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/Title (Appendix C: Ethical Considerations Regarding Stem Cell Research)
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2012-01-25T20:17:06-05:00
2012-01-25T20:17:07-05:00
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Appendix C: Ethical Considerations Regarding Stem Cell Research
The Witherspoon Council on Ethics and the Integrity of Science
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[(s)4(e)4(e)]TJ
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EMC
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[(i)4(n)4(d)4(e)4(e)4(d)4(,)4( )-139(t)4(o)4( )-139(s)4(e)4(e)4( )-139(t)4(h)4(e)4( )-139(e)4(m)4(b)4(r)-21(y)34(o)4( )-139(a)29(t)4( )-139(a)4(l)4(l)4(,)4( )-139(w)17(e)4( )-139(n)4(e)4(e)4(d)4( )-139(a)4( )-139(m)4(i)4(c)4(r)4(o)4(s)4(c)4(o)4(p)4(e)17(.)4( )-139(I)4(t)4( )-139(h)4(a)4(s)4( )-139(n)4(o )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 440.0363 Tm
[(l)4(i)4(m)4(b)4(s)4( )30(o)4(r)4( )30(o)4(r)4(g)26(a)4(n)4(s)44(.)4( )30(I)4(t)4( )30(c)4(a)4(n)4(n)4(o)4(t)4( )30(s)4(u)4(r)-22(v)4(i)4(v)27(e)4( )30(o)4(n)4( )30(i)4(t)4(s)4( )30(o)17(w)4(n)4(.)4( )30(I)4(t)4( )30(l)4(a)4(c)4(k)4(s)4( )30(t)4(h)4(e)4( )30(i)4(n)4(t)4(e)-6(g)-29(r)-8(a)29(t)4(e)4(d)4( )30(d)4(e)14(v)27(e)4(l)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 426.8721 440.0363 Tm
(-)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 73 425.8075 Tm
[(o)4(p)4(m)4(e)4(n)4(t)4( )16(o)4(f)-24( )16(n)4(e)4(r)-22(v)27(e)4(s)44(,)4( )16(m)4(u)4(s)4(c)4(l)4(e)4(s)44(,)4( )16(a)4(n)4(d)4( )16(b)4(o)4(n)4(e)4(s)4( )16(t)4(h)4(a)29(t)4( )16(e)4(n)4(a)17(b)21(l)4(e)4( )16(u)4(s)4( )16(t)4(o)4( )16(m)4(o)23(v)27(e)4( )16(a)4(n)4(d)4( )16(a)4(c)4(t)4( )16(i)4(n)4( )16(t)4(h)4(e )]TJ
T*
[(w)4(o)4(r)4(l)4(d)4(.)4( )13(I)4(t)4( )13(l)4(a)4(c)4(k)4(s)4( )13(a)4( )13(c)4(e)4(n)4(t)4(r)-8(a)4(l)4( )13(n)4(e)4(r)-22(v)41(o)4(u)4(s)4( )13(s)4(y)4(s)4(t)4(e)4(m)]TJ
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EMC
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(\227)Tj
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0.996 0 Td
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EMC
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[(a)4(n)4(d)4( )13(s)4(o)4( )13(c)4(a)4(n)4(n)4(o)4(t)4( )13(t)4(h)4(i)4(n)4(k)4(,)4( )13(c)4(a)4(n)4(n)4(o)4(t)4( )13(f)4(e)4(e)4(l )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 397.3498 Tm
[(p)4(a)4(i)4(n)4(,)4( )38(a)4(n)4(d)4( )38(i)4(s)4( )38(n)4(o)4(t)4( )38(s)4(e)4(l)4(f)4(-)4(a)26(w)4(a)4(r)4(e)17(.)4( )38(I)4(f)-24( )38(t)4(h)4(e)4( )38(p)4(o)4(s)4(s)4(e)4(s)4(s)4(i)4(o)4(n)4( )38(o)4(f)-24( )38(a)4(n)4(y)4( )38(o)4(f)-24( )38(t)4(h)4(o)4(s)4(e)4( )38(c)4(a)4(p)4(a)4(c)4(i)4(t)4(i)4(e)4(s)4( )38(i)4(s)4( )38(t)4(h)4(e )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 383.1209 Tm
[(d)4(e)4(f)4(i)4(n)4(i)4(n)4(g)4( )-77(t)4(h)4(r)4(e)4(s)4(h)4(o)4(l)4(d)4( )-77(f)17(o)4(r)4( )-77(a)4( )-77(b)4(e)4(i)4(n)4(g)4( )-77(t)4(o)4( )-77(m)4(e)4(r)4(i)4(t)4( )-77(m)4(o)4(r)-8(a)4(l)4( )-77(s)4(t)4(a)4(n)4(d)4(i)4(n)4(g)30(,)4( )-77(t)4(h)4(e)4(n)4( )-77(t)4(h)4(e)4( )-77(e)4(m)4(b)4(r)-21(y)34(o )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 368.8921 Tm
[(c)4(a)4(n)4( )-21(b)4(e)4( )-21(t)4(r)4(e)4(a)29(t)4(e)4(d)4( )-21(t)4(h)4(e)4( )-21(s)4(a)4(m)4(e)4( )-21(w)4(a)33(y)4( )-21(w)17(e)4( )-21(m)4(i)4(g)4(h)4(t)4( )-21(t)4(r)4(e)4(a)29(t)4( )-21(a)4(n)4(y)4( )-21(o)4(t)4(h)4(e)4(r)4( )-21(b)4(i)4(t)4( )-21(o)4(f)-24( )-21(t)4(i)4(s)4(s)4(u)4(e)17(.)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 91 354.6632 Tm
[(Many )32(opponents )32(of)-28( )32(embr)-25(y)30(o )32(destr)-13(uction )32(argue )32(tha)25(t )32(it )32(is )32(wrong)26(, )32(or )32(e)10(v)23(en )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 340.4344 Tm
[(dangerous)40(, )-50(to )-50(claim )-50(tha)25(t )-50(human )-50(dignity )-50(and )-50(a )-50(right )-50(to )-50(life )-50(a)25(ttach )-50(onl)25(y )-50(to )]TJ
ET
BT
/T1_3 1 Tf
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[(those )-109(human )-109(org)22(anisms )-109(who )-109(fulfill )-109(specific )-109(criteria. )-109(W)-18(hile )-109(a )-109(de)10(v)23(eloping )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 311.9767 Tm
[(embr)-25(y)30(o )-39(does )-39(not )-39(ha)20(v)23(e )-39(the )-39(manifest )-39(capacities )-39(of)-28( )-39(a )-39(full)25(y )-39(de)10(v)23(eloped )-39(human )]TJ
ET
BT
/T1_3 1 Tf
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[(being)26(, )-128(many )-128(per)-13(sons )-128(who )-128(are )-128(y)30(oung)26(, )-128(sick, )-128(disa)13(b)17(led, )-128(or )-128(de)10(v)23(elopmentall)25(y )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 283.519 Tm
[(challenged )-71(also )-71(lack )-71(some )-71(of)-28( )-71(these )-71(capacities)40(. )-71(W)102(e )-71(ma)29(y )-71(erode )-71(our )-71(respect )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 269.2901 Tm
[(f)13(or )-135(the )-135(human )-135(dignity )-135(and )-135(rights )-135(of)-28( )-135(these )-135(individuals )-135(if)-28( )-135(w)13(e )-135(consider )-135(it )]TJ
T*
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EMC
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EMC
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ET
BT
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[(prone )-25(to )-25(lack )-25(or )-25(lose )-25(in )-25(the )-25(cour)-13(se )-25(of)-28( )-25(a )-25(human )-25(life)13(.)]TJ
ET
BT
/T1_3 1 Tf
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[(T)63(o )28(counter )29(the )28(claim )28(tha)25(t )28(the )28(embr)-25(y)30(o )28(is )29(just )28(a )28(clump )28(of)-28( )28(cells )29(deser)-26(ving )]TJ
ET
BT
/T1_3 1 Tf
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[(no )-69(respect, )-69(critics )-69(of)-28( )-69(embr)-25(y)30(onic )-69(stem )-69(cell )-69(research )-69(point )-69(to )-69(the )-69(standard )]TJ
ET
BT
/T1_3 1 Tf
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[(position )-43(of)-28( )-43(both )-43(tr)-12(aditional )-43(and )-43(contempor)-12(ar)-25(y )-43(embr)-25(y)30(olo)13(g)-40(y)121(, )-43(which )-43(is )-43(tha)25(t )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 183.917 Tm
[(a )-59(human )-59(life )-59(be)-10(gins )-59(a)25(t )-59(fer)-17(tiliza)25(tion.)]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 245.894 187.217 Tm
(3)Tj
ET
BT
/T1_3 1 Tf
12 0 0 12 250.894 183.917 Tm
[( )-59(F)61(er)-17(tiliza)25(tion )-59(is )-59(the )-59(clearest )-59(moment )]TJ
ET
BT
/T1_3 1 Tf
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[(of)-28( )-162(discontinuity )-161(in )-162(life: )-161(it )-162(is )-162(when )-162(a )-161(ne)10(w )-162(org)22(anism, )-162(one )-161(with )-162(a )-162(unique )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 155.4593 Tm
[(genetic )-76(identity)121(, )-76(e)-23(xists )-76(f)13(or )-76(the )-76(fir)-13(st )-76(time)13(. )-76(F)14(rom )-76(fer)-17(tiliza)25(tion )-76(and )-76(the )-76(fir)-13(st )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 141.2305 Tm
[(sta)14(ges )-100(of)-28( )-100(cell )-100(clea)20(v)13(a)14(ge)13(, )-100(embr)-25(y)30(os )-100(e)-23(xhibit )-100(a )-100(highl)25(y )-100(coordina)25(ted )-100(pa)25(tter)-40(n )-100(of)-28( )]TJ
T*
[(de)10(v)23(elopment )7(in )7(pre)-13(par)-12(a)25(tion )7(f)13(or )7(implanta)25(tion )7(in )7(the )7(uter)-13(us)40(, )7(and )7(f)13(or)]TJ
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EMC
26.941 0 Td
[(fur)-17(ther )]TJ
ET
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f*
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S
72 701.5 m
432 701.5 l
S
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f*
0 0 0 rg
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BT
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[(1)-5(0)-5(0)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 106.8951 711.9261 Tm
[(W)63(i)-5(t)-5(h)-5(e)-5(r)-5(s)-5(p)8(o)-17(o)-5(n)-5( )-30(C)-5(o)-5(u)-5(n)-5(c)-5(i)-5(l)-5( )-30(o)-5(n)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(s)-5( )-30(a)-5(n)-5(d)-5( )-30(t)-5(h)-5(e)-5( )-30(I)-5(n)-5(t)-5(e)-5(g)-5(r)-5(i)-5(t)20(y)-5( )-30(o)-5(f)-5( )-30(S)-5(c)-5(i)-5(e)-5(n)-5(c)-5(e)]TJ
ET
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72 44.814 360 12.786 re
f*
0.565 w 10 M
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236.933 46.995 m
340.078 46.995 l
S
0 0 0 rg
BT
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11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
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72 126.004 360 557.996 re
f*
0 0 0 rg
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BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(de)10(v)23(elopment )-116(into )-116(an )-116(adult )-116(org)22(anism. )-116(\(It )-116(is )-116(of)-28( )-116(cour)-13(se )-116(this )-116(v)23(er)-25(y )-116(de)10(v)23(elop)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 674.1921 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(mental )-117(potential )-117(of)-28( )-117(the )-117(human )-117(embr)-25(y)30(o )-117(tha)25(t )-117(mak)39(es )-117(it )-117(such )-117(an )-117(a)25(ttr)-12(activ)23(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.1312 Tm
[(source )18(of)-28( )18(cells )18(f)13(or )18(research )18(pur)-13(poses)40(.\) )18(Human )18(embr)-25(y)30(os )18(ma)29(y )18(appear )18(to )18(lack )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1007 Tm
[(the )-58(char)-12(acteristics )-58(of)-28( )-58(human )-58(beings)40(, )-58(b)14(ut )-58(our )-58(e)-23(xpanding )-58(scientific )-58(kno)13(wl)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 632.1007 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.0703 Tm
[(edge )-57(of)-28( )-57(their )-57(de)10(v)23(elopmental )-57(capacities )-57(and )-57(underl)25(ying )-57(str)-13(uctures )-57(re)10(v)23(eals )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0398 Tm
[(their )-119(intrica)25(te )-119(and )-119(unique )-119(po)13(w)13(er )-119(to )-119(de)10(v)23(elop )-119(as )-119(human )-119(beings)40(. )-119(W)-18(hether )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 590.0093 Tm
[(crea)25(ted )-65(na)25(tur)-12(all)25(y )-65(through )-65(se)-23(xual )-65(re)-13(production, )-65(or )-65(through )-65(IVF )-65(or )-65(other )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.9789 Tm
[(techniques )-151(such )-151(as )-151(cloning)26(, )-151(human )-151(embr)-25(y)30(os )-151(are )-151(all )-151(human )-151(beings )-151(a)25(t )-151(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9484 Tm
[(v)23(er)-25(y )8(earl)25(y )8(sta)14(ge )8(of)-28( )8(de)10(v)23(elopment. )8(Being )8(human, )8(re)-10(g)22(ardless )8(of)-28( )8(one\222s )8(capaci)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 561.9484 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
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[(ties )-74(or )-74(sta)14(ge )-74(of)-28( )-74(de)10(v)23(elopment, )-73(confer)-13(s )-74(cer)-17(tain )-74(fundamental )-74(human )-74(rights)40(, )]TJ
ET
BT
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[(which )8(are )8(g)-33(rounded )8(in )8(the )8(respect )8(w)13(e )8(o)13(w)13(e )8(to )8(the )8(dignity )8(and )8(w)13(ellbeing )8(of)-28( )]TJ
0 -1.169 TD
[(our )-84(fello)13(w )-84(human )-84(beings)40(. )-84(The )-84(most )-84(impor)-17(tant )-84(of)-28( )-84(these )-84(rights)]TJ
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EMC
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[(it )-92(is )-92(the )-92(right )-92(necessar)-25(y )-92(to )-92(secure )-92(all )-92(other)-13(s)]TJ
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EMC
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( )Tj
EMC
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[(is )-92(the )-92(right )-92(to )-92(life)13(, )-92(which )]TJ
ET
BT
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[(demands )-25(tha)25(t )-25(w)13(e )-25(do )-25(not )-25(kill )-25(other )-25(human )-25(beings)40(.)]TJ
ET
BT
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[(Some )-1(people )-1(belie)10(v)23(e )-1(tha)25(t )-1(the )-1(mor)-12(al )-1(sta)25(tus )-1(of)-28( )-1(the )-1(embr)-25(y)30(o )-1(falls )-1(betw)13(een )]TJ
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[(t)10(h)10(e)10( )5(t)10(w)10(o)10( )5(o)10(p)10(p)10(o)10(s)10(i)10(n)10(g)10( )5(p)10(o)10(s)10(i)10(t)10(i)10(o)10(n)10(s)]TJ
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EMC
0.032 0 Td
[(t)10(h)10(a)35(t)10( )5(t)10(h)10(e)10( )5(e)10(m)10(b)10(r)-15(y)40(o)10( )5(d)10(e)10(s)10(e)10(r)-16(v)33(e)10(s)10( )5(\223)10(p)10(r)10(o)10(f)23(o)10(u)10(n)10(d)10( )5(r)10(e)10(s)10(p)10(e)10(c)10(t)10(\224)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 426 467.0351 Tm
(4)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 431 463.7351 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7047 Tm
[(or )-53(\223serious )-53(mor)-12(al )-53(consider)-12(a)25(tion\224)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 232.0336 453.0046 Tm
(5)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 237.0336 449.7047 Tm
[( )-53(as )-53(an )-53(earl)25(y )-53(f)13(or)-22(m )-53(of)-28( )-53(human )-53(life)13(, )-53(though )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6742 Tm
[(w)13(e )-136(need )-136(not )-136(accord )-136(to )-136(it )-136(the )-136(same )-136(rights )-136(as )-136(a )-136(full)25(y )-136(de)10(v)23(eloped )-136(per)-13(son.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 426 438.9742 Tm
(6)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 431 435.6742 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6437 Tm
[(Fur)-17(ther)-22(more)13(, )-90(some )-90(argue )-90(tha)25(t )-90(the )-90(mor)-12(al )-90(sta)25(tus )-90(of)-28( )-90(human )-90(embr)-25(y)30(os )-90(ma)29(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6133 Tm
[(de)-13(pend )-15(par)-17(tl)25(y )-15(on )-15(such )-15(factor)-13(s )-15(as )-15(their )-15(sta)25(te )-15(of)-28( )-15(de)10(v)23(elopment, )-15(their )-15(origins)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5828 Tm
[(and )-73(the )-73(wishes )-73(of)-28( )-73(their )-73(parents)40(. )-73(In )-73(pr)-12(actice)13(, )-73(ho)13(w)13(e)10(v)23(er)66(, )-73(these )-73(inter)-22(media)25(te )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 379.5523 Tm
[(ethical )-16(positions )-16(tend )-16(to )-16(justify )-16(policies )-16(tha)25(t )-16(differ )-16(little )-16(from )-16(policies )-16(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5219 Tm
[(assume )-25(the )-25(embr)-25(y)30(o )-25(has )-25(no )-25(special )-25(mor)-12(al )-25(sta)25(tus)40(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 304.9447 368.8218 Tm
(7)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 351.4914 Tm
[(F)65(o)4(r)4( )-64(t)4(h)4(o)4(s)4(e)4( )-64(w)4(h)4(o)4( )-64(s)4(e)4(e)4( )-64(t)4(h)4(e)4( )-64(e)4(m)4(b)4(r)-21(y)34(o)4( )-64(a)4(s)4( )-64(n)4(o)4( )-64(m)4(o)4(r)4(e)4( )-64(t)4(h)4(a)4(n)4( )-64(a)4( )-64(c)4(l)4(u)4(m)4(p)4( )-64(o)4(f)-24( )-64(c)4(e)4(l)4(l)4(s)4( )-64(w)4(i)4(t)4(h )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4609 Tm
[(s)4(i)4(m)4(i)4(l)4(a)4(r)4( )-74(m)4(o)4(r)-8(a)4(l)4( )-74(s)4(t)4(a)29(t)4(u)4(s)4( )-74(t)4(o)4( )-74(o)4(t)4(h)4(e)4(r)4( )-74(h)4(u)4(m)4(a)4(n)4( )-74(t)4(i)4(s)4(s)4(u)4(e)4(s)44(,)4( )-74(t)4(h)4(e)4( )-74(p)4(r)4(i)4(m)4(a)4(r)-21(y)4( )-74(e)4(t)4(h)4(i)4(c)4(a)4(l)4( )-74(c)4(o)4(n)4(c)4(e)4(r)-36(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.4305 Tm
[(w)4(i)4(t)4(h)4( )-187(r)4(e)4(s)4(p)4(e)4(c)4(t)4( )-187(t)4(o)4( )-187(h)4(a)4(r)-22(v)27(e)4(s)4(t)4(i)4(n)4(g)4( )-187(E)4(S)4( )-187(c)4(e)4(l)4(l)4(s)4( )-187(f)4(r)4(o)4(m)4( )-187(e)4(m)4(b)4(r)-21(y)34(o)4(s)4( )-187(w)4(o)4(u)4(l)4(d)4( )-187(b)4(e)4( )-187(o)4(b)4(t)4(a)4(i)4(n)4(i)4(n)4(g )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.4 Tm
[(i)4(n)4(f)17(o)4(r)-18(m)4(e)4(d)4( )-26(c)4(o)4(n)4(s)4(e)4(n)4(t)4( )-26(f)4(r)4(o)4(m)4( )-26(e)4(m)4(b)4(r)-21(y)34(o)4( )-26(d)4(o)4(n)4(o)4(r)-9(s)44(,)4( )-26(s)4(u)4(c)4(h)4( )-26(a)4(s)4( )-26(I)4(V)4(F)4( )-26(p)4(a)29(t)4(i)4(e)4(n)4(t)4(s)44(.)4( )-26(B)4(y)4( )-26(c)4(o)4(n)4(t)4(r)-8(a)4(s)4(t)4(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3695 Tm
[(f)17(o)4(r)4( )45(t)4(h)4(o)4(s)4(e)4( )45(w)4(h)4(o)4( )45(c)4(o)4(n)4(s)4(i)4(d)4(e)4(r)4( )45(t)4(h)4(e)4( )45(e)4(m)4(b)4(r)-21(y)34(o)4( )45(t)4(o)4( )45(b)4(e)4( )45(a)4( )45(h)4(u)4(m)4(a)4(n)4( )45(b)4(e)4(i)4(n)4(g)4( )45(w)4(i)4(t)4(h)4( )45(a)4( )45(m)4(o)4(r)-8(a)4(l)4( )45(s)4(t)4(a)29(t)4(u)4(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3391 Tm
[(e)4(q)4(u)4(a)4(l)4( )44(t)4(o)4( )44(t)4(h)4(a)29(t)4( )44(o)4(f)-24( )44(a)4( )44(f)4(u)4(l)4(l)29(y)4( )44(d)4(e)14(v)27(e)4(l)4(o)4(p)4(e)4(d)4( )44(p)4(e)4(r)-9(s)4(o)4(n)4(,)4( )44(i)4(t)4( )44(i)4(s)4( )44(c)4(l)4(e)4(a)4(r)4( )44(t)4(h)4(a)29(t)4( )44(d)4(e)4(s)4(t)4(r)4(o)17(y)4(i)4(n)4(g)4( )44(e)4(m)4(b)4(r)-21(y)34(o)4(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3086 Tm
[(f)17(o)4(r)4( )-17(s)4(t)4(e)4(m)4( )-17(c)4(e)4(l)4(l)4( )-17(r)4(e)4(s)4(e)4(a)4(r)4(c)4(h)4( )-17(w)4(o)4(u)4(l)4(d)4( )-17(b)4(e)4( )-18(a)4( )-18(v)4(i)4(o)4(l)4(a)29(t)4(i)4(o)4(n)4( )-17(o)4(f)-24( )-17(t)4(h)4(e)4( )-17(f)4(u)4(n)4(d)4(a)4(m)4(e)4(n)4(t)4(a)4(l)4( )-17(d)4(u)4(t)4(y)4( )-17(n)4(o)4(t)4( )-17(t)4(o )]TJ
