42(Infectious )-42(Vir)-13(us )-42(in )-42(the )-42(Absence )-42(of)-28( )-42(Na)25(tur)-12(al )-42(T)56(empla)25(te)13(,\224)-13( )]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 372.3328 262.9407 Tm
(Science)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 397.6592 262.9407 Tm
[( )-42(297, )-42(no)34(. )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 252.101 Tm
[(5583 )-25(\(A)13(ugust )-25(9, )-25(2002\): )-25(1016-1018.)]TJ
0 -1.581 TD
(2.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(Rick )35(W)102(eiss)40(, )35(\223Mail-Order )35(Molecules )35(Bre)10(w )35(a )35(T)56(er)-13(rorism )35(Deba)25(te; )35(Vir)-13(us )35(Crea)25(ted )35(in )35(La)13(b )35(R)10(aises )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 226.2456 Tm
[(Questions )-25(of)-28( )-25(Scr)-13(utiny )-25(f)13(or )-25(DN)45(A )-25(Supplier)-13(s)40(,\224)-13( )]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 240.967 226.2456 Tm
[(W)106(ashington )-24(P)36(ost)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 301.1627 226.2456 Tm
[(, )-25(J)35(ul)25(y )-25(17, )-25(2002.)]TJ
-24.017 -1.581 Td
(3.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(J)42(effer)-25(y )-239(K. )-238(T)29(aubenberger )-238(and )-238(Da)20(vid )-239(M. )-238(Morens)40(, )-238(\2231918 )-239(Inf)17(luenza: )-238(the )-238(Mother )-238(of)-28( )-238(All )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 200.3902 Tm
[(P)37(andemics)40(,\224)-13( )]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 123.2731 200.3902 Tm
[(Emer)10(ging )-155(Infectious )-155(Diseases)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 229.9529 200.3902 Tm
[( )-158(12, )-158(no)34(. )-158(1 )-158(\(J)39(anuar)-25(y )-158(2006\): )-158(15-22. )-158(A)72(v)13(aila)13(b)17(le )-158(a)25(t )-158(cdc)22(.)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 189.5505 Tm
[(g)10(o)19(v/ncidod/eid/v)37(ol12no01/pdfs/05-0979.pdf.)]TJ
T*
(4.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(T)56(er)-13(rence )36(M. )36(T)14(umpey )]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 169.2132 174.5348 Tm
[(et )35(al.)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 186.0467 174.5348 Tm
[(, )36(\223Char)-12(acteriza)25(tion )36(of)-28( )36(the )36(R)31(econstr)-13(ucted )36(1918 )36(Spanish )36(Inf)17(luenza )]TJ
-11.9 -1.141 Td
[(P)37(andemic )-25(Vir)-13(us)40(,\224)]TJ
/Span<>> BDC
7.015 0 Td
( )Tj
EMC
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 142.0162 163.6951 Tm
(Science)Tj
/T1_2 1 Tf
/Span<>> BDC
2.666 0 Td
( )Tj
EMC
(310,)Tj
/Span<>> BDC
( )Tj
EMC
[(no)34(. )-25(5745)]TJ
/Span<>> BDC
( )Tj
EMC
[(\(October )-25(7, )-25(2005\):)]TJ
/Span<>> BDC
( )Tj
EMC
(77-80.)Tj
-9.931 -1.581 Td
(5.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(Michael )57(P)56(olanyi, )]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 150.4642 148.6794 Tm
[(P)36(er)20(sonal )56(Kno)20(wledg)-13(e: )56(T)97(o)20(war)40(ds )56(a )56(P)36(ost-Critical )56(Philosoph)]TJ
ET
BT
/T1_4 1 Tf
9.5 0 0 9.5 348.102 148.6794 Tm
(y)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 352.6145 148.6794 Tm
[( )57(\(London: )57(R)31(outledge )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 137.8397 Tm
[(and )-52(K)13(e)-10(g)22(an )-52(P)37(aul, )-52(1958\). )-52(R)31(e)10(v)117(. )-52(1962. )-52(\(P)56(olanyi )-52(was )-52(a )-52(chemist )-52(writing )-52(a)13(bout )-52(his )-52(obser)-26(v)13(a)25(tions )-52(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 126.9999 Tm
[(technical )-25(pr)-12(actice)13(.\))]TJ
ET
Q
endstream
endobj
43 0 obj
<<
/Type /Font
/Widths [255 255 255 255 255 255 255 255 255 255 255 255 255 255 255 255
255 255 255 255 255 255 255 255 255 255 255 255 255 255 255 255
255 250 406 667 510 760 490 177 323 323 500 667 250 365 229 510
510 510 510 510 510 510 510 510 510 510 229 250 667 667 667 448
927 719 625 646 781 656 635 771 760 365 396 698 635 938 760 740
625 740 698 521 740 802 698 1063 740 740 646 521 510 521 469 500
333 479 448 469 531 448 417 552 531 292 323 479 417 656 521 510
458 510 510 385 510 490 542 760 552 542 490 396 510 396 667 354
255 354 250 719 375 1000 698 531 333 1083 521 292 1094 354 646 354
354 198 198 375 375 354 500 1000 333 1000 385 292 750 354 490 740
255 250 427 844 677 740 510 479 333 750 292 521 667 365 750 333