0 -1.169 TD
[(k)4(i)4(l)4(l)4(,)4( )-21(w)4(h)4(i)4(c)4(h)4( )-21(w)4(o)4(u)4(l)4(d)4( )-21(o)23(v)27(e)4(r)-9(r)4(i)4(d)4(e)4( )-21(o)4(u)4(r)4( )-21(d)4(u)4(t)4(y)4( )-21(t)4(o)4( )-21(p)4(r)4(o)23(v)4(i)4(d)4(e)4( )-21(m)4(e)4(d)4(i)4(c)4(a)4(l)]TJ
/Span<>> BDC
22.122 0 Td
( )Tj
EMC
0.271 0 Td
[(t)4(r)4(e)4(a)29(t)4(m)4(e)4(n)4(t)4(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 239.2476 Tm
[(T)1(h)1(e)1( )-145(s)1(e)1(c)1(o)1(n)1(d)1( )-145(m)1(o)1(r)-11(a)1(l)1( )-145(c)1(l)1(a)1(i)1(m)1( )-145(a)14(b)1(o)1(u)1(t)1( )-145(s)1(t)1(e)1(m)1( )-145(c)1(e)1(l)1(l)1(s)1( )-145(r)1(e)1(l)1(a)26(t)1(e)1(s)1( )-145(t)1(o)1( )-145(t)1(h)1(e)1( )-145(t)1(h)1(e)1(r)-11(a)1(p)1(e)1(u)1(t)1(i)1(c )]TJ
-1.5 -1.169 Td
[(p)1(r)1(o)1(m)1(i)1(s)1(e)1( )11(o)1(f)-27( )11(s)1(t)1(e)1(m)1( )11(c)1(e)1(l)1(l)1( )11(r)1(e)1(s)1(e)1(a)1(r)1(c)1(h)]TJ
/Span<>> BDC
11.751 0 Td
( )Tj
EMC
0.041 0 Td
(\227)Tj
/Span<>> BDC
0.999 0 Td
( )Tj
EMC
0.041 0 Td
[(t)1(h)1(e)1( )11(p)1(o)1(s)1(s)1(i)1(b)1(i)1(l)1(i)1(t)1(y)1( )11(o)1(f)-27( )11(r)1(e)1(l)1(i)1(e)11(v)1(i)1(n)1(g)1( )11(t)1(h)1(e)1( )11(s)1(u)1(f)1(f)1(e)1(r)1(i)1(n)1(g)1( )11(o)1(f)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1867 Tm
[(m)1(a)1(n)1(y)1( )-51(p)1(e)1(o)1(p)1(l)1(e)1( )-51(a)1(f)1(f)18(l)1(i)1(c)1(t)1(e)1(d)1( )-51(b)14(y)1( )-51(d)1(e)-9(g)1(e)1(n)1(e)1(r)-11(a)26(t)1(i)1(v)24(e)1( )-51(d)1(i)1(s)1(e)1(a)1(s)1(e)1(s)1( )-51(a)1(n)1(d)1( )-51(o)1(t)1(h)1(e)1(r)1( )-51(c)1(o)1(n)1(d)1(i)1(t)1(i)1(o)1(n)1(s)41(.)1( )-51(N)1(o)1(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1562 Tm
[(o)1(n)1(l)26(y)1( )79(d)1(o)1( )79(t)1(h)1(e)1( )79(m)1(e)1(d)1(i)1(c)1(a)1(l)1( )79(a)1(p)1(p)1(l)1(i)1(c)1(a)26(t)1(i)1(o)1(n)1(s)1( )78(o)1(f)-27( )78(s)1(t)1(e)1(m)1( )78(c)1(e)1(l)1(l)1(s)1( )79(o)1(f)1(f)1(e)1(r)1( )79(u)1(s)1( )79(c)1(o)1(n)1(s)1(i)1(d)1(e)1(r)-11(a)14(b)18(l)1(e)1( )79(p)1(o)1(t)1(e)1(n)1(t)1(i)1(a)1(l )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.1258 Tm
[(b)1(e)1(n)1(e)1(f)1(i)1(t)1(s)1( )24(i)1(n)1( )25(t)1(e)1(r)-21(m)1(s)1( )24(o)1(f)-27( )25(h)1(u)1(m)1(a)1(n)1( )25(h)1(e)1(a)1(l)1(t)1(h)1(,)1( )25(b)15(u)1(t)1( )24(m)1(a)1(n)1(y)1( )25(c)1(l)1(a)1(i)1(m)1( )25(t)1(h)1(a)26(t)1( )24(w)14(e)1( )24(a)1(r)1(e)1( )24(d)1(u)1(t)1(y)1(-)1(b)1(o)1(u)1(n)1(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.0953 Tm
[(t)1(o)1( )-48(p)1(u)1(r)-12(s)1(u)1(e)1( )-48(t)1(h)1(e)1( )-48(p)1(o)1(t)1(e)1(n)1(t)1(i)1(a)1(l)1( )-48(r)1(e)1(l)1(i)1(e)1(f)-27( )-48(o)1(f)-27( )-48(h)1(u)1(m)1(a)1(n)1( )-48(s)1(u)1(f)1(f)1(e)1(r)1(i)1(n)1(g)27(.)1( )-48(A)1(l)1(t)1(h)1(o)1(u)1(g)1(h)1( )-48(n)1(o)1(t)1( )-48(e)11(v)24(e)1(r)-24(y)31(o)1(n)1(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.0648 Tm
[(b)1(e)1(l)1(i)1(e)11(v)24(e)1(s)1( )-116(\223)1(t)1(h)1(e)1( )-116(c)1(o)1(n)1(s)1(e)1(r)-25(v)14(a)26(t)1(i)1(o)1(n)1( )-116(o)1(f)-27( )-116(h)1(e)1(a)1(l)1(t)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 244.3891 155.0648 Tm
[(h)-120(.)-120(.)-120(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 264.2849 155.0648 Tm
[(i)1(s)1( )-116(w)1(i)1(t)1(h)1(o)1(u)1(t)1( )-116(d)1(o)1(u)1(b)1(t)1( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 351.6737 155.0648 Tm
[(t)1(h)1(e)1( )-114(p)1(r)1(i)1(m)1(a)1(r)-40(y)1( )-114(g)1(o)1(o)1(d)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 431 155.0648 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0343 Tm
[(a)1(n)1(d)1( )-10(t)1(h)1(e)1( )-10(f)14(o)1(u)1(n)1(d)1(a)26(t)1(i)1(o)1(n)1( )-10(o)1(f)-27( )-10(a)1(l)1(l)1( )-10(o)1(t)1(h)1(e)1(r)1( )-10(g)11(o)1(o)1(d)1(s)1( )-10(o)1(f)-27( )-10(t)1(h)1(i)1(s)1( )-10(l)1(i)1(f)1(e)14(,)1(\224)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 312.2548 144.3344 Tm
(8)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 317.2448 141.0343 Tm
[( )-10(n)1(e)1(a)1(r)1(l)26(y)1( )-10(e)11(v)24(e)1(r)-24(y)31(o)1(n)1(e)1( )-10(w)1(o)1(u)1(l)1(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0039 Tm
[(a)15(g)-32(r)1(e)1(e)1( )-149(t)1(h)1(a)26(t)1( )-149(h)1(e)1(a)1(l)1(t)1(h)1( )-149(i)1(s)1( )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 176.661 127.0039 Tm
[(a)1( )-146(g)1(o)1(o)1(d)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 208.174 127.0039 Tm
[(.)1( )-149(S)1(o)1( )-149(t)1(h)1(e)1(r)1(e)1( )-149(i)1(s)1( )-149(l)1(i)1(t)1(t)1(l)1(e)1( )-149(d)1(i)1(s)1(p)1(u)1(t)1(e)1( )-149(t)1(h)1(a)26(t)1( )-149(t)1(h)1(e)1( )-149(p)1(o)1(t)1(e)1(n)1(t)1(i)1(a)1(l )]TJ
ET
Q
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<<
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37 0 obj
<<
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>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
1 1 1 rg
0 i
/RelativeColorimetric ri
/GS0 gs
72 126.004 360 557.996 re
f*
0 0 0 RG
1 w 4 M 0 j 0 J []0 d
/GS1 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/GS0 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 339.9863 80.9261 Tm
[(W)63(i)-5(n)-5(t)-5(e)-5(r)-5( )-30(2)-5(0)-5(1)-5(2)-5( )-30(~)-5( )-30(1)-5(0)-5(1)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 91.419 711.9261 Tm
[(A)-5(p)-5(p)8(e)-5(n)-5(d)-5(i)-5(x)-5( )-30(C)-5(:)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(a)-5(l)-5( )-30(C)-5(o)-5(n)-5(s)-5(i)-5(d)-5(e)-5(r)8(a)71(t)-5(i)-5(o)-5(n)-5(s)-5( )-30(R)-5(e)-5(g)33(a)-5(r)-5(d)-5(i)-5(n)-5(g)-5( )-30(S)-5(t)-5(e)-5(m)-5( )-30(C)-5(e)-5(l)-5(l)-5( )-30(R)-5(e)-5(s)-5(e)-5(a)-5(r)33(c)-5(h)]TJ
ET
1 1 1 rg
/GS0 gs
72 44.814 360 12.786 re
f*
0.565 w 10 M
/GS1 gs
236.933 46.995 m
340.078 46.995 l
S
0 0 0 rg
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
/RelativeColorimetric ri
/GS0 gs
72 126.002 360 557.998 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(h)1(e)1(a)1(l)1(t)1(h)1( )-117(b)1(e)1(n)1(e)1(f)1(i)1(t)1(s)1( )-117(o)1(f)-27( )-117(s)1(t)1(e)1(m)1( )-117(c)1(e)1(l)1(l)1( )-117(r)1(e)1(s)1(e)1(a)1(r)1(c)1(h)1( )-117(m)1(a)1(k)40(e)1( )-117(i)1(t)1(s)1( )-117(p)1(u)1(r)-12(s)1(u)1(i)1(t)1( )-117(a)1(n)1( )-117(i)1(m)1(p)1(o)1(r)-16(t)1(a)1(n)1(t)1( )-117(a)1(i)1(m )]TJ
0 -1.19 TD
[(t)1(h)1(a)26(t)1( )-24(o)1(u)1(g)1(h)1(t)1( )-24(t)1(o)1( )-24(b)1(e)1( )-24(c)1(a)1(r)-12(r)1(i)1(e)1(d)1( )-24(o)1(u)1(t)1( )-24(a)1(s)1( )-24(f)1(a)1(r)1( )-24(a)1(s)1( )-24(i)1(s)1( )-24(e)1(t)1(h)1(i)1(c)1(a)1(l)1(l)26(y)]TJ
/Span<>> BDC
19.573 0 Td
( )Tj
EMC
0.274 0 Td
[(p)1(e)1(r)-21(m)1(i)1(s)1(s)1(i)1(b)18(l)1(e)14(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 645.6326 Tm
[(T)10(h)10(e)10( )-61(t)10(h)10(i)10(r)10(d)10( )-61(i)10(m)10(p)10(o)10(r)-7(t)10(a)10(n)10(t)10( )-61(m)10(o)10(r)-2(a)10(l)10( )-61(c)10(l)10(a)10(i)10(m)10( )-61(a)23(b)10(o)10(u)10(t)10( )-61(s)10(t)10(e)10(m)10( )-61(c)10(e)10(l)10(l)10(s)10( )-61(h)10(a)10(s)10( )-61(t)10(o)10( )-61(d)10(o)10( )-61(w)10(i)10(t)10(h)10( )-61(h)10(o)23(w )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 631.3529 Tm
[(s)10(t)10(u)10(d)23(y)10(i)10(n)10(g)10( )40(t)10(h)10(e)10(m)10( )40(c)10(a)10(n)10( )40(c)10(o)10(n)10(t)10(r)10(i)10(b)24(u)10(t)10(e)10( )40(t)10(o)10( )40(o)10(u)10(r)10( )40(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )40(o)10(f)-18( )40(b)10(i)10(o)10(l)10(o)23(g)-30(y)123(.)10( )40(B)10(e)10(y)40(o)10(n)10(d)10( )40(t)10(h)10(e)10( )40(f)23(o)10(r)10(e)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 631.3529 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 617.0732 Tm
[(s)10(e)10(e)10(a)23(b)27(l)10(e)10( )-61(m)10(e)10(d)10(i)10(c)10(a)10(l)10( )-61(b)10(e)10(n)10(e)10(f)10(i)10(t)10(s)10( )-61(t)10(h)10(a)35(t)10( )-60(m)10(a)39(y)10( )-61(c)10(o)10(m)10(e)10( )-60(f)10(r)10(o)10(m)10( )-61(s)10(t)10(e)10(m)10( )-60(c)10(e)10(l)10(l)10( )-61(t)10(h)10(e)10(r)-2(a)10(p)10(i)10(e)10(s)50(,)10( )-61(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)10(i)10(c )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 602.7935 Tm
[(a)10(d)10(v)23(a)10(n)10(c)10(e)10(s)10( )-104(m)10(a)10(d)10(e)10( )-104(p)10(o)10(s)10(s)10(i)10(b)27(l)10(e)10( )-104(b)23(y)10( )-104(s)10(t)10(e)10(m)10( )-104(c)10(e)10(l)10(l)10( )-104(r)10(e)10(s)10(e)10(a)10(r)10(c)10(h)10( )-104(m)10(a)39(y)10( )-104(s)10(o)10(m)10(e)10(d)10(a)39(y)10( )-104(a)10(l)10(l)10(o)23(w)10( )-104(f)23(o)10(r)10( )-104(a)10(s)10(-)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 588.5137 Tm
[(y)42(e)10(t)10(-)10(u)10(n)10(f)23(o)10(r)10(e)10(s)10(e)10(e)10(n)10( )5(t)10(e)10(c)10(h)10(n)10(o)10(l)10(o)23(g)10(i)10(c)10(a)10(l)10( )5(a)10(n)10(d)10( )5(m)10(e)10(d)10(i)10(c)10(a)10(l)10( )5(b)10(r)10(e)10(a)10(k)10(t)10(h)10(r)10(o)10(u)10(g)10(h)10(s)50(.)10( )5(F)10(u)10(r)-7(t)10(h)10(e)10(r)-12(m)10(o)10(r)10(e)23(,)10( )5(t)10(h)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 574.234 Tm
[(p)10(u)10(r)-3(s)10(u)10(i)10(t)10( )-88(o)10(f)-18( )-88(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)10(i)10(c)10( )-88(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )-88(i)10(s)10( )-88(o)10(f)10(t)10(e)10(n)10( )-88(h)10(e)10(l)10(d)10( )-88(t)10(o)10( )-88(b)10(e)10( )-88(a)10( )-88(v)23(a)10(l)10(u)10(a)23(b)27(l)10(e)10( )-88(u)10(n)10(d)10(e)10(r)-7(t)10(a)10(k)10(i)10(n)10(g )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 559.9543 Tm
[(t)10(h)10(a)35(t)10( )35(w)23(e)10( )35(s)10(h)10(o)10(u)10(l)10(d)10( )35(e)10(n)10(c)10(o)10(u)10(r)-2(a)24(g)10(e)10( )35(f)23(o)10(r)10( )35(i)10(t)10(s)10( )35(o)23(w)10(n)10( )35(s)10(a)10(k)49(e)23(.)10( )35(S)10(i)10(m)10(i)10(l)10(a)10(r)10(l)35(y)131(,)10( )35(t)10(h)10(e)10( )35(f)10(r)10(e)10(e)10(d)10(o)10(m)10( )35(o)10(f)-18( )35(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 559.9543 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 545.6746 Tm
[(i)10(c)10( )-15(i)10(n)10(q)10(u)10(i)10(r)-15(y)10( )-16(i)10(s)10( )-15(a)10( )-15(w)10(i)10(d)10(e)10(l)35(y)10( )-16(h)10(e)10(l)10(d)10( )-16(p)10(r)10(i)10(n)10(c)10(i)10(p)10(l)10(e)10( )-16(t)10(h)10(a)35(t)10( )-15(o)10(u)10(g)10(h)10(t)10( )-16(n)10(o)10(t)10( )-16(t)10(o)10( )-15(b)10(e)10( )-15(c)10(o)10(n)10(s)10(t)10(r)-2(a)10(i)10(n)10(e)10(d)10( )-15(i)10(n)10( )-16(t)10(h)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 531.3948 Tm
[(a)23(b)10(s)10(e)10(n)10(c)10(e)10( )-2(o)10(f)-18( )-2(o)29(v)33(e)10(r)-3(r)10(i)10(d)10(i)10(n)10(g)10( )-2(e)10(t)10(h)10(i)10(c)10(a)10(l)10( )-2(c)10(o)10(n)10(c)10(e)10(r)-30(n)10(s)50(.)10( )-2(B)10(u)10(t)10( )-2(w)23(e)10( )-2(m)10(u)10(s)10(t)10( )-2(a)10(l)10(s)10(o)10( )-2(b)10(e)10(a)10(r)10( )-2(i)10(n)10( )-2(m)10(i)10(n)10(d)10( )-2(t)10(h)10(a)35(t)10(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 517.1151 Tm
[(w)10(h)10(i)10(l)10(e)10( )12(a)10(d)10(v)23(a)10(n)10(c)10(i)10(n)10(g)10( )12(o)10(u)10(r)10( )12(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)10(i)10(c)10( )12(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )12(o)10(f)-18( )12(b)10(i)10(o)10(l)10(o)23(g)-30(y)10( )12(i)10(s)10( )12(a)10( )12(v)23(a)10(l)10(u)10(a)23(b)27(l)10(e)10( )12(u)10(n)10(d)10(e)10(r)-7(t)10(a)10(k)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 517.1151 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 502.8354 Tm
[(i)10(n)10(g)36(,)10( )-144(t)10(h)10(e)10( )-144(p)10(o)23(w)23(e)10(r)10( )-144(t)10(h)10(i)10(s)10( )-144(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )-144(o)10(f)-18( )-144(b)10(i)10(o)10(l)10(o)23(g)10(i)10(c)10(a)10(l)10( )-144(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10( )-144(g)-23(r)-2(a)10(n)10(t)10(s)10( )-144(u)10(s)10( )-144(m)10(a)39(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 488.5557 Tm
[(b)10(e)10( )-74(f)10(r)-2(a)10(u)10(g)10(h)10(t)10( )-74(w)10(i)10(t)10(h)10( )-74(n)10(e)20(w)10( )-74(e)10(t)10(h)10(i)10(c)10(a)10(l)10( )-74(d)10(a)10(n)10(g)10(e)10(r)-3(s)10( )-74(a)10(s)10( )-74(w)23(e)10(l)10(l)10(.)10( )-74(K)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )-74(g)32(a)10(i)10(n)10(e)10(d)10( )-74(t)10(o)10(d)10(a)39(y)10( )-74(f)23(o)10(r )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 474.2759 Tm
[(t)10(h)10(e)10( )-29(g)20(o)10(a)10(l)10( )-29(o)10(f)-18( )-29(r)10(e)10(l)10(i)10(e)20(v)10(i)10(n)10(g)10( )-29(s)10(u)10(f)10(f)10(e)10(r)10(i)10(n)10(g)36(,)10( )-29(o)10(r)10( )-29(o)10(f)-18( )-29(a)30(v)47(o)10(i)10(d)10(i)10(n)10(g)10( )-29(t)10(h)10(e)10( )-29(t)10(e)10(c)10(h)10(n)10(i)10(c)10(a)10(l)10( )-29(n)10(e)10(e)10(d)10( )-29(t)10(o)10( )-29(d)10(e)10(s)10(t)10(r)10(o)23(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 459.9962 Tm
[(e)10(m)10(b)10(r)-15(y)40(o)10(s)50(,)10( )-177(m)10(a)39(y)10( )-177(b)10(e)10( )-177(u)10(s)10(e)10(d)10( )-177(i)10(n)10( )-177(t)10(h)10(e)10( )-177(f)10(u)10(t)10(u)10(r)10(e)10( )-177(f)23(o)10(r)10( )-177(e)10(t)10(h)10(i)10(c)10(a)10(l)10(l)35(y)10( )-177(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10(a)23(b)27(l)10(e)10( )-177(p)10(u)10(r)-3(p)10(o)10(s)10(e)10(s)50(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 445.7165 Tm
[(s)10(u)10(c)10(h)10( )-76(a)10(s)10( )-76(p)10(r)10(o)10(j)10(e)10(c)10(t)10(s)10( )-76(o)10(f)-18( )-76(h)10(u)10(m)10(a)10(n)10( )-76(\223)10(e)10(n)10(h)10(a)10(n)10(c)10(e)10(m)10(e)10(n)10(t)10(.)10(\224)-3( )-76(I)10(n)10( )-76(t)10(h)10(i)10(s)10( )-76(r)10(e)10(s)10(p)10(e)10(c)10(t)10(,)10( )-76(o)10(u)10(r)10( )-76(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 431.4367 Tm
[(o)10(f)-18( )-171(n)10(a)35(t)10(u)10(r)10(e)10( )-171(c)10(a)10(n)10( )-171(n)10(e)20(v)33(e)10(r)10( )-171(b)10(e)10( )-171(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10(e)10(d)10( )-171(i)10(n)10(e)10(r)-7(t)10(,)10( )-171(n)10(e)10(u)10(t)10(r)-2(a)10(l)10(,)10( )-171(o)10(r)10( )-171(m)10(e)10(r)10(e)10(l)35(y)10( )-171(i)10(n)10(t)10(r)10(i)10(n)10(s)10(i)10(c)10(a)10(l)10(l)35(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 417.157 Tm
[(v)23(a)10(l)10(u)10(a)23(b)27(l)10(e)23(,)10( )-29(a)10(s)10( )-29(i)10(t)10( )-29(a)10(l)50(w)10(a)39(y)10(s)10( )-29(b)10(e)10(a)10(r)-3(s)10( )-29(o)10(n)10( )-29(h)10(u)10(m)10(a)10(n)10( )-29(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10(s)10( )-29(a)10(n)10(d)10( )-29(p)10(u)10(r)-3(s)10(u)10(i)10(t)10(s)50(,)10( )-29(a)10(n)10(d)10(,)10( )-29(w)10(i)10(t)10(h)10(o)10(u)10(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 402.8772 Tm
[(p)10(r)10(o)10(p)10(e)10(r)10( )-15(g)10(u)10(i)10(d)10(a)10(n)10(c)10(e)23(,)10( )-15(h)10(a)10(s)10( )-15(a)10(s)10( )-15(m)10(u)10(c)10(h)10( )-15(p)10(o)10(t)10(e)10(n)10(t)10(i)10(a)10(l)10( )-15(t)10(o)10( )-15(d)10(eg)-23(r)-2(a)10(d)10(e)10( )-15(a)10(s)10( )-15(t)10(o)10( )-15(e)10(l)10(e)20(v)23(a)35(t)10(e)10( )-15(u)10(s)50(.)]TJ
ET
BT
/T1_3 1 Tf
14 0 0 14 119.5651 374.7975 Tm
[(S)-5(o)-5(u)-5(r)-5(c)-5(e)-5(s)-5( )-31(o)-5(f)-33( )-32(S)-5(t)-5(e)-5(m)-5( )-32(C)-5(e)-5(l)-5(l)-5(s)-5(:)-5( )-32(A)-5(n)-5( )-32(E)-5(t)-5(h)-5(i)-5(c)-5(a)-5(l)-5( )-32(A)-5(n)-5(a)-5(l)14(y)-5(s)-5(i)-5(s)]TJ
ET
BT
/T1_2 1 Tf
16 0 0 16 73 355.4778 Tm
(I)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 79 355.4778 Tm
[(n )-201(the )-201(f)13(ollo)13(wing )-201(section, )-201(w)13(e )-201(e)-23(xamine )-201(the )-201(ethical )-201(implica)25(tions )-201(of)-28( )-201(each )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 341.198 Tm
[(of)-28( )-200(the )-200(techniques )-200(f)13(or )-200(obtaining )-200(stem )-200(cells)40(. )-200(Some )-200(techniques )-200(are )-200(more )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 326.9183 Tm
[(prob)17(lema)25(tic )-40(than )-40(other)-13(s)40(. )-40(These )-40(ethical )-40(consider)-12(a)25(tions )-40(should )-40(bear )-40(on )-40(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 312.6385 Tm
[(actions )-25(of)-28( )-25(scientists )-25(and )-25(the )-25(decisions )-25(of)-28( )-25(policymak)39(er)-13(s)40(.)]TJ
ET
BT
/T1_4 1 Tf
12 0 0 12 73 284.0791 Tm
[(Adult )23(Stem )23(Cells)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 156.0762 284.0791 Tm
[(. )21(There )21(are )21(a )21(number )21(of)-28( )21(types )21(of)-28( )21(adult )21(stem )21(cells )21(tha)25(t )21(can )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 269.7993 Tm
[(be )-1(procured )-1(from )-1(living)26(, )-1(or )-1(recentl)25(y )-1(deceased, )-1(children )-1(or )-1(adults )-1(and )-1(used )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 255.5196 Tm
[(f)13(or )-218(ther)-12(apeutic )-218(pur)-13(poses)40(. )-218(This )-218(procedure )-218(is )-218(rela)25(tiv)23(el)25(y )-218(uncontro)19(v)23(er)-13(sial, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 241.2399 Tm
[(and )-39(has )-39(been )-39(car)-13(ried )-39(out )-39(f)13(or )-39(decades )-39(f)13(or )-39(a )-39(v)13(ariety )-39(of)-28( )-39(pur)-13(poses)40(. )-39(Acquiring )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 226.9601 Tm
[(adult )34(stem )34(cells )34(from )34(donor)-13(s )34(does )34(r)-12(aise )34(such )34(ethical )34(issues )34(as )34(proper )34(donor )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 212.6804 Tm
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ET
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[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
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ET
BT
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[(E)14(m)14(b)14(r)-11(y)39(o)14(s)14( )-185(f)14(r)27(o)14(m)14( )-184(I)14(V)14(F)14( )-184(C)14(l)14(i)14(n)14(i)14(c)14(s)14(.)]TJ