396 667 354 354 333 500 750 229 333 354 323 521 740 740 740 448
719 719 719 719 719 719 1031 646 656 656 656 656 365 365 365 365
781 760 740 740 740 740 740 667 740 802 802 802 802 740 625 770
479 479 479 479 479 479 698 469 448 448 448 448 292 292 292 292
531 521 510 510 510 510 510 667 510 490 490 490 490 542 458 542]
/Subtype /Type1
/BaseFont /BellMT-SemiBoldSC
/Encoding /WinAnsiEncoding
/LastChar 255
/FirstChar 0
/ToUnicode 59 0 R
/FontDescriptor 60 0 R
>>
endobj
44 0 obj
<<
/Length 14316
>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
72 75.735 143.98 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(8)-5(0)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 205.8883 711.9261 Tm
[(J)10(o)-5(n)45(a)71(t)-5(h)-5(a)-5(n)-5( )-30(B)9(.)-5( )-30(T)9(u)-5(c)-5(k)-5(e)-5(r)]TJ
ET
1 1 1 scn
/GS1 gs
72 46 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 48.181 m
340.078 48.181 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 49.3107 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 49.3107 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 49.3107 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 49.3107 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 73 676.0271 Tm
(6.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
(H)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 91.8004 676.0271 Tm
(.)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 95.7808 676.0271 Tm
[(M. )12(Collins)40(, )12(\223T)29(acit )12(Kno)13(wledge)13(, )12(Tr)-13(ust )12(and )12(the )12(Q )12(of)-28( )12(Sapphire)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 330.4959 676.0271 Tm
[(Social )11(Studies )11(of)-42( )11(Science )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 419.4196 676.0271 Tm
(31, )Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 665.3113 Tm
[(no)34(. )-58(1 )-58(\(2001\), )-58(71\22685. )-58(See )-58(also )-58(K)-10(a)25(thleen )-58(M. )-58(V)69(o)13(gel, )-58(\223Bio)13(w)13(eapons )-58(Prolifer)-12(a)25(tion: )-58(W)-18(here )-58(Science )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 654.5955 Tm
[(Studies )-136(and )-136(Pub)17(lic )-136(P)56(olicy )-136(Collide)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 214.7016 654.5955 Tm
[(Social )-133(Studies )-133(of)-42( )-133(Science)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 305.5172 654.5955 Tm
[( )-136(36, )-136(no)34(. )-136(5 )-136(\(October )-136(2006\): )-136(659-)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 643.8796 Tm
(690. )Tj
0 -1.568 TD
(7.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(Donald )-103(MacK)13(enzie )-103(and )-103(Gr)-12(aham )-103(Spinardi, )-103(\223T)29(acit )-103(Kno)13(wledge)13(, )-103(W)102(eapons )-103(Design, )-103(and )-103(the )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 618.2721 Tm
[(Unin)13(v)23(ention )1(of)-28( Nuclear )1(W)102(eapons)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 209.8204 618.2721 Tm
[(American )1(J)21(our)-21(nal of)-42( Sociolo)13(g)-71(y )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 322.3784 618.2721 Tm
[(101, no)34(. 1 \(1995\): )1(44-99. See )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 607.5563 Tm
[(also )-39(Laur)-12(a )-39(McNamar)-12(a, )-39(\223W)94(a)29(ys )-39(of)-28( )-39(Kno)13(wing )-39(About )-39(W)102(eapons: )-39(The )-39(Cold )-39(W)94(ar\222s )-39(End )-39(a)25(t )-39(the )-39(Los )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 596.8405 Tm
[(Alamos )-25(Na)25(tional )-25(La)13(bor)-12(a)25(tor)-25(y\224)-13( )-25(\(Ph.D)65(. )-25(diss)40(., )-25(Univ)23(er)-13(sity )-25(of)-28( )-25(Ne)10(w )-25(Me)-23(xico)34(, )-25(2001\).)]TJ
T*
(8.)Tj
/Span<>> BDC
( )Tj
EMC
1.219 0 Td
[(K)-10(a)25(thleen )-240(M. )-240(V)69(o)13(gel, )-240(\223F)14(r)-12(aming )-240(Biosecurity: )-240(An )-240(Alter)-40(na)25(tiv)23(e )-240(to )-240(the )-240(Biotech )-240(R)31(e)10(v)37(olution )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 571.2328 Tm
[(Model?,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 110.2675 571.2328 Tm
[(Science )-24(and )-24(Pub)36(lic )-24(P)36(olic)-55(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 201.385 571.2328 Tm
[( )-25(35, )-25(no)34(. )-25(1 )-25(\(2008\): )-25(45-54.)]TJ
-13.514 -1.568 Td