ET
BT
/T1_2 1 Tf
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[( )-169(T)14(h)14(e)14( )-169(s)14(t)14(a)14(n)14(d)14(a)14(r)14(d)14( )-169(m)14(e)14(t)14(h)14(o)14(d)14( )-169(o)14(f)-14( )-169(o)14(b)14(t)14(a)14(i)14(n)14(i)14(n)14(g)14( )-169(E)14(S)14( )-169(c)14(e)14(l)14(l)14(s )]TJ
ET
BT
/T1_2 1 Tf
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[(i)14(n)27(v)51(o)14(l)14(v)37(e)14(s)14( )-40(u)14(s)14(i)14(n)14(g)14( )-40(c)14(e)14(l)14(l)14(s)14( )-40(e)-9(x)14(t)14(r)2(a)14(c)14(t)14(e)14(d)14( )-40(f)14(r)14(o)14(m)14( )-40(t)14(h)14(e)14( )-40(n)14(u)14(m)14(e)14(r)14(o)14(u)14(s)14( )-40(e)14(m)14(b)14(r)-11(y)44(o)14(s)14( )-40(t)14(h)14(a)39(t)14( )-40(a)14(r)14(e)14( )-40(c)14(r)14(e)14(a)39(t)14(e)14(d )]TJ
ET
BT
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[(d)14(u)14(r)14(i)14(n)14(g)14( )34(I)14(V)14(F)14( )34(t)14(h)14(a)39(t)14( )34(a)14(r)14(e)14( )34(n)14(o)14(t)14( )34(i)14(m)14(p)14(l)14(a)14(n)14(t)14(e)14(d)14( )34(a)14(n)14(d)14( )34(a)14(r)14(e)14( )34(s)14(u)14(b)14(s)14(e)14(q)14(u)14(e)14(n)14(t)14(l)39(y)14( )34(f)14(r)14(o)14(z)14(e)14(n)14( )34(o)14(r)14( )34(d)14(i)14(s)14(c)14(a)14(r)14(d)14(e)14(d)14(. )]TJ
ET
BT
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ET
BT
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ET
BT
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ET
BT
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[(b)14(e)14(i)14(n)14(g)14(s)54(.)14( )47(E)14(v)37(e)14(n)14( )47(f)27(o)14(r)14( )47(t)14(h)14(o)14(s)14(e)14( )47(w)14(h)14(o)14( )47(a)14(c)14(c)14(o)14(r)14(d)14( )47(t)14(h)14(e)14( )47(e)14(m)14(b)14(r)-11(y)44(o)14( )47(m)14(o)14(r)14(e)14( )47(l)14(i)14(m)14(i)14(t)14(e)14(d)14( )47(m)14(o)14(r)2(a)14(l)14( )47(s)14(t)14(a)39(t)14(u)14(s)54(,)14( )47(t)14(h)14(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8875 Tm
[(l)14(a)14(r)14(g)14(e)14(-)14(s)14(c)14(a)14(l)14(e)14( )-74(d)14(e)14(s)14(t)14(r)1(u)14(c)14(t)14(i)14(o)14(n)14( )-74(o)14(f)-14( )-74(e)14(m)14(b)14(r)-11(y)44(o)14(s)14( )-74(f)27(o)14(r)14( )-74(r)14(e)14(s)14(e)14(a)14(r)14(c)14(h)14( )-74(p)14(u)14(r)1(p)14(o)14(s)14(e)14(s)14( )-74(m)14(a)43(y)14( )-74(s)14(e)14(e)14(m)14( )-74(u)14(n)14(s)14(e)14(t)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 533.8875 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.857 Tm
[(t)14(l)14(i)14(n)14(g)40(.)14( )-82(F)14(u)14(r)-3(t)14(h)14(e)14(r)-8(m)14(o)14(r)14(e)27(,)14( )-82(o)14(b)14(t)14(a)14(i)14(n)14(i)14(n)14(g)14( )-82(i)14(n)14(f)27(o)14(r)-8(m)14(e)14(d)14( )-82(c)14(o)14(n)14(s)14(e)14(n)14(t)14( )-82(f)14(r)14(o)14(m)14( )-82(t)14(h)14(e)14( )-82(I)14(V)14(F)14( )-82(p)14(a)39(t)14(i)14(e)14(n)14(t)14(s)14( )-82(f)27(o)14(r )]TJ
ET
BT
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[(w)14(h)14(o)14(m)14( )-11(t)14(h)14(e)14( )-11(e)14(m)14(b)14(r)-11(y)44(o)14(s)14( )-11(w)27(e)14(r)14(e)14( )-11(c)14(r)14(e)14(a)39(t)14(e)14(d)14( )-11(r)14(e)1(p)14(r)14(e)14(s)14(e)14(n)14(t)14(s)14( )-11(a)14(n)14( )-11(i)14(m)14(p)14(o)14(r)-3(t)14(a)14(n)14(t)14( )-11(e)14(t)14(h)14(i)14(c)14(a)14(l)14( )-11(c)14(o)14(n)14(c)14(e)14(r)-26(n)14(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 491.7961 Tm
[(IVF )-95(pa)25(tients )-95(who )-95(ha)20(v)23(e )-95(had )-95(embr)-25(y)30(os )-95(crea)25(ted )-95(on )-95(their )-95(behalf, )-95(usuall)25(y )]TJ
ET
BT
/T1_2 1 Tf
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[(from their o)13(wn se)-23(x cells)40(, must face the difficult decision of)-28( the disposition )]TJ
ET
BT
/T1_2 1 Tf
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[(of)-28( )24(the )25(unused )24(embr)-25(y)30(os )24(crea)25(ted )24(during )25(their )24(IVF )25(trea)25(tment. )25(Some )24(ethicists )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7047 Tm
[(and )-132(scientists )-132(ha)20(v)23(e )-132(argued )-132(tha)25(t )-132(because )-132(these )-132(embr)-25(y)30(os )-132(are )-132(g)10(oing )-132(to )-132(be )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6742 Tm
[(discarded )9(in )9(any )9(e)10(v)23(ent, )9(it )9(would )9(mak)39(e )9(pr)-12(actical )9(and )9(ethical )9(sense )9(to )9(deriv)23(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6437 Tm
[(some )-101(benefit )-101(from )-101(them )-101(b)13(y )-101(using )-101(them )-101(f)13(or )-101(medical )-101(research )-101(or )-101(ther)-12(ap)26(y)113(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6133 Tm
[(Other)-13(s )-100(argue )-100(tha)25(t )-100(these )-100(smallest )-100(human )-100(org)22(anisms )-100(deser)-26(v)23(e )-100(respect )-100(and )]TJ
ET
BT
/T1_2 1 Tf
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[(protection, )-163(and )-163(there )-163(are )-163(pro)13(g)-33(r)-12(ams )-163(to )-163(assist )-163(parents )-163(in )-163(dona)25(ting )-163(their )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 379.5523 Tm
[(unused )-25(IVF )-25(embr)-25(y)30(os )-25(to )-25(other )-25(couples)40(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 260.5936 382.8523 Tm
(9)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 365.5219 Tm
[(Some )-195(IVF )-195(embr)-25(y)30(os )-195(g)10(o )-195(unused )-195(not )-195(because )-195(they )-195(are )-195(\223sur)-13(plus\224)-13( )-195(b)14(ut )]TJ
ET
BT
/T1_2 1 Tf
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[(because )-54(they )-54(are )-54(deemed )-54(to )-54(be )-54(in )-54(some )-54(wa)29(y )-54(deficient. )-54(A )-54(technique )-54(called )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4609 Tm
[(preimplanta)25(tion )39(genetic )39(dia)14(gnosis )39(\(PGD\) )39(is )39(car)-13(ried )39(out )39(b)13(y )39(some )39(IVF )39(pr)-12(ac)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 337.4609 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
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[(titioner)-13(s )-29(to )-29(test )-29(embr)-25(y)30(os )-29(f)13(or )-29(genetic )-29(conditions )-29(prior )-29(to )-29(implanting )-29(them )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.4 Tm
[(in )-156(the )-156(pa)25(tient\222s )-156(uter)-13(us)40(. )-156(Embr)-25(y)30(os )-156(tha)25(t )-156(are )-156(f)13(ound )-156(to )-156(ha)20(v)23(e )-156(genetic )-156(condi)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 309.4 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3695 Tm
[(tions )-15(tha)25(t )-15(might )-15(reduce )-15(their )-15(via)13(bility )-15(or )-15(cause )-15(them )-15(to )-15(ha)20(v)23(e )-15(an )-15(increased )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3391 Tm
[(susce)-13(ptibility )-45(to )-46(genetic )-45(diseases )-45(are )-45(not )-46(implanted; )-45(they )-46(are )-45(re)-10(g)22(arded )-45(as )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3086 Tm
[(defectiv)23(e )-112(and )-111(are )-111(gener)-12(all)25(y )-112(discarded.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 260.7867 270.6086 Tm
(10)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 270.7867 267.3086 Tm
[( )-111(Although )-111(it )-112(is )-111(unlik)39(el)25(y )-111(tha)25(t )-111(ES )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 253.2781 Tm
[(cells )-128(deriv)23(ed )-128(from )-128(embr)-25(y)30(os )-129(with )-128(genetic )-128(a)13(bnor)-22(malities )-128(would )-128(be )-128(useful )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2476 Tm
[(in )-14(ther)-12(apies)40(, )-14(they )-14(are )-14(considered )-14(useful )-14(f)13(or )-14(the )-14(stud)13(y )-14(of)-28( )-14(genetic )-14(disorder)-13(s)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 225.2172 Tm
[(which )-25(is )-25(one )-25(of)-28( )-25(the )-25(major )-25(medical )-25(applica)25(tions )-25(of)-28( )-25(stem )-25(cell )-25(research.)]TJ
ET
BT
/T1_2 1 Tf
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(11)Tj
ET
BT
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[(Non-Destr)-12(uctiv)25(e )-50(Embr)-25(y)25(o )-50(Cell )-50(Extr)25(action)]TJ
ET
BT
/T1_2 1 Tf
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(. )Tj
ET
BT
/T1_2 1 Tf
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[(It )-46(is )-46(possib)17(le )-46(to )-46(e)-23(xtr)-12(act )-46(from )]TJ
ET
BT
/T1_2 1 Tf
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[(an )-5(earl)25(y )-5(sta)14(ge )-5(of)-28( )-5(the )-5(embr)-25(y)30(o )-5(a )-5(single )-5(cell )-5(\(b)17(lastomere\), )-5(or )-5(a )-5(small )-5(number )]TJ
ET
BT
/T1_2 1 Tf
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[(of)-28( )-140(cells)40(, )-140(which )-140(ma)29(y )-140(be )-140(a)13(b)17(le )-140(to )-140(gener)-12(a)25(te )-140(a )-140(line )-140(of)-28( )-140(embr)-25(y)30(onic )-140(stem )-140(cells)40(. )]TJ
ET
BT
/T1_2 1 Tf
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[(Bey)30(ond )-49(the )-49(questions )-49(rela)25(ted )-49(to )-49(the )-49(feasibility )-49(of)-28( )-49(deriving )-49(stem )-49(cell )-49(lines )]TJ
ET
BT
/T1_2 1 Tf
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[(from )-14(one )-14(or )-14(a )-14(v)23(er)-25(y )-14(small )-14(number )-14(of)-28( )-14(biopsied )-14(cells)40(,)]TJ
ET
BT
/T1_2 1 Tf
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(12)Tj
ET
BT
/T1_2 1 Tf
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[( )-14(the )-14(ethical )-14(questions )]TJ
ET
BT
/T1_2 1 Tf
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[(rela)25(ted )-49(to )-49(this )-49(technique )-49(primaril)25(y )-49(concer)-40(n )-49(its )-49(effect )-49(on )-49(the )-49(health )-49(of)-28( )-49(the )]TJ
ET
Q
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q
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q
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f*
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S
72 701.5 m
432 701.5 l
S
/GS0 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 339.9863 80.9261 Tm
[(W)63(i)-5(n)-5(t)-5(e)-5(r)-5( )-30(2)-5(0)-5(1)-5(2)-5( )-30(~)-5( )-30(1)-5(0)-5(3)]TJ
ET
BT
/T1_0 1 Tf
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[(A)-5(p)-5(p)8(e)-5(n)-5(d)-5(i)-5(x)-5( )-30(C)-5(:)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(a)-5(l)-5( )-30(C)-5(o)-5(n)-5(s)-5(i)-5(d)-5(e)-5(r)8(a)71(t)-5(i)-5(o)-5(n)-5(s)-5( )-30(R)-5(e)-5(g)33(a)-5(r)-5(d)-5(i)-5(n)-5(g)-5( )-30(S)-5(t)-5(e)-5(m)-5( )-30(C)-5(e)-5(l)-5(l)-5( )-30(R)-5(e)-5(s)-5(e)-5(a)-5(r)33(c)-5(h)]TJ
ET
1 1 1 rg
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72 44.814 360 12.786 re
f*
0.565 w 10 M
/GS1 gs
236.933 46.995 m
340.078 46.995 l
S
0 0 0 rg
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
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/GS0 gs
72 126.002 360 557.998 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(embr)-25(y)30(o )-23(and )-23(the )-23(possib)17(le )-23(long-ter)-22(m )-23(health )-23(effects )-23(of)-28( )-23(the )-23(procedure )-23(on )-23(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(de)10(v)23(eloping )-75(child. )-75(W)-18(hile )-75(embr)-25(y)30(o )-75(biopsy )-75(f)13(or )-75(PGD )-75(is )-75(a )-75(rela)25(tiv)23(el)25(y )-75(common )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.131 Tm
[(pr)-12(actice )-89(in )-89(IVF )-89(clinics)40(, )-89(embr)-25(y)30(os )-89(biopsied )-89(f)13(or )-89(PGD )-89(tend )-89(to )-89(ha)20(v)23(e )-89(a )-89(lo)13(w)13(er )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1005 Tm
[(r)-12(a)25(te )-96(of)-28( )-96(implanta)25(tion )-96(than )-96(ordinar)-25(y )-96(IVF )-96(embr)-25(y)30(os)40(,)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 317.3156 635.4005 Tm
(13)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 327.3156 632.1005 Tm
[( )-96(which )-96(sug)10(gests )-96(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.07 Tm
[(the )-84(procedure )-84(has )-84(a )-84(risk )-84(of)-28( )-84(killing )-84(the )-84(embr)-25(y)30(o)34(. )-84(Fur)-17(ther)-22(more)13(, )-84(the )-84(proce)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 618.07 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0395 Tm
[(dure )-147(increases )-147(the )-147(risk )-147(of)-28( )-147(complica)25(tions)40(, )-147(including )-147(infant )-147(mor)-17(tality)121(, )-147(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 590.009 Tm
[(twins )-123(and )-123(triplets)40(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 164.2285 593.309 Tm
(14)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 174.2285 590.009 Tm
[( )-123(Additionall)25(y)121(, )-123(the )-123(procedure )-123(has )-123(onl)25(y )-123(been )-123(used )-123(on )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.9785 Tm
[(human )-16(beings )-16(f)13(or )-16(just )-16(o)19(v)23(er )-16(tw)13(enty )-16(y)32(ear)-13(s)40(, )-16(so )-16(long-ter)-22(m )-16(da)25(ta )-16(on )-16(the )-16(health )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9479 Tm
[(consequences )-25(of)-28( )-25(embr)-25(y)30(o )-25(biopsy )-25(are )-25(not )-25(a)20(v)13(aila)13(b)17(le)13(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 312.937 565.2479 Tm
(15)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 91 547.9174 Tm
[(E)5(v)28(e)5(n)5( )-72(i)5(n)5( )-72(c)5(a)5(s)5(e)5(s)5( )-72(w)5(h)5(e)5(r)5(e)5( )-72(e)5(m)5(b)5(r)-20(y)35(o)5( )-72(b)5(i)5(o)5(p)5(s)5(y)5( )-72(d)5(o)5(e)5(s)5( )-72(n)5(o)5(t)5( )-72(r)5(e)5(s)5(u)5(l)5(t)5( )-72(i)5(n)5( )-72(a)5(n)5(y)5( )-72(n)5(o)5(t)5(i)5(c)5(e)5(a)18(b)22(l)5(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8868 Tm
[(h)5(a)5(r)-17(m)5( )-143(t)5(o)5( )-143(t)5(h)5(e)5( )-143(e)5(m)5(b)5(r)-20(y)35(o)39(,)5( )-143(t)5(h)5(e)5( )-143(p)5(r)5(o)5(c)5(e)5(d)5(u)5(r)5(e)5( )-143(r)-7(a)5(i)5(s)5(e)5(s)5( )-143(e)5(t)5(h)5(i)5(c)5(a)5(l)5( )-143(i)5(s)5(s)5(u)5(e)5(s)5( )-143(c)5(o)5(n)5(c)5(e)5(r)-35(n)5(i)5(n)5(g)5( )-143(t)5(h)5(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.8563 Tm
[(t)5(r)5(e)5(a)30(t)5(m)5(e)5(n)5(t)5( )18(o)5(f)-23( )18(e)5(m)5(b)5(r)-20(y)35(o)5(s)5( )19(a)5(s)5( )19(a)5( )18(m)5(e)5(a)5(n)5(s)5( )19(t)5(o)5( )19(a)5(n)5(o)5(t)5(h)5(e)5(r)5(\222)5(s)5( )19(e)5(n)5(d)5(s)45(.)5( )19(E)5(v)28(e)5(n)5( )19(i)5(f)-23( )19(n)5(o)5( )19(h)5(a)5(r)-17(m)5( )18(c)5(o)5(m)5(e)5(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 505.8258 Tm
[(t)5(o)5( )43(t)5(h)5(e)5( )43(e)5(m)5(b)5(r)-20(y)35(o)39(,)5( )43(i)5(t)5( )43(i)5(s)5( )43(u)5(n)5(j)5(u)5(s)5(t)5( )43(t)5(o)5( )43(u)5(s)5(e)5( )43(h)5(u)5(m)5(a)5(n)5( )43(b)5(e)5(i)5(n)5(g)5(s)5( )43(f)18(o)5(r)5( )43(p)5(u)5(r)-8(p)5(o)5(s)5(e)5(s)5( )43(o)5(f)-23( )43(n)5(o)5( )43(b)5(e)5(n)5(e)5(f)5(i)5(t)5( )43(t)5(o )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 491.7953 Tm
[(t)5(h)5(e)5(m)5( )-41(w)5(i)5(t)5(h)5(o)5(u)5(t)5( )-41(t)5(h)5(e)5(i)5(r)5( )-41(c)5(o)5(n)5(s)5(e)5(n)5(t)5( )-41(\()5(c)5(o)5(n)5(s)5(e)5(n)5(t)5( )-41(w)5(h)5(i)5(c)5(h)5(,)5( )-41(o)5(f)-23( )-41(c)5(o)5(u)5(r)-8(s)5(e)18(,)5( )-41(t)5(h)5(e)5( )-41(e)5(m)5(b)5(r)-20(y)35(o)5( )-41(c)5(a)5(n)5(n)5(o)5(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 477.7648 Tm
[(g)5(i)5(v)28(e)5(\))5(.)5( )-71(I)5(t)5( )-71(m)5(a)34(y)5( )-71(b)5(e)5( )-71(a)5(r)5(g)5(u)5(e)5(d)5(,)5( )-71(h)5(o)18(w)18(e)15(v)28(e)5(r)71(,)5( )-71(t)5(h)5(a)30(t)5( )-71(t)5(h)5(i)5(s)5( )-71(p)5(r)5(o)5(c)5(e)5(d)5(u)5(r)5(e)5( )-71(c)5(o)5(u)5(l)5(d)5( )-71(h)5(a)25(v)28(e)5( )-71(b)5(e)5(n)5(e)5(f)5(i)5(t)5(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7343 Tm
[(f)18(o)5(r)5( )32(t)5(h)5(e)5( )32(f)5(u)5(t)5(u)5(r)5(e)5( )32(c)5(h)5(i)5(l)5(d)5( )32(i)5(n)5( )32(t)5(h)5(e)5( )32(f)18(o)5(r)-17(m)5( )32(o)5(f)-23( )32(a)5( )32(l)5(i)5(n)5(e)5( )32(o)5(f)-23( )32(i)5(m)5(m)5(u)5(n)5(o)5(l)5(o)18(g)5(i)5(c)5(a)5(l)5(l)30(y)5( )32(c)5(o)5(m)5(p)5(a)30(t)5(i)5(b)22(l)5(e)5( )32(p)5(l)5(u)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 463.7343 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7037 Tm
[(r)5(i)5(p)5(o)5(t)5(e)5(n)5(t)5( )8(s)5(t)5(e)5(m)5( )8(c)5(e)5(l)5(l)5(s)5( )8(t)5(h)5(a)30(t)5( )8(m)5(a)34(y)5( )8(b)5(e)5( )8(u)5(s)5(e)5(f)5(u)5(l)5( )8(f)18(o)5(r)5( )8(f)5(u)5(t)5(u)5(r)5(e)5( )8(c)5(e)5(l)5(l)5( )8(t)5(h)5(e)5(r)-7(a)5(p)31(y)118(.)5( )8(H)5(o)18(w)18(e)15(v)28(e)5(r)71(,)5( )8(i)5(t)5( )8(i)5(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6732 Tm
[(p)5(o)5(s)5(s)5(i)5(b)22(l)5(e)5( )-2(t)5(o)5( )-2(o)5(b)5(t)5(a)5(i)5(n)5( )-2(g)5(e)5(n)5(e)5(t)5(i)5(c)5(a)5(l)5(l)30(y)5( )-2(m)5(a)30(t)5(c)5(h)5(e)5(d)5( )-2(s)5(t)5(e)5(m)5( )-2(c)5(e)5(l)5(l)5(s)5( )-2(f)18(o)5(r)5( )-2(a)5( )-2(n)5(e)15(w)5(b)5(o)5(r)-35(n)5( )-2(c)5(h)5(i)5(l)5(d)5( )-2(f)5(r)5(o)5(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6427 Tm
[(t)5(h)5(e)5( )-22(n)5(e)15(w)5(b)5(o)5(r)-35(n)5(\222)5(s)5( )-22(u)5(m)5(b)5(i)5(l)5(i)5(c)5(a)5(l)5( )-22(c)5(o)5(r)5(d)5( )-22(b)22(l)5(o)5(o)5(d)5( )-22(\()5(a)5(l)5(t)5(h)5(o)5(u)5(g)5(h)5( )-22(i)5(t)5( )-22(i)5(s)5( )-22(n)5(o)5(t)5( )-22(c)5(l)5(e)5(a)5(r)5( )-22(w)5(h)5(e)5(t)5(h)5(e)5(r)5( )-22(s)5(t)5(e)5(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6122 Tm
[(c)5(e)5(l)5(l)5(s)5( )-30(o)5(b)5(t)5(a)5(i)5(n)5(e)5(d)5( )-30(f)5(r)5(o)5(m)5( )-30(c)5(o)5(r)5(d)5( )-30(b)22(l)5(o)5(o)5(d)5( )-30(w)5(i)5(l)5(l)5( )-30(h)5(a)25(v)28(e)5( )-30(t)5(h)5(e)5( )-30(s)5(a)5(m)5(e)5( )-30(c)5(a)5(p)5(a)5(c)5(i)5(t)5(i)5(e)5(s)5( )-30(a)5(s)5( )-30(e)5(m)5(b)5(r)-20(y)35(o)5(n)5(i)5(c )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5817 Tm
[(s)5(t)5(e)5(m)5( )-20(c)5(e)5(l)5(l)5(s)5( )-20(t)5(h)5(a)30(t)5( )-20(c)5(o)5(u)5(l)5(d)5( )-20(b)5(e)5( )-20(o)5(b)5(t)5(a)5(i)5(n)5(e)5(d)5( )-20(f)5(r)5(o)5(m)5( )-20(e)5(m)5(b)5(r)-20(y)35(o)5( )-20(b)5(i)5(o)5(p)5(s)5(y)5(\))5(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 338.6884 396.8817 Tm
[(1)5(6)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 379.5511 Tm
[(An )-90(additional )-90(line )-90(of)-28( )-90(concer)-40(n )-90(has )-90(to )-90(do )-90(with )-90(the )-90(possibility )-90(tha)25(t )-90(the )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5206 Tm
[(cells )-123(e)-23(xtr)-12(acted )-123(from )-123(the )-123(earl)25(y )-123(embr)-25(y)30(o )-123(ma)29(y )-123(be )-123(totipotent, )-123(and )-123(theref)13(ore )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 351.4901 Tm
[(capa)13(b)17(le )10(of)-28( )10(de)10(v)23(eloping )10(as )10(inde)-13(pendent )10(embr)-25(y)30(os)40(. )10(There )10(is )10(some )10(uncer)-17(tainty )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4596 Tm
[(as )8(to )8(when )8(during )8(embr)-25(y)30(onic )8(de)10(v)23(elopment )8(the )8(totipotency )8(of)-28( )8(individuall)25(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.429 Tm
[(e)-23(xtr)-12(acted )-72(embr)-25(y)30(onic )-72(cells )-72(disappear)-13(s)40(. )-72(W)-18(hile )-72(there )-72(is )-72(some )-72(e)10(vidence )-72(tha)25(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.3985 Tm
[(the )-54(cells )-54(of)-28( )-54(embr)-25(y)30(os )-54(of)-28( )-54(some )-54(mammalian )-54(species )-54(retain )-54(totipotency )-54(until )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.368 Tm
[(the fifth division \(tha)25(t is)40(, )-1(through the sixteen-cell sta)14(ge\),)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 347.6199 298.668 Tm
(17)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 357.6199 295.368 Tm
[( scientists ha)20(v)23(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3375 Tm
[(not )-13(been )-13(a)13(b)17(le )-13(to )-13(isola)25(te )-13(individual )-13(totipotent )-13(stem )-13(cells )-13(from )-13(earl)25(y )-13(human )]TJ
ET
BT
/T1_2 1 Tf
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[(embr)-25(y)30(os)40(.)]TJ
ET
BT
/T1_2 1 Tf
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(18)Tj
ET
BT
/T1_2 1 Tf
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[( )-39(If)-28( )-39(it )-39(is )-39(the )-39(case )-39(tha)25(t )-39(b)13(y )-39(the )-39(eight-cell )-39(sta)14(ge)13(, )-39(when )-39(the )-39(embr)-25(y)30(o )]TJ
ET
BT
/T1_2 1 Tf
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[(biopsy )-22(would )-22(tak)39(e )-22(place)13(, )-22(the )-22(individual )-22(cells )-22(are )-22(sufficientl)25(y )-22(differentia)25(ted )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2459 Tm
[(tha)25(t )-52(they )-52(are )-52(no )-52(longer )-52(totipotent, )-52(then )-52(this )-52(procedure )-52(would )-52(a)20(v)37(oid )-52(con)]TJ
ET
BT
/T1_2 1 Tf
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(cer)-40(ns )-23(o)19(v)23(er )-23(the )-23(destr)-13(uction )-23(of)-28( )-23(earl)25(y )-23(human )-23(life)13(. )-23(On )-23(the )-23(other )-23(hand, )-23(if)-28( )-23(cells )]TJ
ET
BT
/T1_2 1 Tf
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[(a)25(t )-63(this )-63(sta)14(ge )-63(are )-63(still )-63(capa)13(b)17(le )-63(of)-28( )-63(g)-33(ro)13(wing )-63(as )-63(via)13(b)17(le )-63(inde)-13(pendent )-63(embr)-25(y)30(os)40(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1544 Tm
[(then )-94(there )-94(would )-94(be )-94(little )-94(ethical )-94(difference )-94(betw)13(een )-94(this )-94(procedure )-94(and )]TJ
0 -1.169 TD
[(the )-126(har)-26(v)23(esting )-126(of)-28( )-126(ES )-126(cells )-126(b)13(y )-126(destro)13(ying )-126(living )-126(embr)-25(y)30(os)]TJ
/Span<>> BDC
( )Tj
EMC
23.706 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(though )-126(con)]TJ
ET
BT
/T1_2 1 Tf
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(cer)-40(ns )-25(o)19(v)23(er )-25(the )-25(risk )-25(to )-25(the )-25(b)17(lastocyst )-25(would )-25(remain.)]TJ
ET
BT
/T1_2 1 Tf
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(19)Tj
ET
BT
/T1_3 1 Tf
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[(O)10(r)10(g)35(a)10(n)10(i)10(s)10(m)10(i)10(c)10(a)10(l)10(l)-15(y)10( )-279(D)10(e)10(a)10(d)10( )-279(E)10(m)10(b)10(r)-15(y)35(o)10(s)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 231.9242 141.0323 Tm
[(.)10( )-257(O)10(n)10(e)10( )-257(a)10(l)10(t)10(e)10(r)-30(n)10(a)35(t)10(i)10(v)33(e)10( )-256(s)10(o)10(u)10(r)10(c)10(e)10( )-257(o)10(f)-18( )-257(E)10(S)10( )-256(c)10(e)10(l)10(l)10(s)10( )-257(i)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0018 Tm
[(e)10(m)10(b)10(r)-15(y)40(o)10(s)10( )45(t)10(h)10(a)35(t)10( )45(h)10(a)30(v)33(e)10( )45(s)10(t)10(o)10(p)10(p)10(e)10(d)10( )45(d)10(i)10(v)10(i)10(d)10(i)10(n)10(g)10( )45(a)10(n)10(d)10( )45(c)10(a)10(n)10( )45(t)10(h)10(e)10(r)10(e)10(f)23(o)10(r)10(e)10( )45(b)10(e)10( )45(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10(e)10(d)10( )45(\223)10(o)10(r)10(g)32(a)10(n)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 127.0018 Tm
(-)Tj
ET
Q
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S
72 701.5 m
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S
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72 75.735 143.98 14.265 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(1)-5(0)-5(4)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 106.8951 711.9261 Tm
[(W)63(i)-5(t)-5(h)-5(e)-5(r)-5(s)-5(p)8(o)-17(o)-5(n)-5( )-30(C)-5(o)-5(u)-5(n)-5(c)-5(i)-5(l)-5( )-30(o)-5(n)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(s)-5( )-30(a)-5(n)-5(d)-5( )-30(t)-5(h)-5(e)-5( )-30(I)-5(n)-5(t)-5(e)-5(g)-5(r)-5(i)-5(t)20(y)-5( )-30(o)-5(f)-5( )-30(S)-5(c)-5(i)-5(e)-5(n)-5(c)-5(e)]TJ
ET
1 1 1 rg
/GS0 gs
72 44.814 360 12.786 re
f*
0.565 w 10 M
/GS1 gs
236.933 46.995 m
340.078 46.995 l
S
0 0 0 rg
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
/RelativeColorimetric ri
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72 126.004 360 557.996 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(i)10(s)10(m)10(i)10(c)10(a)10(l)10(l)35(y)10( )-69(d)10(e)10(a)10(d)10(.)10(\224)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 147.5936 677.4921 Tm
[(2)10(0)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 157.3935 674.1921 Tm
[( )-69(J)45(u)10(s)10(t)10( )-69(a)10(s)10( )-69(m)10(a)10(n)10(y)10( )-69(o)10(f)-18( )-69(t)10(h)10(e)10( )-69(c)10(e)10(l)10(l)10(s)10( )-69(a)10(n)10(d)10( )-69(o)10(r)10(g)32(a)10(n)10(s)10( )-69(i)10(n)10( )-69(a)10( )-69(p)10(e)10(r)-3(s)10(o)10(n)10(\222)10(s)10( )-69(b)10(o)10(d)23(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(m)10(a)39(y)10( )-10(c)10(o)10(n)10(t)10(i)10(n)10(u)10(e)10( )-10(t)10(o)10( )-10(g)-23(r)10(o)23(w)10( )-10(a)10(n)10(d)10( )-10(f)10(u)10(n)10(c)10(t)10(i)10(o)10(n)10( )-10(f)23(o)10(r)10( )-10(a)10( )-10(t)10(i)10(m)10(e)10( )-10(a)10(f)10(t)10(e)10(r)10( )-10(t)10(h)10(e)10(y)10( )-10(h)10(a)30(v)33(e)10( )-10(d)10(i)10(e)10(d)10(,)10( )-10(s)10(o)10(m)10(e)10( )-10(o)10(f)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.1312 Tm
[(t)10(h)10(e)10( )-60(i)10(n)10(d)10(i)10(v)10(i)10(d)10(u)10(a)10(l)10( )-60(c)10(e)10(l)10(l)10(s)10( )-60(i)10(n)10( )-60(a)10( )-60(d)10(e)10(a)10(d)10( )-60(e)10(m)10(b)10(r)-15(y)40(o)10( )-60(m)10(a)39(y)10( )-60(b)10(e)10( )-60(c)10(a)10(p)10(a)23(b)27(l)10(e)10( )-60(o)10(f)-18( )-60(f)10(u)10(r)-7(t)10(h)10(e)10(r)10( )-60(d)10(i)10(v)10(i)10(s)10(i)10(o)10(n)10( )-60(i)10(f)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1007 Tm
[(p)10(l)10(a)10(c)10(e)10(d)10( )-89(i)10(n)10( )-89(a)10( )-88(s)10(u)10(i)10(t)10(a)23(b)27(l)10(e)10( )-89(e)10(n)23(v)10(i)10(r)10(o)10(n)10(m)10(e)10(n)10(t)10(.)10( )-89(H)10(a)10(r)-16(v)33(e)10(s)10(t)10(i)10(n)10(g)10( )-89(E)10(S)10( )-88(c)10(e)10(l)10(l)10(s)10( )-89(f)10(r)10(o)10(m)10( )-88(I)10(V)10(F)10( )-89(e)10(m)10(b)10(r)-15(y)40(o)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.0703 Tm
[(t)10(h)10(a)35(t)10( )-117(h)10(a)30(v)33(e)10( )-117(d)10(i)10(e)10(d)10( )-117(d)10(e)10(s)10(p)10(i)10(t)10(e)10( )-117(b)10(e)10(s)10(t)10( )-117(e)10(f)10(f)23(o)10(r)-7(t)10(s)10( )-117(t)10(o)10( )-117(s)10(u)10(s)10(t)10(a)10(i)10(n)10( )-117(t)10(h)10(e)10(i)10(r)10( )-117(l)10(i)10(f)10(e)10( )-117(w)10(o)10(u)10(l)10(d)10( )-117(a)10(l)10(l)10(o)23(w)10( )-117(u)10(s)10( )-117(t)10(o )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0398 Tm
[(a)30(v)47(o)10(i)10(d)10( )4(t)10(h)10(e)10( )4(e)10(t)10(h)10(i)10(c)10(a)10(l)10( )4(p)10(r)10(o)10(b)27(l)10(e)10(m)10(s)10( )4(a)10(s)10(s)10(o)10(c)10(i)10(a)35(t)10(e)10(d)10( )4(w)10(i)10(t)10(h)10( )4(d)10(e)10(s)10(t)10(r)10(o)23(y)10(i)10(n)10(g)10( )4(o)10(r)10( )4(k)10(i)10(l)10(l)10(i)10(n)10(g)10( )4(e)10(m)10(b)10(r)-15(y)40(o)10(s)10( )4(i)10(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 590.0093 Tm
[(o)10(r)10(d)10(e)10(r)10( )-89(t)10(o)10( )-89(h)10(a)10(r)-16(v)33(e)10(s)10(t)10( )-89(E)10(S)10( )-89(c)10(e)10(l)10(l)10(s)50(.)10( )-89(T)10(h)10(e)10( )-89(p)10(a)10(r)-2(a)10(m)10(o)10(u)10(n)10(t)10( )-89(e)10(t)10(h)10(i)10(c)10(a)10(l)10( )-89(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10( )-89(r)10(eg)32(a)10(r)10(d)10(i)10(n)10(g)10( )-89(t)10(h)10(i)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.9789 Tm
[(p)10(r)10(o)10(c)10(e)10(d)10(u)10(r)10(e)10( )-15(i)10(s)10( )-15(w)10(h)10(e)10(t)10(h)10(e)10(r)10( )-15(w)23(e)10( )-15(c)10(a)10(n)10( )-15(b)10(e)10( )-15(c)10(e)10(r)-7(t)10(a)10(i)10(n)10( )-15(t)10(h)10(a)35(t)10( )-15(t)10(h)10(e)10( )-15(e)10(m)10(b)10(r)-15(y)40(o)10(s)10( )-15(a)10(r)10(e)10( )-15(i)10(n)10( )-15(f)10(a)10(c)10(t)10( )-15(d)10(e)10(a)10(d)10(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 561.9484 Tm
[(O)10(r)10(d)10(i)10(n)10(a)10(r)-15(y)10( )-32(c)10(r)10(i)10(t)10(e)10(r)10(i)10(a)10( )-32(f)23(o)10(r)10( )-32(o)10(r)10(g)32(a)10(n)10(i)10(s)10(m)10(i)10(c)10( )-32(d)10(e)10(a)35(t)10(h)10( )-32(r)10(e)10(f)10(e)10(r)10( )-32(t)10(o)10( )-32(t)10(h)10(e)10( )-32(f)10(a)10(i)10(l)10(u)10(r)10(e)10( )-32(o)10(f)-18( )-32(i)10(m)10(p)10(o)10(r)-7(t)10(a)10(n)10(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 547.9179 Tm
[(o)10(r)10(g)32(a)10(n)10(s)50(,)10( )-119(s)10(u)10(c)10(h)10( )-119(a)10(s)10( )-119(t)10(h)10(e)10( )-119(b)10(r)-2(a)10(i)10(n)10( )-119(o)10(r)10( )-119(h)10(e)10(a)10(r)-7(t)10(.)10( )-119(T)10(h)10(e)10( )-119(l)10(a)10(r)10(g)10(e)10(l)35(y)10( )-119(u)10(n)10(d)10(i)10(f)10(f)10(e)10(r)10(e)10(n)10(t)10(i)10(a)35(t)10(e)10(d)10( )-119(e)10(m)10(b)10(r)-15(y)40(o)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8875 Tm
[(d)10(i)10(s)10(c)10(u)10(s)10(s)10(e)10(d)10( )-29(i)10(n)10( )-29(t)10(h)10(i)10(s)10( )-29(p)10(r)10(o)10(p)10(o)10(s)10(a)10(l)10( )-29(h)10(a)30(v)33(e)10( )-29(n)10(o)10(t)10( )-29(y)42(e)10(t)10( )-29(d)10(e)20(v)33(e)10(l)10(o)10(p)10(e)10(d)10( )-29(s)10(u)10(c)10(h)10( )-29(o)10(r)10(g)32(a)10(n)10(s)50(,)10( )-29(s)10(o)10( )-29(t)10(h)10(e)10( )-29(m)10(o)10(s)10(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.857 Tm
[(o)10(b)37(v)10(i)10(o)10(u)10(s)10( )36(c)10(r)10(i)10(t)10(e)10(r)10(i)10(a)10( )36(f)23(o)10(r)10( )36(d)10(e)10(t)10(e)10(r)-12(m)10(i)10(n)10(i)10(n)10(g)10( )36(w)10(h)10(e)10(t)10(h)10(e)10(r)10( )36(t)10(h)10(e)10( )36(e)10(m)10(b)10(r)-15(y)40(o)10( )36(h)10(a)10(s)10( )36(d)10(i)10(e)10(d)10( )36(i)10(s)10( )36(t)10(h)10(e)10( )36(a)23(b)10(s)10(e)10(n)10(c)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 505.8265 Tm
[(o)10(f)-18( )-59(c)10(o)10(o)10(r)10(d)10(i)10(n)10(a)35(t)10(e)10(d)10( )-59(c)10(e)10(l)10(l)10( )-59(d)10(i)10(v)10(i)10(s)10(i)10(o)10(n)10(.)10( )-59(S)10(u)10(c)10(h)10( )-59(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10(a)10(l)10( )-59(a)10(r)-3(r)10(e)10(s)10(t)10(,)10( )-59(i)10(f)-18( )-59(i)10(r)-3(r)10(e)20(v)33(e)10(r)-3(s)10(i)10(b)27(l)10(e)23(,)10( )-59(c)10(a)10(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 491.7961 Tm
[(b)10(e)10( )-94(u)10(s)10(e)10(d)10( )-94(a)10(s)10( )-94(a)10(n)10( )-94(o)10(b)10(j)10(e)10(c)10(t)10(i)10(v)33(e)10( )-94(d)10(i)10(a)24(g)10(n)10(o)10(s)10(t)10(i)10(c)10( )-94(c)10(r)10(i)10(t)10(e)10(r)10(i)10(o)10(n)10( )-94(f)23(o)10(r)10( )-94(d)10(e)10(a)35(t)10(h)10(.)10( )-94(M)10(u)10(c)10(h)10( )-94(a)10(s)10( )-94(s)10(t)10(u)10(d)10(i)10(e)10(s)10( )-94(o)10(f)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 477.7656 Tm
[(i)10(r)-3(r)10(e)20(v)33(e)10(r)-3(s)10(i)10(b)27(l)10(e)10( )-47(c)10(o)10(m)10(a)10( )-47(h)10(a)30(v)33(e)10( )-47(a)10(l)10(l)10(o)23(w)23(e)10(d)10( )-47(f)23(o)10(r)10( )-47(a)10( )-47(d)10(e)10(f)10(i)10(n)10(i)10(t)10(i)10(o)10(n)10( )-47(o)10(f)-18( )-47(b)10(r)-2(a)10(i)10(n)10( )-47(d)10(e)10(a)35(t)10(h)10( )-47(i)10(n)10( )-47(d)10(e)20(v)33(e)10(l)10(o)10(p)10(e)10(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7351 Tm
[(h)10(u)10(m)10(a)10(n)10(s)50(,)10( )-79(s)10(t)10(u)10(d)10(i)10(e)10(s)10( )-79(o)10(f)-18( )-79(I)10(V)10(F)10( )-79(e)10(m)10(b)10(r)-15(y)40(o)10(s)10( )-79(a)10(l)10(l)10(o)23(w)10( )-79(d)10(o)10(c)10(t)10(o)10(r)-3(s)10( )-79(t)10(o)10( )-79(d)10(e)10(t)10(e)10(r)-12(m)10(i)10(n)10(e)10( )-79(t)10(h)10(e)10( )-79(d)10(u)10(r)-2(a)35(t)10(i)10(o)10(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7047 Tm
[(o)10(f)-18( )-62(a)10(r)-3(r)10(e)10(s)10(t)10( )-62(b)10(e)10(y)40(o)10(n)10(d)10( )-62(w)10(h)10(i)10(c)10(h)10( )-62(a)10(n)10( )-62(e)10(m)10(b)10(r)-15(y)40(o)44(,)10( )-62(h)10(a)30(v)10(i)10(n)10(g)10( )-62(f)10(a)10(i)10(l)10(e)10(d)10( )-62(t)10(o)10( )-62(d)10(e)20(v)33(e)10(l)10(o)10(p)10( )-62(f)10(u)10(r)-7(t)10(h)10(e)10(r)76(,)10( )-62(n)10(e)20(v)33(e)10(r )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6742 Tm
[(r)10(e)10(s)10(u)10(m)10(e)10(s)10( )17(t)10(h)10(e)10( )16(n)10(o)10(r)-12(m)10(a)10(l)10( )16(p)10(a)35(t)10(h)10( )16(o)10(f)-18( )16(g)-23(r)10(o)23(w)10(t)10(h)10( )16(a)10(n)10(d)10( )16(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10( )16(a)10(n)10(d)10( )16(u)10(l)10(t)10(i)10(m)10(a)35(t)10(e)10(l)35(y)10( )16(b)10(eg)10(i)10(n)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6437 Tm
[(t)10(o)10( )-12(d)10(e)10(c)10(o)10(m)10(p)10(o)10(s)10(e)23(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 140.4362 424.9437 Tm
[(2)10(1)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 150.2362 421.6437 Tm
[( )-12(S)10(t)10(e)10(m)10( )-12(c)10(e)10(l)10(l)10( )-12(l)10(i)10(n)10(e)10(s)10( )-12(d)10(e)10(r)10(i)10(v)33(e)10(d)10( )-12(f)10(r)10(o)10(m)10( )-12(l)10(i)10(v)33(e)10( )-12(c)10(e)10(l)10(l)10(s)10( )-12(i)10(n)10( )-12(d)10(e)10(a)10(d)10( )-12(e)10(m)10(b)10(r)-15(y)40(o)10(s)10( )-12(a)10(r)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6133 Tm
[(g)10(e)10(n)10(e)10(t)10(i)10(c)10(a)10(l)10(l)35(y)10( )5(n)10(o)10(r)-12(m)10(a)10(l)10( )5(a)10(n)10(d)10( )5(e)-13(x)10(p)10(r)10(e)10(s)10(s)10( )5(t)10(h)10(e)10( )5(n)10(o)10(r)-12(m)10(a)10(l)10( )5(m)10(a)10(r)10(k)49(e)10(r)-3(s)10( )5(f)23(o)10(r)10( )5(E)10(S)10( )5(c)10(e)10(l)10(l)10(s)50(,)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 378.4126 410.9132 Tm
[(2)10(2)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 388.2126 407.6133 Tm
[( )5(a)10(n)10(d)10( )5(s)10(e)20(v)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 407.6133 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5828 Tm
[(e)10(r)-2(a)10(l)10( )-15(c)10(e)10(l)10(l)10( )-15(l)10(i)10(n)10(e)10(s)10( )-15(h)10(a)30(v)33(e)10( )-15(b)10(e)10(e)10(n)10( )-15(s)10(h)10(o)23(w)10(n)10( )-15(t)10(o)10( )-15(h)10(a)30(v)33(e)10( )-15(n)10(o)10(r)-12(m)10(a)10(l)10( )-15(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10(a)10(l)10( )-15(p)10(o)10(t)10(e)10(n)10(t)10(i)10(a)10(l)10(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 416.4469 396.8828 Tm
[(2)10(3)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 379.5523 Tm
[(T)4(h)4(e)4( )68(h)4(a)4(r)-22(v)27(e)4(s)4(t)4(i)4(n)4(g)4( )68(o)4(f)-24( )68(E)4(S)4( )68(c)4(e)4(l)4(l)4(s)4( )68(f)4(r)4(o)4(m)4( )68(t)4(h)4(e)4(s)4(e)4( )68(e)4(m)4(b)4(r)-21(y)34(o)4(s)4( )68(c)4(a)4(n)4( )68(b)4(e)4( )68(s)4(e)4(e)4(n)4( )68(a)4(s)4( )68(a)4(n)4(a)4(l)4(o)17(g)14(o)4(u)4(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5219 Tm
[(t)4(o)4( )-116(e)4(n)4(d)4(-)4(o)4(f)4(-)4(l)4(i)4(f)4(e)4( )-116(o)4(r)4(g)26(a)4(n)4( )-116(d)4(o)4(n)4(a)29(t)4(i)4(o)4(n)4(.)4( )-116(O)4(n)4(e)4( )-116(c)4(r)4(i)4(t)4(i)4(c)4(i)4(s)4(m)4( )-116(o)4(f)-24( )-116(t)4(h)4(i)4(s)4( )-116(a)4(n)4(a)4(l)4(o)17(g)-36(y)4( )-116(c)4(o)4(m)4(e)4(s)4( )-116(f)4(r)4(o)4(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 351.4914 Tm
[(t)4(h)4(e)4( )-88(r)4(e)4(l)4(a)29(t)4(i)4(v)27(e)4( )-88(i)4(n)4(d)4(i)4(f)4(f)4(e)4(r)4(e)4(n)4(c)4(e)4( )-88(o)4(f)-24( )-88(I)4(V)4(F)4( )-88(p)4(r)-8(a)4(c)4(t)4(i)4(t)4(i)4(o)4(n)4(e)4(r)-9(s)4( )-88(t)4(o)4( )-88(t)4(h)4(e)4( )-88(d)4(e)4(a)29(t)4(h)4( )-88(o)4(f)-24( )-88(e)4(m)4(b)4(r)-21(y)34(o)4(s)44(,)4( )-88(i)4(n )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4609 Tm