[(9)4(.)]TJ
/Span<>> BDC
0.711 0 Td
( )Tj
EMC
0.496 0 Td
[(K)-6(a)29(t)4(h)4(l)4(e)4(e)4(n)4( )-30(M)4(.)4( )-30(V)73(o)17(g)4(e)4(l)4(,)4( )-30(\223)4(B)4(i)4(o)4(d)4(e)4(f)4(e)4(n)4(s)4(e)4(:)4( )-30(C)4(o)4(n)4(s)4(i)4(d)4(e)4(r)4(i)4(n)4(g)4( )-30(t)4(h)4(e)4( )-30(S)4(o)4(c)4(i)4(o)4(t)4(e)4(c)4(h)4(n)4(i)4(c)4(a)4(l)4( )-30(D)4(i)4(m)4(e)4(n)4(s)4(i)4(o)4(n)4(,)4(\224)-9( )-30(i)4(n)4( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 392.4876 556.3411 Tm
[(B)4(i)4(o)4(s)4(e)4(c)4(u)4(r)4(i)4(t)4(y )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 545.6252 Tm
[(I)4(n)4(t)4(e)4(r)-22(v)4(e)4(n)4(t)4(i)4(o)4(n)4(s)4(:)4( )-54(G)4(l)4(o)4(b)4(a)4(l)4( )-54(H)4(e)4(a)4(l)4(t)4(h)4( )-54(a)4(n)4(d)4( )-54(S)4(e)4(c)4(u)4(r)4(i)4(t)4(y)4( )-54(i)4(n)4( )-54(Q)4(u)4(e)4(s)4(t)4(i)4(o)4(n)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 265.2433 545.6252 Tm
[(,)4( )-56(e)4(d)4(.)4( )-56(A)4(n)4(d)4(r)4(e)14(w)4( )-56(L)4(a)4(k)43(o)4(f)4(f)-24( )-56(a)4(n)4(d)4( )-56(S)4(t)4(e)-9(p)4(h)4(e)4(n)4( )-56(J)86(.)4( )-56(C)4(o)4(l)4(l)4(i)4(e)4(r)70(, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 534.9094 Tm
[(\()4(N)4(e)14(w)4( )-21(Y)114(o)4(r)4(k)4(:)4( )-21(C)4(o)4(l)4(u)4(m)4(b)4(i)4(a)4( )-21(U)4(n)4(i)4(v)27(e)4(r)-9(s)4(i)4(t)4(y)4( )-21(P)4(r)4(e)4(s)4(s)44(,)4( )-21(2)4(0)4(0)4(8)4(\))4( )-21(2)4(4)4(0)4(-)4(2)4(4)4(1)4(.)]TJ
T*
(10.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(P)37(aul )-166(Nighting)22(ale )-166(and )-166(P)37(aul )-166(Mar)-17(tin, )-166(\223The )-166(Myth )-166(of)-28( )-166(the )-166(Biotech )-166(R)31(e)10(v)37(olution,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 394.9162 520.0176 Tm
[(T)47(r)20(ends )-162(in )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 509.3018 Tm
[(Biotec)14(hnolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 122.3993 509.3018 Tm
[( )-25(22, )-25(no)34(. )-25(11 )-25(\(No)19(v)23(ember )-25(2004\): )-25(564\226569.)]TJ
-5.2 -1.568 Td
(11.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Daniel )-155(G)54(. )-155(Gibson, )-155(J)42(ohn )-155(I. )-155(Glass)40(, )-155(Carole )-155(Lar)-17(tigue)13(, )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 292.7561 494.41 Tm
[(et )-152(al.)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 311.3658 494.41 Tm
[(, )-155(\223Crea)25(tion )-155(of)-28( )-155(a )-155(Bacterial )-155(Cell )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 483.6942 Tm
[(Controlled )-25(b)13(y )-25(a )-25(Chemicall)25(y )-25(Synthesized )-25(Genome)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 271.3857 483.6942 Tm
(Science)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 296.7121 483.6942 Tm
[( )-25(329 )-25(\(J)35(ul)25(y )-25(2, )-25(2010\): )-25(52-56.)]TJ
-23.549 -1.568 Td
(12.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Andre)10(w )-20(Mar)-13(shall, )-20(\223The )-20(Sorcerer )-20(of)-28( )-20(Synthetic )-20(Genomes)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 313.4092 468.8024 Tm
[(Na)1(tur)20(e )-20(Biotec)14(hnolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 390.757 468.8024 Tm
[( )-20(27, )-20(no)34(. )-20(12 )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 458.0866 Tm
[(\(December )-25(2009\): )-25(1122. )]TJ
T*
(13.)Tj
/Span<>> BDC
( )Tj
EMC
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 89.3304 443.1949 Tm
[(J)21(our)-21(nal )-24(of)-42( )-24(V)34(isualized )-24(Experiments )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 216.8178 443.1949 Tm
[(w)13(ebsite)13(, )-25(jo)19(v)23(e)13(.com/About.stp)33(.)]TJ
-15.139 -1.568 Td
(14.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Ale)-23(xis )-78(Madrig)22(al, )-78(\223Video )-78(Sites )-78(Help )-78(Scientists )-78(Sho)13(w )-78(Instead )-78(of)-28( )-78(T)56(ell,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 362.0232 428.303 Tm
[(W)13(ir)20(ed)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 384.4716 428.303 Tm
[(, )-78(October )-78(3, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 417.5872 Tm
[(2007, )-25(wired.com/print/science/disco)19(v)23(eries/ne)10(ws/2007/10/jo)19(v)23(e)13(.)]TJ
T*
(15.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Sonia )-138(Ben )-138(Oua)14(g)-33(rham-Gor)-22(mley )-138(and )-138(K)-10(a)25(thleen )-138(M. )-138(V)69(o)13(gel, )-138(\223The )-138(Social )-138(Conte)-23(xt )-138(Shaping )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 391.9796 Tm
[(Bio)13(w)13(eapons )-25(\(Non\)prolifer)-12(a)25(tion,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 200.6018 391.9796 Tm
[(Biosecurity )-24(and )-24(Bioter)-20(r)13(orism)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 303.5611 391.9796 Tm
[( )-25(8, )-25(no)34(. )-25(1 )-25(\(2010\): )-25(15.)]TJ
-24.27 -1.568 Td
(16.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Christopher )6(F)144(. )6(Ch)13(yba, )6(\223Biotechnolo)13(g)-40(y )6(and )6(the )6(Challenge )6(to )6(Ar)-22(ms )6(Control,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 382.7373 377.0878 Tm
[(Arms )6(Contr)13(ol )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 366.372 Tm
[(T)97(oda)-17(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 95.3913 366.372 Tm
[( )-25(36, )-25(no)34(. )-25(8 )-25(\(October )-25(2006\): )-25(11-17. )]TJ
-2.357 -1.568 Td
(17.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Ger)-12(ald )-70(L. )-70(Epstein, )-70(\223The )-70(Challenges )-70(of)-28( )-70(De)10(v)23(eloping )-70(Synthetic )-70(P)37(a)25(tho)13(gens)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 379.2344 351.4802 Tm
[(Bulletin )-68(of)-42( )-68(the )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 340.7644 Tm
[(Atomic )-299(Scientists)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 136.15 340.7644 Tm
[( )-306(w)13(ebsite)13(, )-306(Ma)29(y )-306(19, )-306(2008, )-306(theb)14(ulletin.org/print/w)13(eb-edition/fea)25(tures/the-)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 330.0486 Tm
[(challenges-of-de)10(v)23(eloping-synthetic-pa)25(tho)13(gens)40(.)]TJ
T*
(18.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Michele )-37(S. )-37(Garfink)39(el )-37(\(J)82(. )-37(Cr)-12(aig )-37(V)69(enter )-37(Institute\), )-37(Dre)10(w )-37(End)13(y )-37(\(Massachusetts )-37(Institute )-37(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 304.441 Tm
[(T)56(echnolo)13(g)-40(y\), )-15(Ger)-12(ald )-15(L. )-15(Epstein )-15(\(Center )-14(f)13(or )-15(Str)-12(a)25(te)-10(gic )-15(and )-15(Inter)-40(na)25(tional )-15(Studies\), )-15(and )-14(R)31(ober)-17(t )]TJ
0 -1.128 TD
[(M. )-92(F)14(riedman )-92(\(J)82(. )-92(Cr)-12(aig )-92(V)69(enter )-92(Institute\),)]TJ
/Span<>> BDC
( )Tj
EMC
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 234.1424 293.7252 Tm
[(Synthetic )-90(Genomics: )-90(Options )-90(f)14(or )-90(Go)20(ver)-21(nance)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 394.2933 293.7252 Tm
[(, )-92(October )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 283.0094 Tm
[(2007, )-47(p)33(. )-48(13, )-47(a)20(v)13(aila)13(b)17(le )-47(a)25(t )-48(jcvi.org/cms/fileadmin/site/research/projects/synthetic-genomics-)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 272.2936 Tm
[(re)-13(por)-17(t/synthetic-genomics-re)-13(por)-17(t.pdf.)]TJ
0 -1.568 TD
(19.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Na)25(tional )24(Science )24(Advisor)-25(y )24(Board )24(f)13(or )24(Biosecurity)121(, )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 278.7951 257.4018 Tm
[(Addr)20(essing )24(Biosecurity )24(Concer)-21(ns )24(Rela)1(ted )24(to )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 246.686 Tm
[(the )29(Synthesis )29(of)-42( )29(Select )29(Ag)-13(ents)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 174.9306 246.686 Tm
[( )30(\(Bethesda, )30(MD: )30(Na)25(tional )30(Institutes )30(of)-28( )30(Health, )30(2006\), )30(p)33(. )30(4, )30(a)20(v)13(aila)13(b)17(le )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 235.9702 Tm
[(a)25(t )-25(oba.od.nih.g)10(o)19(v/biosecurity/pdf/Final_NSABB_R)31(e)-13(por)-17(t_on_Synthetic_Genomics)40(.pdf.)]TJ
T*
(20.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(J)42(ens )-160(H. )-160(K)10(uhn, )-160(\223Defining )-160(the )-160(T)56(er)-13(rorist )-160(Risk,\224)-13( )-160(in )-160(the )-160(R)31(oundta)13(b)17(le )-160(discussion )-160(f)13(or)-13(um )-160(\223Is )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 210.3626 Tm
[(the )-40(A)72(v)13(aila)13(bility )-40(of)-28( )-40(Genetic )-40(Inf)13(or)-22(ma)25(tion )-40(Dangerous?,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 282.6207 210.3626 Tm