[(c)4(o)4(n)4(t)4(r)-8(a)4(s)4(t)4( )15(t)4(o)4( )15(t)4(h)4(e)4( )15(c)4(o)4(n)4(c)4(e)4(r)-36(n)4( )15(o)4(f)-24( )15(p)4(h)17(y)4(s)4(i)4(c)4(i)4(a)4(n)4(s)4( )15(c)4(a)4(r)4(i)4(n)4(g)4( )15(f)17(o)4(r)4( )15(d)17(y)4(i)4(n)4(g)4( )15(p)4(a)29(t)4(i)4(e)4(n)4(t)4(s)4( )15(f)4(r)4(o)4(m)4( )15(w)4(h)4(o)4(m )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.4305 Tm
[(o)4(r)4(g)26(a)4(n)4(s)4( )-127(m)4(i)4(g)4(h)4(t)4( )-127(b)4(e)4( )-127(h)4(a)4(r)-22(v)27(e)4(s)4(t)4(e)4(d)4(.)4( )-127(A)4(n)4(o)4(t)4(h)4(e)4(r)4( )-127(c)4(o)4(n)4(c)4(e)4(r)-36(n)4( )-127(i)4(s)4( )-127(t)4(h)4(a)29(t)4( )-127(t)4(h)4(i)4(s)4( )-127(m)4(e)4(t)4(h)4(o)4(d)4( )-127(m)4(i)4(g)4(h)4(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.4 Tm
[(c)4(r)4(e)4(a)29(t)4(e)4( )-35(a)4(n)4( )-35(i)4(n)4(c)4(e)4(n)4(t)4(i)4(v)27(e)4( )-35(f)17(o)4(r)4( )-35(I)4(V)4(F)4( )-35(p)4(r)-8(a)4(c)4(t)4(i)4(t)4(i)4(o)4(n)4(e)4(r)-9(s)4( )-35(t)4(o)4( )-35(c)4(r)4(e)4(a)29(t)4(e)4( )-35(s)4(u)4(r)-9(p)4(l)4(u)4(s)4( )-35(e)4(m)4(b)4(r)-21(y)34(o)4(s)4( )-35(i)4(n)4( )-35(t)4(h)4(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.3695 Tm
[(h)4(o)4(p)4(e)4(s)4( )-22(t)4(h)4(a)29(t)4( )-22(s)4(o)4(m)4(e)4( )-22(m)4(i)4(g)4(h)4(t)4( )-22(b)4(e)4( )-22(u)4(s)4(e)4(d)4( )-22(i)4(n)4( )-22(r)4(e)4(s)4(e)4(a)4(r)4(c)4(h)4(.)4( )-22(B)4(u)4(t)4( )-22(p)4(r)4(o)4(p)4(o)4(s)4(a)4(l)4(s)4( )-22(f)17(o)4(r)4( )-22(t)4(h)4(i)4(s)4( )-22(m)4(e)4(t)4(h)4(o)4(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3391 Tm
[(i)4(n)4(c)4(l)4(u)4(d)4(e)4( )-102(t)4(h)4(e)4( )-102(r)4(e)4(s)4(t)4(r)4(i)4(c)4(t)4(i)4(o)4(n)4( )-102(t)4(h)4(a)29(t)4( )-102(i)4(t)4( )-102(u)4(s)4(e)4( )-102(o)4(n)4(l)29(y)4( )-102(e)4(m)4(b)4(r)-21(y)34(o)4(s)4( )-102(c)4(r)4(e)4(a)29(t)4(e)4(d)4( )-102(f)17(o)4(r)4( )-102(r)4(e)-9(p)4(r)4(o)4(d)4(u)4(c)4(t)4(i)4(v)27(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 267.3086 Tm
[(p)4(u)4(r)-9(p)4(o)4(s)4(e)4(s)4( )-21(t)4(h)4(a)29(t)4( )-21(h)4(a)24(v)27(e)4( )-21(d)4(i)4(e)4(d)4( )-21(d)4(e)4(s)4(p)4(i)4(t)4(e)4( )-21(t)4(h)4(e)4( )-21(b)4(e)4(s)4(t)4( )-21(e)4(f)4(f)17(o)4(r)-13(t)4(s)4( )-21(t)4(o)4( )-21(k)43(e)4(e)-9(p)4( )-21(t)4(h)4(e)4(m)4( )-21(v)4(i)4(a)17(b)21(l)4(e)17(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 400.6917 270.6086 Tm
[(2)4(4)]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 73 239.2476 Tm
[(Somatic )-292(Cell )-292(Nuc)-12(lear )-292(T)38(r)25(ansf)25(er )-292(\(SCNT\).)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 287.8753 239.2476 Tm
[( )-270(Crea)25(ting )-270(embr)-25(y)30(os )-270(through )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 225.2172 Tm
[(SCNT )-43(is )-43(another )-43(possib)17(le )-43(source )-43(of)-28( )-43(ES )-43(cells; )-43(it )-43(allo)13(ws )-43(f)13(or )-43(the )-43(gener)-12(a)25(tion )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1867 Tm
[(of)-28( )-154(ES )-154(cells )-154(tha)25(t )-154(ma)29(y )-154(be )-154(more )-154(safe )-154(and )-154(efficacious )-154(f)13(or )-154(ther)-12(ap)26(y )-154(than )-154(ES )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1562 Tm
[(cells )-57(deriv)23(ed )-57(from )-57(IVF )-57(embr)-25(y)30(os)40(. )-57(In )-57(2008, )-57(scientists )-57(claimed )-57(to )-57(ha)20(v)23(e )-57(suc)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.872 197.1562 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 183.1258 Tm
[(cessfull)25(y )-90(crea)25(ted )-90(cloned )-90(human )-90(embr)-25(y)30(os )-90(from )-90(adult )-90(cells)40(, )-90(although )-90(they )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 169.0953 Tm
[(w)13(ere )-18(not )-18(a)13(b)17(le )-18(to )-18(isola)25(te )-18(ES )-18(cells )-18(from )-18(the )-18(embr)-25(y)30(os)40(, )-18(which )-18(w)13(ere )-18(destro)13(y)32(ed )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.0648 Tm
[(shor)-17(tl)25(y )-55(after)66(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 136.1711 158.3648 Tm
(25)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 146.1711 155.0648 Tm
[( )-55(More )-55(recentl)25(y)121(, )-55(scientists )-55(in )-55(2011 )-55(used )-55(a )-55(modified )-55(v)23(er)-13(sion )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0343 Tm
[(of)-28( )-23(the )-23(SCNT )-23(procedure)13(, )-23(in )-23(which )-23(the )-23(e)-10(g)10(g )-23(nucleus )-23(was )-23(not )-23(remo)19(v)23(ed )-23(prior )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0039 Tm
[(to )-65(adding )-65(the )-65(soma)25(tic )-65(cell, )-65(so )-65(tha)25(t )-65(the )-65(resultant )-65(embr)-25(y)30(os )-65(and )-65(embr)-25(y)30(onic )]TJ
ET
Q
endstream
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42 0 obj
<<
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>>
stream
q
0 0 504 792 re
W n
q
0 864 1008 -936 re
W n
1 1 1 rg
0 i
/RelativeColorimetric ri
/GS0 gs
72 126.004 360 557.996 re
f*
0 0 0 RG
1 w 4 M 0 j 0 J []0 d
/GS1 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/GS0 gs
288.019 75.735 143.981 14.265 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 339.9863 80.9261 Tm
[(W)63(i)-5(n)-5(t)-5(e)-5(r)-5( )-30(2)-5(0)-5(1)-5(2)-5( )-30(~)-5( )-30(1)-5(0)-5(5)]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 91.419 711.9261 Tm
[(A)-5(p)-5(p)8(e)-5(n)-5(d)-5(i)-5(x)-5( )-30(C)-5(:)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(a)-5(l)-5( )-30(C)-5(o)-5(n)-5(s)-5(i)-5(d)-5(e)-5(r)8(a)71(t)-5(i)-5(o)-5(n)-5(s)-5( )-30(R)-5(e)-5(g)33(a)-5(r)-5(d)-5(i)-5(n)-5(g)-5( )-30(S)-5(t)-5(e)-5(m)-5( )-30(C)-5(e)-5(l)-5(l)-5( )-30(R)-5(e)-5(s)-5(e)-5(a)-5(r)33(c)-5(h)]TJ
ET
1 1 1 rg
/GS0 gs
72 44.814 360 12.786 re
f*
0.565 w 10 M
/GS1 gs
236.933 46.995 m
340.078 46.995 l
S
0 0 0 rg
BT
/T1_1 1 Tf
11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
/RelativeColorimetric ri
/GS0 gs
72 126.002 360 557.998 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 12 0 0 12 73 674.1921 Tm
[(stem )-60(cells )-60(had )-60(three )-60(sets )-60(of)-28( )-60(chromosomes )-60(r)-12(a)25(ther )-60(than )-60(the )-60(nor)-22(mal )-60(two)34(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 421 677.4921 Tm
(26)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 431 674.1921 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(The )19(researcher)-13(s )19(w)13(ere )19(then )19(a)13(b)17(le )19(to )19(crea)25(te )19(human )20(embr)-25(y)30(onic )19(stem )19(cell )19(lines )]TJ
0 -1.169 TD
[(using )-4(these )-3(embr)-25(y)30(os)]TJ
/Span<>> BDC
( )Tj
EMC
8.388 0 Td
(\227)Tj
/Span<>> BDC
( )Tj
EMC
1.042 0 Td
[(the )-4(fir)-13(st )-4(time )-4(human )-3(ES )-4(cell )-3(lines )-4(ha)20(v)23(e )-3(been )-4(crea)25(t)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 646.131 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1005 Tm
[(ed )-9(using )-9(SCNT)110(. )-9(W)-18(hile )-9(this )-9(e)-23(xperiment )-9(re)-13(presents )-9(a )-9(major )-9(breakthrough, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 618.07 Tm
[(sho)13(wing )-111(tha)25(t )-111(human )-111(embr)-25(y)30(os )-111(and )-111(ES )-111(cell )-111(lines )-111(can )-111(be )-111(crea)25(ted )-111(through )]TJ
ET
BT
/T1_2 1 Tf
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[(SCNT)119(, )4(the )4(embr)-25(y)30(os )4(and )4(the )4(ES )4(cell )4(lines )4(w)13(ere )4(se)10(v)23(erel)25(y )4(geneticall)25(y )4(a)13(bnor)]TJ
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ET
BT
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[(mal )-105(due )-105(to )-105(the )-105(presence )-105(of)-28( )-105(the )-105(third )-105(set )-105(of)-28( )-105(chromosomes)40(, )-105(making )-105(them )]TJ
ET
BT
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ET
BT
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[(crea)25(te )-69(human )-69(embr)-25(y)30(os )-69(tha)25(t )-69(are )-69(destro)13(y)32(ed )-69(in )-69(order )-69(to )-69(har)-26(v)23(est )-69(stem )-69(cells)40(, )]TJ
ET
BT
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ET
BT
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ET
BT
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ET
BT
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[(destr)-13(uction )-70(in )-70(mind, )-70(the )-70(gener)-12(a)25(tion )-70(of)-28( )-70(embr)-25(y)30(os )-70(through )-70(SCNT )-70(in)13(v)37(olv)23(es )]TJ
ET
BT
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ET
BT
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ET
BT
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[(re)-10(g)22(arding )-25(the )-25(e)-23(xploita)25(tion )-25(and )-25(endanger)-22(ment )-25(of)-28( )-25(e)-10(g)10(g )-25(donor)-13(s)40(.)]TJ
ET
BT
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ET
BT
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[(ha)20(v)23(e )-14(a )-14(genome )-14(identical )-14(with )-14(some )-14(donor )-14(human )-14(being)26(. )-14(It )-14(thus )-14(opens )-14(the )]TJ
ET
BT
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[(door )-78(not )-78(onl)25(y )-78(to )-78(cloned )-78(embr)-25(y)30(os )-78(b)14(ut )-78(to )-78(the )-78(bir)-17(th )-78(of)-28( )-78(cloned )-78(human )-78(chil)]TJ
ET
BT
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(-)Tj
ET
BT
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[(dren. )29(This )29(r)-12(aises )29(v)23(e)-23(xing )29(questions )29(a)13(bout )29(the )29(meaning )29(of)-28( )29(re)-13(production, )29(the )]TJ
T*
[(rela)25(tionship )20(betw)13(een )20(the )20(gener)-12(a)25(tions)40(, )20(and )20(the )20(defense )20(of)-28( )20(human)]TJ
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EMC
25.845 0 Td
(dignity)Tj
/Span<>> BDC
( )Tj
EMC
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(\227)Tj
ET
BT
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[(questions )-181(tha)25(t )-181(ha)20(v)23(e )-181(largel)25(y )-181(led )-181(to )-181(a )-181(pub)17(lic )-181(consensus )-181(in )-181(opposition )-181(to )]TJ
ET
BT
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ET
BT
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ET
BT
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ET
BT
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[(embr)-25(y)30(o )-60(tha)25(t )-60(could )-60(then )-60(be )-60(used )-60(f)13(or )-60(the )-60(pur)-13(poses )-60(of)-28( )-60(research, )-60(ther)-12(ap)26(y)121(, )-60(or )]TJ
ET
BT
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[(re)-13(production. )-173(Tr)-13(ue)13(, )-173(no )-173(successful )-173(implanta)25(tion )-173(and )-173(pre)-10(gnancy )-173(using )-173(a )]TJ
ET
BT
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ET
BT
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[(v)23(erified )-40(to )-41(da)25(te)13(. )-41(But )-40(the )-41(use )-40(of)-28( )-41(cloning )-40(to )-40(produce )-40(children )-40(ma)29(y )-41(someda)29(y )]TJ
ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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(27)Tj
ET
BT
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(\))Tj
ET
BT
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ET
BT
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ET
BT
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[(need )-101(f)13(or )-101(human )-101(e)-10(g)10(g )-101(donor)-13(s )-101(is )-101(called )-101(inter)-13(species )-101(SCNT)59(; )-101(it )-101(in)13(v)37(olv)23(es )-101(the )]TJ
ET
BT
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[(tr)-12(ansfer )28(of)-28( )28(a )28(human )28(nucleus )28(into )28(an )28(enuclea)25(ted )28(animal )28(oocyte)13(. )28(Some )28(scien)]TJ
ET
BT
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(tists )2(ha)20(v)23(e )2(r)-12(aised )2(doubts )2(a)13(bout )1(the )2(technical )2(feasibility )2(of)-28( )2(this )1(procedure)13(.)]TJ
ET
BT
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(28)Tj
ET
BT
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( )Tj
ET
BT
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ET
BT
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ET
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BT
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[(1)-5(0)-5(6)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
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[(W)63(i)-5(t)-5(h)-5(e)-5(r)-5(s)-5(p)8(o)-17(o)-5(n)-5( )-30(C)-5(o)-5(u)-5(n)-5(c)-5(i)-5(l)-5( )-30(o)-5(n)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(s)-5( )-30(a)-5(n)-5(d)-5( )-30(t)-5(h)-5(e)-5( )-30(I)-5(n)-5(t)-5(e)-5(g)-5(r)-5(i)-5(t)20(y)-5( )-30(o)-5(f)-5( )-30(S)-5(c)-5(i)-5(e)-5(n)-5(c)-5(e)]TJ
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BT
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[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
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[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
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(m)Tj
ET
BT
/T1_1 1 Tf
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[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
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[(named )-42(because )-42(they )-43(result )-42(from )-42(the )-42(use )-42(of)-28( )-42(the )-42(inter)-13(species )-42(SCNT )-42(proce)]TJ
ET
BT
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(-)Tj
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BT
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ET
BT
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[(human )-72(cell.)]TJ
ET
BT
/T1_2 1 Tf
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(29)Tj
ET
BT
/T1_2 1 Tf
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[( )-72(W)-18(hile )-72(the )-72(use )-72(of)-28( )-72(inter)-13(species )-72(SCNT )-72(to )-72(obtain )-72(pluripotent )]TJ
ET
BT
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[(stem )-80(cells )-79(would )-79(alle)10(via)25(te )-79(concer)-40(ns )-80(o)19(v)23(er )-79(the )-80(e)-23(xploita)25(tion )-80(of)-28( )-79(e)-10(g)10(g )-80(donor)-13(s)40(, )]TJ
ET
BT
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[(it )-49(remains )-49(a )-49(f)13(or)-22(m )-49(of)-28( )-49(cloning )-49(and )-49(r)-12(aises )-49(a)25(t )-49(least )-49(as )-49(many )-49(ethical )-49(concer)-40(ns )]TJ
ET
BT
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[(re)-10(g)22(arding )-25(re)-13(production )-25(and )-25(human )-25(dignity )-25(as )-25(does )-25(con)13(v)23(entional )-25(SCNT)110(.)]TJ
ET
BT
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(A)Tj
ET
BT
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[(lter)13(ed )-10(Nuc)-12(lear )-10(T)38(r)25(ansf)25(er )-10(\(ANT\).)]TJ
ET
BT
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[( )-9(ANT )-9(in)13(v)37(olv)23(es )-9(the )-9(crea)25(tion )-9(of)-28( )-9(\223biolo)13(gi)]TJ
ET
BT
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(-)Tj
ET
BT
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[(cal )29(ar)-17(tifacts\224)-13( )29(through )29(a )29(modified )29(v)23(er)-13(sion )29(of)-28( )29(the )29(technique )29(of)-28( )29(nuclear )29(tr)-12(ans)]TJ
ET
BT
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(fer)66(.)]TJ
ET
BT
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(30)Tj
ET
BT
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[( )-27(In )-27(ANT)119(, )-27(the )-27(star)-17(ting )-27(ma)25(terials )-27(used )-27(in )-27(the )-27(technique )-27(\(the )-27(adult )-27(cell )]TJ
ET
BT
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[(nucleus )22(and/or )22(the )22(cytoplasm )22(of)-28( )22(the )22(oocyte\) )22(are )22(altered )22(bef)13(ore )22(being )22(com)]TJ
ET
BT
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(-)Tj
ET
BT
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[(bined )-68(so )-68(tha)25(t )-68(the )-68(product )-68(of)-28( )-68(the )-68(procedure )-68(is )-68(not )-68(capa)13(b)17(le )-68(of)-28( )-68(esta)13(b)17(lishing )]TJ
ET
BT
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[(the )-133(inte)-10(g)-33(r)-12(a)25(ted )-133(unity )-133(tha)25(t )-133(char)-12(acterizes )-133(an )-133(embr)-25(y)30(o)34(. )-133(Because )-133(these )-133(\223ar)-17(ti)]TJ
ET
BT
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(-)Tj
ET
BT
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[(facts\224)-13( )-27(contain )-27(pluripotent )-27(b)14(ut )-27(not )-27(totipotent )-27(cells)40(, )-27(they )-27(are )-27(not )-27(capa)13(b)17(le )-27(of)-28( )]TJ
ET
BT
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ET
BT
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ET
BT
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(-)Tj
ET
BT
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[(rounding )-46(the )-46(har)-26(v)23(esting )-46(of)-28( )-46(stem )-46(cells )-46(from )-46(human )-46(embr)-25(y)30(os)40(. )-46(The )-46(centr)-12(al )]TJ
ET
BT
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[(ethical )-43(question )-43(rela)25(ted )-43(to )-43(this )-43(proposal )-43(is )-43(whether )-43(w)13(e )-43(ought )-43(to )-43(consider )]TJ
ET
BT
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ET
BT
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[(entities)40(, )-51(or )-51(whether )-51(there )-51(is )-51(a )-51(kind )-51(of)-28( )-51(similarity )-51(to )-51(na)25(tur)-12(al )-51(embr)-25(y)30(os )-51(such )]TJ
ET
BT