[(Bulletin )-39(of)-42( )-39(the )-39(Atomic )-39(Scientists)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 397.2156 210.3626 Tm
[( )-40(w)13(ebsite)13(, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 199.6468 Tm
[(F)53(e)-8(b)-8(r)-21(u)-8(a)-8(r)-33(y)-8( )-383(2)-8(8)-8(,)-8( )-383(2)-8(0)-8(0)-8(8)-8(,)-8( )-383(t)-8(h)-8(e)-8(b)6(u)-8(l)-8(l)-8(e)-8(t)-8(i)-8(n)-8(.)-8(o)-8(r)-8(g)-8(/)-8(w)5(e)-8(b)-8(-)-8(e)-8(d)-8(i)-8(t)-8(i)-8(o)-8(n)-8(/)-8(r)-8(o)-8(u)-8(n)-8(d)-8(t)-8(a)5(b)9(l)-8(e)-8(s)-8(/)-8(i)-8(s)-8(-)-8(t)-8(h)-8(e)-8(-)-8(a)12(v)5(a)-8(i)-8(l)-8(a)5(b)-8(i)-8(l)-8(i)-8(t)-8(y)-8(-)-8(g)-8(e)-8(n)-8(e)-8(t)-8(i)-8(c)-8(-)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 188.931 Tm
[(inf)13(or)-22(ma)25(tion-dangerous#r)-17(t623. )]TJ
T*
(21.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Gautam )-44(Mukunda, )-44(K)13(enneth )-44(A. )-44(Oy)32(e)13(, )-44(and )-44(Scott )-44(C)17(. )-44(Mohr)66(, )-44(\223W)-18(ha)25(t )-44(R)31(ough )-44(Beast? )-44(Synthetic )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 163.3234 Tm
[(Biolo)13(g)-40(y)121(, )-117(Uncer)-17(tainty)121(, )-117(and )-117(the )-117(Future )-117(of)-28( )-118(Biosecurity)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 285.8028 163.3234 Tm
[(P)36(olitics )-115(and )-115(the )-115(Life )-115(Sciences)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 392.7386 163.3234 Tm
[( )-117(28, )-117(no)34(. )-117(2 )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 152.6076 Tm
[(\(Se)-13(ptember )-25(2009\): )-25(14-15.)]TJ
T*
(22.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(R)31(ober)-17(ta )-18(K)34(wok, )-18(\223Fiv)23(e )-18(Hard )-18(Tr)-13(uths )-18(f)13(or )-18(Synthetic )-18(Biolo)13(g)-40(y)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 315.4885 137.7158 Tm
[(Na)1(tur)20(e)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 340.9198 137.7158 Tm
[( )-18(463, )-18(no)34(. )-18(7279 )-18(\(J)39(anuar)-25(y )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 127 Tm
[(21, )-25(2010\): )-25(288-290.)]TJ
ET
Q
endstream
endobj
45 0 obj
<<
/Length 10407
>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
/CS0 CS 0 0 0 SCN
0 i 1 w 4 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS0 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/CS0 cs 1 1 1 scn
/GS1 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 349.7216 80.9261 Tm
[(S)-5(p)-5(r)-5(i)-5(n)-5(g)-5( )-30(2)-5(0)-5(1)-5(1)-5( )-30(~)-5( )-30(8)-5(1)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 142.4533 711.9261 Tm
[(C)-5(o)-5(u)-5(l)-5(d)-5( )-30(T)5(e)-5(r)-5(r)33(o)-5(r)-5(i)-5(s)-17(t)-5(s)-5( )-30(E)-5(x)-5(p)-5(l)8(o)-5(i)-5(t)-5( )-30(S)16(y)-5(n)-5(t)-5(h)-5(e)-5(t)-5(i)-5(c)-5( )-30(B)-5(i)-5(o)-5(l)8(o)-17(g)-5(y)-5(?)]TJ
ET
1 1 1 scn
/GS1 gs
72 42.714 360 12.786 re
f*
0.565 w 10 M
/GS0 gs
236.933 44.895 m
340.078 44.895 l
S
0 0 0 scn
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 46.025 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(1)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 46.025 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 46.025 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 46.025 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
/CS0 cs 1 1 1 scn
0 i
/RelativeColorimetric ri
/GS1 gs
72 126 360 558 re
f*
0 0 0 scn
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 73 676.0271 Tm
(23.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(J)42(ona)25(than )-135(B)14(. )-135(T)14(uck)39(er )-135(and )-135(R)10(a)29(ymond )-135(A. )-135(Zilinskas)40(, )-135(\223The )-135(Promise )-135(and )-135(P)56(erils )-135(of)-28( )-135(Synthetic )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 665.5271 Tm
[(Biolo)13(g)-40(y)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 111.0858 665.5271 Tm
[(T)29(he )-87(New )-87(Atlantis)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 176.9828 665.5271 Tm
[(, )-89(no)34(. )-89(12 )-89(\(Spring )-89(2006\): )-89(25-45. )-89(Also )-89(a)20(v)13(aila)13(b)17(le )-89(a)25(t )-89(TheNe)10(wAtlantis)40(.)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 655.0271 Tm
[(com/pub)17(lica)25(tions/the-promise-and-perils-of-synthetic-biolo)13(g)-40(y)113(.)]TJ