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[(tha)25(t )-4(they )-4(ha)20(v)23(e )-4(intrinsic )-4(mor)-12(al )-4(v)13(alue)13(. )-4(Proponents )-4(of)-28( )-4(ANT )-4(argue )-4(tha)25(t )-4(since )]TJ
ET
BT
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[(the )-116(modifica)25(tions )-116(made )-116(to )-116(the )-116(nucleus )-116(\(or )-116(the )-116(cytoplasm )-116(of)-28( )-116(the )-116(e)-10(g)10(g\) )-116(to )]TJ
ET
BT
/T1_2 1 Tf
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[(pre)10(v)23(ent )-6(embr)-25(y)30(o)13(genesis )-6(are )-6(made )]TJ
ET
BT
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[(bef)14(or)20(e)]TJ
ET
BT
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[( )-6(it )-6(is )-6(tr)-12(ansfer)-13(red )-6(to )-6(the )-6(oocyte)13(, )-6(and )]TJ
ET
BT
/T1_2 1 Tf
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[(since )34(the )34(ar)-17(tifact )34(crea)25(ted )34(b)13(y )34(the )34(procedure )34(has )34(cells )34(tha)25(t )34(are )34(not )34(totipotent, )]TJ
ET
BT
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ET
BT
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(31)Tj
ET
BT
/T1_2 1 Tf
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[( )-17(But )-17(if, )-17(as )-17(some )]TJ
ET
BT
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[(critics )-195(contend, )-196(ANT )-196(actuall)25(y )-196(crea)25(tes )-195(altered )-196(b)14(ut )-196(disordered )-195(embr)-25(y)30(os)40(, )]TJ
ET
BT
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[(then )23(it )23(r)-12(aises )23(questions )23(both )23(a)13(bout )23(the )23(ethics )23(of)-28( )23(destro)13(ying )23(human )23(embr)-25(y)]TJ
ET
BT
/T1_2 1 Tf
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(os )-45(and )-45(a)13(bout )-45(the )-45(ethics )-45(of)-28( )-45(intentionall)25(y )-45(crea)25(ting )-45(defectiv)23(e )-45(embr)-25(y)30(os)40(. )-45(Also)34(, )]TJ
ET
BT
/T1_2 1 Tf
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[(lik)39(e )-21(SCNT)119(, )-21(ANT )-21(de)-13(pends )-21(on )-21(human )-21(e)-10(g)10(g )-21(donor)-13(s)40(, )-21(r)-12(aising )-21(ethical )-21(concer)-40(ns )]TJ
ET
BT
/T1_2 1 Tf
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[(a)13(bout )-25(their )-25(possib)17(le )-25(e)-23(xploita)25(tion )-25(and )-25(endanger)-22(ment.)]TJ
ET
BT
/T1_2 1 Tf
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(32)Tj
ET
BT
/T1_2 1 Tf
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[(I)10(n)10( )9(t)10(h)10(e)10( )9(v)33(e)10(r)-3(s)10(i)10(o)10(n)10( )9(o)10(f)-18( )9(A)10(N)10(T)10( )9(k)10(n)10(o)23(w)10(n)10( )9(a)10(s)10( )9(t)10(h)10(e)10( )9(A)10(N)10(T)115(-)10(C)10(d)10(x)10(2)10( )9(p)10(r)10(o)10(c)10(e)10(d)10(u)10(r)10(e)23(,)10( )9(t)10(h)10(e)10( )9(e)-13(x)10(p)10(r)10(e)10(s)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 253.2781 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2476 Tm
[(s)10(i)10(o)10(n)10( )-100(o)10(f)-18( )-100(t)10(h)10(e)10( )-100(g)10(e)10(n)10(e)10( )-100(C)10(d)10(x)10(2)10( )-100(i)10(s)10( )-100(p)10(r)10(e)10(e)10(m)10(p)10(t)10(i)10(v)33(e)10(l)35(y)10( )-100(a)10(l)10(t)10(e)10(r)10(e)10(d)10(.)10( )-100(I)10(n)10( )-100(n)10(a)35(t)10(u)10(r)-2(a)10(l)10( )-100(e)10(m)10(b)10(r)-15(y)40(o)23(g)10(e)10(n)10(e)10(s)10(i)10(s)50(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 225.2172 Tm
[(t)10(h)10(e)10( )-7(e)-13(x)10(p)10(r)10(e)10(s)10(s)10(i)10(o)10(n)10( )-7(o)10(f)-18( )-7(C)10(d)10(x)10(2)10( )-7(i)10(s)10( )-7(a)10(n)10( )-7(e)10(a)10(r)10(l)35(y)10( )-7(i)10(n)10(d)10(i)10(c)10(a)35(t)10(o)10(r)10( )-7(o)10(f)-18( )-7(i)10(n)10(t)10(eg)-23(r)-2(a)35(t)10(e)10(d)10( )-7(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10( )-7(a)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1867 Tm
[(o)10(r)10(d)10(e)10(r)10(l)35(y)10( )41(c)10(e)10(l)10(l)10( )41(d)10(i)10(f)10(f)10(e)10(r)10(e)10(n)10(t)10(i)10(a)35(t)10(i)10(o)10(n)10(,)10( )41(a)10(n)10(d)10( )41(C)10(d)10(x)10(2)10( )41(i)10(s)10( )41(a)10(n)10( )41(i)10(m)10(p)10(o)10(r)-7(t)10(a)10(n)10(t)10( )41(f)10(a)10(c)10(t)10(o)10(r)10( )41(i)10(n)10( )41(t)10(h)10(e)10( )41(f)23(o)10(r)-12(m)10(a)35(t)10(i)10(o)10(n )]TJ
0 -1.169 TD
[(o)10(f)-18( )-86(t)10(h)10(e)10( )-86(t)10(r)10(o)10(p)10(h)10(e)10(c)10(t)10(o)10(d)10(e)10(r)-12(m)]TJ
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( )Tj
EMC
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(\227)Tj
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( )Tj
EMC
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[(a)10( )-86(s)10(t)10(r)-3(u)10(c)10(t)10(u)10(r)10(e)10( )-86(e)10(s)10(s)10(e)10(n)10(t)10(i)10(a)10(l)10( )-86(f)23(o)10(r)10( )-86(n)10(o)10(r)-12(m)10(a)10(l)10( )-86(e)10(m)10(b)10(r)-15(y)40(o)10(n)10(i)10(c)10( )-86(d)10(e)20(v)33(e)10(l)]TJ
ET
BT
/T1_2 1 Tf
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(-)Tj
ET
BT
/T1_2 1 Tf
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[(o)10(p)10(m)10(e)10(n)10(t)10( )-9(a)10(n)10(d)10( )-9(i)10(m)10(p)10(l)10(a)10(n)10(t)10(a)35(t)10(i)10(o)10(n)10(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 195.9096 186.4258 Tm
[(3)10(3)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 205.7096 183.1258 Tm
[( )-9(W)-8(h)10(e)10(n)10( )-9(C)10(d)10(x)10(2)10( )-9(i)10(s)10( )-9(\223)10(s)10(i)10(l)10(e)10(n)10(c)10(e)10(d)10(,)10(\224)-3( )-9(o)10(r)10( )-9(i)10(n)10(t)10(e)10(r)10(f)10(e)10(r)10(e)10(d)10( )-9(w)10(i)10(t)10(h)10( )-9(i)10(n )]TJ
ET
BT
/T1_2 1 Tf
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[(s)10(u)10(c)10(h)10( )10(a)10( )10(w)10(a)39(y)10( )10(t)10(h)10(a)35(t)10( )10(i)10(t)10( )10(i)10(s)10( )10(n)10(o)10(t)10( )10(e)-13(x)10(p)10(r)10(e)10(s)10(s)10(e)10(d)10( )10(b)23(y)10( )10(t)10(h)10(e)10( )10(c)10(e)10(l)10(l)10(,)10( )10(i)10(t)10( )10(b)10(e)10(c)10(o)10(m)10(e)10(s)10( )10(i)10(m)10(p)10(o)10(s)10(s)10(i)10(b)27(l)10(e)10( )10(f)23(o)10(r)10( )10(t)10(h)10(e )]TJ
ET
BT
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[(\223)10(b)10(i)10(o)10(l)10(o)23(g)10(i)10(c)10(a)10(l)10( )12(a)10(r)-7(t)10(i)10(f)10(a)10(c)10(t)10(\224)-3( )12(t)10(o)10( )12(d)10(e)20(v)33(e)10(l)10(o)10(p)10( )12(i)10(n)10( )12(t)10(h)10(e)10( )12(m)10(a)10(n)10(n)10(e)10(r)10( )12(o)10(f)-18( )12(a)10( )12(n)10(a)35(t)10(u)10(r)-2(a)10(l)10( )12(e)10(m)10(b)10(r)-15(y)40(o)44(.)10( )12(W)-8(h)10(e)10(t)10(h)10(e)10(r )]TJ
ET
BT
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[(t)10(h)10(e)10( )-106(e)10(n)10(t)10(i)10(t)10(y)10( )-106(c)10(r)10(e)10(a)35(t)10(e)10(d)10( )-106(b)23(y)10( )-106(t)10(h)10(e)10( )-106(A)10(N)10(T)115(-)10(C)10(d)10(x)10(2)10( )-106(p)10(r)10(o)10(c)10(e)10(d)10(u)10(r)10(e)10( )-106(c)10(a)10(n)10( )-106(b)10(e)10( )-106(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10(e)10(d)10( )-106(a)10( )-106(k)10(i)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0039 Tm
[(o)10(f)-18( )-108(d)10(e)10(f)10(e)10(c)10(t)10(i)10(v)33(e)10( )-108(e)10(m)10(b)10(r)-15(y)40(o)44(,)10( )-108(o)10(r)10( )-108(r)-2(a)35(t)10(h)10(e)10(r)10( )-108(i)10(s)10( )-108(s)10(i)10(m)10(p)10(l)35(y)10( )-108(a)10( )-108(m)10(a)10(s)10(s)10( )-108(o)10(f)-18( )-108(p)10(l)10(u)10(r)10(i)10(p)10(o)10(t)10(e)10(n)10(t)10( )-108(s)10(t)10(e)10(m)10( )-108(c)10(e)10(l)10(l)10(s)50(, )]TJ
ET
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f*
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BT
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[(W)63(i)-5(n)-5(t)-5(e)-5(r)-5( )-30(2)-5(0)-5(1)-5(2)-5( )-30(~)-5( )-30(1)-5(0)-5(7)]TJ
ET
BT
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[(A)-5(p)-5(p)8(e)-5(n)-5(d)-5(i)-5(x)-5( )-30(C)-5(:)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(a)-5(l)-5( )-30(C)-5(o)-5(n)-5(s)-5(i)-5(d)-5(e)-5(r)8(a)71(t)-5(i)-5(o)-5(n)-5(s)-5( )-30(R)-5(e)-5(g)33(a)-5(r)-5(d)-5(i)-5(n)-5(g)-5( )-30(S)-5(t)-5(e)-5(m)-5( )-30(C)-5(e)-5(l)-5(l)-5( )-30(R)-5(e)-5(s)-5(e)-5(a)-5(r)33(c)-5(h)]TJ
ET
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f*
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236.933 46.995 m
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BT
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[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
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11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
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11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
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f*
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BT
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[(d)10(e)-3(p)10(e)10(n)10(d)10(s)10( )12(o)10(n)10( )12(a)10( )12(n)10(u)10(m)10(b)10(e)10(r)10( )12(o)10(f)-18( )12(c)10(o)10(m)10(p)10(l)10(e)-13(x)10( )12(p)10(h)10(i)10(l)10(o)10(s)10(o)10(p)10(h)10(i)10(c)10(a)10(l)10( )12(a)10(n)10(d)10( )12(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)10(i)10(c)10( )12(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10(s)50(.)10( )12(F)71(o)10(r )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 660.1616 Tm
[(i)10(n)10(s)10(t)10(a)10(n)10(c)10(e)23(,)10( )-116(t)10(h)10(e)10( )-116(p)10(r)10(e)10(c)10(i)10(s)10(e)10( )-116(r)10(o)10(l)10(e)10( )-116(o)10(f)-18( )-116(t)10(h)10(e)10( )-116(C)10(d)10(x)10(2)10( )-116(g)10(e)10(n)10(e)10( )-116(i)10(n)10( )-116(e)10(m)10(b)10(r)-15(y)40(o)10(n)10(i)10(c)10( )-116(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10( )-116(i)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 646.131 Tm
[(s)10(t)10(i)10(l)10(l)10( )-20(s)10(u)10(b)10(j)10(e)10(c)10(t)10( )-20(t)10(o)10( )-20(s)10(o)10(m)10(e)10( )-20(c)10(o)10(n)10(t)10(r)10(o)29(v)33(e)10(r)-3(s)10(y)10(:)10( )-20(w)10(h)10(i)10(l)10(e)10( )-20(i)10(t)10( )-20(i)10(s)10( )-20(c)10(l)10(e)10(a)10(r)10( )-20(t)10(h)10(a)35(t)10( )-20(C)10(d)10(x)10(2)10( )-20(i)10(s)10( )-20(e)10(s)10(s)10(e)10(n)10(t)10(i)10(a)10(l)10( )-20(f)23(o)10(r )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 632.1005 Tm
[(t)10(h)10(e)10( )13(p)10(r)10(o)10(p)10(e)10(r)10( )13(f)10(u)10(n)10(c)10(t)10(i)10(o)10(n)10(i)10(n)10(g)10( )13(o)10(f)-18( )13(t)10(h)10(e)10( )13(t)10(r)10(o)10(p)10(h)10(e)10(c)10(t)10(o)10(d)10(e)10(r)-12(m)10( )13(a)10(n)10(d)10( )13(f)23(o)10(r)10( )13(t)10(h)10(e)10( )13(s)10(p)10(e)10(c)10(i)10(f)10(i)10(c)10(a)35(t)10(i)10(o)10(n)10( )13(o)10(f)-18( )13(t)10(h)10(e )]TJ
ET
BT
/T1_2 1 Tf
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[(a)10(x)10(i)10(a)10(l)10( )-8(b)10(o)10(d)23(y)10( )-8(p)10(l)10(a)10(n)10( )-8(i)10(n)10( )-8(t)10(h)10(e)10( )-8(e)10(a)10(r)10(l)35(y)10( )-8(e)10(m)10(b)10(r)-15(y)40(o)44(,)]TJ
ET
BT
/T1_2 1 Tf
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[(3)10(4)]TJ
ET
BT
/T1_2 1 Tf
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[( )-8(t)10(h)10(e)10(r)10(e)10( )-8(r)10(e)10(m)10(a)10(i)10(n)10(s)10( )-8(s)10(o)10(m)10(e)10( )-8(d)10(i)10(s)10(p)10(u)10(t)10(e)10( )-8(o)29(v)33(e)10(r)10( )-8(t)10(h)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 604.0395 Tm
[(e)-13(x)10(t)10(e)10(n)10(t)10( )-29(t)10(o)10( )-29(w)10(h)10(i)10(c)10(h)10( )-29(C)10(d)10(x)10(2)10( )-29(i)10(s)10( )-29(r)10(e)10(s)10(p)10(o)10(n)10(s)10(i)10(b)27(l)10(e)10( )-29(f)23(o)10(r)10( )-29(d)10(i)10(r)10(e)10(c)10(t)10(i)10(n)10(g)10( )-29(t)10(h)10(e)10( )-29(o)10(r)10(g)32(a)10(n)10(i)10(z)10(a)35(t)10(i)10(o)10(n)10( )-29(o)10(f)-18( )-29(e)10(a)10(r)10(l)35(y )]TJ
ET
BT
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[(e)10(m)10(b)10(r)-15(y)40(o)10(n)10(i)10(c)10( )-87(c)10(e)10(l)10(l)10(s)50(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 150.5806 593.309 Tm
[(3)10(5)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 160.3806 590.009 Tm
[( )-87(F)10(u)10(r)-7(t)10(h)10(e)10(r)-12(m)10(o)10(r)10(e)23(,)10( )-87(s)10(o)10(m)10(e)10( )-87(p)10(h)10(i)10(l)10(o)10(s)10(o)10(p)10(h)10(e)10(r)-3(s)10( )-87(h)10(a)30(v)33(e)10( )-87(r)-2(a)10(i)10(s)10(e)10(d)10( )-87(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 575.9785 Tm
[(a)10(s)10( )-18(t)10(o)10( )-18(w)10(h)10(e)10(t)10(h)10(e)10(r)10( )-18(o)10(r)10( )-18(n)10(o)10(t)10( )-18(t)10(h)10(e)10( )-18(e)10(n)10(t)10(i)10(t)10(i)10(e)10(s)10( )-18(c)10(r)10(e)10(a)35(t)10(e)10(d)10( )-18(b)23(y)10( )-18(p)10(r)10(o)10(c)10(e)10(d)10(u)10(r)10(e)10(s)10( )-18(l)10(i)10(k)49(e)10( )-18(A)10(N)10(T)115(-)10(C)10(d)10(x)10(2)10( )-18(a)10(r)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 561.9479 Tm
[(s)10(u)10(f)10(f)10(i)10(c)10(i)10(e)10(n)10(t)10(l)35(y)10( )-75(d)10(i)10(s)10(o)10(r)10(g)32(a)10(n)10(i)10(z)10(e)10(d)10( )-74(t)10(o)10( )-75(b)10(e)10( )-75(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10(e)10(d)10( )-75(n)10(o)10(n)10(-)10(e)10(m)10(b)10(r)-15(y)40(o)10(n)10(i)10(c)10( )-75(e)10(n)10(t)10(i)10(t)10(i)10(e)10(s)50(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 390.7855 565.2479 Tm
[(3)10(6)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 400.5854 561.9479 Tm
[( )-75(M)10(o)10(r)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 547.9174 Tm
[(s)10(c)10(i)10(e)10(n)10(t)10(i)10(f)10(i)10(c)10( )-23(r)10(e)10(s)10(e)10(a)10(r)10(c)10(h)10( )-23(i)10(n)10( )-23(a)10(n)10(i)10(m)10(a)10(l)10( )-23(m)10(o)10(d)10(e)10(l)10(s)10( )-23(m)10(a)39(y)10( )-23(h)10(e)10(l)10(p)10( )-23(t)10(o)10( )-23(c)10(l)10(a)10(r)10(i)10(f)10(y)10( )-23(c)10(e)10(r)-7(t)10(a)10(i)10(n)10( )-23(i)10(s)10(s)10(u)10(e)10(s)50(,)10( )-23(s)10(u)10(c)10(h )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 533.8868 Tm
[(a)10(s)10( )-112(t)10(h)10(o)10(s)10(e)10( )-112(r)10(e)10(l)10(a)35(t)10(e)10(d)10( )-112(t)10(o)10( )-112(t)10(h)10(e)10( )-112(p)10(r)10(e)10(c)10(i)10(s)10(e)10( )-112(b)10(i)10(o)10(l)10(o)23(g)10(i)10(c)10(a)10(l)10( )-112(r)10(o)10(l)10(e)10( )-112(o)10(f)-18( )-112(g)10(e)10(n)10(e)10(s)10( )-112(l)10(i)10(k)49(e)10( )-112(C)10(d)10(x)10(2)10(,)10( )-112(i)10(n)10(c)10(l)10(u)10(d)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 533.8868 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 519.8563 Tm
[(i)10(n)10(g)10( )-105(t)10(h)10(e)10( )-105(p)10(o)10(t)10(e)10(n)10(t)10(i)10(a)10(l)10( )-105(r)10(e)20(v)33(e)10(r)-3(s)10(i)10(b)10(i)10(l)10(i)10(t)10(y)10( )-105(o)10(r)10( )-105(i)10(r)-3(r)10(e)20(v)33(e)10(r)-3(s)10(i)10(b)10(i)10(l)10(i)10(t)10(y)10( )-105(o)10(f)-18( )-105(t)10(h)10(e)10( )-105(i)10(n)10(t)10(e)10(r)-16(v)33(e)10(n)10(t)10(i)10(o)10(n)10(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 399.5521 523.1563 Tm
[(3)10(7)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 409.3521 519.8563 Tm
[( )-105(B)10(u)10(t )]TJ
-28.029 -1.169 Td
[(t)10(o)10( )-94(s)10(o)10(m)10(e)10( )-94(e)-13(x)10(t)10(e)10(n)10(t)10(,)10( )-94(t)10(h)10(e)10(r)10(e)10( )-94(a)10(r)10(e)10( )-94(c)10(o)10(n)10(c)10(e)-3(p)10(t)10(u)10(a)10(l)10( )-94(q)10(u)10(e)10(s)10(t)10(i)10(o)10(n)10(s)]TJ
/Span<>> BDC
19.047 0 Td
( )Tj
EMC
0.032 0 Td
(\227)Tj
/Span<>> BDC
0.99 0 Td
( )Tj
EMC
0.032 0 Td
[(w)10(h)10(a)35(t)10( )-94(d)10(o)10( )-94(w)23(e)10( )-94(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10( )-94(a)10(n )]TJ
-20.1 -1.169 Td
[(e)10(m)10(b)10(r)-15(y)40(o)10( )-15(t)10(o)10( )-15(b)10(e)10(?)]TJ
/Span<>> BDC
5.697 0 Td
( )Tj
EMC
0.032 0 Td
(\227)Tj
/Span<>> BDC
0.99 0 Td
( )Tj
EMC
0.032 0 Td
[(t)10(h)10(a)35(t)10( )-15(w)10(i)10(l)10(l)10( )-15(c)10(a)10(l)10(l)10( )-15(f)23(o)10(r)10( )-15(c)10(o)10(n)10(t)10(i)10(n)10(u)10(e)10(d)10( )-15(d)10(e)10(b)10(a)35(t)10(e)23(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 477.7648 Tm
[(In )-104(another )-104(v)23(er)-13(sion )-104(of)-28( )-104(the )-104(procedure)13(, )-104(Altered )-104(Nuclear )-104(Tr)-12(ansfer )-104(with )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 463.7343 Tm
[(Oocyte-Assisted )-126(R)31(e)-13(pro)13(g)-33(r)-12(amming )-126(\(ANT)105(-O)53(AR\), )-126(r)-12(a)25(ther )-126(than )-126(silencing )-126(or )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 449.7037 Tm
[(remo)19(ving )-44(from )-44(the )-44(nucleus )-44(the )-44(genetic )-44(elements )-44(tha)25(t )-44(are )-44(associa)25(ted )-44(with )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 435.6732 Tm
[(totipotency)121(, )-11(factor)-13(s )-11(associa)25(ted )-11(with )-11(pluripotency )-10(are )]TJ
ET
BT
/T1_3 1 Tf
12 0 0 12 330.2265 435.6732 Tm
(added)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 357.0939 435.6732 Tm
[( )-11(to )-11(the )-11(nucleus)40(. )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 421.6427 Tm
[(In )-90(this )-90(wa)29(y)121(, )-90(the )-90(procedure )-90(aims )-90(a)25(t )-90(directl)25(y )-90(re)-13(pro)13(g)-33(r)-12(amming )-90(the )-90(cell )-90(to )-90(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 407.6122 Tm
[(pluripotent )14(sta)25(te)13(. )14(In )14(essence)13(, )14(instead )14(of)-28( )14(suppressing )14(some )14(factor)-13(s )14(required )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 393.5817 Tm
[(f)13(or )-193(totipotency)121(, )-193(this )-193(procedure )-193(e)-23(xpresses )-193(onl)25(y )-193(the )-193(factor)-13(s )-193(required )-193(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 379.5511 Tm
[(pluripotency)113(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 136.1432 379.5511 Tm
( )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 140.608 379.5511 Tm