0 -1.545 TD
(24.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(BioBricks )-25(F)61(ounda)25(tion )-25(w)13(ebsite)13(, )-25(BioBricks)40(.org)26(.)]TJ
-1.719 -1.545 Td
(25.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(iGEM )-25(w)13(ebsite)13(, )-25(ung)26(.igem.org)26(.)]TJ
-1.719 -1.545 Td
[(2)-7(6)-7(.)]TJ
/Span<>> BDC
1.239 0 Td
( )Tj
EMC
0.5 0 Td
[(V)51(a)-7(l)-7(d)-7(a)-7( )-382(V)-7(i)-7(n)-7(s)-7(o)-7(n)-7(,)-7( )-382(\223)-7(I)-7(n)6(v)16(e)-7(n)-7(t)-7(i)-7(v)16(e)-7( )-382(C)-7(o)-7(n)-7(s)-7(t)-7(r)-20(u)-7(c)-7(t)-7(i)-7(o)-7(n)-7(s)-7( )-382(U)-7(s)-7(i)-7(n)-7(g)-7( )-382(B)-7(i)-7(o)-7(b)-7(r)-7(i)-7(c)-7(k)-7(s)33(,)-7(\224)-20( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 339.806 610.9991 Tm
[(S)-7(c)-7(i)-6(e)-7(n)-7(c)-7(e)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 365.5703 610.9991 Tm
[( )-382(3)-7(3)-7(0)-7(,)-7( )-382(n)-7(o)27(.)-7( )-382(6)-7(0)-7(1)-7(1 )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 600.4991 Tm
[(\(December )-25(17, )-25(2010\): )-25(1629. )]TJ
T*
(27.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Marcus )-194(W)102(ohlsen, )-194(\223)127(Ama)25(teur)-13(s )-194(Are )-194(Tr)-25(ying )-194(Genetic )-194(Engineering )-194(a)25(t )-194(Home)13(,\224)-13( )-194(Associa)25(ted )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 575.3231 Tm
[(Press)40(, )-92(December )-92(25, )-92(2008; )-92(Carol)25(yn )-92(Y)152(. )-92(J)42(ohnson, )-92(\223)127(As )-92(Synthetic )-92(Biolo)13(g)-40(y )-92(Becomes )-92(Aff)13(orda)13(b)17(le)13(, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 564.8231 Tm
[(Ama)25(teur )13(La)13(bs )13(Thriv)23(e)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 164.0049 564.8231 Tm
[(Boston )13(Globe)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 210.8528 564.8231 Tm
[(, )13(Se)-13(ptember )13(16, )13(2008; )13(Phil )13(McK)13(enna, )13(\223Rise )13(of)-28( )13(the )13(Gar)-12(a)14(ge )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 554.3231 Tm
[(Genome )-25(Hack)39(er)-13(s)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 147.3932 554.3231 Tm
[(New )-24(Scientist)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 196.9583 554.3231 Tm
[(, )-25(No)34(. )-25(2689 )-25(\(J)39(anuar)-25(y )-25(7, )-25(2009\): )-25(20-21. )]TJ
-13.048 -1.545 Td
(28.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(DIYbio )-25(w)13(ebsite)13(, )-25(DIYbio)34(.org)26(.)]TJ
-1.719 -1.545 Td
(29.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Ga)29(ymon )-184(Bennett )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 161.2461 524.9711 Tm
[(et )-181(al.)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 180.1307 524.9711 Tm
[(, )-185(\223F)14(rom )-184(Synthetic )-185(Biolo)13(g)-40(y )-185(to )-185(Biohacking: )-184(Are )-184(W)102(e )-185(Pre)-13(pared?\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 514.4711 Tm
[(Na)1(tur)20(e )-24(Biotec)14(hnolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 150.3909 514.4711 Tm
[( )-25(27, )-25(no)34(. )-25(12 )-25(\(December )-25(2009\): )-25(1109. )]TJ
-8.146 -1.545 Td
(30.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(F)14(reeman )-121(Dyson, )-121(\223Our )-121(Biotech )-121(Future)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 249.0277 499.7951 Tm
[(New )-119(Y)100(or)20(k )-119(Re)8(view )-119(of)-42( )-119(Books)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 351.0344 499.7951 Tm
[( )-121(54, )-121(no)34(. )-121(12 )-121(\(J)35(ul)25(y )-121(19, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 489.2951 Tm
[(2007\) )-25(nybooks)40(.com/ar)-17(ticles/archiv)23(es/2007/jul/19/our-biotech-future/. )]TJ
T*
(31.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Helen )-143(Anne )-143(Cur)-13(r)-25(y)121(, )-143(\223The )-143(Ev)37(olution )-143(Engineer)-13(s: )-143(Plant )-143(Breeding )-143(with )-143(Chemicals )-143(in )-143(the )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 464.1191 Tm
[(La)13(bor)-12(a)25(tor)-25(y )-75(and )-75(a)25(t )-75(Home)13(, )-75(1937-1950,\224)-13( )-75(\(Science )-74(and )-74(T)56(echnolo)13(g)-40(y )-74(Studies )-75(Colloquium )-74(Series)40(, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 453.6191 Tm
[(Cor)-40(nell )-14(Univ)23(er)-13(sity)121(, )-14(F)61(ebr)-13(uar)-25(y )-14(7, )-14(2011\). )-14(See )-14(also)34(, )-14(Cur)-13(r)-25(y)121(, )-14(\223)127(Acceler)-12(a)25(ting )-14(Ev)37(olution, )-14(Engineering )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 443.1191 Tm
[(Life: )37(Science)13(, )36(Ag)-33(riculture)13(, )37(and )36(T)56(echnolo)13(gies )37(of)-28( )36(Genetic )37(Modifica)25(tion, )37(1925-1955\224)-13( )36(\(Ph.D)65(. )37(diss)40(., )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 432.6191 Tm
[(Y)80(ale )-25(Univ)23(er)-13(sity)121(, )-25(2011\). )]TJ
0 -1.56 TD
(32.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Markus )-13(Schmidt, )-13(\223Diffusion )-13(of)-28( )-13(Synthetic )-13(Biolo)13(g)-40(y: )-13(A )-13(Challenge )-13(to )-13(Biosafety)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 387.7758 417.7991 Tm
[(Systems )-13(and )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 407.2991 Tm
[(Synthetic )-24(Biolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 135.2762 407.2991 Tm
[( )-25(2, )-25(no)34(. )-25(1-2 )-25(\(J)35(une )-25(2008\): )-25(1-6.)]TJ
-6.555 -1.545 Td
(33.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Mukunda, )-25(Oy)32(e)13(, )-25(and )-25(Mohr)66(, )-25(\223W)-18(ha)25(t )-25(R)31(ough )-25(Beast?,\224)-13( )-25(14.)]TJ
-1.719 -1.545 Td
(34.)Tj
/Span<>> BDC
( )Tj
EMC
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 89.3304 377.9471 Tm
(Economist)Tj
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 126.3416 377.9471 Tm
[(, )-105(\223Hacking )-105(Goes )-105(Squish)13(y)121(,\224)-13( )-105(392, )-105(no)34(. )-105(8647 )-105(\(Se)-13(ptember )-105(5, )-105(2009\): )-105(special )-105(section )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 367.4471 Tm
(30-31.)Tj
0 -1.545 TD
(35.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Andre)10(w )-44(Ellington, )-44(\223Opinion: )-44(On )-44(R)31(e)-10(gula)25(tion,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 270.2187 352.7711 Tm
[(T)29(he )-43(Scientist)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 316.904 352.7711 Tm
[( )-44(w)13(ebsite)13(, )-44(March )-44(3, )-44(2011, )-44(the-)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 342.2711 Tm
[(scientist.com/ne)10(ws/displa)29(y/58035/.)]TJ
T*
(36.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Mark )-16(W)-18(heelis)40(, )-16(Lajos )-16(R\363za, )-16(and )-16(Malcolm )-16(Dando)34(, )-16(eds)40(.,)]TJ
/Span<>> BDC
( )Tj
EMC
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 299.632 327.5951 Tm
[(Deadl)-28(y )-16(Cultur)20(es: )-16(Biolo)13(gical )-16(W)92(ea)-27(pons )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 73 317.0951 Tm
[(Since )-24(1945)]TJ
/T1_2 1 Tf
/Span<>> BDC
4.218 0 Td
( )Tj
EMC
[(\(Cambridge)13(, )-25(MA: )-25(Har)-26(v)13(ard )-25(Univ)23(er)-13(sity )-25(Press)40(, )-25(2006\).)]TJ
-4.218 -1.545 Td
(37.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Oua)14(g)-33(rham-Gor)-22(mley )-25(and )-25(V)69(o)13(gel, )-25(\223The )-25(Social )-25(Conte)-23(xt,\224)-13( )-25(23.)]TJ
-1.719 -1.545 Td
(38.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Michael )-226(A. )-226(Le)10(vi, )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 161.69 287.7431 Tm
[(On )-221(Nuc)13(lear )-221(T)87(er)-20(r)13(orism)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 246.2667 287.7431 Tm
[( )-226(\(Cambridge)13(, )-226(MA: )-226(Har)-26(v)13(ard )-226(Univ)23(er)-13(sity )-226(Press)40(, )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 277.2431 Tm
(2009\).)Tj
T*
(39.)Tj
/Span<>> BDC
( )Tj
EMC
1.719 0 Td
[(Michael )-73(L)20(ynch, )-73(\223Protocols)40(, )-73(Pr)-12(actices)40(, )-73(and )-73(the )-73(R)31(e)-13(production )-73(of)-28( )-73(T)56(echnique )-73(in )-73(Molecular )]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 73 252.0671 Tm
[(Biolo)13(g)-40(y)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
9.5 0 0 9.5 110.4769 252.0671 Tm
[(British )-24(J)21(our)-21(nal )-24(of)-42( )-24(Sociolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 212.0253 252.0671 Tm
[( )-25(53, )-25(no)34(. )-25(2 )-25(\(J)35(une )-25(2002\): )-25(203-220.)]TJ
ET
Q
endstream
endobj
46 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
47 0 obj
<<
/Type /FontDescriptor
/Flags 131106
/StemV 68
/Ascent 879