[(W)-18(hile )-122(the )-122(ANT)105(-Cdx2 )-122(technique )-122(ma)29(y )-122(be )-122(thought )-122(of)-28( )-122(as )-122(an )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 365.5206 Tm
[(alter)-40(na)25(tiv)23(e )-33(v)23(er)-13(sion )-33(of)-28( )-33(SCNT )-33(where )-33(the )-33(ar)-17(tifact )-33(crea)25(ted )-33(is )-33(not )-33(an )-33(embr)-25(y)30(o)34(, )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 351.4901 Tm
[(ANT)105(-O)53(AR )-52(is )-52(more )-52(similar )-52(to )-52(other )-52(techniques )-52(f)13(or )-52(re)-13(pro)13(g)-33(r)-12(amming )-52(adult )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 337.4596 Tm
[(cells )-67(to )-67(a )-67(pluripotent )-67(sta)25(te)13(. )-67(The )-67(mor)-12(al )-67(sta)25(tus )-67(of)-28( )-67(the )-67(ar)-17(tifact )-67(produced )-67(b)13(y )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 323.429 Tm
[(ANT)105(-O)53(AR )23(would )23(argua)13(b)17(l)25(y )23(be )23(v)23(er)-25(y )23(similar )23(to )23(an )23(induced )23(pluripotent )23(stem )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 309.3985 Tm
[(cell, )15(as )15(there )15(is )15(no )15(dispute )15(tha)25(t )15(the )15(cells )15(produced )15(would )15(ne)10(v)23(er )15(ha)20(v)23(e )15(any )15(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 295.368 Tm
[(the )29(char)-12(acteristics )29(of)-28( )29(embr)-25(y)30(os )29(\(see )29(belo)13(w )29(f)13(or )29(an )29(ethical )29(anal)25(ysis )29(of)-28( )29(induced )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 281.3375 Tm
[(pluripotent )-25(stem )-25(cells\).)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 91 267.307 Tm
[(R)41(eg)32(a)10(r)10(d)10(l)10(e)10(s)10(s)10( )-148(o)10(f)-18( )-148(t)10(h)10(e)10( )-148(p)10(a)10(r)-7(t)10(i)10(c)10(u)10(l)10(a)10(r)10( )-148(t)10(e)10(c)10(h)10(n)10(i)10(q)10(u)10(e)10(s)10( )-147(t)10(h)10(a)35(t)10( )-148(a)10(l)10(r)10(e)10(a)10(d)23(y)10( )-148(e)-13(x)10(i)10(s)10(t)10(,)10( )-147(A)10(N)10(T)10( )-148(i)10(s)10( )-147(a )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 253.2765 Tm
[(b)10(r)10(o)10(a)10(d)10( )-93(c)10(o)10(n)10(c)10(e)-3(p)10(t)10(u)10(a)10(l)10( )-93(p)10(r)10(o)10(p)10(o)10(s)10(a)10(l)10( )-93(a)10(n)10(d)10( )-93(i)10(s)10( )-93(n)10(o)10(t)10( )-93(t)10(i)10(e)10(d)10( )-93(t)10(o)10( )-93(a)10(n)10(y)10( )-93(s)10(p)10(e)10(c)10(i)10(f)10(i)10(c)10( )-93(c)10(a)10(n)10(d)10(i)10(d)10(a)35(t)10(e)10( )-93(g)10(e)10(n)10(e)10(s )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 239.2459 Tm
[(o)10(r)10( )12(f)10(a)10(c)10(t)10(o)10(r)-3(s)50(.)10( )12(A)10(s)10( )12(k)10(n)10(o)23(w)10(l)10(e)10(d)10(g)10(e)10( )12(o)10(f)-18( )12(d)10(e)20(v)33(e)10(l)10(o)10(p)10(m)10(e)10(n)10(t)10(a)10(l)10( )12(b)10(i)10(o)10(l)10(o)23(g)-30(y)10( )12(i)10(n)10(c)10(r)10(e)10(a)10(s)10(e)10(s)50(,)10( )12(i)10(t)10( )12(m)10(a)39(y)10( )12(b)10(e)10( )12(t)10(h)10(a)35(t )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 225.2154 Tm
[(a)10( )-33(n)10(u)10(m)10(b)10(e)10(r)10( )-33(o)10(f)-18( )-33(g)10(e)10(n)10(e)10(s)10( )-33(o)10(r)10( )-33(g)10(e)10(n)10(e)10( )-33(c)10(o)10(m)10(b)10(i)10(n)10(a)35(t)10(i)10(o)10(n)10(s)10( )-33(w)10(i)10(l)10(l)10( )-33(p)10(r)10(o)29(v)10(i)10(d)10(e)10( )-33(r)10(e)10(l)10(i)10(a)23(b)27(l)10(e)10( )-33(a)10(n)10(d)10( )-33(e)10(f)10(f)10(e)10(c)10(t)10(i)10(v)33(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 211.1849 Tm
[(i)10(n)10(t)10(e)10(r)-16(v)33(e)10(n)10(t)10(i)10(o)10(n)10(,)10( )28(t)10(o)23(g)10(e)10(t)10(h)10(e)10(r)10( )28(w)10(i)10(t)10(h)10( )28(s)10(o)10(l)10(i)10(d)10( )28(e)20(v)10(i)10(d)10(e)10(n)10(c)10(e)10( )28(f)23(o)10(r)10( )28(t)10(h)10(e)10( )28(k)10(i)10(n)10(d)10( )28(o)10(f)-18( )28(p)10(r)10(e)10(e)10(m)10(p)10(t)10(i)10(v)33(e)10( )28(a)10(l)10(t)10(e)10(r)-2(a)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 426.8721 211.1849 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 73 197.1544 Tm
[(t)10(i)10(o)10(n)10( )-15(e)10(n)23(v)10(i)10(s)10(i)10(o)10(n)10(e)10(d)10( )-15(i)10(n)10( )-15(t)10(h)10(e)10( )-15(e)10(t)10(h)10(i)10(c)10(a)10(l)10( )-15(a)10(r)10(g)10(u)10(m)10(e)10(n)10(t)10( )-15(i)10(n)10( )-15(s)10(u)10(p)10(p)10(o)10(r)-7(t)10( )-15(o)10(f)-18( )-15(A)10(N)10(T)120(.)]TJ
ET
BT
/T1_4 1 Tf
12 0 0 12 73 169.0933 Tm
[(E)10(m)10(b)10(r)-15(y)35(o)10(n)10(i)10(c)10( )-112(S)10(t)10(e)10(m)10( )-112(C)10(e)10(l)10(l)10( )-112(F)10(u)10(s)10(i)10(o)10(n)10(.)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 221.2693 169.0933 Tm
[( )-102(R)41(e)10(s)10(e)10(a)10(r)10(c)10(h)10(e)10(r)-3(s)10( )-102(h)10(a)30(v)33(e)10( )-102(f)23(o)10(u)10(n)10(d)10( )-102(t)10(h)10(a)35(t)10( )-103(f)10(u)10(s)10(i)10(n)10(g)10( )-103(a)10(n)10( )-103(E)10(S )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 155.0628 Tm
[(c)10(e)10(l)10(l)10( )-53(w)10(i)10(t)10(h)10( )-53(a)10(n)10( )-53(o)10(r)10(d)10(i)10(n)10(a)10(r)-15(y)10( )-53(a)10(d)10(u)10(l)10(t)10( )-53(\()10(s)10(o)10(m)10(a)35(t)10(i)10(c)10(\))10( )-53(c)10(e)10(l)10(l)10( )-53(c)10(a)10(n)10( )-53(t)10(r)-2(a)10(n)10(s)10(f)23(o)10(r)-12(m)10( )-53(t)10(h)10(e)10( )-53(a)10(d)10(u)10(l)10(t)10( )-53(c)10(e)10(l)10(l)10( )-53(i)10(n)10(t)10(o )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 141.0323 Tm
[(a)10( )-61(c)10(e)10(l)10(l)10( )-61(t)10(h)10(a)35(t)10( )-61(w)10(i)10(l)10(l)10( )-61(b)10(e)10( )-61(p)10(l)10(u)10(r)10(i)10(p)10(o)10(t)10(e)10(n)10(t)10(,)10( )-61(j)10(u)10(s)10(t)10( )-61(l)10(i)10(k)49(e)10( )-61(a)10(n)10( )-61(E)10(S)10( )-61(c)10(e)10(l)10(l)10(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 314.4752 144.3323 Tm
[(3)10(8)]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 324.2751 141.0323 Tm
[( )-61(W)-8(h)10(i)10(l)10(e)10( )-61(t)10(h)10(i)10(s)10( )-61(p)10(r)10(o)10(c)10(e)10(d)10(u)10(r)10(e )]TJ
ET
BT
/T1_2 1 Tf
12 0 0 12 73 127.0018 Tm
[(d)10(o)10(e)10(s)10( r)10(e)10(q)10(u)10(i)10(r)10(e)10( t)10(h)10(e)10( u)10(s)10(e)10( o)10(f)-18( E)10(S)10( c)10(e)10(l)10(l)10(s)50(,)10( i)10(t)10( c)10(o)10(u)10(l)10(d)10( a)10(l)10(l)10(o)23(w)10( f)23(o)10(r)10( t)10(h)10(e)10( c)10(r)10(e)10(a)35(t)10(i)10(o)10(n)10( o)10(f)-18( a)10( l)10(i)10(m)10(i)10(t)10(l)10(e)10(s)10(s )]TJ
ET
Q
endstream
endobj
45 0 obj
<<
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>>
stream
q
0 0 504 792 re
W n
q
-504 864 1008 -936 re
W n
1 1 1 rg
0 i
/RelativeColorimetric ri
/GS0 gs
72 126.002 360 557.998 re
f*
0 0 0 RG
1 w 4 M 0 j 0 J []0 d
/GS1 gs
72 108 m
432 108 l
S
72 701.5 m
432 701.5 l
S
/GS0 gs
72 75.735 143.98 14.265 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 11 0 0 11 73 80.9261 Tm
[(1)-5(0)-5(8)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
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BT
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ET
BT
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[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
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ET
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[(i)10(n)10(g)10( )-145(s)10(t)10(e)10(m)10( )-145(c)10(e)10(l)10(l)10( )-145(l)10(i)10(n)10(e)10(s)10( )-145(a)10(l)10(o)10(n)10(e)23(.)10( )-145(H)10(o)23(w)23(e)20(v)33(e)10(r)76(,)10( )-145(t)10(h)10(i)10(s)10( )-145(p)10(r)10(o)10(p)10(o)10(s)10(a)10(l)10( )-145(f)10(a)10(c)10(e)10(s)10( )-145(d)10(i)10(f)10(f)10(i)10(c)10(u)10(l)10(t)10( )-145(t)10(e)10(c)10(h)10(n)10(i)10(c)10(a)10(l )]TJ
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ET
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ET
BT
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ET
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(-)Tj
ET
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[(onic )-67(stem )-67(cells)40(. )-67(And )-67(lik)39(e )-67(SCNT)105(-crea)25(ted )-67(cells)40(, )-67(and )-67(in )-67(contr)-12(ast )-67(to )-67(ES )-67(cells )]TJ
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[(e)-23(xtr)-12(acted )-128(from )-128(unused )-128(IVF )-128(embr)-25(y)30(os)40(, )-128(iPS )-128(cells )-128(deriv)23(ed )-128(from )-128(a )-128(pa)25(tient\222s )]TJ
ET
BT
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[(system. )-101(But )-101(unlik)39(e )-101(SCNT)119(, )-101(the )-101(procedure )-101(f)13(or )-101(crea)25(ting )-101(iPS )-101(cells )-101(does )-101(not )]TJ
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ET
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ET
BT
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ET
BT
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ET
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ET
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ET
BT
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ET
BT
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ET
BT
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ET
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ET
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(-)Tj
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[(ity)113(.)]TJ
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ET
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ET
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10 0 0 10 308.6118 590.3649 Tm
[( )-25(and )-25(De)10(v)23(elopmental )-25(P)56(otential )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 578.0691 Tm
[(of)-28( )-25(Inner )-25(and )-25(Outer )-25(Blastomeres )-25(of)-28( )-25(16- )-25(and )-25(32-Cell )-25(Embr)-25(y)30(os)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 328.4564 578.0691 Tm
[(De)8(velopmental )-24(Biolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 415.2003 578.0691 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 565.7733 Tm
[(322, )-25(no)34(. )-25(1 )-25(\(2008\): )-25(133-144.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 547.7174 Tm
[(18. )-25(Douglas )-25(A. )-25(Melton )-25(and )-25(Chad )-25(Co)13(w)13(en, )-25(\223\221Stemness\222: )-25(Definitions)40(, )-25(Criteria, )-25(and )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 535.4215 Tm
[(Standards)40(,\224)-13( )-25(in )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 132.709 535.4215 Tm
[(Essentials )-24(of)-42( )-24(Stem )-24(Cell )-24(Biolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 250.5268 535.4215 Tm
(,)Tj
ET
BT
/T1_3 1 Tf
10 0 0 10 252.7168 535.4215 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 255.4117 535.4215 Tm
[(2nd )-25(ed., )-25(ed. )-25(R)31(ober)-17(t )-25(Lanza )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 362.7803 535.4215 Tm
[(et )-24(al)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 378.905 535.4215 Tm
(. )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 523.1257 Tm
[(\(Burlington, )-25(Mass)40(.: )-25(Else)10(vier )-25(Academic )-25(Press)40(, )-25(2009\), )-25(xxiii.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 505.0698 Tm
[(19. )-25(PCBE, )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 118.1996 505.0698 Tm
[(Alter)-21(na)1(ti)8(ve )-24(Sour)27(ces )-24(of)-42( )-24(Pluripotent )-24(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 288.0815 505.0698 Tm
[(, )-25(29.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 487.014 Tm
[(20. )-25(F)61(or )-25(a )-25(discussion )-25(of)-28( )-25(the )-25(scientific )-25(details )-25(of)-28( )-25(this )-25(procedure)13(, )-25(fir)-13(st )-25(proposed )-25(b)13(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 474.7181 Tm
[(W)10(ither)-13(spoon )-25(Council )-25(chair)-22(man )-25(Donald )-25(W)169(. )-25(Landr)-25(y )-25(and )-25(his )-25(Columbia )-25(Univ)23(er)-13(sity )-25(col)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 415.9752 474.7181 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 462.4223 Tm
[(lea)14(gue )-25(Ho)13(ward )-25(A. )-25(Zuck)39(er)66(, )-25(see )-25(PCBE, )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 227.6782 462.4223 Tm
[(Alter)-21(na)1(ti)8(ve )-24(Sour)27(ces )-24(of)-42( )-24(Pluripotent )-24(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 397.5602 462.4223 Tm
[(, )-25(8-)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 450.1264 Tm
[(23. )-25(See )-25(also )-25(Donald )-25(W)169(. )-25(Landr)-25(y )-25(and )-25(Ho)13(ward )-25(A. )-25(Zuck)39(er)66(, )-25(\223Embr)-25(y)30(onic )-25(Dea)25(th )-25(and )-25(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 437.8306 Tm
[(Crea)25(tion )-25(of)-28( )-25(Human )-25(Embr)-25(y)30(onic )-25(Stem )-25(Cells)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 254.5173 437.8306 Tm
[(T)29(he )-24(J)21(our)-21(nal )-24(of)-42( )-24(Clinical )-24(In)22(vestig)15(a)1(tion)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 394.9148 437.8306 Tm
[( )-25(114, )-25(no)34(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 425.5347 Tm
[(9 )-25(\(2004\): )-25(1184-1186.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 407.4789 Tm
[(21. )-25(Donald )-25(W)169(. )-25(Landr)-25(y )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 167.249 407.4789 Tm
[(et )-24(al)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 183.3736 407.4789 Tm
[(., )-25(\223Hypocellularity )-25(and )-25(Absence )-25(of)-28( )-25(Compaction )-25(as )-25(Criteria )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 395.183 Tm
[(f)13(or )-25(Embr)-25(y)30(onic )-25(Dea)25(th,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 168.5587 395.183 Tm
[(Re)1(g)-13(ener)55(a)1(ti)8(ve )-24(Medicine)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 253.3324 395.183 Tm
[( )-25(1, )-25(no)34(. )-25(3 )-25(\(2006\): )-25(367-371.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 377.1271 Tm
[(22. )-25(Sv)23(etlana )-25(Ga)20(vrilo)19(v )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 163.9791 377.1271 Tm
[(et )-24(al)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 180.1038 377.1271 Tm
[(., )-25(\223Deriv)13(a)25(tion )-25(of)-28( )-25(T)30(wo )-25(Ne)10(w )-25(Human )-25(Embr)-25(y)30(onic )-25(Stem )-25(Cell )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 364.8313 Tm
[(Lines )-25(from )-25(Non)13(via)13(b)17(le )-25(Human )-25(Embr)-25(y)30(os)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 242.658 364.8313 Tm
[(Stem )-24(Cells )-24(Inter)-21(na)1(tional)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 334.1662 364.8313 Tm
[( )-25(2011, )-25(ar)-17(ticle )-25(ID )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 352.5354 Tm
(765378.)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 334.4796 Tm
[(23. )-25(Xin )-25(Zhang )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 135.4194 334.4796 Tm
[(et )-24(al)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 151.544 334.4796 Tm
[(., )-25(\223Deriv)13(a)25(tion )-25(of)-28( )-25(Human )-25(Embr)-25(y)30(onic )-25(Stem )-25(Cells )-25(from )-25(De)10(v)23(eloping )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 322.1837 Tm
[(and )-25(Ar)-13(rested )-25(Embr)-25(y)30(os)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 174.6084 322.1837 Tm
[(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 213.8626 322.1837 Tm
[( )-25(24, )-25(no)34(. )-25(12 )-25(\(2006\): )-25(2669-2676.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 304.1279 Tm
[(24. )-25(PCBE, )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 118.1996 304.1279 Tm
[(Alter)-21(na)1(ti)8(ve )-24(Sour)27(ces )-24(of)-42( )-24(Pluripotent )-24(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 288.0815 304.1279 Tm
[(, )-25(14.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 286.072 Tm
[(2)3(5)3(.)3( )-22(T)3(h)3(e)3( )-22(f)3(i)3(r)-10(s)3(t)3( )-22(s)3(u)3(c)3(c)3(e)3(s)3(s)3(f)3(u)3(l)3( )-22(a)28(t)3(t)3(e)3(m)3(p)3(t)3( )-22(t)3(o)3( )-22(c)3(l)3(o)3(n)3(e)3( )-22(h)3(u)3(m)3(a)3(n)3( )-22(e)3(m)3(b)3(r)-22(y)33(o)3(s)3( )-22(u)3(s)3(i)3(n)3(g)3( )-22(S)3(C)3(N)3(T)3( )-22(w)3(a)3(s)3( )-22(r)3(e)-10(p)3(o)3(r)-14(t)3(e)3(d)3( )-22(i)3(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 273.7762 Tm
[(A)3(n)3(d)3(r)3(e)13(w)3( )-22(J)85(.)3( )-22(F)17(r)3(e)3(n)3(c)3(h)3( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 147.5993 273.7762 Tm
[(e)3(t)3( )-21(a)3(l)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 163.574 273.7762 Tm
[(.)3(,)3( )-22(\223)3(D)3(e)13(v)26(e)3(l)3(o)3(p)3(m)3(e)3(n)3(t)3( )-22(o)3(f)-25( )-22(H)3(u)3(m)3(a)3(n)3( )-22(C)3(l)3(o)3(n)3(e)3(d)3( )-22(B)3(l)3(a)3(s)3(t)3(o)3(c)3(y)3(s)3(t)3(s)3( )-22(F)64(o)3(l)3(l)3(o)16(w)3(i)3(n)3(g)3( )-22(S)3(o)3(m)3(a)28(t)3(i)3(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 261.4803 Tm
[(C)3(e)3(l)3(l)3( )-22(N)3(u)3(c)3(l)3(e)3(a)3(r)3( )-22(T)3(r)-9(a)3(n)3(s)3(f)3(e)3(r)3( )-22(w)3(i)3(t)3(h)3( )-22(A)3(d)3(u)3(l)3(t)3( )-22(F)3(i)3(b)3(r)3(o)3(b)20(l)3(a)3(s)3(t)3(s)43(,)3(\224)-10( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 265.9072 261.4803 Tm
[(S)3(t)3(e)3(m)3( )-21(C)3(e)3(l)3(l)3(s)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 304.8615 261.4803 Tm
[( )-22(2)3(6)3(,)3( )-22(n)3(o)37(.)3( )-22(2)3( )-22(\()3(2)3(0)3(0)3(8)3(\))3(:)3( )-22(4)3(8)3(5)3(-)3(4)3(9)3(3)3(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 249.1844 Tm
[(W)-15(h)3(i)3(l)3(e)3( )-22(t)3(h)3(e)3( )-22(a)3(u)3(t)3(h)3(o)3(r)-10(s)3( )-22(d)3(i)3(d)3( )-22(m)3(a)3(n)3(a)17(g)3(e)3( )-22(t)3(o)3( )-22(s)3(u)3(c)3(c)3(e)3(s)3(s)3(f)3(u)3(l)3(l)28(y)3( )-22(c)3(r)3(e)3(a)28(t)3(e)3( )-22(a)3( )-22(h)3(u)3(m)3(a)3(n)3( )-22(e)3(m)3(b)3(r)-22(y)33(o)37(,)3( )-22(t)3(h)3(e)3(y)3( )-22(w)16(e)3(r)3(e)3( )-22(u)3(n)3(a)16(b)20(l)3(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 236.8886 Tm