/Descent -266
/XHeight 420
/FontBBox [-207 -266 1059 879]
/FontName /BellMT-RegularSC
/CapHeight 638
/FontFile3 61 0 R
/FontFamily (Bell MT RegularSC)
/FontWeight 400
/FontStretch /Normal
/ItalicAngle 0
>>
endobj
48 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
49 0 obj
<<
/Type /FontDescriptor
/Flags 32
/StemV 76
/Ascent 923
/Descent -250
/XHeight 487
/FontBBox [-79 -250 1060 923]
/FontName /OfficinaSans-Book
/CapHeight 685
/FontFile3 62 0 R
/FontFamily (ITC Officina Sans Book)
/FontWeight 400
/FontStretch /Normal
/ItalicAngle 0
>>
endobj
50 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
51 0 obj
<<
/Type /FontDescriptor
/Flags 34
/StemV 68
/Ascent 879
/Descent -266
/XHeight 410
/FontBBox [-207 -266 1059 879]
/FontName /BellMT-Regular
/CapHeight 638
/FontFile3 63 0 R
/FontFamily (Bell MT Regular)
/FontWeight 400
/FontStretch /Normal
/ItalicAngle 0
>>
endobj
52 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
53 0 obj
<<
/Type /FontDescriptor
/Flags 34
/StemV 112
/Ascent 882
/Descent -267
/XHeight 421
/FontBBox [-212 -267 1158 882]
/FontName /BellMT-Bold
/CapHeight 647
/FontFile3 64 0 R
/FontFamily (Bell MT Regular)
/FontWeight 700
/FontStretch /Normal
/ItalicAngle 0
>>
endobj
54 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
55 0 obj
<<
/Type /FontDescriptor
/Flags 98
/StemV 60
/Ascent 883
/Descent -270
/XHeight 417
/FontBBox [-196 -270 1091 883]
/FontName /BellMT-Italic
/CapHeight 630
/FontFile3 65 0 R
/FontFamily (Bell MT Regular)
/FontWeight 400
/FontStretch /Normal
/ItalicAngle -16
>>
endobj
56 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
57 0 obj
<<
/Type /FontDescriptor
/Flags 98
/StemV 104
/Ascent 883
/Descent -270
/XHeight 417
/FontBBox [-245 -270 1157 883]
/FontName /BellMT-BoldItalic
/CapHeight 635
/FontFile3 66 0 R
/FontFamily (Bell MT Regular)
/FontWeight 700
/FontStretch /Normal
/ItalicAngle -16
>>
endobj
58 0 obj
<<
/N 3
/Length 560
>>
stream
0ADBE mntrRGB XYZ acspAPPL none -ADBE
cprt 2desc 0 kwtpt bkpt rTRC gTRC bTRC rXYZ gXYZ bXYZ text Copyright 1999 Adobe Systems Incorporated desc Adobe RGB (1998) XYZ Q XYZ curv 3 curv 3 curv 3 XYZ O XYZ 4 , XYZ &1 /
endstream
endobj
59 0 obj
<<
/Filter [/FlateDecode]
/Length 1248
>>
stream
HdN#GusK\`f2̂OJ4n~M*w>]vz/pZ^etܘtxڿ_~Z^7k?ޗfc)^,6Wuriߧv:,/t^p~gLgerX^u\n~,7\qIsv=g3ݐÐwC\\܆d37~37~37~37s6d%o-*;SdA9Sɳr"'Lʅ\+yu6rSXV~o[-~+o[V~o[-~+o;N~;~'ww;N~;~'ww{^~{=~/{^~{=~/A?V,,YYP@ffA͂54jh,,YYP@ffA"͢EE54jiDQ?G#(?GQ?G[Vݰp|fVs̻@sEnozμ_W7D2k:ѻ:xVY|=dFjuْL_p-~hoz7|Yz?_zns'˙Igb~MO=dKO$'9''i~$=$4?IꛆI'?i3,Ɵ?gY?˟g3,Ɵ?gY?˟g"_//E2d>{!++*V(VTPXXQBbbE
Ŋ*V)VURXXUJbbU*ŪUU}0WU_**_
o7M7&o
o7M7&ow]w;.w]w;ueSqTm/Λet:o[֝Һ_N|LNo
endstream
endobj
60 0 obj
<<
/Type /FontDescriptor
/Flags 34
/StemV 84
/Ascent 873
/Descent -280
/XHeight 422
/FontBBox [-213 -280 1061 873]
/FontName /BellMT-SemiBoldSC
/CapHeight 636
/FontFile3 67 0 R
/FontFamily (Bell MT SemiBoldSC)
/FontWeight 400
/FontStretch /Normal
/ItalicAngle 0
>>
endobj
61 0 obj
<<
/Filter [/FlateDecode]
/Length 26089
/Subtype /Type1C
>>
stream
H|yTSgcHB9EߋKQA-(
@BY5%,A.L]pAX)Ι֣Z 3sל{~wRfΠPԀ(AiibdA/Kv{9ToL2x3FG(---
;mc2:84ǩHOX ysCnݙ/pSrqYX&rAZ.wgi)7y/&2;]WXseB/L&e|/+EnL,WK7@Xƕ})=|9w75`-By9e&A9HPSȡD3t
,~T?OQDfݚs%aY=g`%<|C975
jXp뷺߃s"BP.f-~\dݒ%߇
Y)ceˎ,/^V:Wek
\:
Phˍèaӛm"ؚ#ED܌8yl_}¨QEMFό.cޘΏMc*nW\uܩ_mwd'w'lLLM%=ٽg={?$3E}SC&:Iff\gg=7?/wA^H|`e!UxXVO:DYRٷSIT#^>YaWZUC)ꍚ 7*nWUTiw.d =n0<5f2E,<g s25g+knu.L
$Q*%.eߑ>Ee _/yAǽt˯Н6g;|RԬ$2TVc>\M.?,\ GAQQxx!XtɏOfGNl:|#ZA%~x:|C<(LrS ΚP
Lŝ P{Z
`hzAD2;)BZ٠lznl;Jr7{TF~2zl̋/OO# <aL܂]`rPLޞKKg
'!_yʇpyE9߈xuMÉo{;nCI.xwU]C
3"ے~!@c}l
<ç^.LmIE)6m/+~ސ+//]wk=`? 7A;d6AtQIraUݖ:<3&҄>M1%B6̻s(Yy3vqar1bF1}#BZmjezVBWV%~@4A!xmK\*+3EiЭ;6T+D\Ac}PYz|%
ZfX
+BRc00N ןEDHLfzn,>#/$"QϩS>b@,c#vAn%4 j'2J
c4P! ]\C<̄c5f_Nz:%CrVkJxX.Duì oxn32U@m;סAm(94$l56LX0`)BũU7jqW0mAq#֪ݺNu-Fm6jt"D*Y\W6{oPolj&7թŰ(%zO`6µ6jZȚ[mrꝆ4dVj;NWWd9
Ĉs۬h̜ lmpkEZ6Ns]Xׂ]#T09Bn救4 #0>#%k̈́m48A0LY{[Qޅ|6qxS!ZvLRu)8B%2&KvivWEKݰF$4 @@f`8ViE8TौdaDe|48#ʚ}Z;mMN[?P&3&!u-!]va,th
J5e ѝR;jrW! |7dv/YEm+9Y )S
wI*VBKE 4;wJMM10,kk~&XpӡdďnӶ&'P1vZT٢jTrHWOV7|ֻl 18cJ]eN{wka]{4s;=_٬̱F*ߐ vy.:sӛƮE&=*(8QlH P7?ndUWbc&Fx\l~`m 8e+QW=7U̪aPX'4S}eSM碿/q
;#mUQ\ɴ%]WJ'wDUֻk?<ENEP
R6}5.M(M}atꔰUT d]ԛrR֊油dJ
/23'
Y`[ք]XmP'Jd^+W1DFyFCnJ Nc/bVvCz:Ӻ'wz.L|=7f^N96U?I|pGR)O['_ ^sJ91x
ƛWO[>}K%jY5N!Qa`M
K`OƓ%|mmDS3Ow!jC8Dsjߙ23t;ν^Zxo`o'-]sK!*UP1ZmK"-Tuc5nTdFlT$6&h &X