[(t)3(o)3( )-22(d)3(e)3(r)3(i)3(v)26(e)3( )-22(a)3(n)3( )-22(e)3(m)3(b)3(r)-22(y)33(o)3(n)3(i)3(c)3( )-22(s)3(t)3(e)3(m)3( )-22(c)3(e)3(l)3(l)3( )-22(l)3(i)3(n)3(e)3( )-22(f)3(r)3(o)3(m)3( )-22(i)3(t)3(.)3( )-22(P)3(r)3(e)13(v)3(i)3(o)3(u)3(s)3(l)28(y)124(,)3( )-22(H)3(w)3(a)3(n)3(g)3( )-22(W)105(o)3(o)3( )-22(S)3(u)3(k)3( )-22(h)3(a)3(d)3( )-22(c)3(l)3(a)3(i)3(m)3(e)3(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 224.5927 Tm
[(t)3(o)3( )-22(h)3(a)23(v)26(e)3( )-22(d)3(e)3(r)3(i)3(v)26(e)3(d)3( )-22(p)3(a)28(t)3(i)3(e)3(n)3(t)3(-)3(s)3(p)3(e)3(c)3(i)3(f)3(i)3(c)3( )-22(E)3(S)3( )-22(c)3(e)3(l)3(l)3(s)3( )-22(f)3(r)3(o)3(m)3( )-22(c)3(l)3(o)3(n)3(e)3(d)3( )-22(b)20(l)3(a)3(s)3(t)3(o)3(c)3(y)3(s)3(t)3(s)43(,)3( )-22(b)17(u)3(t)3( )-22(i)3(t)3( )-22(w)3(a)3(s)3( )-22(l)3(a)28(t)3(e)3(r)3( )-22(s)3(h)3(o)16(w)3(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 212.2969 Tm
[(t)3(h)3(a)28(t)3( )-22(h)3(e)3( )-22(h)3(a)3(d)3( )-22(f)3(a)16(b)3(r)3(i)3(c)3(a)28(t)3(e)3(d)3( )-22(h)3(i)3(s)3( )-22(r)3(e)3(s)3(u)3(l)3(t)3(s)43(.)3( )-22(H)3(w)3(a)3(n)3(g)3( )-22(W)105(o)3(o)3( )-22(S)3(u)3(k)3( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 281.7278 212.2969 Tm
[(e)3(t)3( )-21(a)3(l)3(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 299.8624 212.2969 Tm
[(,)3( )-22(\223)3(P)40(a)28(t)3(i)3(e)3(n)3(t)3(-)3(s)3(p)3(e)3(c)3(i)3(f)3(i)3(c)3( )-22(E)3(m)3(b)3(r)-22(y)33(o)3(n)3(i)3(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 200.001 Tm
[(S)3(t)3(e)3(m)3( )-22(C)3(e)3(l)3(l)3(s)3( )-22(D)3(e)3(r)3(i)3(v)26(e)3(d)3( )-22(f)3(r)3(o)3(m)3( )-22(H)3(u)3(m)3(a)3(n)3( )-22(S)3(C)3(N)3(T)3( )-22(B)3(l)3(a)3(s)3(t)3(o)3(c)3(y)3(s)3(t)3(s)43(,)3(\224)-10( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 292.0572 200.001 Tm
[(S)3(c)3(i)3(e)3(n)3(c)3(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 318.5066 200.001 Tm
[( )-22(3)3(0)3(8)3(,)3( )-22(n)3(o)37(.)3( )-22(5)3(7)3(2)3(9)3( )-22(\()3(2)3(0)3(0)3(5)3(\))3(: )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 187.7052 Tm
[(1)3(7)3(7)3(7)3(-)3(1)3(7)3(8)3(3)3(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 169.6493 Tm
[(26. )-25(Scott )-25(No)13(g)10(gle )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 144.6894 169.6493 Tm
[(et )-24(al.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 163.004 169.6493 Tm
[(, )-25(\223Human )-25(Oocytes )-25(R)31(e)-13(pro)13(g)-33(r)-12(am )-25(Soma)25(tic )-25(Cells )-25(to )-25(a )-25(Pluripotent )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 157.3535 Tm
[(Sta)25(te)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 101.9695 157.3535 Tm
[(Na)1(tur)20(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 128.7394 157.3535 Tm
[( )-25(478, )-25(no)34(. )-25(7367 )-25(\(2011\): )-25(70-77.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 139.2976 Tm
[(27. )-25(Na)25(tional )-25(Conference )-25(of)-28( )-25(Sta)25(te )-25(Le)-10(gisla)25(tor)-13(s)40(, )-25(\223Human )-25(Cloning )-25(La)22(ws)40(,\224)-13( )-25(http)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 377.3954 139.2976 Tm
(:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 378.8353 139.2976 Tm
[(/)180(/)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 385.2353 139.2976 Tm
[(www)109(.ncsl.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 127.0018 Tm
[(org/IssuesR)31(esearch/Health/HumanCloningLa)22(ws/ta)13(bid/14284/Default.aspx.)]TJ
ET
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BT
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[(1)-5(1)-5(2)-5( )-30(~)-5( )-30(T)5(h)-5(e)-5( )-30(N)-5(e)-5(w)-5( )-30(A)53(t)-5(l)33(a)-5(n)-5(t)-5(i)-5(s)]TJ
ET
BT
/T1_0 1 Tf
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[(W)63(i)-5(t)-5(h)-5(e)-5(r)-5(s)-5(p)8(o)-17(o)-5(n)-5( )-30(C)-5(o)-5(u)-5(n)-5(c)-5(i)-5(l)-5( )-30(o)-5(n)-5( )-30(E)12(t)-5(h)-5(i)-5(c)-5(s)-5( )-30(a)-5(n)-5(d)-5( )-30(t)-5(h)-5(e)-5( )-30(I)-5(n)-5(t)-5(e)-5(g)-5(r)-5(i)-5(t)20(y)-5( )-30(o)-5(f)-5( )-30(S)-5(c)-5(i)-5(e)-5(n)-5(c)-5(e)]TJ
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11.3 0 0 11.3 73 48.125 Tm
[(C)50(o)50(p)50(y)50(r)50(i)68(g)50(h)68(t)50( )7(2)50(0)50(1)50(2)50(.)50( )7(A)50(l)50(l)50( )7(r)50(i)68(g)50(h)68(t)50(s)50( )7(r)68(e)50(s)50(e)50(r)50(v)50(e)50(d)68(.)50( )7(S)50(e)50(e)50( )]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 236.9333 48.125 Tm
[(w)50(w)50(w)123(.)50(T)50(h)68(e)50(N)68(e)50(w)50(A)68(t)50(l)50(a)50(n)68(t)50(i)50(s)68(.)50(c)50(o)]TJ
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 332.4848 48.125 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
11.3 0 0 11.3 340.0782 48.125 Tm
[( )7(f)68(o)50(r)50( )7(m)68(o)50(r)68(e)50( )7(i)50(n)50(f)68(o)50(r)50(m)68(a)50(t)50(i)68(o)50(n)50(.)]TJ
ET
Q
1 1 1 rg
0 i
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72 126.004 360 557.996 re
f*
0 0 0 rg
/GS1 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 10 0 0 10 73 675.66 Tm
[(28. )-25(Y)110(oung )-25(Chung)]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 144.8994 675.66 Tm
[( )-24(et )-24(al)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 163.719 675.66 Tm
[(., )-25(\223R)31(e)-13(pro)13(g)-33(r)-12(amming )-25(of)-28( )-25(Human )-25(Soma)25(tic )-25(Cells )-25(Using )-25(Human )-25(and )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 663.5426 Tm
[(Animal )-25(Oocytes)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 146.7787 663.5426 Tm
[(Cloning )-24(and )-24(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 235.4719 663.5426 Tm
[( )-25(11, )-25(no)34(. )-25(2 )-25(\(2009\): )-25(213-223. )-25(See )-25(Appendix )-25(A )-25(f)13(or )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 651.4252 Tm
[(more )-25(details )-25(on )-25(the )-25(technical )-25(feasibility )-25(of)-28( )-25(this )-25(procedure)13(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 633.5477 Tm
[(29. )-25(United )-25(Kingdom, )-25(P)37(arliament, )-25(Human )-25(F)61(er)-17(tiliza)25(tion )-25(and )-25(Embr)-25(y)30(olo)13(g)-40(y )-25(Act )-25(\(2008\), )-25(c)22(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 621.4302 Tm
[(22, )-25(http)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 105.0298 621.4302 Tm
(:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 106.4697 621.4302 Tm
[(/)180(/)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 112.8697 621.4302 Tm
[(www)109(.le)-10(gisla)25(tion.g)10(o)19(v)117(.uk/ukpg)22(a/2008/22/contents)40(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 603.5528 Tm
[(30. )-25(A )-25(detailed )-25(re)10(vie)10(w )-25(of)-28( )-25(the )-25(scientific )-25(issues )-25(sur)-13(rounding )-25(ANT )-25(appear)-13(s )-25(in )-25(Appendix )-25(A.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 585.6753 Tm
[(31. )-25(PCBE, )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 118.1996 585.6753 Tm
[(Alter)-21(na)1(ti)8(ve )-24(Sour)27(ces )-24(of)-42( )-24(Pluripotent )-24(Stem )-24(Cells)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 288.0815 585.6753 Tm
[(, )-25(36-50.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 567.7979 Tm
[(32. )-25(W)10(illiam )-25(Hurlb)14(ut, )-25(member )-25(of)-28( )-25(the )-25(W)10(ither)-13(spoon )-25(Council )-25(and )-25(the )-25(author )-25(of)-28( )-25(the )-25(ANT )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 555.6804 Tm
[(proposal, )-25(opposes )-25(the )-25(use )-25(of)-28( )-25(potentiall)25(y )-25(dangerous )-25(supero)19(vula)25(tion )-25(techniques )-25(to )-25(pro)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 415.8552 555.6804 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 543.5629 Tm
[(cure )-25(human )-25(e)-10(g)10(g )-25(cells )-25(f)13(or )-25(the )-25(sole )-25(and )-25(specific )-25(objectiv)23(e )-25(of)-28( )-25(obtaining )-25(e)-10(g)10(gs )-25(f)13(or )-25(research )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 531.4454 Tm
[(pur)-13(poses)40(, )-25(arguing )-25(f)13(or )-25(the )-25(use )-25(of)-28( )-25(alter)-40(na)25(tiv)23(e )-25(sources )-25(of)-28( )-25(human )-25(e)-10(g)10(g )-25(cells)40(. )-25(See )-25(W)10(illiam )-25(B)14(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 519.328 Tm
[(Hurlb)14(ut, )-25(\223F)14(r)-12(aming )-25(the )-25(Future: )-25(Embr)-25(y)30(onic )-25(Stem )-25(Cells)40(, )-25(Ethics )-25(and )-25(the )-25(Emerging )-25(Er)-12(a )-25(of)-28( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 507.2105 Tm
[(De)10(v)23(elopmental )-25(Biolo)13(g)-40(y)121(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 176.7384 507.2105 Tm
[(P)36(edia)1(tric )-24(Resear)27(c)14(h)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 246.3524 507.2105 Tm
[( )-25(59, )-25(no)34(. )-25(4 )-25(\(2006\): )-25(4R-12R.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 489.3331 Tm
[(33. )-25(Ha)25(thaitip )-25(Sritanaudomchai )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 200.3884 489.3331 Tm
[(et )-24(al.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 218.703 489.3331 Tm
[(, )-25(\223CDX2 )-25(in )-25(the )-25(F)61(or)-22(ma)25(tion )-25(of)-28( )-25(the )-25(Trophectoder)-22(m )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 477.2156 Tm
[(Linea)14(ge )-25(in )-25(Prima)25(te )-25(Embr)-25(y)30(os)40(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 199.1281 477.2156 Tm
[(De)8(velopmental )-24(Biolo)13(g)-71(y)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 285.8719 477.2156 Tm
[( )-25(335 )-25(\(2009\): )-25(179-187.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 459.3381 Tm
[(34. )-25(K)-10(alla)29(y)17(anee )-25(Cha)22(w)13(engsaksophak )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 217.1382 459.3381 Tm
[(et )-24(al.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 235.4529 459.3381 Tm
[(, )-25(\223Cdx2 )-25(is )-25(essential )-25(f)13(or )-25(axial )-25(elong)22(a)25(tion )-25(in )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 447.2206 Tm
[(mouse )-25(de)10(v)23(elopment,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 162.2485 447.2206 Tm
[(Pr)13(oceedings )-24(of)-42( )-24(the )-24(Na)1(tional )-24(Academ)-13(y )-24(of)-42( )-24(Sciences)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 345.8951 447.2206 Tm
[( )-25(101, )-25(no)34(. )-25(20 )-25(\(2004\).)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 429.3431 Tm
(35. )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 87.94 429.3431 Tm
[(G)2(u)2(a)2(n)2(g)2(m)2(i)2(n)2(g)2( )-23(W)69(u)2( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 156.9792 429.3431 Tm
[(e)2(t)2( )-22(a)2(l)2(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 175.1738 429.3431 Tm
[(,)2( )-23(\223)2(I)2(n)2(i)2(t)2(i)2(a)27(t)2(i)2(o)2(n)2( )-23(o)2(f)-26( )-23(T)2(r)2(o)2(p)2(h)2(e)2(c)2(t)2(o)2(d)2(e)2(r)-20(m)2( )-23(L)2(i)2(n)2(e)2(a)16(g)2(e)2( )-23(S)2(p)2(e)2(c)2(i)2(f)2(i)2(c)2(a)27(t)2(i)2(o)2(n)2( )-23(i)2(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 417.2257 Tm
[(M)2(o)2(u)2(s)2(e)2( )-23(E)2(m)2(b)2(r)-23(y)32(o)2(s)2( )-23(i)2(s)2( )-23(I)2(n)2(d)2(e)-11(p)2(e)2(n)2(d)2(e)2(n)2(t)2( )-23(o)2(f)-26( )-23(C)2(d)2(x)2(2)2(,)2(\224)-11( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 246.8973 417.2257 Tm
[(D)2(e)10(v)2(e)2(l)2(o)2(p)2(m)2(e)2(n)2(t)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 294.5265 417.2257 Tm
[( )-23(1)2(3)2(7)2(,)2( )-23(n)2(o)36(.)2( )-23(2)2(4)2( )-23(\()2(2)2(0)2(1)2(0)2(\))2(:)2( )-23(4)2(1)2(5)2(9)2(-)2(4)2(1)2(6)2(9)2(. )]TJ
ET
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/T1_2 1 Tf
10 0 0 10 73 405.1082 Tm
[(A)2(c)2(c)2(o)2(r)2(d)2(i)2(n)2(g)2( )-23(t)2(o)2( )-23(t)2(h)2(i)2(s)2( )-23(p)2(a)2(p)2(e)2(r)68(,)2( )-23(C)2(d)2(x)2(2)2( )-23(h)2(a)2(s)2( )-23(a)2( )-23(v)25(e)2(r)-23(y)2( )-23(i)2(m)2(p)2(o)2(r)-15(t)2(a)2(n)2(t)2( )-23(r)2(o)2(l)2(e)15(,)2( )-23(b)16(u)2(t)2( )-23(i)2(s)2( )-23(n)2(o)2(t)2( )-23(a)15(b)2(s)2(o)2(l)2(u)2(t)2(e)2(l)27(y)2( )-23(n)2(e)2(c)]TJ
ET
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/T1_2 1 Tf
10 0 0 10 405.7658 405.1082 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 392.9908 Tm
[(e)2(s)2(s)2(a)2(r)-23(y)2( )-23(f)15(o)2(r)2( )-23(t)2(h)2(e)2( )-23(d)2(i)2(f)2(f)2(e)2(r)2(e)2(n)2(t)2(i)2(a)27(t)2(i)2(o)2(n)2( )-23(o)2(f)-26( )-23(t)2(h)2(e)2( )-23(t)2(r)2(o)2(p)2(h)2(e)2(c)2(t)2(o)2(d)2(e)2(r)-20(m)2(,)2( )-23(s)2(u)2(g)12(g)2(e)2(s)2(t)2(i)2(n)2(g)2( )-23(t)2(h)2(a)27(t)2( )-23(C)2(d)2(x)2(2)2(-)2(d)2(e)2(f)2(i)2(c)2(i)2(e)2(n)2(t )]TJ
ET
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/T1_2 1 Tf
10 0 0 10 73 380.8733 Tm
[(e)2(m)2(b)2(r)-23(y)32(o)2(s)2( )-23(d)2(o)2( )-23(r)2(e)2(t)2(a)2(i)2(n)2( )-23(s)2(o)2(m)2(e)2( )-23(o)2(f)-26( )-23(t)2(h)2(e)2( )-23(i)2(m)2(p)2(o)2(r)-15(t)2(a)2(n)2(t)2( )-23(d)2(e)12(v)25(e)2(l)2(o)2(p)2(m)2(e)2(n)2(t)2(a)2(l)2( )-23(c)2(a)2(p)2(a)2(c)2(i)2(t)2(i)2(e)2(s)2( )-23(t)2(h)2(a)27(t)2( )-23(a)2(r)2(e)2( )-23(c)2(h)2(a)2(r)-10(a)2(c)]TJ
ET
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/T1_2 1 Tf
10 0 0 10 406.5446 380.8733 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 368.7558 Tm
[(t)2(e)2(r)2(i)2(s)2(t)2(i)2(c)2( )-23(o)2(f)-26( )-23(n)2(o)2(r)-20(m)2(a)2(l)2( )-23(e)2(m)2(b)2(r)-23(y)32(o)2(s)42(.)2( )-23(A)2( )-23(2)2(0)2(0)2(6)2( )-23(p)2(a)2(p)2(e)2(r)2( )-23(p)2(u)2(b)19(l)2(i)2(s)2(h)2(e)2(d)2( )-23(i)2(n)2( )]TJ
ET
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10 0 0 10 295.4071 368.7558 Tm
[(S)2(c)2(i)2(e)2(n)2(c)2(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 321.9265 368.7558 Tm
[( )-23(c)2(l)2(a)2(i)2(m)2(e)2(d)2( )-23(t)2(h)2(a)27(t)2( )-23(C)2(d)2(x)2(2)2( )-23(w)2(a)2(s )]TJ
ET
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/T1_2 1 Tf
10 0 0 10 73 356.6383 Tm
[(r)2(e)2(s)2(p)2(o)2(n)2(s)2(i)2(b)19(l)2(e)2( )-23(f)15(o)2(r)2( )-23(s)2(p)2(e)2(c)2(i)2(f)2(y)2(i)2(n)2(g)2( )-23(t)2(r)2(o)2(p)2(h)2(e)2(c)2(t)2(o)2(d)2(e)2(r)-20(m)2( )-23(c)2(e)2(l)2(l)2(s)2( )-23(f)2(r)2(o)2(m)2( )-23(t)2(h)2(e)2( )-23(2)2(-)2(c)2(e)2(l)2(l)2( )-23(s)2(t)2(a)16(g)2(e)15(,)2( )-23(b)16(u)2(t)2( )-23(t)2(h)2(e)2( )-23(l)2(e)2(a)2(d)2( )-23(a)2(u)2(t)2(h)2(o)2(r )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 344.5209 Tm
[(o)2(f)-26( )-23(t)2(h)2(e)2( )-23(s)2(t)2(u)2(d)15(y)123(,)2( )-23(K)-8(a)2(u)2(s)2(h)2(i)2(k)2( )-23(D)2(e)2(b)36(,)2( )-23(w)2(a)2(s)2( )-23(l)2(a)27(t)2(e)2(r)2( )-23(f)15(o)2(u)2(n)2(d)2( )-23(t)2(o)2( )-23(h)2(a)22(v)25(e)2( )-23(f)2(a)15(b)2(r)2(i)2(c)2(a)27(t)2(e)2(d)2( )-23(d)2(a)27(t)2(a)2(,)2( )-23(l)2(e)2(a)2(d)2(i)2(n)2(g)2( )-23(t)2(o)2( )-23(t)2(h)2(e)2( )-23(r)2(e)2(t)2(r)-10(a)2(c)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 427.0852 344.5209 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73 332.4034 Tm
[(t)2(i)2(o)2(n)2( )-23(o)2(f)-26( )-23(t)2(h)2(e)2( )-23(p)2(a)2(p)2(e)2(r)68(.)2( )-23(K)-8(a)2(u)2(s)2(h)2(i)2(k)2( )-23(D)2(e)2(b)2( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 200.1683 332.4034 Tm
[(e)2(t)2( )-22(a)2(l)2(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 218.3629 332.4034 Tm
[(,)2( )-23(\223)2(C)2(d)2(x)2(2)2( )-23(G)2(e)2(n)2(e)2( )-23(E)2(x)2(p)2(r)2(e)2(s)2(s)2(i)2(o)2(n)2( )-23(a)2(n)2(d)2( )-23(T)2(r)2(o)2(p)2(h)2(e)2(c)2(t)2(o)2(d)2(e)2(r)-20(m )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 320.2859 Tm
[(L)2(i)2(n)2(e)2(a)16(g)2(e)2( )-23(S)2(p)2(e)2(c)2(i)2(f)2(i)2(c)2(a)27(t)2(i)2(o)2(n)2( )-23(i)2(n)2( )-23(M)2(o)2(u)2(s)2(e)2( )-23(E)2(m)2(b)2(r)-23(y)32(o)2(s)42(,)2(\224)-11( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 247.4071 320.2859 Tm
[(S)2(c)2(i)2(e)2(n)2(c)2(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 273.9265 320.2859 Tm
[( )-23(3)2(1)2(1)2(,)2( )-23(n)2(o)36(.)2( )-23(5)2(7)2(6)2(3)2( )-23(\()2(2)2(0)2(0)2(6)2(\))2(:)2( )-23(9)2(9)2(2)2(-)2(9)2(9)2(6)2(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 302.4084 Tm
[(36. )-25(See )-25(the )-25(2005 )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 142.8595 302.4084 Tm
(Communio )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 186.1839 302.4084 Tm
[(deba)25(te )-25(on )-25(ANT)119(, )-25(a)20(v)13(aila)13(b)17(le )-25(a)25(t )-25(http)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 318.5826 302.4084 Tm
(:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 320.0226 302.4084 Tm
[(/)180(/)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 326.4225 302.4084 Tm
[(www)109(.communio-icr)66(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 290.291 Tm
[(com/ant.htm. )-25(See )-25(in )-25(par)-17(ticular )-25(Adrian )-25(J)82(. )-25(W)94(alk)39(er)66(, )-25(\223)127(Altered )-25(Nuclear )-25(Tr)-12(ansfer: )-25(A )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73 278.1735 Tm
[(Philosophical )-25(Critique)13(,\224)-13( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 172.4585 278.1735 Tm
(Communio)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 213.0879 278.1735 Tm
[( )-25(31, )-25(W)10(inter )-25(2004, )-25(http)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 305.3473 278.1735 Tm
(:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 306.7872 278.1735 Tm
[(/)180(/)]TJ
ET
BT
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